Screening methods used to identify compounds that modulate a response of a cell to ultraviolet radiation exposure

ABSTRACT

The cellular response to ultraviolet radiation exposure has been characterized on the molecular level through the use of high density gene array technology. Nucleic acid molecules and protein molecules, the expression of which are repressed or induced in response to ultraviolet radiation exposure, are identified according to a temporal pattern of altered expression post ultraviolet radiation exposure. Methods are disclosed that utilized these ultraviolet radiation-regulated molecules as markers for ultraviolet radiation exposure. Other screening methods of the invention are designed for the identification of compounds that modulate the response of a cell to ultraviolet radiation exposure. The invention also provides compositions useful for drug screening or pharmaceutical purposes.

FIELD OF THE INVENTION

[0001] The invention relates to the fields of molecular biology, cellbiology and dermatology. More specifically, the invention relates to themolecular events underlying the response of a cell to exposure toultraviolet radiation and, thereby, to the molecular processescontributing towards the development of premature tissue aging andcancer.

BACKGROUND OF THE INVENTION

[0002] Human skin is relatively simple tissue that performs varied andcomplex functions such as temperature regulation, the processing ofvitamin D precursors, the excretion of urea, and the storage ofcarbohydrate and fat. The skin contains many unique cell types to effectits specialized functions. On a gross level, the skin consists ofepidermis and a basement membrane zone overlying dermis and subcutaneousfat. Skin tissue arises embryologically from ectoderm, neuroectoderm,and mesoderm. The epidermis, hair and sebaceous glands (pilosebaceousunits), sweat glands (eccrine units), and nails are all ectodermalderivatives. Neuroectodermal derivatives include melanocytes, nerves,and special neuroreceptors, while mesenchymal derivatives includecollagen, reticulin and elastic fibers, blood vessels, muscle, and fat.Probably the most important function of the skin is that of protection;the skin produces a scaling surface impermeable to many substances, hasan elaborate network of immunocompetent cells constantly monitoring forpotentially harmful antigens, and produces pigment which filters outharmful rays of ultraviolet radiation from the sun.

[0003] Ultraviolet radiation is a major environmental damaging agentcausing photodamage to the skin, including cutaneous malignancies andphotoaging (see generally, Fitzpatrick's Dermatology in Medicine, FifthEdition, I. M. Freedberg, et al., eds., McGraw-Hill (1999)). Clinicalfeatures of photoaging include wrinkles, skin laxity and coarseness, andpigmentation disorders. While histological manifestations of photoaginghave been well known for some time, the molecular mechanisms that causethem have only recently become a focus of concerted studies.

[0004] Solar light contains a broad spectrum of energy wavelengths, andultraviolet radiation which is among the relatively short wavelengthsoccurring at between 100 and 400 nanometers (in contrast to the visiblelight spectrum which occurs at between about 490 and 690 nanometers).Ultraviolet radiation is composed of three segments, designated as A, B,and C. Ultraviolet-C radiation (between 100 and 280 nanometers) isfiltered out by the earth's ozone layer and is not known to pose ahealth threat. There is evidence, however, that exposure to bothultraviolet-A radiation (between 315 and 400 nanometers) andultraviolet-B radiation (between 280 and 315 nanometers) can haveadverse short-term and long-term effects on skin health and visualhealth. For example, ultraviolet radiation is known to play an importanta role in both the development of skin cancers and premature aging ofthe skin.

[0005] The cell type most affected by ultraviolet radiation in humans isthe keratinocyte. When illuminated by ultraviolet radiation, thekeratinocyte reacts in three generally non-overlapping ways. First, itinitiates a DNA repair response, which is activated by the DNA damageitself (Herrlick et al. (1994) Adv. Enzyme Reg. 34:381-95). Second, itsignals to the surrounding tissue by releasing pro-inflammatorycytokines, such as IL-1 and TNFα (Ullrich et al. (2000) J. Dermatol.Sci. 23:S10-2; Ouhtit et al. (2000) Am. J. Pathol. 156:201-7; andBeissert et al. (1999) J. Investig. Dermatol. Symp. Proc. 4:61-4).Third, the keratinocyte activates its inherent responses to ultravioletradiation by changing its physiology, including regulation of geneexpression, cytoskeletal rearrangements, and induction of apoptosis(Zhuang et al. (2000) J. Interferon Cytokine Res. 20:445-54; and Assefaet al. (1997) J. Invest. Detmatol. 108:886-891).

[0006] The inherent responses of keratinocytes to ultraviolet radiation,by analogy with responses to other extracellular signals, can beseparated into two phases, the immediate and delayed. The immediatephase contains the ultraviolet radiation-specific signal transductioncascades and results in activation of transcription factors. In thedelayed phase one sees the changes in gene expression. The inventionherein provides a characterization of the ultravioletradiation-responsive induced and suppressed genes in human epidermalkeratinocytes.

[0007] The histological signs of photoaging at the epidermal levelinclude the following: (1) variation in the thickness of the epidermis(atrophy or hyperplasia according to the zones observed); (2) a cellularatypia (Kligman et al. (1986) Photodernatol. 3:215-227); (3) a loss ofcell polarity; (4) an unevenness of the horny layer; (5) a reduction inthe number of Langerhans' cells (Lavker et al. (1987) J. Invest.Dennatol. 88:44s-51s); (6) a pigmentation characterized by a mosaicappearance with hypo- or hyperpigmentation zones; and (7) alinearization of the dermo-epidermal junction (Lavker (1979) J. Invest.Dermatol. 73:59). For a review of photoaging of the skin, seeGilchourest, Skin and Aging Processes, 1989, CRC Press.

[0008] The biologic responses of cells exposed to ultraviolet radiationhave been studied in a wide variety of systems, from Esherichia coli toman. In humans, the molecular effects of ultraviolet radiation includeDNA damage, apoptosis and activation of the Jun N-terminal kinase (JNK)and the nuclear factor kappa-beta (NFkB). Both studied recently,although not extensively in epidermal keratinocytes, which are theprimary target of ultraviolet radiation. A major impetus for studies ofthe molecular response to ultraviolet radiation came with theidentification of the protein kinase that bound to and activated thec-Jun transcription factor in response to ultraviolet radiation(Derijard et al. (1994) Cell 76:1025-1037). The kinase was named “JNK”for Jun N-terminal kinase, or “SAPK” for stress activated protein kinase(Kyriakis et al. (1994) Nature 369:156-160). Soon it was realized thatJNK responds to several extracellular signals in addition to ultravioletradiation, such as osmotic shock, arsenate, and pro-inflammatorycytokines (Rosette et al. (1996) Science 274:1194-7; Cavigelli et al.(1996) E.M.B.O. Journal 15:6269-79). JNK can phosphorylate additionaltranscription factors, including Elk1 and ATF2 (Kallunki et al. (1996)Cell 87:929-39). JNK is itself activated by a small number of relativelyspecific kinases, designated “JNKKs.” Many kinases, designated JNKKKs,respond to a large variety of stimuli to phosphorylate and activate“JNKKs;” the ultraviolet radiation-responsive JNKKK has not yet beenidentified (Fanger et al. (1997) Curr. Opin. Genet. Dev. 7:67-74).

[0009] Another clear molecular effect of ultraviolet radiation is theactivation of the NFkB transcription factor (Devary et al. (1993)Science 261:1442-5). The activation of NFkB by ultraviolet radiation isnot associated with DNA damage and occurs even in cytoplasts devoid ofnuclear DNA (Devary et al. (1993) Science 261:1442-5; Simon et al.(1994) J. Invest. Dermatol. 102:422-7). Inactive NFkB resides in thecytoplasm complexed with IkB protein. Upon activation by a very largeand varied set of extracellular stimuli, IkB is phosphorylated and thusdesignated for proteolysis. This results in the release of NFKB, whichis then free to enter the nucleus and activate gene transcription(Barnes et al. (1997) NE J. Med. 336:1066-71). The ultravioletradiation-responsive kinases that mark IkB for degradation have not yetbeen identified (Li et al. (1998) Proc. Natl. Acad. Sci (USA)95:13012-13017).

[0010] Methods to evaluate photodamage to skin or to cells containedtherein have been described in the art. For example, U.S. Pat. No.6,079,415 provides methods and markers useful for establishingultraviolet-A radiation damage to the dermis, and more specifically, tothe production of collagen by fibroblasts of the dermis. Moreover,methods useful for the prevention of ultraviolet radiation damage to theskin or cells contained therein have been described. For example, U.S.Pat. No. 5,908,836 provides methods for protecting skin from ultravioletradiation damage using sulphated sugars, and U.S. Pat. No. 5,916,880provides a method to reduce wrinkles by treatment with sulfated sugars.Numerous other examples have been described in the field. For example,U.S. Pat. No. 5,939,457 describes the use of a hydroxy acid productuseful for the reduction of wrinkles, U.S. Pat. No. 5,939,082 describesthe use of a vitamin B compound for the regulation of signs of skinaging, and U.S. Pat. No. 5,962,534 describes the use of certainretenoids.

[0011] However, studies to date examining the response at the molecularlevel of skin and the specialized skin cells to exposure to ultravioletradiation almost exclusively have been limited to the examination of oneor several genes and/or proteins specific to a particular cellularprocess. For example, the study by Garmyn et al. ((1991) Lab. Invest.65:471-478) describes an immediate and early temporal pattern ofkeratinocyte response to exposure to ultraviolet radiation, but thisstudy was limited to an analysis of the expression patterns of only afew genes. Moreover, no study has successfully provided an analysis ofthe complete response of the skin and/or the specialized cells of theskin to exposure to ultraviolet radiation. For example, while the studyby Abts et al. ((1997) Photochem. Photobio. 66(3):363-367) utilized themethodology of mRNA differential display to study alterations in geneexpression mediated by ultraviolet radiation exposure, the studyidentified only a very small number of ultraviolet radiation-regulatedgenes due to the difficulty of the technique used.

[0012] The role of the ultraviolet-B radiation has been clearlydemonstrated in the induction of ultraviolet radiation-induced skincancers. It has, as a principal chromophore, nucleic acids and, inparticular, deoxyribonucleic acid, in which it induces lesions and/ormutations (Eller, in Photodamage, pp. 26-56, Blackwell, ed. (1995)). Inaddition, ultraviolet-B radiation has been linked to premature aging ofthe skin, characterized by a dry, rough clinical appearance associatedwith a loss of elasticity, as well as marked wrinkles.

[0013] Gene array technology is a powerful, new technique for geneexpression monitoring, enabling a global view into changes of expressionfor an extremely large set of genes. The technology has been applied tothe study of many biologic processes (see, e, Lockhart et al. (1966)Nat. Biotechnol. 14:1675-1680; Johnston (1998) Curr: Biol. 8:171-174).For example, the technique has been used in the study of cancer (Scherfet al. (2000) Nat. Genet. 24:236-44; Ross et al. (2000) Nat. Genet.24:227-35; Welford et al. (1998) Nuc. Acids Res. 26:3059-3065; Alon etal. (1999) Proc. Natl. Acad. Sci. (USA) 96:6745-6750; and Golub et al.(1999) Science 286:531-537); for the study of complex pathways of geneexpression (Fambrough et al. (1999) Cell 97:727-741; and Galitski et al.(1999) Science 285:251-254); for the study of the aging process(Cheol-Koo Lee (1999) Science 285:1390-1393; Ly et al. (2000) Science287:2486-92; Harkin (1999) Cell 97:575-586); and for the study of thestress response of cells to particular damaging agents (Jelinsky et al.(1999) Proc. Natl. Acad. Sci. (USA) 96:1486-1491)).

[0014] Pharmacological agents useful in the treatment of photodamagedskin have been identified. For example, the normal repair processes inphotodamaged skin have been enhanced pharmacologically. The first to beassessed for this property was Tretinoin (all-trans-retinoic acid).Studies have demonstrated that the reconstruction zone of new collagenwas significantly deeper in tretinoin-treated mice, with the enhancedrepair being dose and time related. In addition, new collagen washistochemically, ultrastructurally, and biochemically normal. Asdetermined by radioimmunoassay, collagen content was increased two-fold,and mRNAs for types I and III collagen were increased two- to threefoldin the tretinoin-treated skin. New collagen synthesis was localized withimmunofluorescence techniques in the histologically definedreconstruction zone, and the presence of new elastin and increasedfibronectin were also established in the region. Isotretinoin(13-cis-retinoic acid) has also been demonstrated to enhance dermalrepair in mice. This repair activity remains retinoid-specific.(Fitzpatrick's Dermatology in Medicine, Fifth Edition, I. M. Freedberg,et al., eds., McGraw-Hill (1999), pp. 1717-1721).

[0015] Studies at the molecular level have shown that ultraviolet-Bradiation up-regulates the collagen-degrading enzymes collagenase andgelatinase, and that tretinoin reduces the mnRNA's, protein, andactivities of these enzymes by 50 to 80 percent. Id. at 1721. Thus,pharmacological agents may be used to reverse skin damage resulting fromaltered expression of proteins and nucleic acid molecules due toultraviolet radiation exposure.

[0016] Because exposure of specialized cells of the skin to ultravioletradiation plays an important role in the generation of skin cancer andin the process of premature aging, it would be beneficial tocharacterize at the molecular level the full response of the skin toexposure to ultraviolet radiation. The present invention provides suchinformation, which was previously lacking in the field. Moreover,epidermal keratinocytes, the main target of environmental ultravioletradiation, have seldom been used as the model system. The inventiondescribed herein redresses this deficiency in the art. Furthermore,nucleic acid molecules and protein molecules in skin cells that areregulated by ultraviolet radiation and the methods provided herein areuseful resources for the identification of pharmacological agents forthe prevention and treatment of skin cancer and premature aging of theskin.

SUMMARY OF THE INVENTION

[0017] It has been discovered that certain molecular events occur in theresponse of a cell to exposure to ultraviolet radiation. Moreparticularly, it has been determined that the expression of a pluralityof specific nucleic acid molecules and proteins are regulated inresponse to ultraviolet radiation exposure. The term “regulated” is usedherein to mean that the expression of RNA molecules and/or proteinsencoded therein are increased or decreased in response to ultravioletradiation exposure of a cell relative to the expression levels found ina non-ultraviolet radiation irradiated cell. These ultravioletradiation-regulated nucleic acid molecules and proteins are furthercharacterized temporally in relation to the cellular response (a firstresponse, a second response, and a third response) and in a quantitativefashion (induced or repressed) in relation to the normal expressionlevels found in a cell not exposed to ultraviolet radiation.

[0018] These discoveries have been exploited to provide the presentinvention, which includes compositions of matter, pharmaceuticalcompositions, methods of identifying a cell exposed to ultravioletradiation, and screening methods for the identification of compoundsthat modulate a response by a cell to ultraviolet radiation exposure,the response comprising the altered expression of nucleic acid moleculesand/or proteins in the cell.

[0019] The cellular responses defined by the present invention relate tothe altered expression of RNA molecules and/or protein molecules in acell exposed to ultraviolet radiation. These responses include thefollowing: (1) a primary first response, a primary second response, anda primary third response, all of which relate to the altered expressionof RNA molecules in a cell exposed to ultraviolet radiation; (2) asecondary first response, a secondary second response, and a secondarythird response, all of which relate to the altered expression of RNAmolecules in a cell exposed to ultraviolet radiation; (3) a tertiaryfirst response, a tertiary second response, and a tertiary thirdresponse, all of which relate to the altered expression of proteins in acell exposed to ultraviolet radiation; and (4) a quaternary firstresponse, a quaternary second response, and a quaternary third response,all of which relate to the altered expression of proteins in a cellexposed to ultraviolet radiation. Thus, the invention provides for anumber of groups of RNA molecules or proteins that are regulated inresponse the exposure of a cell to ultraviolet radiation. These groupsinclude the following: (1) a primary first response group, a primarysecond response group, and a primary third response group, all of whichrelate to the altered expression of RNA molecules in a cell exposed toultraviolet radiation; (2) a secondary first response group, a secondarysecond response group, and a secondary third response group, all ofwhich relate to the altered expression of RNA molecules in a cellexposed to ultraviolet radiation; (3) a tertiary first response group, atertiary second response group, and a tertiary third response group, allof which relate to the altered expression of proteins in a cell exposedto ultraviolet radiation; and (4) a quaternary first response group, aquaternary second response group, and a quaternary third response group,all of which relate to the altered expression of proteins in a cellexposed to ultraviolet radiation. The specific differences between thesegroups are detailed below.

[0020] In accordance with a further aspect of the invention, there isprovided a composition of matter comprising: (1) a plurality of nucleicacid molecules at least 90% identical to the group of polynucleotidesregulated by a cell in response to ultraviolet radiation exposure; and(2) a substrate suitable for binding the nucleic acid molecules of (1).The group of polynucleotides regulated by the cell in response toultraviolet radiation exposure comprises the following: M20030 Humansmall proline rich protein (sprII) mRNA, clone 930, X53065, M13903 Humaninvolucrin gene, exon 2, L10343 Huma elafin gene, complete cds, M21302Human small proline rich protein (sprII) mRNA, clone 174N, L05188 H.sapiens small proline-rich protein 2 (SPRR2B) gene, complete cds, Y00787Human mRNA for MDNCF (monocyte-derived neutrophil chemotactic factor),D50840 H. sapiens mRNA for ceramide glucosyltransferase, complete cds,M22918 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629),Non-Muscle, Alt. Splice, X70326 Macmarcks, X52426 H. sapiens mRNA forcytokeratin 13, S81914 IEX-1=radiation-inducible immediate-early gene[human, placenta, mRNA Partial, 1, M80254 H. sapiens cyclophilin isoform(hCyP3) mRNA, complete cds, L08069 Human heat shock protein, E. coliDnaJ homolog mRNA, complete cds, U62800 Human cystatin M (CST6) mRNA,complete cds, L24564 Human Rad mRNA, complete cds, M59465 Human tumornecrosis factor alpha inducible protein A20 mRNA, complete cds, Z49989H. sapiens mRNA for smoothelin, X57985 H. sapiens genes for histonesH2B.1 and H2A, L19779 H. sapiens histone H2A.2 mRNA, complete cds,D42040 Human mRNA for KIAA9001 gene, complete cds, M63573 Human secretedcyclophilin-like protein (SCYLP) mRNA, complete cds, X54489 Human genefor melanoma growth stimulatory activity (MGSA), M92934 Human connectivetissue growth factor, complete cds, Z14244 H. sapiens coxVIIb mRNA forcytochrome c oxidase subunit VIIb, M60278 Human heparin-binding EGF-likegrowth factor mRNA, complete cds, M72885 Human GOS2 gene, 5′ flank andcds, X62083 H. sapiens mRNA for Drosophila female sterile homeotic (FSH)homolog, X67325 H. sapiens p27 mRNA, U04636 Human cyclooxygenase-2(hCox-2) gene, complete cds, M26311 Human cystic fibrosis antigen mRNA,complete cds, L20688 Human GDP-dissociation inhibitor protein (Ly-GDI)mRNA, complete cds, M27436 Human tissue factor gene, complete cds, witha Alu repetitive sequence in the 3′, AF001294 H. sapiens IPL (IPL) mRNA,complete cds, M22918 Myosin, Light Chain, Alkali, Smooth Muscle(Gb:U02629), Non-Muscle, Alt. Splice, X74874 H. sapiens gene for RNA polII largest subunit, exon 1, M22919 Myosin, Light Chain, Alkali, SmoothMuscle (Gb:U02629), Smooth Muscle, Alt. Spli, V00594 Human mRNA formetallothionein from cadmium-treated cells, V00599 Tubulin, Beta, X99920H. sapiens mRNA for S100 calcium-binding protein A13, M21005 Humanmigration inhibitory factor-related protein 8 (MRP8) gene, complete cds,U07919 Human aldehyde dehydrogenase 6 mRNA, complete cds, M37583 Humanhistone (H2A.Z) mRNA, complete cds, S54005 thymosin beta-10 [human,metastatic melanoma cell line, mRNA, 453 nt], D49824 Human HLA-B nullallele mRNA, S78771 NAT=CpG island-associated gene [human, mRNA, 1741nt], M90657 Human tumor antigen (L6) mRNA, complete cds, U09937 Humanurokinase-type plasminogen receptor, exon 7, X77794 H. sapiens mRNA forcyclin G1, M28130 Human interleukin 8 (IL8) gene, complete cds, X14850Human H2A.X mnRNA encoding histone H2A.X, AB000584 H. sapiens mRNA forTGF-beta superfamily protein, complete cds, U52101 Human YMP mRNA,complete cds, M57731 Human gro-beta mRNA, complete cds, D45248 HumanmRNA for proteasome activator hPA28 subunit beta, complete cds, X83416H. sapiens PrP gene, exon 2, X52882 Human t-complex polypeptide 1 gene,X57351 Human 1-8D gene from interferon-inducible gene family, X53800Human mRNA for macrophage inflammatory protein-2beta (MIP2beta), Z69043H. sapiens mRNA translocon-associated protein delta subunit precursor,D38305 Human mRNA for Tob, complete cds, X52979 Human gene for smallnuclear ribonucleoproteins SmB and S miB′, S80437 fatty acid synthase{3′ region} [human, breast and HepG2 cells, mRNA Partial, 22, X87679Major Histocompatibility Complex, Class I, E (Gb:M21533), Z29505 H.sapiens mRNA for nucleic acid binding protein sub2.3, D21853 Human mRNAfor KIAA0111 gene, complete cds, X78687 H. sapiens G9 gene encodingsialidase, M13755 Human interferon-induced 17-kD/15-kD protein mRNA,complete cds, M21186 Human neutrophil cytochrome b light chain p22phagocyte b-cytochrome mRNA, compl, D28235 Human PTGS2 gene forprostaglandin endoperoxide synthase-2, complete cds, M14328 Human alphaenolase mRNA, complete cds, V00599 Tubulin, Beta 2, U90546 Humanbutyrophilin (BTF4) mRNA, complete cds, K02574, X15729 Human mRNA fornuclear p68 protein, D89052 H. sapiens mRNA for proton-ATPase-likeprotein, complete cds, M60974 Human growth arrest andDNA-damage-inducibile protein (gadd45) mRNA, complete cds, X06956Tubulin, Alpha 1, Isoform 44, X04654 Human mRNA for U1 RNA-associated70K protein, M79463 Human PML-2 mRNA, complete CDS, L76568 H. sapiensexcision and cross link repair protein (ERCC4) gene, complete genome,Y09022 H. sapiens mRNA for Not56-like protein, X57579 H. sapiens activinbeta-A subunit (exon 2), U37690 Human RNA polymerase II subunit(hsRPB10) mRNA, complete cds, X61123 Human BTG1 mRNA, J04456 Human 14 kDlectin mRNA, complete cds, Z49254 H. sapiens L23-related mRNA, U70660Human copper transport protein HAH1 (HAH1) mRNA, complete cds, D86974Human mRNA for KIAA0220 gene, partial cds, Y07604 H. sapiens mRNA fornucleoside-diphosphate kinase, AF006084 H. sapiens Arp2/3 proteincomplex subunit p41-Arc (ARC41) mRNA, complete cds, Y00503 Human mRNAfor keratin 19, L26336 Heat Shock Protein, 70 KD (Gb:Y00371), M62831Human transcription factor ETR101 mRNA, complete cds, Z22548 H. sapiensthiol-specific antioxidant protein mRNA, U40369 Humanspermidine/spermine N1-acetyltransferase (SSAT) gene, complete cds,M12125 Human fibroblast muscle-type tropomyosin mRNA, complete cds,X51345 Human jun-B mRNA for JUN-B protein, Z21507 H. sapiens EF-1deltagene encoding human elongation factor-1-delta, U20734 Humantranscription factor junB (junB) gene, 5′ region and complete cds,D13413 Human mRNA for tumor-associated 120 kD nuclear protein p120,partial cds(carbox, L42379 H. sapiens bone-derived growth factor(BPGF-1) mRNA, complete cds, X15822 Human COX VIIa-L mRNA forliver-specific cytochrome c oxidase (EC 1.9.3.1.), D86988 Human mRNA forKIAA0221 gene, complete cds, M26730 Human mitochondrialubiquinone-binding protein (QP) gene, exon 4, M69043 H. sapiens MAD-3mRNA encoding IkB-like activity, complete cds, D38251 Human mRNA forRPB5 (XAP4), complete cds, M30703 Human amphiregulin (AR) gene, exon 6,clones lambda-ARH(6,12), L76200 Human guanylate kinase (GUK1) mRNA,complete cds, M34516 Human omega light chain protein 14.1 (Ig lambdachain related) gene, exon 3, U26727 Human p16INK4/MTS l mRNA, completecds, U53830 H. sapiens interferon regulatory factor 7A mRNA, completecds, M22960 Human protective protein mRNA, complete cds, D89667 H.sapiens mRNA for c-myc binding protein, complete cds, L16862 H. sapiensG protein-coupled receptor kinase (GRK6) mRNA, complete cds, M19309Human slow skeletal muscle troponin T mRNA, clone H22h, D64142 HumanmRNA for histone H1x, complete cds, U41515 Human deleted in splithand/split foot 1 (DSS1) mRNA, complete cds, J04611 Human lupus p70 (Ku)autoantigen protein mRNA, complete cds, U35048 Human TSC-22 proteinmRNA, complete cds, X82693 H. sapiens mRNA for E48 antigen, M92843 H.sapiens zinc finger transcriptional regulator mRNA, complete cds, U72649Human BTG2 (BTG2) mRNA, complete cds, X92896 H. sapiens mRNA for ITBA2protein, X74104 H. sapiens mRNA for TRAP beta subunit, M84332 HumanADP-ribosylation factor 1 gene, exons 2-5, D15050 Human mRNA fortranscription factor AREB6, complete cds, D10923 Human mRNA for HM74,M84739 Human autoantigen calreticulin mRNA, complete cds, U09813 Humanmitochondrial ATP synthase subunit 9, P3 gene copy, mRNA, nuclear geneenc, X67951 H. sapiens mRNA for proliferation-associated gene (pag),X82200 H. sapiens Staf50 mRNA, L27706 Human chaperonin protein (Tcp20)gene complete cds, U69126 Human FUSE binding protein 2 (FBP2) mRNA,partial cds, M12529 Human apolipoprotein E mRNA, complete cds, X71129 H.sapiens mRNA for electron transfer flavoprotein beta subunit, U28386Human nuclear localization sequence receptor hSRP1alpha mRNA, completecds, U41766 Human metalloprotease/disintegrin/cysteine-rich proteinprecursor (MDC9) mRNA, c, AF006041 H. sapiens Fas-binding protein (DAXX)mRNA, partial cds, U28749 Human high-mobility group phosphoproteinisoform I-C (HMGIC) mRNA, complete cds, M60483 Human protein phosphatase2A catalytic subunit-alpha gene, complete cds, U07664 Human HB9 homeoboxgene, exons 2 and 3 and complete cds, U13991 Human TATA-binding proteinassociated factor 30 kD subunit (tafII30) mRNA, comp, J04794 Humanaldehyde reductase mRNA, complete cds, U51586 Human siah binding protein1 (SiabBP1) mRNA, partial cds, M58026 Human NB-1 mRNA, complete cds,X52425 Human IL-4-R mRNA for the interleukin 4 receptor, X94563 H.sapiens dbi/acbp gene exon 1 & 2, X68277 H. sapiens CL 100 mRNA forprotein tyrosine phosphatase, X56681 Human junD mRNA, V01512 Humancellular oncogene c-fos (complete sequence), U09578 H. sapiens MAPKAPkinase (3pK) mRNA, complete cds, L13391 Human helix-loop-helix basicphosphoprotein (G0S8) gene, complete cds, U62317 Chromosome 22q13 BACClone CIT987SK-384D8 complete sequence, M16364 Human creatine kinase-BmRNA, complete cds, L19437 Human transaldolase mRNA containingtransposable element, complete cds, X53416 Human mRNA for actin-bindingprotein (filamin) (ABP-280), X52560 Nuclear Factor Nf-I16, X78549 H.sapiens brk mRNA for tyrosine kinase, L11066 Human mRNA sequence, X74008H. sapiens mRNA for protein phosphatase 1 gamma, X87241 H. sapiens mRNAfor hFat protein, S68616 Na+/H+ exchanger NHE-1 isoform [human, heart,mRNA, 4516 nt], D13705 Human mRNA for fatty acids omega-hydroxylase(cytochrome P-450HKV), complete cds, D86966 Human mnRNA for KIAA0211gene, complete cds, U17327 Human neuronal nitric oxide synthase (NOS1)mRNA, complete cds, U89336 Human HLA class III region containing NOTCH4gene, partial sequence, homeobox PB, D85527 H. sapiens mRNA for LIMdomain, partial cds, L07517 Mucin 6, Gastric (Gb:L07517), M58459 Humanribosomal protein (RPS4Y) isoform mRNA, complete cds, U65579 Humanmitochondrial NADH dehydrogenase-ubiquinone Fe-S protein 8, 23 kDsubunit, M19961 Human cytochrome c oxidase subunit Vb (coxVb) mRNA,complete cds, M29064 Human hnRNP B1 protein mRNA, X64330 H. sapiens mRNAfor ATP-citrate lyase, X89267 H. sapiens DNA for uroporphyrinogendecarboxylase gene, X91247 H. sapiens mRNA for thioredoxin reductase,L11672 Human Kruppel related zinc finger protein (HTF10) mRNA, completecds, X78992 H. sapiens ERF-2 mRNA, L19314 Human HRY gene, complete cds,D90086 Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunit gene,exons 1-10, X12794 Human v-erbA related ear-2 gene, L22005 Humanubiquitin conjugating enzyme mRNA, partial cds, U01337 Human Ser/Thrprotein kinase (A-RAF-1) gene, complete cds, M34182 Humantestis-specific protein kinase gamma-subunit mRNA, complete cds, L08246Human myeloid cell differentiation protein (MCL1) mRNA, L37042 H.sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds,L04731 H. sapiens translocation T(4:11) of ALL-1 gene to chromosome 4,D87071 Human mRNA for KIAA0233 gene, complete cds, S74017Nrf2=NF-E2-like basic leucine zipper transcriptional activator [human,hemin-ind, L41351 H. sapiens prostasin mRNA, complete cds, L00352 Humanlow density lipoprotein receptor gene, exon 18, D50683 H. sapiens mRNAfor TGF-betaIIR alpha, complete cds, X89750 H. sapiens mRNA for TGIFprotein, D13988 Human rab GDI mRNA, complete cds, M12886 Human T-cellreceptor active beta-chain mRNA, complete cds, M55265 Human caseinkinase II alpha subunit mRNA, complete cds, J03161 Human serum responsefactor (SRF) mRNA, complete cds, M58286 H. sapiens tumor necrosis factorreceptor mRNA, complete cds, U88629 Human RNA polymerase II elongationfactor ELL2, complete cds, X04412 Human mRNA for plasma gelsolin, L27943H. sapiens cytidine deaminase (CDA) mRNA, complete cds, U90716 Humancell surface protein HCAR mRNA, complete cds, M24547 Amyloid Beta (A4)Precursor Protein, Alt. Splice 2, A4(751), U05875 Human clone pSK1interferon gamma receptor accessory factor-1 (AF-1) mRNA, compl, Z11585Potassium Channel Protein (Gb:Z11585), M58603 Human nuclear factorkappa-B DNA binding subunit (NF-kappa-B) mRNA, complete cds, D87442Human mRNA for KIAA0253 gene, partial cds, M76482 Human 130-kD pemphigusvulgaris antigen mRNA, complete cds, U56418 Human lysophosphatidic acidacyltransferase-beta mRNA, complete cds, J00120 Proto-Oncogene C-Myc,Alt. Splice 3, Orf 114, U68142 Human RalGDS-like 2 (RGL2) mRNA, partialcds, U88898 Human endogenous retroviral H protease/integrase-derivedORF1 mRNA, complete cds, M91083 Human DNA-binding protein (HRC1) mRNA,complete cds, Z30643 H. sapiens mRNA for chloride channel (putative)2139bp, X12953 Human rab2 mRNA, YPT1-related and member of ras family,D78129 H. sapiens mRNA for squalene epoxidase, partial cds, U63825 Humanhepatitis delta antigen interacting protein A (dipA) mRNA, complete cds,S78825 Id1, M54915 Human h-pim-1 protein (h-pim-1) mRNA, complete cds,X04828 Human mRNA for G(i) protein alpha-subunit (adenylate cyclaseinhibiting GTP-bind, X06323 Human MRL3 mRNA for ribosomal protein L3homolog (MRL3=mammalian ribosome L, D14043 Human mRNA for MGC-24,complete cds, L38951 H. sapiens importin beta subunit mRNA, completecds, U34252 Human gamma-aminobutyraldehyde dehydrogenase mRNA, completecds, M13829 Human putative raf related protein (pks/a-raf) mRNA, partialcds, U33821 Human tax1-binding protein TXBP151 mRNA, complete cds,U66616 Human SWI/SNF complex 170 KD subunit (BAF170) mRNA, complete cds,U29607 Human methionine aminopeptidase mRNA, complete cds, D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, D14874 H. sapiensmRNA for adrenomedullin precursor, complete cds, D85429 H. sapiens genefor heat shock protein 40, complete cds, M69181 Human nonmuscle myosinheavy chain-B (MYH10) mRNA, partial cds, U60205 Human methyl steroloxidase (ERG25) mRNA, complete cds, X75342 H. sapiens SHB mRNA, D45906H. sapiens mRNA for LIMK-2, complete cds, X59434 Human rohu mRNA forrhodanese, M96803 Human general beta-spectrin (SPTBN1) mRNA, completecds, D79994 Human mRNA for KIAA0172 gene, partial cds, D86965 Human mRNAfor KIAA0210 gene, complete cds, Y13647 Stearoyl-Coenzymea Desaturase,X52541 Human mRNA for early growth response protein 1 (hEGR1), Z26317 H.sapiens mRNA for desmoglein 2, M57763 Human ADP-ribosylation factor(hARF6) mRNA, complete cds, L38490 H. sapiens ADP-ribosylation factormRNA, complete cds, D87438 Human mRNA for KIAA0251 gene, partial cds,M31627 Human X box binding protein-1 (XBP-1) mRNA, complete cds, X80692H. sapiens ERK3 mRNA, U37122 Human adducin gamma subunit mRNA, completecds, M83667 Human NF-IL6-beta protein mRNA, complete cds, J05211Desmoplakin I, D42123 H. sapiens mRNA for ESP1/CRP2, complete cds,X90858 H. sapiens mRNA for uridine phosphorylase, X76717 H. sapiensMT-11 mRNA, Y08915 H. sapiens mRNA for alpha 4 protein, U30999 Human(memc) mRNA, 3′UTR, L77886 Human protein tyrosine phosphatase mRNA,complete cds, U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA,partial sequence, U28480 Uncoupling Protein Ucp, X53586 Human mRNA forintegrin alpha 6, M64347 Human novel growth factor receptor mRNA, 3′cds, U52100 Human XMP mRNA, complete cds, D21852 Human mRNA for KIAA0029gene, partial cds, X05409 Human RNA for mitochondrial aldehydedehydrogenase I ALDH I (EC 1.2.1.3), D87462 Human mRNA for KIAA0272gene, partial cds, L40391 H. sapiens (clone s153) mRNA fragment, D87469Human mRNA for KIAA0279 gene, partial cds, S73591 brain-expressedHHCPA78 homolog [human, HL-60 acute promyelocytic leukemia cells, L19267H. sapiens 59 protein mRNA, 3′ end, M81601 Human transcriptionelongation factor (SII) mRNA, complete cds, X52611 Human mRNA fortranscription factor AP-2, U28811 Human cysteine-rich fibroblast growthfactor receptor (CFR-1) mRNA, complete cds, L31801 H. sapiensmonocarboxylate transporter 1 (SLC16A1) mRNA, complete cds, M13929 Humanc-myc-P64 mRNA, initiating from promoter P0, (HLmyc2.5) partial cds,L48546 H. sapiens tuberin (TSC2) gene, exons 38, 39, 40 and 41, L00058Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank, U09587Human glycyl-tRNA synthetase mRNA, complete cds, L37127 H. sapiens RNApolymerase II mRNA, complete cds, U52426 H. sapiens GOK (STIM1) mRNA,complete cds, U72066 H. sapiens CtBP interacting protein CtIP (CtIP)mRNA, complete cds, U83115 Human non-lens beta gamma-crystallin likeprotein (AIM1) mRNA, partial cds, M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, D90209 Human mRNA for DNA bindingprotein TAXREB67, D83777 Human mRNA for KIAA0193 gene, complete cds,U42031 Human 54 kD progesterone receptor-associated immunophilin FKBP54mRNA, partial, M80244 Human E16 mRNA, complete cds, D31883 Human mRNAfor KIAA0059 gene, complete cds, J04444 Human cytochrome c-1 gene,complete cds, M38258 Human retinoic acid receptor gamma 1 mRNA, completecds, M95787 Human 22kD smooth muscle protein (SM22) mRNA, complete cds,U00968 Human SREBP-1 mRNA, complete cds, K03195 Human (HepG2) glucosetransporter gene mRNA, complete cds, X92720 H. sapiens mRNA forphosphoenolpyruvate carboxykinase, X77366 H. sapiens HBZ17 mRNA, U53347Human neutral amino acid transporter B mRNA, complete cds, X80695 H.sapiens OXA1Hs mRNA, J04102 Human erythroblastosis virus oncogenehomolog 2 (ets-2) mRNA, complete cds, S75762 Oncogene Tls/Chop, FusionActivated, U14550 Human sialyltransferase SThM (sthm) mRNA, completecds, L09229 Human long-chain acyl-coenzyme A synthetase (FACL1) mRNA,complete cds, X76534 H. sapiens NMB mRNA, M55268 Human casein kinase IIalpha' subunit mRNA, complete cds, M27396 Human asparagine synthetasemRNA, complete cds, U37519 Human aldehyde dehydrogenase (ALDH8) mRNA,complete cds, X69111 H. sapiens HLH 1R21 mRNA for helix-loop-helixprotein, M77836 Human pyrroline 5-carboxylate reductase mRNA, completecds, D32050 Human mRNA for alanyl-tRNA synthetase, complete cds, X01630Human mRNA for argininosuccinate synthetase. This group of ultravioletradiation-regulated polynucleotides is hereinafter referred to as the“complete response group” of ultraviolet radiation-regulatedpolynucleotides.

[0021] In accordance with a further aspect of the invention, there isprovided a composition of matter comprising: (1) a plurality of nucleicacid molecules at least 90% identical to the group of polynucleotidesregulated by a cell in response to ultraviolet radiation exposure; and(2) a substrate suitable for binding the nucleic acid molecules of (1).The group of polynucleotides regulated by the cell in response toultraviolet radiation exposure comprises the following: M20030 Humansmall proline rich protein (sprII) mRNA, clone 930, X53065, M13903 Humaninvolucrin gene, exon 2, L10343 Huma elafin gene, complete cds, M21302Human small proline rich protein (sprII) mRNA, clone 174N, L05188 H.sapiens small proline-rich protein 2 (SPRR2B) gene, complete cds, Y00787Human mRNA for MDNCF (monocyte-derived neutrophil chemotactic factor),D50840 H. sapiens mRNA for ceramide glucosyltransferase, complete cds,M22918 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629),Non-Muscle, Alt. Splice, X70326 Macmarcks, X52426 H. sapiens mRNA forcytokeratin 13, S81914 IEX-1=radiation-inducible immediate-early gene[human, placenta, mRNA Partial, 1, M80254 H. sapiens cyclophilin isoform(hCyP3) mRNA, complete cds, L08069 Human heat shock protein, E. coliDnaJ homolog mRNA, complete cds, U62800 Human cystatin M (CST6) mRNA,complete cds, L24564 Human Rad mRNA, complete cds, M59465 Human tumornecrosis factor alpha inducible protein A20 mRNA, complete cds, Z49989H. sapiens mRNA for smoothelin, X57985 H. sapiens genes for histonesH2B.1 and H2A, L19779 H. sapiens histone H2A.2 mRNA, complete cds,D42040 Human mRNA for KIAA9001 gene, complete cds, M63573 Human secretedcyclophilin-like protein (SCYLP) mRNA, complete cds, X54489 Human genefor melanoma growth stimulatory activity (MGSA), M92934 Human connectivetissue growth factor, complete cds, Z14244 H. sapiens coxVIIb mRNA forcytochrome c oxidase subunit VIIb, M60278 Human heparin-binding EGF-likegrowth factor mRNA, complete cds, M72885 Human GOS2 gene, 5′ flank andcds, X62083 H. sapiens mRNA for Drosophila female sterile homeotic (FSH)homolog, X67325 H. sapiens p27 mRNA, U04636 Human cyclooxygenase-2(hCox-2) gene, complete cds, M26311 Human cystic fibrosis antigen mRNA,complete cds, L20688 Human GDP-dissociation inhibitor protein (Ly-GDI)mRNA, complete cds, M27436 Human tissue factor gene, complete cds, witha Alu repetitive sequence in the 3′, AF001294 H. sapiens IPL (IPL) mRNA,complete cds, M22918 Myosin, Light Chain, Alkali, Smooth Muscle(Gb:U02629), Non-Muscle, Alt. Splice, X74874 H. sapiens gene for RNA polII largest subunit, exon 1, M22919 Myosin, Light Chain, Alkali, SmoothMuscle (Gb:U02629), Smooth Muscle, Alt. Spli, V00594 Human mRNA formetallothionein from cadmium-treated cells, V00599 Tubulin, Beta, X99920H. sapiens mRNA for S100 calcium-binding protein A13, M21005 Humanmigration inhibitory factor-related protein 8 (MRP8) gene, complete cds,U07919 Human aldehyde dehydrogenase 6 mRNA, complete cds, M37583 Humanhistone (H2A.Z) mRNA, complete cds, S54005 thymosin beta-10 [human,metastatic melanoma cell line, mRNA, 453 nt], D49824 Human HLA-B nullallele mRNA, S78771 NAT=CpG island-associated gene [human, mRNA, 1741nt], M90657 Human tumor antigen (L6) mRNA, complete cds, U09937 Humanurokinase-type plasminogen receptor, exon 7, X77794 H. sapiens mRNA forcyclin G1, M28130 Human interleukin 8 (IL8) gene, complete cds, X14850Human H2A.X mRNA encoding histone H2A.X, AB000584 H. sapiens mRNA forTGF-beta superfamily protein, complete cds, U52101 Human YMP mRNA,complete cds, M57731 Human gro-beta mRNA, complete cds, D45248 HumanmRNA for proteasome activator hPA28 subunit beta, complete cds, X83416H. sapiens PrP gene, exon 2, X52882 Human t-complex polypeptide 1 gene,X57351 Human 1-8D gene from interferon-inducible gene family, X53800Human mRNA for macrophage inflammatory protein-2beta (MIP2beta), Z69043H. sapiens mRNA translocon-associated protein delta subunit precursor,D38305 Human mRNA for Tob, complete cds, t X52979 Human gene for smallnuclear ribonucleoproteins SmB and SmB′, S80437 fatty acid synthase {3′region} [human, breast and HepG2 cells, mRNA Partial, 22, X87679 MajorHistocompatibility Complex, Class I, E (Gb:M21533), Z29505 H. sapiensmRNA for nucleic acid binding protein sub2.3, D21853 Human mRNA forKIAA0111 gene, complete cds, X78687 H. sapiens G9 gene encodingsialidase, M13755 Human interferon-induced 17-kD/15-kD protein mRNA,complete cds, M21186 Human neutrophil cytochrome b light chain p22phagocyte b-cytochrome mRNA, compl, 8235_s_at D28235 Human PTGS2 genefor prostaglandin endoperoxide synthase-2, complete cds, M14328 Humanalpha enolase mRNA, complete cds, V00599 Tubulin, Beta 2, U90546 Humanbutyrophilin (BTF4) mRNA, complete cds, K02574, X15729 Human mRNA fornuclear p68 protein, D89052 H. sapiens mRNA for proton-ATPase-likeprotein, complete cds, M60974 Human growth arrest andDNA-damage-inducible protein (gadd45) mRNA, complete cds, X06956Tubulin, Alpha 1, Isoform 44, X04654 Human mRNA for U1 RNA-associated70K protein, M79463 Human PML-2 mRNA, complete CDS, L76568 H. sapiensexcision and cross link repair protein (ERCC4) gene, complete genom,Y09022 H. sapiens mRNA for Not56-like protein, X57579 H. sapiens activinbeta-A subunit (exon 2), 37690 Human RNA polymerase II subunit (hsRPB10)mRNA, complete cds, X61123 Human BTG1 mRNA, J04456 Human 14 kD lectinmRNA, complete cds, Z49254 H. sapiens L23-related mRNA, U70660 Humancopper transport protein HAH1 (HAH1) mRNA, complete cds, D86974 HumanmRNA for KIAA0220 gene, partial cds, AF006084 H. sapiens Arp2/3 proteincomplex subunit p4l-Arc (ARC41) mRNA, complete cds, Y00503 Human mRNAfor keratin 19, M62831 Human transcription factor ETR101 mRNA, completecds, Z22548 H. sapiens thiol-specific antioxidant protein mRNA, U40369Human spermidine/spermine N1-acetyltransferase (SSAT) gene, completecds, M12125 Human fibroblast muscle-type tropomyosin mRNA, complete cds,X51345 Human jun-B mRNA for JUN-B protein, Z21507 H. sapiens EF-1deltagene encoding human elongation factor-1-delta, U20734 Humantranscription factor junB (unB) gene, 5′ region and complete cds, D13413Human mRNA for tumor-associated 120 kD nuclear protein p120, partialcds(carbox, L42379 H. sapiens bone-derived growth factor (BPGF-1) mRNA,complete cds, X15822 Human COX VIIa-L mRNA for liver-specific cytochromec oxidase (EC 1.9.3.1.), D86988 Human mRNA for KIAA0221 gene, completecds, M26730 Human mitochondrial ubiquinone-binding protein (QP) gene,exon 4, M69043 H. sapiens MAD-3 mRNA encoding IkB-like activity,complete cds, D38251 Human mRNA for RPB5 (XAP4), complete cds, L76200Human guanylate kinase (GUK1) mRNA, complete cds, M34516 Human omegalight chain protein 14.1 (Ig lambda chain related) gene, exon 3, U26727Human p16INK4/MTS1 mRNA, complete cds, U53830 H. sapiens interferonregulatory factor 7A mRNA, complete cds, M22960 Human protective proteinmRNA, complete cds, D89667 H. sapiens mRNA for c-myc binding protein,complete cds, M19309 Human slow skeletal muscle troponin T mRNA, cloneH22h, D64142 Human mRNA for histone H1x, complete cds, U41515 Humandeleted in split hand/split foot 1 (DSS1) mRNA, complete cds, J04611Human lupus p70 (Ku) autoantigen protein mRNA, complete cds, U35048Human TSC-22 protein mRNA, complete cds, X82693 H. sapiens mRNA for E48antigen, M92843 H. sapiens zinc finger transcriptional regulator mRNA,complete cds, U72649 Human BTG2 (BTG2) mRNA, complete cds, X92896 H.sapiens mRNA for ITBA2 protein, D10923 Human mRNA for HM74, M84739 Humanautoantigen calreticulin mRNA, complete cds, U09813 Human mitochondrialATP synthase subunit 9, P3 gene copy, mRNA, nuclear gene enc, X67951 H.sapiens mRNA for proliferation-associated gene (pag), L27706 Humanchaperonin protein (Tcp20) gene complete cds, U69126 Human FUSE bindingprotein 2 (FBP2) mRNA, partial cds, M12529 Human apolipoprotein E mRNA,complete cds, X71129 H. sapiens mRNA for electron transfer flavoproteinbeta subunit, U13991 Human TATA-binding protein associated factor 30 kDsubunit (tafII30) mRNA, comp, J04794 Human aldehyde reductase mRNA,complete cds, U51586 Human siah binding protein 1 (SiahBP1) mRNA,partial cds, M58026 Human NB-1 mRNA, complete cds, X68277 H. sapiens CL100 mRNA for protein tyrosine phosphatase, X56681 Human jund mRNA,V01512 Human cellular oncogene c-fos (complete sequence), U09578 H.sapiens MAPKAP kinase (3pK) mRNA, complete cds, L13391 Humanhelix-loop-helix basic phosphoprotein (G0S8) gene, complete cds, U62317Chromosome 22q13 BAC Clone CIT987SK-384D8 complete sequence, M16364Human creatine kinase-B mRNA, complete cds, L19437 Human transaldolasemRNA containing transposable element, complete cds, X53416 Human mRNAfor actin-binding protein (filamin) (ABP-280), X52560 Nuclear FactorNf-I16, M58459 Human ribosomal protein (RPS4Y) isoform mRNA, completecds, U65579 Human mitochondrial NADH dehydrogenase-ubiquinone Fe-Sprotein 8, 23 kD subunit, M19961 Human cytochrome c oxidase subunit Vb(coxVb) mRNA, complete cds, M29064 Human hnRNP B1 protein mRNA, D90086Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunit gene, exons 1-10,L04731 H. sapiens translocation T(4:11) of ALL-1 gene to chromosome 4,D87071 Human mRNA for KIAA0233 gene, complete cds, X04412 Human mRNA forplasma gelsolin, L27943 H. sapiens cytidine deaminase (CDA) mRNA,complete cds, U68142 Human RalGDS-like 2 (RGL2) mRNA, partial cds,U63825 Human hepatitis delta antigen interacting protein A (dipA) mRNA,complete cds, X04828 Human mRNA for G(i) protein alpha-subunit(adenylate cyclase inhibiting GTP-bind, L38951 H. sapiens importin betasubunit mRNA, complete cds, M31627 Human X box binding protein-1 (XBP-1)mRNA, complete cds, J04444 Human cytochrome c-1 gene, complete cds,S75762 Oncogene Tls/Chop, Fusion Activated. This group of ultravioletradiation-regulated polynucleotides is hereinafter referred to as the“induced response group” of ultraviolet radiation-regulatedpolynucleotides.

[0022] In accordance with a further aspect of the invention, there isprovided a composition of matter comprising: (1) a plurality of nucleicacid molecules at least 90% identical to the group of polynucleotidesregulated by a cell in response to ultraviolet radiation exposure; and(2) a substrate suitable for binding the nucleic acid molecules of (1).The group of polynucleotides regulated by the cell in response toultraviolet radiation exposure comprises the following: D50840 H.sapiens mRNA for ceramide glucosyltransferase, complete cds, L08069Human heat shock protein, E. coli DnaJ homolog mRNA, complete cds,X77794 H. sapiens mRNA for cyclin G1, D89052 H. sapiens mRNA forproton-ATPase-like protein, complete cds, L26336 Heat Shock Protein, 70KD (Gb:Y00371), M30703 Human amphiregulin (AR) gene, exon 6, cloneslambda-ARH(6,12), L16862 H. sapiens G protein-coupled receptor kinase(GRK6) mRNA, complete cds, M92843 H. sapiens zinc finger transcriptionalregulator mRNA, complete cds, U72649 Human BTG2 (BTG2) mRNA, completecds, X74104 H. sapiens mRNA for TRAP beta subunit, M84332 HumanADP-ribosylation factor 1 gene, exons 2-5, D15050 Human mRNA fortranscription factor AREB6, complete cds, U28386 Human nuclearlocalization sequence receptor hSRP1alpha mRNA, complete cds, U41766Human metalloprotease/disintegrin/cysteine-rich protein precursor (MDC9)mRNA, c, AF006041 H. sapiens Fas-binding protein (DAXX) mRNA, partialcds, U28749 Human high-mobility group phosphoprotein isoform I-C (HMGIC)mRNA, complete cds, M60483 Human protein phosphatase 2A catalyticsubunit-alpha gene, complete cds, U07664 Human HB9 homeobox gene, exons2 and 3 and complete cds, X52425 Human IL-4-R mRNA for the interleukin 4receptor, X94563 H. sapiens dbi/acbp gene exon 1 & 2, L11066 Human mRNAsequence, X74008 H. sapiens mRNA for protein phosphatase 1 gamma, X87241H. sapiens mRNA for hFat protein, S68616 Na+/H+ exchanger NHE-1 isoform[human, heart, mRNA, 4516 nt], D13705 Human mRNA for fatty acidsomega-hydroxylase (cytochrome P-450HKV), complete cds, D86966 Human mRNAfor KIAA0211 gene, complete cds, U17327 Human neuronal nitric oxidesynthase (NOS1) mRNA, complete cds, U89336 Human HLA class III regioncontaining NOTCH4 gene, partial sequence, homeobox PB, D85527 H. sapiensmRNA for LIM domain, partial cds, L07517 Mucin 6, Gastric (Gb:L07517),X64330 H. sapiens mRNA for ATP-citrate lyase, X89267 H. sapiens DNA foruroporphyrinogen decarboxylase gene, X91247 H. sapiens mRNA forthioredoxin reductase, L11672 Human Kruppel related zinc finger protein(HTF10) mRNA, complete cds, X78992 H. sapiens ERF-2 mRNA, L19314 HumanHRY gene, complete cds, X12794 Human v-erbA related ear-2 gene, L22005Human ubiquitin conjugating enzyme mRNA, partial cds, U01337 HumanSer/Thr protein kinase (A-RAF-1) gene, complete cds, M34182 Humantestis-specific protein kinase gamma-subunit mRNA, complete cds, L08246Human myeloid cell differentiation protein (MCL1) mRNA, L37042 H.sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds,D87071 Human mRNA for KIAA0233 gene, complete cds, S74017Nrf2=NF-E2-like basic leucine zipper transcriptional activator [human,hemin-ind, L41351 H. sapiens prostasin mRNA, complete cds, L00352 Humanlow density lipoprotein receptor gene, exon 18, D50683 H. sapiens mRNAfor TGF-betaIIR alpha, complete cds, X89750 H. sapiens mRNA for TGIFprotein, t D13988 Human rab GDI mRNA, complete cds, M12886 Human T-cellreceptor active beta-chain mRNA, complete cds, M55265 Human caseinkinase II alpha subunit mRNA, complete cds, J03161 Human serum responsefactor (SRF) mRNA, complete cds, M58286 H. sapiens tumor necrosis factorreceptor mRNA, complete cds, U88629 Human RNA polymerase II elongationfactor ELL2, complete cds, U90716 Human cell surface protein HCAR mRNA,complete cds, M24547 Amyloid Beta (A4) Precursor Protein, Alt. Splice 2,A4(751), U05875 Human clone pSK1 interferon gamma receptor accessoryfactor-1 (AF-1) mRNA, compl, M58603 Human nuclear factor kappa-B DNAbinding subunit (NF-kappa-B) mRNA, complete cds, D87442 Human mRNA forKIAA0253 gene, partial cds, M76482 Human 130-kD pemphigus vulgarisantigen mRNA, complete cds, U56418 Human lysophosphatidic acidacyltransferase-beta mRNA, complete cds, J00120 Proto-Oncogene C-Myc,Alt. Splice 3, Orf 114, U88898 Human endogenous retroviral Hprotease/integrase-derived ORF1 mRNA, complete cds, M91083 HumanDNA-binding protein (HRC1) mRNA, complete cds, Z30643 H. sapiens mRNAfor chloride channel (putative) 2139bp, X12953 Human rab2 mRNA,YPT1-related and member of ras family, D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, S78825 Id1, M54915 Human h-pim-1protein (h-pim-1) mRNA, complete cds, X06323 Human MRL3 mRNA forribosomal protein L3 homolog (MRL3=mammalian ribosome L, D14043 HumanmRNA for MGC-24, complete cds, U34252 Human gamma-aminobutyraldehydedehydrogenase mRNA, complete cds, M13829 Human putative raf relatedprotein (pks/a-raf) mRNA, partial cds, U33821 Human taxl-binding proteinTXBP151 mRNA, complete cds, U66616 Human SWI/SNF complex 170 KD subunit(BAF170) mRNA, complete cds, U29607 Human methionine aminopeptidasemRNA, complete cds, D14520 Human mRNA for GC-Box binding protein BTEB2,complete cds, D14874 H. sapiens mRNA for adrenomedullin precursor,complete cds, D85429 H. sapiens gene for heat shock protein 40, completecds, t M69181 Human nonmuscle myosin heavy chain-B (MYH10) mRNA, partialcds, U60205 Human methyl sterol oxidase (ERG25) mRNA, complete cds,X75342 H. sapiens SHB mRNA, t D45906 H. sapiens mRNA for LIMK-2,complete cds, X59434 Human rohu mRNA for rhodanese, M96803 Human generalbeta-spectrin (SPTBN1) mRNA, complete cds, D79994 Human mnRNA forKIAA0172 gene, partial cds, D86965 Human mRNA for KIAA0210 gene,complete cds, Y13647 Stearoyl-Coenzymea Desaturase, X52541 Human mRNAfor early growth response protein 1 (hEGR1), Z26317 H. sapiens mRNA fordesmoglein 2, t M57763 Human ADP-ribosylation factor (hARF6) mRNA,complete cds, L38490 H. sapiens ADP-ribosylation factor mRNA, completecds, D87438 Human mRNA for KIAA0251 gene, partial cds, M31627 Human Xbox binding protein-1 (XBP-1) mRNA, complete cds, X80692 H. sapiens ERK3mRNA, U37122 Human adducin gamma subunit mRNA, complete cds, M83667Human NF-IL6-beta protein mRNA, complete cds, J05211 Desmoplakin I,D42123 H. sapiens mRNA for ESP1/CRP2, complete cds, X90858 H. sapiensmRNA for uridine phosphorylase, X76717 H. sapiens MT-11 mRNA, Y08915 H.sapiens mRNA for alpha 4 protein, U30999 Human (memc) mRNA, 3′UTR,L77886 Human protein tyrosine phosphatase mRNA, complete cds, U14603Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partial sequence,U28480 Uncoupling Protein Ucp, X53586 Human mRNA for integrin alpha 6,M64347 Human novel growth factor receptor mRNA, 3′ cds, U52100 Human XMPmRNA, complete cds, D21852 Human mRNA for KIAA0029 gene, partial cds,X05409 Human RNA for mitochondrial aldehyde dehydrogenase I ALDH I (EC1.2.1.3), D87462 Human mRNA for KIAA0272 gene, partial cds, L40391 H.sapiens (clone s153) mRNA fragment, D87469 Human mRNA for KIAA0279 gene,partial cds, S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, L19267 H. sapiens 59 protein mRNA, 3′ end,M81601 Human transcription elongation factor (SII) mRNA, complete cds,X52611 Human mRNA for transcription factor AP-2, U28811 Humancysteine-rich fibroblast growth factor receptor (CFR-1) mRNA, completecds, L31801 H. sapiens monocarboxylate transporter 1 (SLC16A1) mRNA,complete cds, M13929 Human c-myc-P64 mRNA, initiating from promoter P0,(HLmyc2.5) partial cds, L48546 H. sapiens tuberin (TSC2) gene, exons 38,39, 40 and 41, L00058 Human (GH) germline c-myc proto-oncogene, exon 3and 3′ flank, U09587 Human glycyl-tRNA synthetase mRNA, complete cds,L37127 H. sapiens RNA polymerase II mRNA, complete cds, U52426 H.sapiens GOK (STIM1) mRNA, complete cds, U72066 H. sapiens CtBPinteracting protein CtIP (CtIP) mRNA, complete cds, U83115 Humannon-lens beta gamma-crystallin like protein (AIM1) mRNA, partial cds,M90656 Human gamma-glutamylcysteine synthetase (GCS) mRNA, complete cds,D90209 Human mRNA for DNA binding protein TAXREB67, D83777 Human mRNAfor KIAA0193 gene, complete cds, U42031 Human 54 kD progesteronereceptor-associated immunophilin FKBP54 mRNA, partial, M80244 Human E16mRNA, complete cds, 134. D31883 Human mRNA for KIAA0059 gene, completecds, J04444 Human cytochrome c-1 gene, complete cds, M38258 Humanretinoic acid receptor gamma 1 mRNA, complete cds, M95787 Human 22 kDsmooth muscle protein (SM22) mRNA, complete cds, U00968 Human SREBP-1MrRNA, complete cds, K03195 Human (HepG2) glucose transporter gene mRNA,complete cds, X92720 H. sapiens mRNA for phosphoenolpyruvatecarboxykinase, X77366 H. sapiens HBZ17 mRNA, U53347 Human neutral aminoacid transporter B mRNA, complete cds, X80695 H. sapiens OXA1Hs mRNA,J04102 Human erythroblastosis virus oncogene homolog 2 (ets-2) mRNA,complete cds, S75762 Oncogene Tls/Chop, Fusion Activated, U14550 Humansialyltransferase SThM (sthm) mRNA, complete cds, L09229 Humanlong-chain acyl-coenzyme A synthetase (FACL1) mRNA, complete cds, X76534H. sapiens NMB mRNA, M55268 Human casein kinase II alpha' subunit mRNA,complete cds, M27396 Human asparagine synthetase mRNA, complete cds,U37519 Human aldehyde dehydrogenase (ALDH8) mRNA, complete cds, X69111H. sapiens HLH 1R21 mRNA for helix-loop-helix protein, M77836 Humanpyrroline 5-carboxylate reductase mRNA, complete cds, D32050 Human mRNAfor alanyl-tRNA synthetase, complete cds, X01630 Human mRNA forargininosuccinate synthetase. This group of ultravioletradiation-regulated polynucleotides is hereinafter referred to as the“repressed response group” of ultraviolet radiation-regulatedpolynucleotides.

[0023] In one embodiment thereof, the composition of matter is a genearray suitable for monitoring gene expression. In one embodiment, thegene array is a low density gene array. In another embodiment, the genearray is a high density gene array. Polynucleotides utilized in theconstruction of the low or high density gene array include genomicclones, cDNAs, oligonucleotides, and the like.

[0024] In accordance with another aspect of the invention, there areprovided pharmaceutical compositions for modulating the response of acell to ultraviolet radiation exposure. The pharmaceutical compositionsof the invention comprise a compound in sufficient quantity to modulatethe response of the cell to ultraviolet radiation exposure and apharmaceutically acceptable carrier. The response of the cell toultraviolet radiation comprises a pattern of expression comprising atleast one of the following: a first response group, a second responsegroup, and a third response group. In one embodiment, the first responsegroup comprises altered expression of at least one nucleic acid moleculeencoding a transcription factor protein, at least one nucleic acidmolecule encoding a signal transducing protein, and at least one nucleicacid molecule encoding a mitochondrial protein. The second responsegroup comprises altered expression of at least one nucleic acid moleculeencoding a secreted growth factor, at least one nucleic acid moleculeencoding a cytokine, and at least one nucleic acid molecule encoding achemokine. The third response group comprises altered expression of atleast one nucleic acid molecule encoding an actin-binding protein, atleast one nucleic acid molecule encoding a desmosomal protein, at leastone nucleic acid molecule encoding a tubulin protein, at least onenucleic acid molecule encoding a conified envelope protein.

[0025] These groups are hereinafter referred to as the “primary firstresponse group,” the “primary second response group,” and the “primarythird response group,” respectively.

[0026] In other embodiments thereof, the pharmaceutical compositions ofthe invention comprise a compound in sufficient quantity to modulate theresponse of the cell to ultraviolet radiation exposure, the responsecomprising a pattern of expression comprising at least one of thefollowing: (1) the primary first response group; or (2) the primarysecond response group; or (3) the primary third response group. In otherembodiments, the pattern comprises the primary first response group andthe primary second response group. In another embodiment, the patterncomprises the primary first response group and the primary thirdresponse group. In yet another embodiment, the response comprises theprimary second response group and the primary third response group. Instill another embodiment, the response comprises the primary firstresponse group, the primary second response group, and the primary thirdresponse group.

[0027] Additional embodiments of the invention provide pharmaceuticalcompositions comprising a compound in sufficient quantity to modulatethe response of the cell to ultraviolet radiation exposure, comprisingultraviolet radiation energy at a wavelength in the range of about 220nm to about 440 nm, or ultraviolet radiation energy at a wavelength fromabout 290 nm to about 320 nm, or ultraviolet radiation energy at awavelength from about 320 to about 440 nm, or a total ultravioletradiation energy exposure in the range from about 0.2 mJ/cm² to about 40mJ/cm². Other embodiments thereof provide a pharmaceutical formulationto modulate the response of a cell that is a skin cell (epidermal ordermal) or the cell is selected from the group consisting of akeratinocyte, a Langerhans cell, a melanocyte, and a fibroblast cell.

[0028] In yet another embodiment, the pharmaceutical compositions of theinvention comprise a compound in sufficient quantity to modulate theresponse of the cell to ultraviolet radiation exposure and apharmaceutically acceptable carrier, wherein the response comprises apattern of expression comprising at least one of the following: a firstresponse group, a second response group, and a third response group. Thefirst response group comprises at least one polynucleotide that is atleast 90% identical to a nucleic acid molecule selected from the groupconsisting of: M62831 Human transcription factor ETR101 mRNA, completecds, X68277 H. sapiens CL 100 mRNA for protein tyrosine phosphatase,L04731 H. sapiens translocation T(4:11) of ALL-1 gene to chromosome 4,X56681 Human jund mRNA, U20734 Human transcription factor junB (junB)gene, 5′ region and complete cds, L38951 H. sapiens importin betasubunit mRNA, complete cds, D87071 Human mRNA for E IAA0233 gene,complete cds, M72885 Human GOS2 gene, 5′ flank and cds, M92843 H.sapiens zinc finger transcriptional regulator mRNA, complete cds, S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, U72649 Human BTG2 (BTG2) mRNA, complete cds, D86988 Human mRNAfor KIAA0221 gene, complete cds, L19779 H. sapiens histone H2A.2 mRNA,complete cds, U62317 Chromosome 22q13 BAC Clone CIT987SK-384D8 completesequence, X04412 Human mRNA for plasma gelsolin, L27706 Human chaperoninprotein (Tcp20) gene complete cds, X61123 Human BTG1 mRNA, M60974growtharrest and DNA-damage-inducible protein (gadd45) mRNA, complete cds,L19437 Human transaldolase mRNA containing transposable element,complete cds, X57985 H. sapiens genes for histones H2B.1 and H2A, D90086Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunit gene, exons 1-10,M34182 Human testis-specific protein kinase gamma-subunit mRNA, completecds, L16862 H. sapiens G protein-coupled receptor kinase (GRK6) mRNA,complete cds, D13705 Human mRNA for fatty acids omega-hydroxylase(cytochrome P-450HKV), complete cd, U37122 Human adducin gamma subunitmRNA, complete cds, D45906 H. sapiens mRNA for LIMK-2, complete cds,U07664 Human HB9 homeobox gene, exons 2 and 3 and complete cds, D87438Human mRNA for KIAA0251 gene, partial cds, L37042 H. sapiens caseinkinase I alpha isoform (CSNK1A1) mRNA, complete cds, D14043 Human mRNAfor MGC-24, complete cds, D13988 Human rab GDI mRNA, complete cds,U28480 Uncoupling Protein Uc, D50840 H. sapiens mRNA for ceramideglucosyltransferase, complete cds, M55265 Human casein kinase II alphasubunit mRNA, complete cds, M96803 Human general beta-spectrin (SPTBN1)mRNA, complete cds, U89336 Human HLA class III region containing NOTCH4gene, partial sequence, homeobox P, D87442 Human mRNA for KIAA0253 gene,partial cds, J03161 Human serum response factor (SRF) mRNA, completecds, D86965 Human mRNA for KIAA0210 gene, complete cds, U17327 Humanneuronal nitric oxide synthase (NOS1) mRNA, complete cds, D86966 HumanmRNA for KIAA0211 gene, complete cds, D85527 H. sapiens mRNA for LIMdomain, partial cds, U42031 Human 54 kD progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, X59434 Human rohu mRNA for rhodanese,M13929 Human c-myc-P64 mRNA, initiating from promoter P0, (HLmyc2.5)partial cds, J05211 Desmoplakin.

[0029] The second response group of this embodiment comprises at leastone polynucleotide that is at least 90% identical to a nucleic acidmolecule selected from the group consisting of: M57731 Human gro-betamRNA, complete cds, S81914 IEX-1=radiation-inducible immediate-earlygene [human, placenta, mRNA Partial, 1, Y00787 Human mRNA for MDNCF(monocyte-derived neutrophil chemotactic factor), X54489 Human gene formelanoma growth stimulatory activity (MGSA), M72885 Human GOS2 gene, 5′flank and cds, M62831 Human transcription factor ETR101 mRNA, completecds, M28130 Human interleukin 8 (IL8) gene, complete cds, X57985 H.sapiens genes for histones H2B.1 and H2A, X53800 Human mRNA formacrophage inflammatory protein-2beta (MIP2beta), L19779 H. sapienshistone H2A.2 mRNA, complete cds, AF001294 H. sapiens IPL (IPL) mRNA,complete cds, X56681 Human junD mRNA, S75762 Oncogene Tls/Chop, FusionActivate, M84739 Human autoantigen calreticulin mRNA, complete cds,M21302 Human small proline rich protein (sprII) mRNA, clone 174N, V00599Tubulin, Bet, X70326 Macmarck, D10923 Human mRNA for HM74, D64142 HumanmRNA for histone H1x, complete cds, D86974 Human mRNA for KIAA0220 gene,partial cds, M60974 Human growth arrest and DNA-damage-inducible protein(gadd45) mRNA, complete cds, X68277 H. sapiens CL 100 mRNA for proteintyrosine phosphatase, L13391 Human helix-loop-helix basic phosphoprotein(G0S8) gene, complete cds, M31627 Human X box binding protein-1 (XBP-1)mRNA, complete cds, U40369 Human spermidine/spermineN1-acetyltransferase (SSAT) gene, complete cds, X52560 Nuclear FactorNf-Il, X61123 Human BTG1 mRNA, U20734 Human transcription factor junB(junB) gene, 5′ region and complete cds, U35048 Human TSC-22 proteinmRNA, complete cds, M69043 H. sapiens MAD-3 mRNA encoding IkB-likeactivity, complete cds, X51345 Human jun-B mRNA for JUN-B protein,S68616 Na+/H+ exchanger NHE-1 isoform [human, heart, mRNA, 4516 nt],X89750 H. sapiens mRNA for TGIF protein, X69111 H. sapiens HLH 1R21 mRNAfor helix-loop-helix protein, U14603 Human protein-tyrosine phosphatase(HU-PP-1) mRNA, partial sequence, X52541 Human mRNA for early growthresponse protein 1 (hEGR1), D50683 H. sapiens mRNA for TGF-betaIIRalpha, complete cds, M92843 H. sapiens zinc finger transcriptionalregulator mRNA, complete cds, X91247 H. sapiens mRNA for thioredoxinreductase, U05875 Human clone pSK1 interferon gamma receptor accessoryfactor-1 (AF-1) mRNA, comp, L19314 Human HRY gene, complete cds, M30703Human amphiregulin (AR) gene, exon 6, clones lambda-ARH(6,12), U34252Human gamma-aminobutyraldehyde dehydrogenase mRNA, complete cds, S78825Id1, D85429 H. sapiens gene for heat shock protein 40, complete cds,U41766 Human metalloprotease/disintegrin/cysteine-rich protein precursor(MDC9) mRNA, U89336 Human HLA class III region containing NOTCH4 gene,partial sequence, homeobox PB, M69181 Human nonmuscle myosin heavychain-B (MYH10) mRNA, partial cds, D15050 Human mRNA for transcriptionfactor AREB6, complete cds, U28386 Human nuclear localization sequencereceptor hSRP1alpha mRNA, complete cds, L77886 Human protein tyrosinephosphatase mRNA, complete cds, X64330 H. sapiens mRNA for ATP-citratelyase, U37122 Human adducin gamma subunit mRNA, complete cds, X74008 H.sapiens mRNA for protein phosphatase 1 gamma, U60205 complete cds,U90716 Human cell surface protein HCAR mRNA, complete cds, M91083 HumanDNA-binding protein (HRC1) mRNA, complete cds, U29607 Human methionineaminopeptidase mRNA, complete cds, M76482 Human 130-kD pemphigusvulgaris antigen mRNA, complete cds, U72066 H. sapiens CtBP interactingprotein CtIP (CtIP) nmRNA, complete cds, K03195 Human (HepG2) glucosetransporter gene mRNA, complete cds, X12953 Human rab2 mRNA,YPT1-related and member of ras family, M60483 Human protein phosphatase2A catalytic subunit-alpha gene, complete cds, U72649 Human BTG2 (BTG2)mRNA, complete cds, D14520 Human mRNA for GC-Box binding protein BTEB2,complete cds, L08069 Human heat shock protein, E. coli DnaJ homologmRNA, complete cds, D50840 H. sapiens mRNA for ceramideglucosyltransferase, complete cds, L31801 H. sapiens monocarboxylatetransporter 1 (SLC16A1) mRNA, complete cds, S74017 Nrf2=NF-E2-like basicleucine zipper transcriptional activator [human, hemin-in, X87241 H.sapiens mRNA for hFat protein, X52425 Human IL-4-R mRNA for theinterleukin 4 receptor, D79994 Human mRNA for KIAA0172 gene, partialcds, M58286 H. sapiens tumor necrosis factor receptor mRNA, completecds, M13829 Human putative raf related protein (pks/a-raf) mRNA, partialcds, X78992 H. sapiens ERF-2 mRNA, U42031 Human 54 kD progesteronereceptor-associated immunophilin FKBP54 mRNA, partial, U88629 Human RNApolymerase II elongation factor ELL2, complete cds, X52611 Human mRNAfor transcription factor AP-2, U28749 Human high-mobility groupphosphoprotein isoform I-C (HMGIC) mRNA, complete cds, L00058 Human (GH)germ line c-myc proto-oncogene, exon 3 and 3′ flank, L26336 Heat ShockProtein, 70 KD (Gb:Y00371, L08246 Human myeloid cell differentiationprotein (MCL1) mRNA, S73591 brain-expressed HHCPA78 homolog [human,HL-60 acute promyelocytic, leukemia cells, J05211 Desmoplakin, L00352Human low density lipoprotein receptor gene, exon 18, Y13647Stearoyl-Coenzymea Desaturase, X77794 H. sapiens mRNA for cyclin G1,M90656 Human gamma-glutamylcysteine synthetase (GCS) mRNA, complete cds,M13929 Human c-myc-P64 mRNA, initiating from promoter P0, (HLmyc2.5)partial cds, D78129 H. sapiens mRNA for squalene epoxidase, partial cds,X80692 H. sapiens ERK3 mRNA, J00120 Proto-Oncogene C-Myc, Alt. Splice 3,Orf 114.

[0030] The third response group of this embodiment comprises at leastone polynucleotide that is at least 90% identical to a nucleic acidmolecule selected from the group consisting of: M20030 Human smallproline rich protein (sprIl) mRNA, clone 930, X53065, M13903 Humaninvolucrin gene, exon 2, M22918 Myosin, Light Chain, ALkali, SmoothMuscle (Gb:U02629), Non-Muscle, Alt. Splice, L10343 Huma elafin gene,complete cds, M63573 Human secreted cyclophilin-like protein (SCYLP)mRNA, complete cds, M21302 Human small proline rich protein (sprl I)mRNA, clone 174N, Y00787 Human mRNA for MDNCF (monocyte-derivedneutrophil chemotactic factor), X57985 H. sapiens genes for histonesH2B.1 and H2A, L05188 H. sapiens small proline-rich protein 2 (SPRR2B)gene, complete cds, X70326 Macmarcks, X67325 H. sapiens p27 mRNA, L19779H. sapiens histone H2A.2 mRNA, complete cds, S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, D45248 Human mRNA for proteasome activator hPA28 subunitbeta, complete cds, Z22548 H. sapiens thiol-specific antioxidant proteinmRNA, M22918 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629),Non-Muscle, Alt. Splice, X06956 Tubulin, Alpha 1, Isoform 44, V00594Human mRNA for metallothionein from cadmium-treated cells, M80254 H.sapiens cyclophilin isoform (hCyP3) mRNA, complete cds, U04636 Humancyclooxygenase-2 (hCox-2) gene, complete cds, Z14244 H. sapiens coxVIIbmRNA for cytochrome c oxidase subunit VIIb, X99920 H. sapiens mRNA forS100 calcium-binding protein A13, U62800 Human cystatin M (CST6) mRNA,complete cds, L08069 Human heat shock protein, E. coli DnaJ homologmRNA, complete cds, L20688 Human GDP-dissociation inhibitor protein(Ly-GDI) mRNA, complete cds, M13755 Human interferon-induced 17-kD/15-kDprotein mRNA, complete cds, M60278 Human heparin-binding EGF-like growthfactor mRNA, complete cds, AF001294 H. sapiens IPL (IPL) mRNA, completecds, X54489 Human gene for melanoma growth stimulatory activity (MGSA),M21186 Human neutrophil cytochrome b light chain p22 phagocyteb-cytochrome mRNA, compl, D42040 Human mRNA for KIAA9001 gene, completecds, V00599 Tubulin, Beta, U37690 Human RNA polymerase II subunit(hsRPB10) mRNA, complete cds, M21005 Human migration inhibitoryfactor-related protein 8 (MRP8) gene, complete cds, M37583 Human histone(H2A.Z) mRNA, complete cds, Z49989 H. sapiens mRNA for smoothelin,L24564 Human Rad mRNA, complete cds, D49824 Human HLA-B null allelemRNA, M59465 Human tumor necrosis factor alpha inducible protein A20mRNA, complete cds, S54005 thymosin beta-10 [human, metastatic melanomacell line, mRNA, 453 nt], Z49254 H. sapiens L23-related mRNA, M22919Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629), Smooth Muscle,Alt. Spli, U70660 Human copper transport protein HAH1 (HAH1) mRNA,complete cds, AF006084 H. sapiens Arp2/3 protein complex subunit p41-Arc(ARC41) mRNA, complete cds, X62083 H. sapiens mRNA for Drosophila femalesterile homeotic (FSH) homolog, D86974 Human mRNA for KIAA0220 gene,partial cds, M72885 Human GOS2 gene, 5′ flank and cds, S80437 fatty acidsynthase {3′ region} [human, breast and HepG2 cells, mRNA Partial, 22,X04654 Human mRNA for U1 RNA-associated 70K protein, t M26311 Humancystic fibrosis antigen mRNA, complete cds, X14850 Human H2A.X mRNAencoding histone H2A.X, M14328 Human alpha enolase mRNA, complete cds,U07919 Human aldehyde dehydrogenase 6 mRNA, complete cds, M28130 Humaninterleukin 8 (IL8) gene, complete cds, Z21507 H. sapiens EF-1delta geneencoding human elongation factor-1-delta, M92934 Human connective tissuegrowth factor, complete cds, M27436 Human tissue factor gene, completecds, with a Alu repetitive sequence in the 3′, X74874 H. sapiens genefor RNA pol II largest subunit, exon 1, X57351 Human 1-8D gene frominterferon-inducible gene family, X52979 Human gene for small nuclearribonucleoproteins SmB and SmB′, U41515 Human deleted in splithand/split foot 1 (DSS 1) mRNA, complete cds, D28235 Human PTGS2 genefor prostaglandin endoperoxide synthase-2, complete cds, Y00503 HumanmRNA for keratin 19. M57731 Human gro-beta mRNA, complete cds, D50840 H.sapiens mRNA for ceramide glucosyltransferase, complete cds, U52101Human YMP mRNA, complete cds. D13413 Human mRNA for tumor-associated 120kD nuclear protein p120, partial cds(carbox, L42379 H. sapiensbone-derived growth factor (BPGF-1) mRNA, complete cds, X52426 H.sapiens mRNA for cytokeratin 13, J04456 Human 14 kD lectin mRNA,complete cds, S78771 NAT=CpG island-associated gene [human, mRNA, 1741nt], M26730 Human mitochondrial ubiquinone-binding protein (QP) gene,exon 4, U26727 Human p16INK4/MTS1 mRNA, complete cds, X92896 H. sapiensmRNA for ITBA2 protein, Z69043 H. sapiens mRNA translocon-associatedprotein delta subunit precursor, L76568 H. sapiens excision and crosslink repair protein (ERCC4) gene, complete genom, M12125 Humanfibroblast muscle-type tropomyosin mRNA, complete cds, U09937 Humanurokinase-type plasminogen receptor, exon 7, X15822 Human COX VIIa-LmRNA for liver-specific cytochrome c oxidase (EC 1.9.3.1.), M34516 Humanomega light chain protein 14.1 (Ig lambda chain related) gene, exon 3,U53830 H. sapiens interferon regulatory factor 7A mRNA, complete cds,X82693 H. sapiens mRNA for E48 antigen, M58026 Human NB-1 mRNA, completecds, M90657 Human tumor antigen (L6) mRNA, complete cds, X57579 H.sapiens activin beta-A subunit (exon 2), D38251 Human mRNA for RPB5(XAP4), complete cds, D89667 H. sapiens mRNA for c-myc binding protein,complete cds, AB000584 H. sapiens mRNA for TGF-beta superfamily protein,complete cds, L76200 Human guanylate kinase (GUK1) mRNA, complete cds,J04794 Human aldehyde reductase mRNA, complete cds, X52882 Humant-complex polypeptide 1 gene, M79463 Human PML-2 mRNA, complete CDS,Y09022 H. sapiens mRNA for Not56-like protein, M12529 Humanapolipoprotein E mRNA, complete cds, X71129 H. sapiens mRNA for electrontransfer flavoprotein beta subunit, X83416 H. sapiens PrP gene, exon 2,D89052 H. sapiens mRNA for proton-ATPase-like protein, complete cds,M60974 Human growth arrest and DNA-damage-inducible protein (gadd45)mRNA, complete cds, M16364 Human creatine kinase-B mRNA, complete cds,D38305 Human mRNA for Tob, complete cds, X87679 Major HistocompatibilityComplex, Class I, E (Gb:M21533), Z29505 H. sapiens mRNA for nucleic acidbinding protein sub2.3, K02574, U09813 Human mitochondrial ATP synthasesubunit 9, P3 gene copy, mRNA, nuclear gene enc, X67951 H. sapiens mRNAfor proliferation-associated gene (pag), J04611 Human lupus p70 (Ku)autoantigen protein mRNA, complete cds, U09578 H. sapiens MAPKAP kinase(3pK) mRNA, complete cds, X53800 Human mRNA for macrophage inflammatoryprotein-2beta (MIP2beta), V00599 Tubulin, Beta 2, U69126 Human FUSEbinding protein 2 (FBP2) mRNA, partial cds, X53416 Human mRNA foractin-binding protein (filamin) (ABP-280), U90546 Human butyrophilin(BTF4) mRNA, complete cds, M58459 Human ribosomal protein (RPS4Y)isoform mRNA, complete cds, M19961 Human cytochrome c oxidase subunit Vb(coxVb) mRNA, complete cds, U65579 Human mitochondrial NADHdehydrogenase-ubiquinone Fe-S protein 8, 23 kD subunit, X77794 H.sapiens mRNA for cyclin G1, M29064 Human hnRNP B1 protein mRNA, D21853Human mRNA for KIAA0111 gene, complete cds, X78687 H. sapiens G9 geneencoding sialidase, X15729 Human mRNA for nuclear p68 protein, X04828Human mRNA for G(i) protein alpha-subunit (adenylate cyclase inhibitingGTP-bind, L27943 H. sapiens cytidine deaminase (CDA) mRNA, complete cds,L40391 H. sapiens (clone s153) mRNA fragment, D42123 H. sapiens mRNA forESP1/CRP2, complete cds, X74104 H. sapiens mRNA for TRAP beta subunit,M84332 Human ADP-ribosylation factor 1 gene, exons 2-5, L37127 H.sapiens RNA polymerase II mRNA, complete cds, M92843 H. sapiens zincfmger transcriptional regulator mRNA, complete cds, U07664 Human HB9homeobox gene, exons 2 and 3 and complete cds, L48546 H. sapiens tuberin(TSC2) gene, exons 38, 39, 40 and 41, X53586 Human mRNA for integrinalpha 6, t D21852 Human mRNA for KIAA0029 gene, partial cds, L11066Human mRNA sequence, J04444 Human cytochrome c-1 gene, complete cds,M95787 Human 22 kD smooth muscle protein (SM22) mRNA, complete cds,L07517 Mucin 6, Gastric (Gb:L07517), X91247 H. sapiens mRNA forthioredoxin reductase, L11672 Human Kruppel related zinc finger protein(HTF10) mRNA, complete cds, U30999 Human (memc) mRNA, 3′UTR, U01337Human Ser/Thr protein kinase (A-RAF-1) gene, complete cds, U28480Uncoupling Protein Ucp, X12794 Human v-erbA related ear-2 gene, L22005Human ubiquitin conjugating enzyme mRNA, partial cds, M12886 HumanT-cell receptor active beta-chain mRNA, complete cds, Y08915 H. sapiensmRNA for alpha 4 protein, M24547 Amyloid Beta (A4) Precursor Protein,Alt. Splice 2, A4(751), X76717 H. sapiens MT-11 mRNA, M64347 Human novelgrowth factor receptor mRNA, 3′ cds, X05409 Human RNA for mitochondrialaldehyde dehydrogenase I ALDH I (EC 1.2.1.3), D87469 Human mRNA forKIAA0279 gene, partial cds, M58603 Human nuclear factor kappa-B DNAbinding subunit (NF-kappa-B) mRNA, complete cds, M76482 Human 130-kDpemphigus vulgaris antigen mRNA, complete cds, X06323 Human MRL3 mRNAfor ribosomal protein L3 homolog (MRL3=mammalian ribosome L, X78992 H.sapiens ERF-2 mRNA, L41351 H. sapiens prostasin mRNA, complete cds,X75342 H. sapiens SHB mRNA, U83115 Human non-lens beta gamma-crystallinlike protein (AIM1) mRNA, partial cds, U88629 Human RNA polymerase IIelongation factor ELL2, complete cds, S78825 Id1, U28811 Humancysteine-rich fibroblast growth factor receptor (CFR-1) mRNA, completecds, M58286 H. sapiens tumor necrosis factor receptor mRNA, completecds, D78129 H. sapiens mRNA for squalene epoxidase, partial cds, D14874H. sapiens mRNA for adrenomedullin precursor, complete cds, Z26317 H.sapiens mRNA for desmoglein 2, L19267 H. sapiens 59 protein mRNA, 3′end, J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114, U33821 Humantax1-binding protein TXBP151 mRNA, complete cds, U52100 Human XMP mRNA,complete cds, L31801 H. sapiens monocarboxylate transporter 1 (SLC16A1)mRNA, complete cds, L00058 Human (GH) germline c-myc proto-oncogene,exon 3 and 3′ flank, U52426 H. sapiens GOK (STIM1) mRNA, complete cds,M80244 Human E16 mRNA, complete cds, U56418 Human lysophosphatidic acidacyltransferase-beta mRNA, complete cds, L38490 H. sapiensADP-ribosylation factor mRNA, complete cds, U14603 Humanprotein-tyrosine phosphatase (HU-PP-1) mRNA, partial sequence, L77886Human protein tyrosine phosphatase mRNA, complete cds, M38258 Humanretinoic acid receptor gamma 1 mRNA, complete cds, X89750 H. sapiensmRNA for TGIF protein, D85429 H. sapiens gene for heat shock protein 40,complete cds, J05211 Desmoplakin I, M31627 Human X box binding protein-1(XBP-1) mRNA, complete cds, X80695 H. sapiens OXA1Hs mRNA, M54915 Humanh-pim-1 protein (h-pim-1) mRNA, complete cds, D83777 Human mRNA forKIAA0193 gene, complete cds, D31883 Human mRNA for KIAA0059 gene,complete cds, U00968 Human SREBP-1 mRNA, complete cds, K03195 Human(HepG2) glucose transporter gene mRNA, complete cds, D86965 Human mRNAfor KIAA0210 gene, complete cds, Z30643 H. sapiens mRNA for chloridechannel (putative) 2139bp, D14520 Human mRNA for GC-Box binding proteinBTEB2, complete cds, D87462 Human mRNA for KIAA0272 gene, partial cds,X80692 H. sapiens ERK3 mRNA, X90858 H. sapiens mRNA for uridinephosphorylase, M57763 Human ADP-ribosylation factor (hARF6) mRNA,complete cds, X92720 H. sapiens mRNA for phosphoenolpyruvatecarboxykinase, M81601 Human transcription elongation factor (SII) mRNA,complete cds, X52611 Human mRNA for transcription factor AP-2, U09587Human glycyl-tRNA synthetase mRNA, complete cds, U14550 Humansialyltransferase SThM (sthm) mRNA, complete cds, D90209 Human mRNA forDNA binding protein TAXREB67, X77366 H. sapiens HBZ17 mRNA, X76534 H.sapiens NMB mRNA, U37519 Human aldehyde dehydrogenase (ALDH8) mRNA,complete cds, M83667 Human NF-IL6-beta protein mRNA, complete cds,U53347 Human neutral amino acid transporter B mRNA, complete cds, L09229Human long-chain acyl-coenzyme A synthetase (FACL1) mRNA, complete cds,S73591 brain-expressed HHCPA78 homolog [human, HL-60 acute promyelocyticleukemia cells, M13929 Human c-myc-P64 mRNA, initiating from promoterP0, (HLmyc2.5) partial cds, M55268 Human casein kinase II alpha' subunitmRNA, complete cds, M77836 Human pyrroline 5-carboxylate reductase mRNA,complete cds, HG2724-HT2820_at S75762 Oncogene Tls/Chop, FusionActivated, U72066 H. sapiens CtBP interacting protein CtIP (CtIP) mRNA,complete cds, U42031 Human 54 kD progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, M27396 Human asparagine synthetasemRNA, complete cds, X01630 Human mRNA for argininosuccinate synthetase,D32050 Human mRNA for alanyl-tRNA synthetase, complete cds, M90656 Humangamma-glutamylcysteine synthetase (GCS) mRNA, complete cds, J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,and X69111 H. sapiens HLH 1R21 mRNA for helix-loop-helix protein.

[0031] These groups are hereinafter referred to as the “secondary firstresponse group,” the “secondary second response group,” and the“secondary third response group,” respectively.

[0032] In another aspect of the invention, pharmaceutical compositionsof the invention comprise a compound in sufficient quantity to modulatethe response of the cell to ultraviolet radiation exposure and apharmaceutically acceptable carrier, wherein the response comprises thealtered regulation of a protein encoded by a polynucleotide selectedfrom the first response group, second response group, and the thirdresponse group. Furthermore, in this embodiment, the first responsegroup comprises altered expression of at least one transcription factorprotein, at least one signal transducing protein, and at least onemitochondrial protein. The second response group comprises alteredexpression of at least one secreted growth factor, at least onecytokine, and at least one chemokine. The third response group comprisesaltered expression of at least one actin-binding protein, at least onedesmosomal protein, and at least one tubulin protein.

[0033] These groups are hereinafter referred to as the “tertiary firstresponse group,” the “tertiary second response group,” and the “tertiarythird response group,” respectively. Thus, where the primary first,second, and third response groups relate to nucleic acid molecules, thetertiary first, second, and third response groups relate to the proteinsencoded by nucleic acid molecules of the primary groups.

[0034] In other embodiments thereof, the pharmaceutical compositions ofthe invention comprise a compound in sufficient quantity to modulate theresponse of the cell to ultraviolet radiation exposure, the responsecomprising a pattern of expression comprising at least one of thefollowing: (1) the tertiary first response group; or (2) the tertiarysecond response group; or (3) the tertiary third response group; or (4)the tertiary firs t response group and the tertiary second responsegroup; or (5) the tertiary first response group and the tertiary thirdresponse group; or (6) the tertiary second response group and thetertiary third response group; or (7) the tertiary first response groupand the tertiary second response group and the tertiary third responsegroup.

[0035] Additional embodiments thereof provide pharmaceuticalcompositions comprising a compound in sufficient quantity to modulatethe response of the cell to ultraviolet radiation exposure, comprisingultraviolet radiation energy at a wavelength in the range of about 220nm to about 440 nm, or ultraviolet radiation energy at a wavelength ofabout 290 nm to about 320 nm, or ultraviolet radiation energy at awavelength of about 320 to about 440 nm, or a total ultravioletradiation energy exposure in the range of about 0.2 mJ/cm² to about 40mJ/cm². Other embodiments of the invention provide a pharmaceuticalformulation for modulating the expression of a response of a skin cell(epidermal or dermal) or a cell selected from the group consisting of akeratinocyte, a Langerhans cell, a melanocyte, and a fibroblast cell, inresponse to ultraviolet radiation.

[0036] In yet another embodiment, the pharmaceutical compositions of theinvention comprise a compound in sufficient quantity to modulate theresponse of the cell to ultraviolet radiation exposure, the responsecomprising at least one of the following: a first response group; asecond response group, and a third response group. In this embodiment,the first response group comprises the altered expression of a pluralityof protein molecules, each encoded by a polynucleotide that is at least90% identical to a nucleic acid molecule selected from the groupconsisting of the secondary first response group. The second responsegroup comprises the altered expression of a plurality of proteinmolecules, each encoded by a polynucleotide that is at least 90%identical to a nucleic acid molecule selected from the group consistingof the secondary second response group. The third response groupcomprises the altered expression of a plurality of protein molecules,each encoded by a polynucleotide that is at least 90% identical to anucleic acid molecule selected from the group consisting of thesecondary third response group. These first, second and third responsegroups are hereinafter referred to as the “quaternary first responsegroup,” the “quaternary second response group,” and the “quaternarythird response group.” These groups are, in effect, the proteinmolecules encoded by the nucleic acid molecules of the secondary first,second and third response groups.

[0037] In other embodiments, the pharmaceutical compositions of theinvention comprise a compound in sufficient quantity to modulate theresponse of the cell to ultraviolet radiation exposure, the responsecomprising: (1) the quaternary first response group; or (2) thequaternary second response group; or (3) the quaternary third responsegroup; or (4) the quaternary first response group and the quaternarysecond response group; or (5) the quaternary first response group andthe quaternary third response group; or (6) the quaternary secondresponse group and the quaternary third response group; or (7) thequaternary first response group and the quaternary second response groupand the quaternary third response group.

[0038] Additional embodiments thereof provide pharmaceuticalcompositions comprising a compound in sufficient quantity to modulatethe response of the cell to ultraviolet radiation exposure, comprising:(1) ultraviolet radiation energy at a wavelength in the range of about220 nm to about 440 nm; or (2) ultraviolet radiation energy at awavelength of about 290 nm to about 320 nm; or (3) ultraviolet radiationenergy at a wavelength of about 320 to about 440 nm; or (4) a totalultraviolet radiation energy exposure in the range of about 0.2 mJ/cm²to about 40 mJ/cm². Other embodiments thereof provide a therapeuticcomposition to modulate the response of a skin cell (epidermal ordermal) or a cell selected from the group consisting of a keratinocyte,a Langerhans cell, a melanocyte, and a fibroblast cell, to ultravioletradiation.

[0039] Another aspect of the invention provides a pharmaceuticalcomposition for modulating a response of a cell to ultraviolet radiationexposure. This pharmaceutical composition comprises a compound insufficient quantity to modulate the response of the cell to ultravioletradiation exposure, the response being an altered pattern of expressioncomprising at least one of the following: the primary first responsegroup, the primary second response group and the primary third responsegroup; and a pharmaceutically acceptable carrier. In embodimentsthereof, modulation of the cellular response is an inhibition of theultraviolet radiation exposure-induced RNA expression or an inhibitionof the ultraviolet radiation exposure-repressed RNA expression.

[0040] In yet another aspect, the invention provides a pharmaceuticalcomposition for modulating a response of a cell to ultraviolet radiationexposure. This pharmaceutical composition comprises a compound insufficient quantity to modulate the response of the cell to ultravioletradiation exposure, the response being an altered pattern of expressioncomprising at least one of the following: a secondary first responsegroup, a secondary second response group, and a secondary third responsegroup.

[0041] Another aspect of the invention provides a pharmaceuticalcomposition for modulating a response of a cell to ultraviolet radiationexposure. This pharmaceutical composition comprises a compound insufficient quantity to modulate the response of the cell to ultravioletradiation exposure, the response being an altered pattern of expressioncomprising at least one of the following: the tertiary first responsegroup, the tertiary second response group and the tertiary thirdresponse group; and a pharmaceutically acceptable carrier. Inembodiments thereof, modulation of the cellular response is aninhibition of the ultraviolet radiation exposure-induced proteinexpression or an inhibition of the ultraviolet radiationexposure-repressed protein expression.

[0042] Another aspect of the invention provides a pharmaceuticalcomposition for modulating a response of a cell to ultraviolet radiationexposure. This pharmaceutical composition comprises a compound insufficient quantity to modulate the response of the cell to ultravioletradiation exposure, the response being an altered pattern of expressioncomprising at least one of the following: the quaternary first responsegroup, the quaternary second response group and the quaternary thirdresponse group; and a pharmaceutically acceptable carrier. Inembodiments thereof, modulation of the cellular response is aninhibition of the ultraviolet radiation exposure-induced proteinexpression or an inhibition of the ultraviolet radiationexposure-repressed protein expression. In embodiments thereof,modulation of the cellular response is an inhibition of the ultravioletradiation exposure-induced protein expression or an inhibition of theultraviolet radiation exposure-repressed protein expression.

[0043] Another aspect of the invention provides methods for detectingexposure of a cell to ultraviolet radiation. The method comprisesmeasuring the levels of a plurality of RNA molecules in the cell,wherein a pattern of expression is established and the pattern isindicative of ultraviolet radiation exposure. In various embodimentsthereof, this pattern of expression comprises a first response group, asecond response, and/or a third response. In one embodiment thereof, thefirst response group is the primary first response group previouslydescribed above; the second response is the primary second responsepreviously described above; and the third response is the primary thirdresponse previously described above. Other embodiments of this aspect ofthe invention include the following: (1) the pattern of expression isthe primary first response group; or (2) the pattern of expression isthe primary second response group; or (3) the pattern of expression isthe primary third response group; or (4) the pattern of expression isthe primary first response group and the primary second response group;or (5) the pattern of expression is the primary first response group andthe primary third response group; or (6) the pattern of expression isthe primary second response group and the primary third response group;or (7) the pattern of expression is the primary first response group,the primary second response group, and the primary third response group.

[0044] Additional embodiments thereof provide methods in which theultraviolet radiation exposure of the cell comprises: (1) ultravioletradiation energy at a wavelength in the range of about 220 nm to about440 nm; or (2) ultraviolet radiation energy at a wavelength of about 290nm to about 320 nm; or (3) ultraviolet radiation energy at a wavelengthof about 320 to about 440 nm; or (4) a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².Other embodiments thereof provide that the exposed cell is a skin cell(epidermal or dermal) or a cell selected from the group consisting of akeratinocyte, a Langerhans cell, a melanocyte, and a fibroblast cell.

[0045] In another embodiment, the method for detecting exposure of acell to ultraviolet radiation comprises measuring the levels of aplurality of RNA molecules in the cell for at least one time point,wherein a pattern of expression is established and the pattern isindicative of ultraviolet radiation exposure. In this embodiment, thepattern of expression comprises a first response group which is thesecondary first response group previously described above; a secondresponse which is the secondary second response previously describedabove; and a third response which is the primary third responsepreviously described above.

[0046] In various embodiments thereof, this pattern of expressioncomprises a first response group, and/or a second response, and/or athird response. In this embodiment, the first response group is thesecondary first response group previously described above; the secondresponse is the secondary second response previously described above;and the third response is the secondary third response previouslydescribed above. Embodiments thereof include the following: (1) thepattern of expression is the secondary first response group; or (2) thepattern of expression is the secondary second response group; or (3) thepattern of expression is the secondary third response group; or (4) thepattern of expression is the secondary first response group and thesecondary second response group; or (5) the pattern of expression is thesecondary first response group and the secondary third response group;or (6) the pattern of expression is the secondary second response groupand the secondary third response group; or (7) the pattern of expressionis the secondary first response group, the secondary second responsegroup, and the secondary third response group.

[0047] Additional embodiments of this aspect of the invention providedetection methods in which the ultraviolet radiation exposure of thecell comprises: (1) ultraviolet radiation energy at a wavelength in therange of 220 nm to 440 nm; or (2) ultraviolet radiation energy at awavelength of about 290 nm to 320 nm; or (3) ultraviolet radiationenergy at a wavelength of about 320 to 440 nm; or (4) a totalultraviolet radiation energy exposure in the range of about 0.2 mJ/cm²to about 40 mJ/cm². Other embodiments thereof provide that the exposedcell is a skin cell (epidermal or dermal) or the cell is selected fromthe group consisting of a keratinocyte, a Langerhans cell, a melanocyte,and a fibroblast cell.

[0048] The invention also provides methods for detecting exposure of acell to ultraviolet radiation in which the measurement of the level ofthe plurality of RNA molecules is done by expression array analysis. Inthis method, RNA is isolated from the cell at a time post-ultravioletradiation exposure. A test expression array is created through nucleicacid hybridization between a labeled probe complementary to the RNA andan expression array substrate. The test expression array is analyzed tocreate a test expression array data set, which is then compared to thecontrol expression array data. The levels of the plurality of RNAmolecules in the cell is then analyzed to establish a response patternof the cell, the normal response pattern of a cell exposed toultraviolet radiation comprising: (i) a first response group comprisingaltered expression of at least one nucleic acid molecule encoding atranscription factor protein, at least one nucleic acid moleculeencoding a signal transducing protein, and at least one nucleic acidmolecule encoding a mitochondrial protein; (ii) a second responsecomprising altered expression of at least one nucleic acid moleculeencoding a secreted growth factor, at least one nucleic acid encoding acytokine, and at least one nucleic acid encoding a chemokine; and/or(iii) a third response comprising altered expression of at least onenucleic acid molecule encoding an actin-binding protein, at least onenucleic acid molecule encoding a desmosomal protein, at least onenucleic acid molecule encoding a tubulin protein, and at least onenucleic acid molecule encoding a cornified envelope protein. If the testexpression array data set is substantially similar to the normalresponse of a cell to ultraviolet radiation, then the cell was exposedto ultraviolet radiation.

[0049] Another aspect of the invention provides other methods fordetecting exposure of a cell to ultraviolet radiation. These methodscomprise measuring a plurality of protein molecules in the cell, whereina pattern of expression is established and the pattern is indicative ofultraviolet radiation exposure. In various embodiments thereof, thispattern of expression comprises a first response group, a secondresponse, and/or a third response. In one embodiment thereof, the firstresponse group is the tertiary first response group previously describedabove; the second response is the tertiary second response previouslydescribed above; and the third response is the tertiary third responsepreviously described above. Embodiments of this method include thefollowing: (1) the pattern of expression is the tertiary first responsegroup; or (2) the pattern of expression is the tertiary second responsegroup; or (3) the pattern of expression is the tertiary third responsegroup; or (4) the pattern of expression is the tertiary first responsegroup and the tertiary second response group; or (5) the pattern ofexpression is the tertiary first response group and the tertiary thirdresponse group; or (6) the pattern of expression is the tertiary secondresponse group and the tertiary third response group; or (7) the patternof expression is the tertiary first response group, the tertiary secondresponse group, and the tertiary third response group.

[0050] Additional embodiments thereof provide methods in which the cellis exposed to ultraviolet radiation comprising ultraviolet radiationenergy at a wavelength in the range of about 220 nm to about 440 nm;ultraviolet radiation energy at a wavelength of about 290 nm to about320 nm; ultraviolet radiation energy at a wavelength of about 320 toabout 440 nm; or a total ultraviolet radiation energy exposure in therange of about 0.2 mJ/cm² to about 40 mJ/cm². Other embodiments of thisaspect of the invention provide methods in which the cell exposed toultraviolet radiation is a skin cell (epidermal or dermal) or a cellselected from the group consisting of a keratinocyte, a Langerhans cell,a melanocyte, and a fibroblast cell.

[0051] In another embodiment, the method for detecting exposure of acell to ultraviolet radiation comprises measuring the levels of aplurality of protein molecules in the cell for at least one time point,wherein a pattern of expression is established and the pattern isindicative of ultraviolet radiation exposure. In this embodiment, thepattern of expression comprises a first response group which is thequaternary first response group previously described above; a secondresponse which is the quaternary second response previously describedabove; and a third response which is the tertiary third responsepreviously described above.

[0052] In other embodiments, the first response group is the quaternaryfirst response group previously described above; the second response isthe quaternary second response previously described above; and the thirdresponse is the quaternary third response previously described above. Inyet another embodiment, the pattern of expression is the quaternaryfirst response group; the pattern of expression is the quaternary secondresponse group; the pattern of expression is quaternary third responsegroup; the pattern of expression is the quaternary first response groupand the quaternary second response group; the pattern of expression isthe quaternary first response group and the quaternary third responsegroup; the pattern of expression is the quaternary second response groupand the quaternary third response group; or the pattern of expression isthe quaternary first response group, the quaternary second responsegroup, and the quaternary third response group.

[0053] Additional embodiments thereof provide methods in which theultraviolet radiation exposure comprising ultraviolet radiation energyat a wavelength in the range of about 220 nm to about 440 nm;ultraviolet radiation energy at a wavelength of about 290 nm to about320 nm; ultraviolet radiation energy at a wavelength of about 320 toabout 440 nm; or a total ultraviolet radiation energy exposure in therange of about 0.2 mJ/cm² to about 40 mJ/cm². Other embodiments thereofprovide that the cell exposed to ultraviolet radiation is a skin cell(epidermal or dermal) or a cell selected from the group consisting of akeratinocyte, a Langerhans cell, a melanocyte, and a fibroblast cell. Inone embodiment, the measurement of the level of the plurality of proteinmolecules is done by ELISA.

[0054] Another aspect of the invention provides a screening method forthe detection of a compound that modulates a response of a cell toultraviolet radiation exposure. The screening method comprisescontacting a cell with a compound, exposing the cell to ultravioletradiation that would otherwise induce a response of the cell toultraviolet radiation exposure, and measuring the levels of a pluralityof RNA molecules in the cell after ultraviolet radiation exposure,wherein any change in the first, second, and/or third response indicatesthat the compound modulates the response of the cell to ultravioletradiation exposure. In one embodiment thereof, the response comprises atleast one of the following: a first response group that is the primaryfirst response group, a second response that is the primary secondresponse, and a third response that is the primary third response.

[0055] In other embodiments thereof, the response, or pattern ofexpression, comprises the following: (1) the pattern of expression isthe primary first , response group; or (2) the pattern of expression isthe primary second response group; or (3) the pattern of expression isthe primary third response group; or (4) the pattern of expression isthe primary first response group and the primary second response group;or (5) the pattern of expression is the primary first response group andthe primary third response group; or (6) the pattern of expression isthe primary second response group and the primary third response group;or (7) the pattern of expression is the primary first response group,the primary second response group, and the primary third response group.

[0056] Additional embodiments thereof provide methods in which theultraviolet radiation exposure of the cell comprises: (1) ultravioletradiation energy at a wavelength in the range of about 220 nm to about440 nm; or (2) ultraviolet radiation energy at a wavelength of about 290nm to about 320 nm; or (3) ultraviolet radiation energy at a wavelengthof about 320 to about 440 nm; or (4) a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².Other embodiments thereof provide that the exposed cell is a skin cell(epidermal or dermal) or a cell selected from the group consisting of akeratinocyte, a Langerhans cell, a melanocyte, and a fibroblast cell.

[0057] In another embodiment, the screening method for the detection ofa compound that modulates a response of a cell to ultraviolet radiationcomprises contacting a cell with a compound, exposing the cell toultraviolet radiation that would otherwise induce a response of the cellto ultraviolet radiation exposure, and measuring the levels of aplurality of RNA molecules in the cell after ultraviolet radiationexposure, wherein any change in the first, second, and/or third responseindicates that the compound modulates the response of the cell toultraviolet radiation exposure. In this embodiment, the pattern ofexpression comprises a first response group that is the secondary firstresponse group; a second response that is the secondary second response;and/or a third response that is the secondary third response.

[0058] In various embodiments thereof, this pattern of expressioncomprises a first response group, and/or a second response, and/or athird response. In this embodiment, the first response group is thesecondary first response group previously described above; the secondresponse is the secondary second response previously described above;and the third response is the secondary third response previouslydescribed above. Embodiments thereof include the following: (1) thepattern of expression is the secondary first response group; or (2) thepattern of expression is the secondary second response group; or (3) thepattern of expression is secondary third response group; or (4) thepattern of expression is the secondary first response group and thesecondary second response group; or (5) the pattern of expression is thesecondary first response group and the secondary third response group;or (6) the pattern of expression is the secondary second response groupand the secondary third response group; or (7) the pattern of expressionis the secondary first response group, the secondary second responsegroup, and the secondary third response group.

[0059] Additional embodiments of this aspect of the invention providedetection methods in which the ultraviolet radiation exposure of thecell comprises: (1) ultraviolet radiation energy at a wavelength in therange of 220 nm to 440 nm; or (2) ultraviolet radiation energy at awavelength of about 290 nm to 320 nm; or (3) ultraviolet radiationenergy at a wavelength of about 320 to 440 nm; or (4) a totalultraviolet radiation energy exposure in the range of about 0.2 mJ/cm²to about 40 mJ/cm². Other embodiments thereof provide that the exposedcell is a skin cell (epidermal or dermal) or the cell is selected fromthe group consisting of a keratinocyte, a Langerhans cell, a melanocyte,and a fibroblast cell.

[0060] The invention also provides methods for the detection of acompound that modulates a response of a cell to ultraviolet radiation inwhich the measurement of the level of the plurality of RNA molecules isdone by expression array analysis. In this method, RNA is isolated fromthe cell at a time post-ultraviolet radiation exposure. A testexpression array is created through nucleic acid hybridization between alabeled probe complementary to the RNA and an expression arraysubstrate. The test expression array is analyzed to create a testexpression array data set, which is then compared to the controlexpression array data set to identify a modulation response of theexposed cell. Modulation indicates that the compound modulates theresponse of the cell to ultraviolet radiation. The levels of theplurality of RNA molecules in the cell are then analyzed to establish aresponse pattern of the cell, the response pattern comprising at leastone of the following: a secondary first response group, a secondarysecond response group, and a secondary third response group.

[0061] Another aspect of the invention provides other methods for thedetection of a compound that modulates a response of a cell toultraviolet radiation. These methods comprise measuring a plurality ofprotein molecules in the cell, wherein a pattern of expression isestablished and the pattern is indicative of ultraviolet radiationexposure. In various embodiments thereof, this pattern of expressioncomprises a first response group, a second response, and/or a thirdresponse. In one embodiment thereof, the first response group is thetertiary first response group previously described above; the secondresponse is the tertiary second response previously described above; andthe third response is the tertiary third response previously describedabove. Embodiments of this method include the following: (1) the patternof expression is the tertiary first response group; or (2) the patternof expression is the tertiary second response group; or (3) the patternof expression is the tertiary third response group; or (4) the patternof expression is the tertiary first response group and the tertiarysecond response group; or (5) the pattern of expression is the tertiaryfirst response group and the tertiary third response group; or (6) thepattern of expression is the tertiary second response group and thetertiary third response group; or (7) the pattern of expression is thetertiary first response group, the tertiary second response group, andthe tertiary third response group.

[0062] Additional embodiments thereof provide methods in which the cellis exposed to ultraviolet radiation comprising ultraviolet radiationenergy at a wavelength in the range of about 220 nm to about 440 nm;ultraviolet radiation energy at a wavelength of about 290 nm to about320 nm; ultraviolet radiation energy at a wavelength of about 320 toabout 440 nm; or a total ultraviolet radiation energy exposure in therange of about 0.2 mJ/cm² to about 40 mJ/cm². Other embodiments of thisaspect of the invention provide methods in which the cell exposed toultraviolet radiation is a skin cell (epidermal or dermal) or a cellselected from the group consisting of a keratinocyte, a Langerhans cell,a melanocyte, and a fibroblast cell.

[0063] In another embodiment, the method for the detection of a compoundthat modulates a response of a cell to ultraviolet radiation comprisesmeasuring the levels of a plurality of protein molecules in the cell forat least one time point, wherein a pattern of expression is establishedand the pattern is indicative of ultraviolet radiation exposure. In thisembodiment, the pattern of expression comprises a first response groupwhich is the quaternary first response group previously described above;a second response which is the quaternary second response previouslydescribed above; and a third response which is the quaternary thirdresponse previously described above.

[0064] In other embodiments, the first response group is the quaternaryfirst response group previously described above; the second response isthe quaternary second response previously described above; and the thirdresponse is the quaternary third response previously described above. Inyet another embodiment, the pattern of expression is the quaternaryfirst response group; the pattern of expression is the quaternary secondresponse group; the pattern of expression is quaternary third responsegroup; the pattern of expression is the quaternary first response groupand the quaternary second response group; the pattern of expression isthe quaternary first response group and the quaternary third responsegroup; the pattern of expression is the quaternary second response groupand the quaternary third response group; or the pattern of expression isthe quaternary first response group, the quaternary second responsegroup, and the quaternary third response group.

[0065] Additional embodiments thereof provide methods in which theultraviolet radiation exposure comprising ultraviolet radiation energyat a wavelength in the range of about 220 nm to about 440 nm;ultraviolet radiation energy at a wavelength of about 290 nm to about320 nm; ultraviolet radiation energy at a wavelength of about 320 toabout 440 nm; or a total ultraviolet radiation energy exposure in therange of about 0.2 mJ/cm² to about 40 mJ/cm². Other embodiments thereofprovide that the cell exposed to ultraviolet radiation is a skin cell(epidermal or dermal) or a cell selected from the group consisting of akeratinocyte, a Langerhans cell, a melanocyte, and a fibroblast cell. Inone embodiment, the measurement of the level of the plurality of proteinmolecules is done by ELISA.

[0066] Another aspect of the invention provides a screening method forthe detection of a compound that simulates a response of a cell toultraviolet radiation exposure. The method comprises contacting the cellwith the compound, and measuring a level of at least one RNA molecule inthe contacted cell, and determining that the level of at least one RNAmolecule is substantially similar to that found in the response of thecell to ultraviolet radiation exposure, the response of the cellcharacterized by at least one of the following: a first response groupthat is the primary first response group, a second response that is theprimary second response group, and a third response that is the primarythird response group. A determination that the level of at least one RNAmolecule is substantially similar to the altered expression found in theprimary first response group, the primary second response group and/orthe primary third response group indicates that the compound simulatesthe response of the cell to ultraviolet radiation exposure.

[0067] In other embodiments of the screening method for the detection ofa compound that simulates a response of a cell to ultraviolet radiationexposure include the following: (1) the pattern of expression is theprimary first response group; or (2) the pattern of expression is theprimary second response group; or (3) the pattern of expression is theprimary third response group; or (4) the pattern of expression is theprimary first response group and the primary second response group; or(5) the pattern of expression is the primary first response group andthe primary third response group; or (6) the pattern of expression isthe primary second response group and the primary third response group;or (7) the pattern of expression is the primary first response group,the primary second response group, and the primary third response group.

[0068] Additional embodiments thereof provide methods in which theultraviolet radiation exposure of the cell comprises: (1) ultravioletradiation energy at a wavelength in the range of about 220 nm to about440 nm; or (2) ultraviolet radiation energy at a wavelength of about 290nm to about 320 nm; or (3) ultraviolet radiation energy at a wavelengthof about 320 to about 440 nm; or (4) a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².Other embodiments thereof provide that the exposed cell is a skin cell(epidermal or dermal) or a cell selected from the group consisting of akeratinocyte, a Langerhans cell, a melanocyte, and a fibroblast cell.

[0069] In another embodiment, the screening method for the detection ofa compound that simulates a response of a cell to ultraviolet radiationexposure, the method comprises contacting the cell with the compound,and measuring a level of at least one RNA molecule in the contactedcell, and determining that the level of at least one RNA molecule issubstantially similar to that found in the response of the cell toultraviolet radiation exposure, the response of the cell characterizedby at least one of the following: a secondary first response group, asecondary second response group, and a secondary third response group.

[0070] In other embodiments thereof, this response comprises thefollowing: (1) the pattern of expression is the secondary first responsegroup; or (2) the pattern of expression is the secondary second responsegroup; or (3) the pattern of expression is the secondary third responsegroup; or (4) the pattern of expression is the secondary first responsegroup and the secondary second response group; or (5) the pattern ofexpression is the secondary first response group and the secondary thirdresponse group; or (6) the pattern of expression is the secondary secondresponse group and the secondary third response group; or (7) thepattern of expression is the secondary first response group, thesecondary second response group, and the secondary third response group.

[0071] Additional embodiments of this aspect of the invention providemethods in which the ultraviolet radiation exposure of the cellcomprises: (1) ultraviolet radiation energy at a wavelength in the rangeof 220 nm to 440 nm; or (2) ultraviolet radiation energy at a wavelengthof about 290 nm to 320 nm; or (3) ultraviolet radiation energy at awavelength of about 320 to 440 nm; or (4) a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².Other embodiments thereof provide that the exposed cell is a skin cell(epidermal or dermal) or the cell is selected from the group consistingof a keratinocyte, a Langerhans cell, a melanocyte, and a fibroblastcell.

[0072] Another aspect of the invention provides a screening method forthe detection of a compound that simulates the response of a cell toultraviolet radiation exposure. The method comprises contacting the cellwith the compound, and measuring a level of at least one proteinmolecule in the contacted cell, and determining that the level of atleast one protein molecule is substantially similar to that found in theresponse of the cell to ultraviolet radiation exposure, the response ofthe cell characterized by at least one of the following: a firstresponse group that is the tertiary first response group, a secondresponse group that is the tertiary second response group, and a thirdresponse group that is the tertiary third response group. Adetermination that the level of at least one protein molecule issubstantially similar to the altered expression found in the tertiaryfirst response group, the tertiary second response group and/or thetertiary third response group indicates that the compound simulates theresponse of the cell to ultraviolet radiation exposure.

[0073] In another embodiment, the screening method for the detection ofa compound that simulates a response of a cell to ultraviolet radiationexposure, the method comprises contacting the cell with the compound,and measuring a level of at least one protein molecule in the contactedcell, and determining that the level of at least one protein molecule issubstantially similar to that found in the response of the cell toultraviolet radiation exposure, the response of the cell characterizedby at least one of the following: a tertiary first response group, atertiary second response group, and a tertiary third response group.

[0074] In other embodiments thereof, this response comprises thefollowing: (1) the pattern of expression is the tertiary first responsegroup; or (2) the pattern of expression is the tertiary second responsegroup; or (3) the pattern of expression is tertiary third responsegroup; or (4) the pattern of expression is the tertiary first responsegroup and the tertiary second response group; or (5) the pattern ofexpression is the tertiary first response group and the tertiary thirdresponse group; or (6) the pattern of expression is the tertiary secondresponse group and the tertiary third response group; or (7) the patternof expression is the tertiary first response group, the tertiary secondresponse group, and the tertiary third response group.

[0075] Additional embodiments of this aspect of the invention providemethods in which the ultraviolet radiation exposure of the cellcomprises: (1) ultraviolet radiation energy at a wavelength in the rangeof 220 nm to 440 nm; or (2) ultraviolet radiation energy at a wavelengthof about 290 nm to 320 nm; or (3) ultraviolet radiation energy at awavelength of about 320 to 440 nm; or (4) a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².Other embodiments thereof provide that the exposed cell is a skin cell(epidermal or dermal) or the cell is selected from the group consistingof a keratinocyte, a Langerhans cell, a melanocyte, and a fibroblastcell.

[0076] Another aspect of the invention provides a screening method forthe detection of a compound that simulates the response of a cell toultraviolet radiation exposure. The method comprises contacting the cellwith the compound, and measuring a level of at least one RNA molecule inthe contacted cell, and determining that the level of at least oneprotein molecule is substantially similar to that found in the responseof the cell to ultraviolet radiation exposure, the response of the cellcharacterized by at least one of the following: a first response groupthat is the quaternary first response group, a second response groupthat is the quaternary second response group, and a third response groupthat is the quaternary third response group. A determination that thelevel of at least one RNA molecule is substantially similar to thealtered expression found in the primary first response group, theprimary second response group and/or the primary third response groupindicates that the compound simulates the response of the cell toultraviolet radiation exposure.

[0077] In another embodiment, the screening method for the detection ofa compound that simulates a response of a cell to ultraviolet radiationexposure, the method comprises contacting the cell with the compound,and measuring a level of at least one protein molecule in the contactedcell, and determining that the level of at least one protein molecule issubstantially similar to that found in the response of the cell toultraviolet radiation exposure, the response of the cell characterizedby at least one of the following: a quaternary first response group, aquaternary second response group, and a quaternary third response group.

[0078] In other embodiments thereof, this response comprises thefollowing: (1) the pattern of expression is the quaternary firstresponse group; or (2) the pattern of expression is the quaternarysecond response group; or (3) the pattern of expression is quaternarythird response group; or (4) the pattern of expression is the quaternaryfirst response group and the quaternary second response group; or (5)the pattern of expression is the quaternary first response group and thequaternary third response group; or (6) the pattern of expression is thequaternary second response group and the quaternary third responsegroup; or (7) the pattern of expression is the quaternary first responsegroup, the quaternary second response group, and the quaternary thirdresponse group.

[0079] Additional embodiments of this aspect of the invention providemethods in which the ultraviolet radiation exposure of the cellcomprises: (1) ultraviolet radiation energy at a wavelength in the rangeof 220 nm to 440 nm; or (2) ultraviolet radiation energy at a wavelengthof about 290 nm to 320 nm; or (3) ultraviolet radiation energy at awavelength of about 320 to 440 nm; or (4) a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².Other embodiments thereof provide that the exposed cell is a skin cell(epidermal or dermal) or the cell is selected from the group consistingof a keratinocyte, a Langerhans cell, a melanocyte, and a fibroblastcell.

[0080] In an alternative aspect, the invention provides another methodfor detecting exposure of a cell to ultraviolet radiation. This methodcomprises measuring the levels of a plurality of RNA molecules in thecell for at least one time point, wherein an altered pattern ofexpression is established and is indicative of ultraviolet radiationexposure. This pattern comprises a first response comprising an alteredpattern of expression of at least one polynucleotide selected from thegroup consisting of a nucleic acid molecule encoding a transcriptionfactor protein, a nucleic acid molecule encoding a signal transducingprotein, and a nucleic acid molecule encoding a mitochondrial protein; asecond response comprising an altered pattern of expression of at leastone polynucleotide selected from the group consisting of a nucleic acidmolecule encoding a secreted growth factor, a nucleic acid moleculeencoding a cytokine, and a nucleic acid molecule encoding a chemokine;and a third response comprising an altered pattern of expression of atleast one polynucleotide selected from the group consisting of a nucleicacid molecule encoding an actin-binding protein, a nucleic acid moleculeencoding a desmosomal protein, a nucleic acid molecule encoding atubulin protein, and at least one nucleic acid molecule encoding acornified envelope protein.

[0081] In embodiments of the method thereof, the cell is a skin cell(epidermal or dermal) or the cell is selected from the group consistingof a keratinocyte, a Langerhans cell, a melanocyte, and a fibroblastcell. Embodiments of the method also vary by the wavelength ofultraviolet radiation and/or the total amount of ultraviolet radiationto which the cell is exposed. For example, in various embodiments, theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength in the range of about 220 nm to about 440 nm; or theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength of about 290 nm to about 320 nm; or the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 320 nm to about 440 nm; or theultraviolet radiation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².

[0082] Other embodiments of the method thereof vary according to thetime period post-ultraviolet radiation exposure defining the firstresponse, second response, and third response. In one embodiment, thefirst response is from about 0.5 hours to about two hours post-exposureto ultraviolet radiation. In another embodiment, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation. In another embodiment, the third response is from about 16hours to about 24 hours post-exposure to ultraviolet radiation. Inanother embodiment, the first response is from about 0.5 hours to abouttwo hours post-exposure to ultraviolet radiation, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation, and the third response is from about 16 hours to about 24hours post-exposure to ultraviolet radiation.

[0083] The invention also provides an embodiment of the method thereofwherein altered expression comprises an increase or decrease in RNAlevel. Thus, in one particular embodiment, the expression level of amember of the first response group, and/or second response group, and/orthird response group increases. In another embodiment thereof, theexpression level of a member of the first response group, and/or secondresponse group, and/or third response group decreases.

[0084] The invention also provides another method for detecting exposureof a cell to ultraviolet radiation. This method comprises measuring thelevels of a plurality of RNA molecules in the cell for at least one timepoint, wherein an altered pattern of expression is established and isindicative of ultraviolet radiation exposure. This pattern comprises afirst response comprising an altered pattern of expression of at leastone polynucleotide selected from the group consisting of the secondaryfirst response group; a second response comprising an altered pattern ofexpression of at least one polynucleotide selected from the groupconsisting of the secondary second response group; and a third responsecomprising an altered pattern of expression of at least onepolynucleotide selected from the group consisting of the secondary thirdresponse group.

[0085] In embodiments of the method thereof, the cell is a skin cell(epidermal or dermal) or the cell is selected from the group consistingof a keratinocyte, a Langerhans cell, a melanocyte, and a fibroblastcell. Embodiments of the method also vary by the wavelength ofultraviolet radiation and/or the total amount of ultraviolet radiationto which the cell is exposed. For example, in various embodiments, theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength in the range of about 220 nm to about 440 nm; or theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength of about 290 nm to about 320 nm; or the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 320 nm to about 440 nm; or theultraviolet radiation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².

[0086] Other embodiments of the method thereof vary according to thetime period post-ultraviolet radiation exposure defining the firstresponse, second response, and third response. In one embodiment, thefirst response is from about 0.5 hours to about two hours post-exposureto ultraviolet radiation. In another embodiment, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation. In another embodiment, the third response is from about 16hours to about 24 hours post-exposure to ultraviolet radiation. Inanother embodiment, the first response is from about 0.5 hours to abouttwo hours post-exposure to ultraviolet radiation, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation, and the third response is from about 16 hours to about 24hours post-exposure to ultraviolet radiation.

[0087] The invention also comprises an embodiment of the method thereofwherein altered expression comprises an increase or decrease in RNAlevel. Thus, in one particular embodiment, the expression level of amember of the first response group, and/or second response group, and/orthird response group increases. In another embodiment thereof, theexpression level of a member of the first response group, and/or secondresponse group, and/or third response group decreases.

[0088] In yet another aspect of the invention, a method is provided fordetecting exposure of a cell to ultraviolet radiation comprisingmeasuring the levels of a plurality of RNA molecules in the cell byexpression array analysis. This method comprises isolating RNA from thecell post ultraviolet radiation exposure, creating a test expressionarray through nucleic acid hybridization between a labeled probecomplementary to the RNA and an expression array substrate. An analysisof the levels of the plurality of RNA molecules in the cell establishesan expression response pattern of the cell. Exposure of the cell toultraviolet radiation is indicated by an altered pattern of expressioncomprising the following: (1) a first response comprising an alteredpattern of expression of at least one polynucleotide selected from thegroup consisting of a nucleic acid molecule encoding a transcriptionfactor protein, a nucleic acid molecule encoding a signal transducingprotein, and a nucleic acid molecule encoding a mitochondrial protein;(2) a second response comprising an altered pattern of expression of atleast one polynucleotide selected from the group consisting of a nucleicacid molecule encoding a secreted growth factor, a nucleic acid moleculeencoding a cytokine, and (3) a nucleic acid molecule encoding achemokine; and a third response comprising an altered pattern ofexpression of at least one polynucleotide selected from the groupconsisting of a nucleic acid molecule encoding an actin-binding protein,a nucleic acid molecule encoding a desmosomal protein, a nucleic acidmolecule encoding a tubulin protein, and at least one nucleic acidmolecule encoding a cornified envelope protein.

[0089] In embodiments of the method thereof, the cell is a skin cell(epidermal or dermal) or the cell is selected from the group consistingof a keratinocyte, a Langerhans cell, a melanocyte, and a fibroblastcell. Embodiments of the method also vary by the wavelength ofultraviolet radiation and/or the total amount of ultraviolet radiationto which the cell is exposed. For example, in various embodiments, theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength in the range of about 220 nm to about 440 nm; or theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength of about 290 nm to about 320 nm; or the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 320 nm to about 440 nm; or theultraviolet radiation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².

[0090] Other embodiments of the method thereof vary according to thetime period post-ultraviolet radiation exposure defining the firstresponse, second response, and third response. In one embodiment, thefirst response is from about 0.5 hours to about two hours post-exposureto ultraviolet radiation. In another embodiment, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation. In another embodiment, the third response is from about 16hours to about 24 hours post-exposure to ultraviolet radiation. Inanother embodiment, the first response is from about 0.5 hours to abouttwo hours post-exposure to ultraviolet radiation, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation, and the third response is from about 16 hours to about 24hours post-exposure to ultraviolet radiation.

[0091] The invention also comprises an embodiment of the method thereofwherein altered expression comprises an increase or decrease in RNAlevel. Thus, in one particular embodiment, the expression level of amember of the first response group, and/or second response group, and/orthird response group increases. In another embodiment thereof, theexpression level of a member of the first response group, and/or secondresponse group, and/or third response group decreases.

[0092] In another embodiment, the method thereof comprises measuring thelevels of a plurality of RNA molecules in the cell for at least one timepoint, wherein an altered pattern of expression is established and isindicative of ultraviolet radiation exposure. This pattern comprises afirst response comprising an altered pattern of expression of at leastone polynucleotide selected from the group consisting of the secondaryfirst response group; a second response comprising an altered pattern ofexpression of at least one polynucleotide selected from the groupconsisting of the secondary second response group; and a third responsecomprising an altered pattern of expression of at least onepolynucleotide selected from the group consisting of the secondary thirdresponse group.

[0093] In an alternative aspect, the invention provides another methodfor detecting exposure of a cell to ultraviolet radiation. This methodcomprises measuring the levels of a plurality of proteins in the cellfor at least one time point, wherein an altered pattern of expression isestablished and is indicative of ultraviolet radiation exposure. Thispattern comprises a first response comprising an altered pattern ofexpression of at least one protein selected from the group consisting ofa transcription factor protein, a signal transducing protein, and amitochondrial protein; a second response comprising an altered patternof expression of at least one protein selected from the group consistingof a secreted growth factor, a cytokine, and a chemokine; and a thirdresponse comprising an altered pattern of expression of at least oneprotein selected from the group consisting of an actin-binding protein,a desmosomal protein, a tubulin protein, and a cornified envelopeprotein.

[0094] In embodiments of the method thereof, the cell is a skin cell(epidermal or dermal) or the cell is selected from the group consistingof a keratinocyte, a Langerhans cell, a melanocyte, and a fibroblastcell. Embodiments of the method also vary by the wavelength ofultraviolet radiation and/or the total amount of ultraviolet radiationto which the cell is exposed. For example, in various embodiments, theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength in the range of about 220 nm to about 440 nm; or theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength of about 290 nm to about 320 nm; or the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 320 nm to about 440 nm; or theultraviolet radiation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².

[0095] Other embodiments of the method thereof vary according to thetime period post-ultraviolet radiation exposure defining the firstresponse, second response, and third response. In one embodiment, thefirst response is from about 0.5 hours to about two hours post-exposureto ultraviolet radiation. In another embodiment, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation. In another embodiment, the third response is from about 16hours to about 24 hours post-exposure to ultraviolet radiation. Inanother embodiment, the first response is from about 0.5 hours to abouttwo hours post-exposure to ultraviolet radiation, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation, and the third response is from about 16 hours to about 24hours post-exposure to ultraviolet radiation.

[0096] The invention also comprises an embodiment of the method thereofwherein altered expression comprises an increase or decrease in proteinlevel. Thus, in one particular embodiment, the expression level of amember of the first response group, and/or second response group, and/orthird response group increases. In another embodiment thereof, theexpression level of a member of the first response group, and/or secondresponse group, and/or third response group decreases.

[0097] In another embodiment, the invention provides another method fordetecting exposure of a cell to ultraviolet radiation. This methodcomprises measuring the levels of a plurality of protein molecules inthe cell for at least one time point, wherein an altered pattern ofexpression is established and is indicative of ultraviolet radiationexposure. This pattern comprises a first response comprising an alteredpattern of expression of at least one protein that is at least 90%identical to a polypeptide encoded by a polynucleotide selected from thegroup consisting of the secondary first response group; a secondresponse comprising an altered pattern of expression of at least onepolynucleotide selected from the group consisting of the secondarysecond response group; and a third response comprising an alteredpattern of expression of at least one polynucleotide selected from thegroup consisting of the secondary third response group.

[0098] In various embodiments related to a protein expression profile ofa cell exposed to ultraviolet radiation, ELISA is used to measure thelevels of the plurality of proteins in a cell presumptively exposed toultraviolet radiation.

[0099] Another aspect of the invention relates to a screening method forthe detection of a compound that modulates a response of a cell toultraviolet radiation exposure. The method comprises contacting the cellwith the compound and exposing the cell to ultraviolet radiation thatwould otherwise induce the response, the response being an alteredpattern of expression comprising the following: (1) a first responsecomprising the altered pattern of expression of at least onepolynucleotide selected from the group consisting of a nucleic acidmolecule encoding a transcription factor protein, a nucleic acidmolecule encoding a signal transducing protein, and a nucleic acidmolecule encoding a mitochondrial protein; (2) a second responsecomprising the altered pattern of expression of at least onepolynucleotide selected from the group consisting of a nucleic acidmolecule encoding a secreted growth factor, a nucleic acid moleculeencoding a cytokine, and a nucleic acid molecule encoding a chemokine;and (3) a third response comprising the altered pattern of expression ofat least one polynucleotide selected from the group consisting of anucleic acid molecule encoding an actin-binding protein, a nucleic acidmolecule encoding a desmosomal protein, a nucleic acid molecule encodinga tubulin protein, and a nucleic acid molecule encoding a cornifiedenvelope protein. Next, the levels of a plurality of RNA molecules inthe cell are measured for at least one time point after ultravioletradiation exposure. A change in the altered pattern of expression of thefirst response, the second response, and/or the third response indicatesthat the compound modulates the response of the cell to ultravioletradiation exposure.

[0100] In one embodiment of the method thereof, the cell is contactedwith the compound in vitro.

[0101] In another embodiment of the method thereof, the cell iscontacted with the compound in vivo. In other embodiments of the methodthereof, the cell is a skin cell (epidermal or dermal) or the cell isselected from the group consisting of a keratinocyte, a Langerhans cell,a melanocyte, and a fibroblast cell. Embodiments of the method also varyby the wavelength of ultraviolet radiation and/or the total amount ofultraviolet radiation to which the cell is exposed. For example, invarious embodiments, the ultraviolet radiation exposure comprisesultraviolet radiation energy at a wavelength in the range of about 220nm to about 440 nm; or the ultraviolet radiation exposure comprisesultraviolet radiation energy at a wavelength of about 290 nm to about320 nm; or the ultraviolet radiation exposure comprises ultravioletradiation energy at a wavelength in the range of about 320 nm to about440 nm; or the ultraviolet radiation exposure comprises a totalultraviolet radiation energy exposure in the range of about 0.2 mJ/cm²to about 40 mJ/cm².

[0102] Other embodiments of the method thereof vary according to thetime period post-ultraviolet radiation exposure defining the firstresponse, second response, and third response. In one embodiment, thefirst response is from about 0.5 hours to about two hours post-exposureto ultraviolet radiation. In another embodiment, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation. In another embodiment, the third response is from about 16hours to about 24 hours post-exposure to ultraviolet radiation. Inanother embodiment, the first response is from about 0.5 hours to abouttwo hours post-exposure to ultraviolet radiation, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation, and the third response is from about 16 hours to about 24hours post-exposure to ultraviolet radiation.

[0103] The invention also comprises an embodiment of the method thereofwherein altered expression comprises an increase or decrease in RNAlevel. Thus, in one particular embodiment, the expression level of amember of the first response group, and/or second response group, and/orthird response group increases. In another embodiment thereof, theexpression level of a member of the first response group, and/or secondresponse group, and/or third response group decreases.

[0104] Another aspect of the invention relates to a screening method forthe detection of a compound that modulates a response of a cell toultraviolet radiation exposure. The method comprises contacting the cellwith the compound and exposing the cell to ultraviolet radiation thatwould otherwise induce the response, the response being an alteredpattern of expression. This pattern comprises a first responsecomprising an altered pattern of expression of at least onepolynucleotide selected from the group consisting of the secondary firstresponse group; a second response comprising an altered pattern ofexpression of at least one polynucleotide selected from the groupconsisting of the secondary second response group; and a third responsecomprising an altered pattern of expression of at least onepolynucleotide selected from the group consisting of the secondary thirdresponse group. The levels of a plurality of RNA molecules in the cellare measured for at least one time point after ultraviolet radiationexposure, and a change in the altered pattern of expression of the firstresponse group, the second response group, and/or the third responsegroup indicates that the compound modulates the response of the cell toultraviolet radiation exposure.

[0105] In embodiments of the method thereof, the cell is a skin cell(epidermal or dermal) or the cell is selected from the group consistingof a keratinocyte, a Langerhans cell, a melanocyte, and a fibroblastcell. Embodiments of the method also vary by the wavelength ofultraviolet radiation and/or the total amount of ultraviolet radiationto which the cell is exposed. For example, in various embodiments, theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength in the range of about 220 nm to about 440 nm; or theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength of about 290 nm to about 320 nm; or the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 320 nm to about 440 nm; or theultraviolet radiation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².

[0106] Other embodiments of the method thereof vary according to thetime period post-ultraviolet radiation exposure defining the firstresponse, second response, and third response. In one embodiment, thefirst response is from about 0.5 hours to about two hours post-exposureto ultraviolet radiation. In another embodiment, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation. In another embodiment, the third response is from about 16hours to about 24 hours post-exposure to ultraviolet radiation. Inanother embodiment, the first response is from about 0.5 hours to abouttwo hours post-exposure to ultraviolet radiation, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation, and the third response is from about 16 hours to about 24hours post-exposure to ultraviolet radiation.

[0107] In yet another aspect of the invention, a screening method isprovided for the detection of a compound that modulates a response of acell to ultraviolet radiation exposure. The method comprises contactingthe cell with the compound and exposing the cell to ultravioletradiation that would otherwise induce the response, the response beingan altered pattern of expression. This method comprises isolating RNAfrom the cell post ultraviolet radiation exposure, creating a testexpression array through nucleic acid hybridization between a labeledprobe complementary to the RNA and an expression array substrate,analyzing the test expression array to create a test expression arraydata set; and comparing the test expression array data set to theresponse of a cell that is the same or like cell type and exposed toultraviolet radiation in the absence of the drug, the response being analtered pattern of expression comprising the following a primary firstresponse group, a primary second response group, and a primary thirdresponse group. A change in the altered pattern of expression of theprimary first response, the primary second response, and/or the primarythird response indicates that the compound modulates the response of thecell to ultraviolet radiation exposure.

[0108] In embodiments of the method thereof, the cell is a skin cell(epidermal or dermal) or the cell is selected from the group consistingof a keratinocyte, a Langerhans cell, a melanocyte, and a fibroblastcell. Embodiments of the method also vary by the wavelength ofultraviolet radiation and/or the total amount of ultraviolet radiationto which the cell is exposed. For example, in various embodiments, theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength in the range of about 220 nm to about 440 nm; or theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength of about 290 nm to about 320 nm; or the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 320 nm to about 440 nm; or theultraviolet radiation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm² .

[0109] Other embodiments of the method thereof vary according to thetime period post-ultraviolet radiation exposure defining the firstresponse, second response, and third response. In one embodiment, thefirst response is from about 0.5 hours to about two hours post-exposureto ultraviolet radiation. In another embodiment, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation. In another embodiment, the third response is from about 16hours to about 24 hours post-exposure to ultraviolet radiation. Inanother embodiment, the first response is from about 0.5 hours to abouttwo hours post-exposure to ultraviolet radiation, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation, and the third response is from about 16 hours to about 24hours post-exposure to ultraviolet radiation.

[0110] Other embodiments of the method thereof are included in theinvention. For example, in one embodiment, cell contact with thecompound is topical contact. In another embodiment, the compoundmodulates the cellular response by inhibiting ultravioletradiation-induced RNA expression. In another embodiment, the compoundinhibits the ultraviolet radiation-repressed expression. In these lattertwo embodiments, ultraviolet radiation-induced expression is the“induced response group” and ultraviolet radiation-repressed expressionis the “repressed response group.”

[0111] Another aspect of the invention relates to a screening method forthe detection of a compound that modulates a response of a cell toultraviolet radiation exposure. The screening method comprisescontacting the cell with the compound and exposing the cell toultraviolet radiation that would otherwise induce the response, theresponse being an altered pattern of expression comprising thefollowing: (1) a tertiary first response group, (2) a tertiary secondresponse group, and (3) a tertiary third response group; and measuringthe levels of a plurality of RNA molecules in the cell for at least onetime point after ultraviolet radiation exposure. A change in the alteredpattern of expression of the tertiary first response, the tertiarysecond response, and/or the tertiary third response indicates that thecompound modulates the response of the cell to ultraviolet radiationexposure.

[0112] In various embodiments of the screening method thereof, the cellis contacted with the compound in vitro or in vivo. In other embodimentsof the screening method thereof, the cell is a skin cell (epidermal ordermal), or the cell is selected from the group consisting of akeratinocyte, a Langerhans cell, a melanocyte, and a fibroblast cell.Embodiments of the method also vary by the wavelength of ultravioletradiation and/or the total amount of ultraviolet radiation to which thecell is exposed. For example, in various embodiments, the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 220 nm to about 440 nm; or theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength of about 290 nm to about 320 nm; or the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 320 nm to about 440 nm; or theultraviolet radiation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².

[0113] Other embodiments of the screening method thereof vary accordingto the time period post-ultraviolet radiation exposure defining thefirst response, second response, and third response. In one embodiment,the first response is from about 0.5 hours to about two hourspost-exposure to ultraviolet radiation. In another embodiment, thesecond response is from about four hours to about eight hourspost-exposure to ultraviolet radiation. In another embodiment, the thirdresponse is from about 16 hours to about 24 hours post-exposure toultraviolet radiation. In another embodiment, the first response is fromabout 0.5 hours to about two hours post-exposure to ultravioletradiation, the second response is from about four hours to about eighthours post-exposure to ultraviolet radiation, and the third response isfrom about 16 hours to about 24 hours post-exposure to ultravioletradiation.

[0114] In various embodiments related to screening method thereof, ELISAis used to measure the levels of the plurality of proteins in a cell indetermining the response of the cell to ultraviolet radiation in thepresence and absence of the compound.

[0115] Another aspect of the invention relates to a screening method forthe detection of a compound that modulates a response of a cell toultraviolet radiation exposure. The screening method comprisescontacting the cell with the compound and exposing the cell toultraviolet radiation that would otherwise induce the response, theresponse being an altered pattern of expression comprising thefollowing: (1) a quaternary first response group, (2) a quaternarysecond response group, and (3) a quaternary third response group; andmeasuring the levels of a plurality of RNA molecules in the cell for atleast one time point after ultraviolet radiation exposure. A change inthe altered pattern of expression of the quaternary first response, thequaternary second response, and/or the quaternary third responseindicates that the compound modulates the response of the cell toultraviolet radiation exposure.

[0116] In various embodiments of the screening method thereof, the cellis contacted with the compound in vitro or in vivo. In other embodimentsof the screening method thereof, the cell is a skin cell (epidermal ordermal) or the cell is selected from the group consisting of akeratinocyte, a Langerhans cell, a melanocyte, and a fibroblast cell.Embodiments of the method also vary by the wavelength of ultravioletradiation and/or the total amount of ultraviolet radiation to which thecell is exposed. For example, in various embodiments, the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 220 nm to about 440 nm; or theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength of about 290 nm to about 320 nm; or the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 320 nm to about 440 nm; or theultraviolet radiation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².

[0117] Other embodiments of the screening method thereof vary accordingto the time period post-ultraviolet radiation exposure defining thefirst response, second response, and third response. In one embodiment,the first response is from about 0.5 hours to about two hourspost-exposure to ultraviolet radiation. In another embodiment, thesecond response is from about four hours to about eight hourspost-exposure to ultraviolet radiation. In another embodiment, the thirdresponse is from about 16 hours to about 24 hours post-exposure toultraviolet radiation. In another embodiment, the first response is fromabout 0.5 hours to about two hours post-exposure to ultravioletradiation, the second response is from about four hours to about eighthours post-exposure to ultraviolet radiation, and the third response isfrom about 16 hours to about 24 hours post-exposure to ultravioletradiation.

[0118] In various embodiments related to screening method thereof, ELISAis used to measure the levels of the plurality of proteins in a cell indetermining the response of the cell to ultraviolet radiation in thepresence and absence of the compound.

[0119] Another aspect of the invention provides a screening method forthe detection of a compound that simulates the response of a cell toultraviolet radiation exposure. This screening method comprisescontacting the cell with the compound; measuring a level of at least oneRNA molecule in the contacted cell; and determining that the level of atleast one RNA molecule in the cell after exposure to the compound issubstantially similar to the level of the RNA found in the cell inresponse to ultraviolet radiation exposure, the response of the cell toultraviolet radiation exposure being characterized by altered expressionof the following: a primary first response group, a primary secondresponse group, and a primary third response group. A determination thatthe level of expression of at least one RNA molecule is substantiallysimilar to the altered expression found for the RNA molecule in theprimary first response, the primary second response or the primary thirdresponse indicates that the compound simulates exposure of the cell toultraviolet radiation.

[0120] Another aspect of the invention provides a screening method forthe detection of a compound that simulates the response of a cell toultraviolet radiation exposure. This screening method comprisescontacting the cell with the compound; measuring a level of at least oneRNA molecule in the contacted cell; and determining that the level of atleast one RNA molecule in the cell after exposure to the compound issubstantially similar to the level of the RNA found in the cell inresponse to ultraviolet radiation exposure, the response of the cell toultraviolet radiation exposure being characterized by altered expressionof the following: a secondary first response group, a secondary secondresponse group, and a secondary third response group. A determinationthat the level of expression of at least one RNA molecule issubstantially similar to the altered expression found for the RNAmolecule in the secondary first response, the secondary second responseor the secondary third response indicates that the compound simulatesexposure of the cell to ultraviolet radiation.

[0121] Another aspect of the invention provides a screening method forthe detection of a compound that simulates the response of a cell toultraviolet radiation exposure. This screening method comprisescontacting the cell with the compound; measuring a level of at least oneProtein in the contacted cell; and determining that the level of atleast one protein in the cell after exposure to the compound issubstantially similar to the level of the protein found in the cell inresponse to ultraviolet radiation exposure, the response of the cell toultraviolet radiation exposure being characterized by altered expressionof the following: a tertiary first response group, a tertiary secondresponse group, and a tertiary third response group. A determinationthat the level of expression of at least one protein is substantiallysimilar to the altered expression found for the protein in the tertiaryfirst response group, the tertiary second response group or the tertiarythird response group indicates that the compound simulates exposure ofthe cell to ultraviolet radiation.

[0122] Another aspect of the invention provides a screening method forthe detection of a compound that simulates the response of a cell toultraviolet radiation exposure. This screening method comprisescontacting the cell with the compound; measuring a level of at least oneprotein in the contacted cell; and determining that the level of atleast one protein in the cell after exposure to the compound issubstantially similar to the level of the protein found in the cell inresponse to ultraviolet radiation exposure, the response of the cell toultraviolet radiation exposure being characterized by altered expressionof the following: a quaternary first response group, a quaternary secondresponse group, and a quaternary third response group. A determinationthat the level of expression of at least one protein is substantiallysimilar to the altered expression found for the protein in thequaternary first response group, the quaternary second response group orthe quaternary third response group indicates that the compoundsimulates exposure of the cell to ultraviolet radiation.

BRIEF DESCRIPTION OF THE FIGURES

[0123]FIG. 1A is a representation of a Northern blot in which RNAisolated from exposed to ultraviolet radiation is screened to monitorthe quality of the RNA's prior to use in experiments utilizingexpression array hybridization. RNA samples were isolated fromkeratinocytes at 0.5, 1, 2, 4, 8, 16, 24 hours after ultravioletirradiation. The glyceraldehyde-3-phosphate dehydrogenase (GAPDH) probewas used as a control, and the one hour untreated sample was used as acontrol for the 0.5, 1 and 2 hour treated samples.

[0124]FIG. 1B is a representation of a Northern blot. The RNA sampleswere isolated from irradiated keratinocytes and harvested at 0.5, 1, 2,4, 8, 16, 24 hours after ultraviolet irradiation. These RNA samples werehybridized to probes specific for c-Myc, jun-B, SPRRII, and gro-β RNAs,four RNA molecules that are ultraviolet radiation-regulated. Dataobtained by Northern blot analysis closely correlate with the resultsobtained using expression array analysis. The GAPDH probe was used as acontrol to monitor the amount of RNA loaded in each lane.

[0125]FIG. 2 is a graphic representation of a representative data setanalysis showing three waves of regulated expression eventspost-ultraviolet radiation exposure. The clustering algorithm was usedto group the time points. Those time points closest to one another withrespect to the height of the terminal branches are most closely relatedto each other. For example, the terminal brances for the one and twohour time points are the shortest and most similar to each other thanall other branches in the graph, therefore, these two time points areclustered together.

[0126]FIG. 3A is a representation of a Western blot demonstrating thatthe ultraviolet radiation-induced changes in protein levels parallel thechanges in mRNA levels. Protein extracts were prepared from irradiatedkeratinocytes and harvested at 0.5, 1, 2, 4, 8, 16, and 24 hours afterultraviolet irradiation. These samples were screened with antibodiesspecific for c-Myc, c-jun, COX-2, involucrin, gro-β, and LDL receptorproteins. Antibody specific for JNK1 protein was used as a control forgel loading.

[0127]FIG. 3B is a representation of a Western blot demonstrating thatthe ultraviolet radiation-induced changes in protein levels parallel thechanges in mRNA levels. Protein extracts were prepared from irradiatedkeratinocytes and harvested at0.5, 1, 2, 3, 4, 8, 12, 16, and 24 hoursafter ultraviolet irradiation. These samples were screened withantibodies specific for γ-Gly-Cys synthetase and squalene oxidase.

[0128]FIG. 4 is a representation of immunohistological stainingdemonstrating that ultraviolet radiation exposure enhances theexpression of involucrin in human skin organ culture and at 2, 8 and 16hours after ultraviolet radiation. Suprabasal staining of the epidermiswith the involucrin antibody is greatly augmented 16 hours afterultraviolet irradiation.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0129] The patent and scientific literature cited herein establishes theknowledge that is available to those with skill in the art. The issuedU.S. patents, allowed applications, published foreign applications, andreferences cited herein are hereby incorporated by reference.

[0130] Aspects of the invention utilize techniques and methods common tothe fields of molecular biology, cell biology and immunology. Usefullaboratory references for these types of methodologies are readilyavailable to those skilled in the art. See, for example, MolecularCloning , A Laboratory Manual, 2nd. edition, edited by Sambrook, J.,Fritsch, B. F. and Maniatis, T., (1989), Cold Spring Harbor LaboratoryPress; Harlow & Lane, Antibodies: A Laboratory Manual, Cold SpringHarbor Press, Cold Spring Harbor, N.Y. (1988). All nucleic acidsequences and the respective amino acid sequences encoded therebyidentified above by the appropriate GenBank accession number are hereinincorporated by reference. This information is also disclosed in theappropriate tables provided herein.

[0131] The invention provides a detailed analysis of the molecularevents underlying the response of a cell to exposure to ultravioletradiation by identifying a plurality of nucleic acid molecules andprotein molecules, the expression of which is regulated in response toultraviolet radiation exposure. These ultraviolet radiation-regulatednucleic acid and protein molecules are further characterized temporallyin relation to the cellular response (a first response, a secondresponse, and a third response) and in a quantitative fashion (inducedor repressed) in relation to expression levels. These data are alsopresented in the following table format.

[0132] Table 1 presents a list of gene sequences that occur more thanonce on the gene array, which were used as a monitor of the fidelity ofgene array hybridization. TABLE 1 Genes Multiply Present on the GeneArray Duplicate genes. Fold regulation Description 0.5 hr 1 hr 2 hr 4 hr8 hr 16 hr 24 hr U20734_s_at U20734 Human transcription 1.9 3.2 3.9 3−1.8 −1.9 1.9 factor junB (junB) gene, 5′ region and complete cds.X51345_at X51345 Human jun-B mRNA for 1.5 2.1 2 2.7 −2.4 −1.3 2 JUN-Bprotein. L00058_at L00058 Human (GH) germline c- 1.7 1.6 1.1 −1.7 −4.3−1.7 −3 myc proto-oncogene, exon 3 and 3′ flank. M13929_s_at M13929Human c-myc-P64 −3.1 −3 −2.3 −2.3 −5 −4.3 −2.9 mRNA, initiating frompromoter P0, (HLmyc2.5) partial cds. HG3523-HT4899_s_at J00120 Proto-−1.2 −1.9 −1.4 −3.9 −5.8 −3.4 −1.3 Oncogene C-Myc, Alt. Splice 3, Orf114 U04636_ran1_at U04636 Human 1 1 1 1.5 2.4 4.5 3.9 cyclooxygenase-2(hCox-2) gene, complete cds. D28235_s_at D28235 Human PTGS2 gene for 1 11 1.6 2 2.5 2.6 prostaglandin endoperoxide synthase-2, complete cds.M21302_at M21302 Human small proline rich −1.1 −1.1 1 2.4 3.5 3.3 7.6protein (sprII) mRNA, clone 174N. L05188_f_at L05188 H. sapiens small −11 1.6 1.2 1.9 3.1 7.1 proline-rich protein 2 (SPRR2B) gene, completecds. M20030_f_at M20030 Human small proline 1.3 2.1 1.5 1.1 1.6 5.9 21.1rich protein (sprII) mRNA, clone 930. HG4322-HT4592_at V00599 Tubulin,Beta 2 1.9 1.7 2.7 3 3.4 3.6 HG1980-HT2023_at V00599 Tubulin, Beta 2 11.3 1.4 1 1.3 1.1 2.6 HG2815-HT4023_s_at M22919 Myosin, 1.1 −1.2 1 −11.1 2.5 3.7 Light Chain, Alkali, Smooth Muscle (Gb:U02629), SmoothMuscle, Alt. Spli HG2815-HT2931_at M22918 Myosin, Light 1.1 −1.1 1.1−1.1 −1 9.9 6.6 Chain, Alkali, Smooth Muscle (Gb:U02629), Non-Muscle,Alt. Splice HG2815-HT2931_s_at M22918 Myosin, 1.5 1 1.1 −1 −1.3 5.2 3.7Light Chain, Alkali, Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice

[0133] and

[0134] Table 2 presents a list of DNA metabolism and DNA repair genesthat are ultraviolet radiation-regulated. TABLE 2 UltravioletRadiation-Regulated DNA Metabolism And Repair Genes DNA repair proteins.Fold regulation NO. Accession Gene Description 0.5 hr 1 hr 2 hr 4 hr 8hr 16 hr 24 hr 1 X57985 Histones H2B.1 and H2A. 1 1 3.1 3.1 4.4 5.9 4.82 L19779 Histone H2A.2. 1.6 2.3 3.1 3.3 3.4 5.1 4.6 3 M72885 GOS2 1.62.8 3.5 4.7 3.9 1.7 4 4 M37583 Histone (H2A.Z). 1.2 −1 1.1 1.4 1.2 3.43.4 5 X77794 Cyclin G1. 2.2 1.4 1.5 −2.4 −4.7 −1.3 3.2 6 X14850 HistoneH2A.X. 1.4 1.7 2 2 1.7 2.5 3.1 7 L76568 Excision and cross link repairprotein 1.8 1.7 1.5 −1.2 −1.4 2 2.5 ERCC4. 8 M60974 Growth arrest andDNA-damage- 1.6 1.5 2.6 3.1 1.6 1.5 2.5 inducible protein gadd45 9Y07604 Nucleoside-diphosphate kinase. 1.2 1.3 1.4 1.1 1.6 2.3 2.1 10U40369 Spermidine/spermine N1- 1.9 1.7 1.8 2.5 1.3 2.3 2acetyltransferase 11 U26727 p16INK4/MTS1 2 1.4 1 −1 1.1 3 1.6 12 L76200Guanylate kinase 2.4 1.4 1.3 1.5 1.1 2.6 1.6 13 D64142 Histone H1x,. 1.51.4 1.3 2.6 2.3 1.6 1.4 14 X61123 BTG1 1.2 1.2 2.7 2.8 −1.4 1 2.3 15U72649 BTG2 1.7 2.8 2.7 −1.3 −2.8 −1.8 1.4 16 D38305 Tob 1.6 1.4 1.6 −2−1.2 1.2 2.7 17 U28749 High-mobility group phosphoprotein 1.3 −1 −2 −2.7−3.2 1 1.2 isoform I-C (HMGIC). 18 L19437 Transaldolase. 2.5 1.6 1.5 1.1−1 1.9 1 19 L27943 Cytidine deaminase (CDA). 1.1 1.2 −1.1 −1.3 −1.5 2.6−1.3 20 X90858 Uridine phosphorylase. 1.3 1.1 1.1 1.6 −1.2 −3 −2.5

[0135] and

[0136] Table 3 presents a list of signal transducer and transcriptionfactor proteins that are ultraviolet radiation regulated. TABLE 3Ultraviolet Radiation-Regulated Signal Transducers And TranscriptionFactors Signaling molecules. Gene and its Fold regulation No Accession #description 0.5 hr 1 hr 2 hr 4 hr 8 hr 16 hr 24 hr Function 1 D50840Ceramide glucosyltransferase −1.5 −2 −2.9 −1.6 −2.8 −2 6.8 Enzyme 2U04636 Cyclooxygenase-2 (hCox-2) 1 1 1 1.5 2.4 4.5 3.9 Enzyme 3 D28235PTGS2 gene for prostaglandin 1 1 1 1.6 2 2.5 2.6 Enzyme endoperoxidesynthase-2 4 U56418 Lysophosphatidic acid −1.1 −2.2 −1 −1.1 −1.7 −3.5−1.3 Enzyme acyltransferase-□ 5 HG2855 Heat Shock Protein, 70 KD 1.9 1.71.3 −1.3 −4.8 −1.3 2.1 HSP 6 L11066 Human mRNA sequence. 1.1 1.1 1.1−1.1 1.1 −2.9 1 HSP 7 D85429 Heat shock protein 40 −1 −1 1 1 −4.2 −3.2−1.8 HSP 8 D86965 KIAA0210 gene −2.6 −2.6 −1.8 −1.2 −1.1 −3.3 −2Immunophilin 9 Y08915 □4 protein. 1.5 1.7 1.4 1 −1.3 −1.4 −2.6Immunophilin 10 U42031 54 kD progesterone receptor- −2.2 −2.8 −3 −2.6−2.9 −4.6 −3.4 Immunophilin associated immunophilin FKBP54 11 M26311Cystic fibrosis antigen 1.8 1.5 1.4 1.1 −1 1.7 3.9 Kinase 12 U09578MAPKAP kinase (3pK) 2.8 1.8 2 1.6 −1 2.8 1 Kinase 13 X78549 Brk tyrosinekinase. 1.5 1.2 2 1.8 −1 −2 1 Kinase 14 M34182 Testis-specific proteinkinase −1.2 −2.5 −1.3 1.2 −1 −1.5 −1.1 Kinase □ subunit 15 L37042 Caseinkinase I □ (CSNK1A1) −1.3 −2 −2.7 −1 −2.3 −2.2 −1.1 Kinase 16 U01337Ser/Thr protein kinase (A- 1.2 −1.1 −1 −1 −1.2 −2.6 −1.1 Kinase RAF-1)17 X12794 v-erbA related ear-2 gene. 1.2 1 1.3 −1.6 −1.9 −2.8 −1.1Kinase 18 M55265 Casein kinase II □ −1.5 −2.1 −2.8 −1.4 −1.6 −2.4 −1.2Kinase 19 M54915 H-pim-1 protein (h-pim-1) −1 −1.9 −1.1 1.2 −1.5 −3.7−1.5 Kinase 20 D45906 LIMK-2 −1.4 −1.2 −2.8 −1.1 −1.3 −2 −1.9 Kinase 21X80692 ERK3 1.7 1.4 1.1 −2.2 −6.9 −3.2 −2.3 Kinase 22 L19267 59 protein−1.2 −1.1 −1.8 −1.8 −1.9 −1.8 −2.8 Kinase 23 M55268 Casein kinase II □1.3 1.1 −1.2 −1.1 −1.7 −2.6 −4.7 Kinase 24 M60483 Protein phosphatase 2A1.2 −1.6 −1.1 −1.4 −2.7 −1.9 1.2 Phosphatase (PP2A) 25 X68277 MKP1protein tyrosine 2.3 4.9 6.6 6.2 −1.6 −1 1 Phosphatase phosphatase(CL100). 26 X74008 Protein phosphatase 1 gamma 1.3 1.2 1.1 −1.1 −2.8−2.3 1 Phosphatase (PP1G) 27 U14603 Protein-tyrosine phosphatase 1.1−1.3 −1.5 1.1 −2.5 −2.2 −2.6 Phosphatase (HU-PP-1) 28 L77886 Proteintyrosine phosphatase 1.3 1 −1 −1.2 −2.6 −2.3 −2.6 Phosphatase 29 U72066CtBP interacting protein CtIP −1 −1.3 −1.6 −1.2 −2.8 −4.5 −3.2Rb-binding (CtIP) 30 U09937 Urokinase-type plasminogen 1 −1.2 1.1 −1.1 11.2 3.2 Receptor receptor 31 D38305 Tob 1.6 1.4 1.6 2 −1.2 1.2 2.7Receptor 32 D10923 HM74. 1 1 1 2.8 2.2 1.5 1.3 Receptor 33 AF006041Fas-binding protein (DAXX) −1.5 −2.6 −2.1 1.1 1 −1.5 1.2 Receptor 34X52425 IL-4-R interleukin 4 receptor. 1.4 1.1 −1 −1.9 −2.9 −1.1 1.1Receptor 35 M12886 T-cell receptor active □-chain −1.7 −1.7 −1.7 −1 −1.3−2.7 −1.2 Receptor 36 L00352 Low density lipoprotein 1.6 1.3 1 −1.2 −5.7−1.3 −1.2 Receptor receptor 37 D50683 TGF-□IIR□□1 1.2 −1.4 −1.8 1.1 −2.7−1.7 −1.2 Receptor 38 M58286 Tumor necrosis factor recepto −1.2 −1.2−1.2 −1.6 −3.3 −3.4 −1.2 Receptor 39 U05875 pSK1 interferon gamma 1.3−1.1 −1.3 1.3 −3.3 −2 −1.3 Receptor receptor accessory factor-1 (AF-1)40 X75342 SHB 1.1 1.1 1.3 −1.5 −1.5 −2.5 −1.9 Receptor 41 M64347 Novelgrowth factor receptor 1.6 1.4 1.3 1.1 −2.1 −1.4 −2.7 Receptor 42 U28811Cysteine-rich fibroblast −1 −1.1 −1.2 −1 −2 −1.6 −2.9 Receptor growthfactor receptor (CFR- 1) 43 L24564 Rad 1 1 1 1 1 1 5.5 Small, GTPbinding 44 L20688 GDP-dissociation inhibitor −1 −1 1 1 1.6 3.8 3.9Small, GTP protein (Ly-GDI) binding 45 L16862 G protein-coupled receptor−1.4 −2.8 −1 1.1 −1.2 −1 1.5 Small, GTP kinase (GRK6) binding 46 M84332ADP-ribosylation factor 1.3 −1 1 −1.1 −2 −2.6 1.4 Small, GTP binding 47D13988 Rab GDI −1.6 −2.5 −2.1 −1.2 −1 −1.7 −1.2 Small, GTP binding 48U68142 RalGDS-like 2 (RGL2) 2.4 2.2 2.6 1.3 1.1 1.1 −1.4 Small, GTPbinding 49 X12953 Rab2 YPT1-related member −1.4 −2.2 −1.6 −1.6 −2.5 −2.3−1.4 Small, GTP of ras family. binding 50 X04828 G(i) proteinalpha-subunit 1.2 1 1.2 −1 −1 3.1 −1.6 Small, GTP (adenylate cyclaseinhibiting) binding 51 M13829 Raf related protein (pks/a-raf) 1 1 1 −2.8−2.2 1 −1.7 Small, GTP binding 52 M57763 ADP-ribosylation factor −1.7 −2−1.9 −1 −2.1 −3.8 −2.1 Small, GTP (hARF6) binding 53 L38490ADP-ribosylation factor 1.5 1.7 2.2 −1.4 −2 −2.6 −2.2 Small, GTP binding54 L48546 Tuberin (TSC2) −1.6 −2.2 −1.5 1 1.7 1.4 −3 Small, GTP binding55 D42040 KIAA9001 gene 1.3 1.6 1.3 −1 1.1 2.4 4.6 Transcription Factor56 X62083 Drosophila female sterile 1.8 1.1 1 1.7 −1.1 1.9 4Transcription homeotic (FSH) homolog. Factor 57 X74874 RNA pol IIlargest subunit 1.7 1.4 1.5 −1.2 −1.3 1.7 3.7 Transcription Factor 58S78771 NAT=CpG island-associated 1.4 1.3 1.2 1.1 −1 1.4 3.3Transcription gene Factor 59 X15729 Nuclear p68 protein. 1.6 −1.1 1.21.1 −1.5 −1.1 2.6 Transcription Factor 60 M79463 PML-2 mRNA 1.5 1.8 2.1−1 −1 1.6 2.5 Transcription Factor 61 U37690 RNA polymerase II subunit1.6 1.3 1.3 1.2 1.1 4.7 2.3 Transcription (hsRPB10) Factor 62 M62831Transcription factor ETR101 4.6 5.7 5.8 9.4 −1.3 1 2 TranscriptionFactor 63 X51345 JunB 1.5 2.1 2 2.7 −2.4 −1.3 2 Transcription Factor 64U20734 JunB 1.9 3.2 3.9 3 −1.8 −1.9 1.9 Transcription Factor 65 D38251RPB5 (XAP4), 2.2 1.4 1 −1.1 −1.1 2.6 1.7 Transcription Factor 66 M69043MAD-3 encoding IkB-like 1.4 1.4 1.6 2.5 −1.7 1.4 1.7 Transcriptionactivity. Factor 67 D89667 c-myc 1.8 1.1 1.1 1.6 1.4 2.8 1.5Transcription Factor 68 J04611 Lupus p70 (Ku) autoantigen 1.8 1.2 1 1.71.2 2.5 1.4 Transcription Factor 69 D15050 Transcription factor AREB6−1.4 −2 −2 −1.2 −2.5 −1.1 1.4 Transcription Factor 70 U35048 TSC-22 1.81.3 1.6 2.7 −1.8 −1.9 1.4 Transcription Factor 71 M92843 Zinc fingertranscriptional 1.4 2.8 3.6 1.2 −2.9 −2.8 1.4 Transcription regulatorFactor 72 U69126 FUSE binding protein 2 1.6 −0.02 1.6 −1 1.7 2.5 1.2Transcription (FBP2) Factor 73 U07664 HB9 homeobox gene −1.8 −2.5 −1.6 1−1.2 −2.8 1.2 Transcription Factor 74 U13991 TATA-binding protein 2.91.18 2 1.6 1.4 1.7 1.1 Transcription associated factor 30 kD Factorsubunit (tafII30) 75 D86966 KIAA0211 gene −2.5 −2.5 −2.5 −1 1.3 −1.7 1Transcription Factor 76 X56681 JunD 2 3 4.6 3.2 2.9 1.2 1 TranscriptionFactor 77 V01512 c-fos 2.3 3.2 2.8 1 1 1 1 Transcription Factor 78L13391 Helix-loop-helix basic 1 1 1 3.2 1 1 1 Transcriptionphosphoprotein (GOS8) Factor 79 HG3494 Nuclear Factor Nf-I16 1.7 1.7 22.9 −1.1 −1.1 1 Transcription Factor 80 L11672 Kruppel related zincfinger −1.4 −1.3 −1.5 −1.7 −1.6 −2.5 −1 Transcription protein (HTF10)Factor 81 X78992 ERF-2 −1.2 −1.2 −1.7 −1.3 −3.9 −3.3 −1 TranscriptionFactor 82 L19314 HRY 1.5 1.78 2.4 1.1 −3.1 −1.9 −1.1 TranscriptionFactor 83 L04731 Translocation T(4:11) of ALL- 3.2 3.1 3.8 −1.2 1.1 1.5−1.2 Transcription 1 gene to chromosome 4. Factor 84 X89750 TGIF −1 −1.3−1.4 1.5 −2.5 −3.8 −1.2 Transcription Factor 85 S74017 Nrf2=NF-E2-likebasic leucine 1.5 1.4 1.1 −1.6 −2.9 −1.9 −1.2 Transcription zippertranscriptional activator Factor 86 U88629 RNA polymerase II elongation−1.4 −1.8 −1.7 −2.5 −3.2 −3.3 −1.2 Transcription factor ELL2, Factor 87J03161 Serum response factor (SRF) −1.6 −2.7 −2.6 −1.3 −2.3 −1.3 −1.2Transcription Factor 88 M58603 NF-□B) −1.2 −1.3 −1.2 −1 −1.5 −2.9 −1.3Transcription Factor 89 HG3523 c-Myc −1.2 −1.9 −1.4 −3.9 −5.8 −3.4 −1.3Transcription Factor 90 M91083 DNA-binding protein (HRC1) −1.4 −1.3 −1.7−1.3 −2.6 −1.8 −1.4 Transcription Factor 91 HG3342 Id1 2 2.2 1.5 1.1−3.6 −3 −1.5 Transcription Factor 92 U66616 SWI/SNF complex 170 KD −3.1−2.1 −1.6 1.7 −1 −1.3 −1.7 Transcription subunit (BAF170) Factor 93D14520 GC-Box binding protein −1.2 −1.8 −2.4 −1.4 −2.8 −3.7 −1.7Transcription BTEB2, Factor 94 X52541 Early growth response protein 1.51.4 1 2.2 −3.8 −2.1 −2.1 Transcription 1 (hEGR1). Factor 95 M31627 X boxbinding protein-1 −1.1 −1.1 1 2.6 1.5 −2.8 −2.3 Transcription (XBP-1)Factor 96 M83667 NF-IL6-□ 1.4 1.4 1.6 1.4 −1.9 −4.2 −2.4 TranscriptionFactor 97 D42123 ESP1/CRP2 1.3 1 1.4 1.3 1.1 1.5 −2.5 TranscriptionFactor 98 M81601 Transcription elongation factor −1.1 −1.3 −1.4 −1.1−1.7 −3.3 −2.8 Transcription (SII) Factor 99 X52611 AP-2. −1.3 −1.2 −1.6−2.4 −3.4 −3.3 −2.8 Transcription Factor 100 M13929 c-myc −3.1 −3 −2.3−2.3 −5 −4.3 −2.9 Transcription Factor 101 L00058 c-myc 1.7 1.6 1.1 −1.7−4.3 −1.7 −3 Transcription Factor 102 L37127 RNA polymerase II mRNA 1 11 1.8 −1.9 1.9 −3.1 Transcription Factor 103 D90209 DNA binding protein1.6 1.6 1.7 2.4 1.3 −2.8 −3.4 Transcription TAXREB67. Factor 104 M38258Retinoic acid receptor gamma 1.3 1.2 −1 −1.7 −1.3 −1.3 −3.6Transcription Factor 105 U00968 SREBP-1 1.8 1.4 1.2 −1.2 −2.3 −1.5 −3.7Transcription Factor 106 X77366 HBZ17 1.8 1.2 −1.1 −1 −2.4 −2.5 −3.9Transcription Factor 107 J04102 ets-2 −1.8 −1.8 −1.8 −1.7 −2.2 −5.5 −4.1Transcription Factor 108 HG2724 Oncogene Tls/Chop, 1 1 1 5.1 1 −3.4 −4.2Transcription Factor 109 X69111 HLH 1R21 helix-loop-helix 1.5 0.58 2 1.5−2.8 −6 −5.3 Transcription protein. Factor 110 M59465 Tumor necrosisfactor alpha 1.2 1 1 1.1 −1 1.4 5 Zn finger inducible protein A20 111D85527 LIM domain −2.8 −2.1 −2.7 −1.9 −2.1 −1.8 1 Zn finger 112 U33821Tax1-binding protein 1.4 −1.1 −1 1.2 −1.6 −3 −1.7 Zn finger TXBP151

[0137] and

[0138] Table 4 presents a list of cytoskeletal and structural proteinsthat are ultraviolet radiation-regulated. TABLE 4 UltravioletRadiation-Regulated Cytoskeletal and Structural Proteins Structuralproteins. Gene and its Fold regulation No. Accession description 0.5 hr1 hr 2 hr 4 hr 8 hr 16 hr 24 hr Function 1 M20030 Small proline rich 1.32.1 1.5 1.1 1.6 5.9 21.1 differentiation protein (sprII). 2 X53065 Smallproline rich 1.1 1.3 1.3 1.5 1.7 2.9 21 differentiation protein SPRR2A 3M13903 Involucrin 1.2 −1.2 −2.3 −1.1 −1.1 5.8 13.5 differentiation 4L10343 Elafin. 1.2 −1.1 −1.1 1.5 1.2 3.4 10 differentiation 5 M21302Small proline rich −1.1 −1.1 1 2.4 3.5 3.3 7.6 differentiation protein(sprII). 6 L05188 Small proline-rich −1 1 1.6 1.2 1.9 3.1 7.1differentiation protein 2 (SPRR2B). 7 HG2815 Myosin, Light Chain 1.1−1.1 1.1 −1.1 −1 9.9 6.6 cytoskeletal Smooth Muscle. 8 HG1612 Macmarcks1.4 1.3 1.7 2.6 2.7 3.5 6.5 cytoskeletal 9 X52426 Keratin 13. −1.1 −1.11.2 −1.1 −1.2 −1.5 6.2 cytoskeletal 10 Z49989 Smoothelin. 1.5 1.2 1.11.2 1.9 1.8 4.9 cytoskeletal 11 HG2815 Myosin, Light Chain, 1.5 1 1.1 −1−1.3 5.2 3.7 cytoskeletal Smooth Muscle. 12 HG2815 Myosin, Light Chain,1.1 −1.2 1 −1 1.1 2.5 3.7 cytoskeletal Smooth Muscle. 13 X99920 X99920S100 calcium- 1.9 1.7 1.6 1 1 4.3 3.6 differentiation binding proteinA13. 14 HG4322 Tubulin □ 2 1.9 1.7 2.7 3 3.4 3.6 cytoskeletal 15 S54005Thymosin □-10. 1.5 1 1.2 1.1 −1 3 3.4 cytoskeletal 16 X83416 PrP prionprotein. 1.2 1.2 1.9 −1.4 −1.1 1.1 2.9 structural 17 HG1980 Tubulin, □ 21 1.3 1.4 1 1.3 1.1 2.6 cytoskeletal 18 HG2259 Tubulin, □ 1. 2.2 1.3 1.9−1.2 −1 6.4 2.5 cytoskeletal 19 X57579 Activin □-A subunit. −1.7 −1.5−2.1 1.2 −1.7 1.8 2.5 cytoskeletal 20 AF006084 Arp2/3 protein complex1.8 1.1 −1.2 1.3 1.2 4 2.1 cytoskeletal subunit p41-Arc (ARC41). 21Y00503 Keratin 19. 1.5 1.2 1.2 −1 −1.3 2.9 2.1 cytoskeletal 22 M12125Fibroblast muscle-type 1.3 1 1.3 1.1 1.2 2.5 2 cytoskeletal tropomyosin.23 X82693 Desmoglein III, E48 1.3 1.3 1.1 −1.4 −2 3 1.4 differentiationantigen. 24 M19309 Slow skeletal muscle 2.6 2 2 1.4 1.1 2.4 1.4cytoskeletal troponin T. 25 X53416 Filamin (ABP-280). 1.6 1.5 1.5 1 −12.7 1 Cytoskeletal 26 X04412 Plasma gelsolin. 3 1.9 1.2 1 −1.5 2 −1.3cytoskeletal 27 M76482 130-kD pemphigus −1 −1.3 −1.4 −1.5 −2.5 −2.9 −1.3cytoskeletal vulgaris antigen.. 28 M69181 Nonmuscle myosin −1 −1.1 −1−2.6 −1.1 −1.3 −1.8 cytoskeletal heavy chain-B (MYH10) 29 M96803 □□spectrin (SPTBN1). −1.7 −2.6 −2.2 −1.5 −1.5 −2.3 −1.9 cytoskeletal 30Z26317 Desmoglein 2. −1.4 −1.3 1 −1.3 −2 −2.5 −2.1 cytoskeletal 31U37122 Adducin □ subunit. −1.3 −2.5 −1.5 −1.1 −2.7 −1.3 −2.3cytoskeletal 32 HG174 Desmoplakin I −1.8 −2.9 −3.8 −2.6 −4.1 −2.6 −2.4cytoskeletal 33 X53586 Integrin □ 6. 1.8 1.4 1.4 −1.4 −2 1 −2.7cytoskeletal 34 U83115 Non-lens beta gamma- 1.1 1 1 −1.2 −1.7 −1.1 −3.3cytoskeletal crystallin like protein (AIM1). 35 D31883r KIAA0059 geneproduct, 1.5 1.3 1 −1.1 −1.6 −1.7 −3.5 cytoskeletal actin binding 36M95787 22kD smooth muscle 1.6 1 1 −1.6 −2.4 1.2 −3.7 cytoskeletaltransgelin (SM22).

[0139] and

[0140] Table 5 presents a list of secreted peptides that are ultravioletradiation regulated. TABLE 5 Ultraviolet Radiation-Regulated SecretedPeptides Growth factors, cytokines and chemokines. Fold regulation NoAccession Gene and its description 0.5 hr 1 hr 2 hr 4 hr 8 hr 16 hr 24hr 1 M57731 Gro-□ 1 1 2.1 19.6 8.7 1.9 3 2 Y00787 Interleukin-8 (IL-8) 11 1 6.7 5.9 4 6.8 3 X54489 Melanocyte growth stimulatory activity 1 1 13.9 5.7 2.7 4.4 (MGSA, Gro-□). 4 X53800 Macrophage inflammatoryprotein-2□ 1 1 1 3.4 3.8 1 2.7 (MIP2□). 6 M60278 Heparin-bindingEGF-like growth factor −1.2 −1.2 −1.2 1 2.3 3.2 4.2 (HB-EGF) 8 M63573Secreted cyclophilin-like protein 2.7 2.7 1.8 1 1.3 7.1 4.5 (SCYLP) 9L42379 Bone-derived growth factor (BPGF-1) 1.2 1.2 −1.3 1 1 2.9 1.9 10J04456 14 kD lectin 1.3 1.3 1 1.2 1 2.5 2.2 11 M92934 Connective tissuegrowth factor (CTGF) 1 1 1 1 1 1.1 4.3 12 AB000584 TGF-□ superfamilyprotein 1 1 1 1 1 1.1 3.1 14 M12529 Apolipoprotein E 1.7 1.7 −1 1.7 −1.12.9 1.2 16 D14874 Adrenomedullin precursor 1.6 1.6 1.6 −1 −2.4 −2.8 −1.817 M30703 Amphiregulin (AR) 1.2 1.2 −1 1.6 −3.8 −2 1.7 7 X94563 dbi/acbp−3.4 −3.4 −1.5 1.6 2 −1 1.1

[0141] and

[0142] Table 6 presents a list of mitochondrial proteins that areultraviolet radiation-regulated. TABLE 6 Ultraviolet Radiation-RegulatedMitochondrial Proteins Mitochondrial proteins Fold regulation AccessionGene and description 0.5 hr 1 hr 2 hr 4 hr 8 hr 16 hr 24 hr J04444Cytochrome c-1. 4.3 2.9 1.6 1.6 1.3 1.7 −3.6 Z49254 Mitochondrialribosome L23 subunit-related 3.1 2.1 2.7 1.2 1.2 4.2 2.1 U65579Mitochondrial NADH dehydrogenase-ubiquinone 2.8 2 2 1.4 1 3 −1 Fe—Sprotein 8, 23 kD subunit M19961 Cytochrome c oxidase subunit Vb (coxVb). 2.6 1.7 1 1.2 1.3 3.1 −1 M21186 Neutrophil cytochrome b lightchain. 2 1.6 1.2 1.3 1.3 4.5 2.6 Z14244 Cox VIIb mRNA for cytochrome coxidase subunit 1.9 1.2 1.7 1.5 −1.6 4.1 4.2 VIIb. M26730 Mitochondrialubiquinone-binding protein (QP) 1.8 1.7 2 −1 1.2 2.8 1.8 gene, exon 4.X15822 COX VIIa-L mRNA for liver-specific cytochrome c 1.8 1.4 1.9 1.1 12.6 1.8 oxidase (EC 1.9.3.1.). U09813 Mitochondrial ATP synthase subunit9 1.5 1 1.1 1 −1.2 2.6 1.3 X05409). Mitochondrial aldehyde dehydrogenaseI ALDH I 1.4 1.2 1 1.2 −1.3 −1.3 −2.8 (EC 1.2.1.3). Y07604Nucleoside-diphosphate kinase. 1.2 1.3 1.4 1.1 1.6 2.3 2.1 X80695cytochrome oxidase assembly protein OXA1Hs 1.2 1.2 1.4 −1.4 −1 −1 −4.1X71129 Electron transfer flavoprotein beta subunit. 1.2 1.1 −1.5 1.9−1.4 2.9 1.2 J03824 Uroporphyrinogen III synthase 1.1 1 1.2 2.5 1.1 1.51 X89267 Uroporphyrinogen decarboxylase −1.8 −2.7 −1.6 1.3 1.7 −1.2 −1HG3492 Thermogenic uncoupling protein Ucp −1.8 −2.7 −1.8 −1.5 −1.3 −1.1−2.6 X59434 Rhodanese. −3 −2.6 −2.7 −1.1 −1.2 −1 −1.9

[0143] Table 7 presents a list of first, second and third response groupgene sets that are ultraviolet radiation regulated. TABLE 7 UltravioletRadiation-Regulated First, Second And Third Response Gene Sets 0.5 hr 1hr 2 hr ##### 4 hr 8 hr ##### 16 hr 24 hr ##### Description Function##### comment First Response Gene Set 4.6 5.7 5.8 16.1 9.4 −1 8.1 1 2 3M62831_at M62831 Human transcription TF 27.2 Immediate early factorETR101 mRNA, complete cds. 2.3 4.9 6.6 13.8 6.2 −2 4.6 −1 1 0 X68277_atX68277 H. sapiens CL 100 signaling 18.4 mRNA for protein tyrosinephosphatase. 3.2 3.1 3.8 10.1 −1.2 1.1 −0.1 1.5 −1 0.3 L04731_at L04731H. sapiens signaling 10.3 Tritorax-like translocation T(4:11) of ALL-1gene to chromosome 4. 2 3 4.6 9.6 3.2 2.9 6.1 1.2 1 2.2 X56681_s_atX56681 Human junD TF 17.9 Immediate early mRNA. 1.9 3.2 3.9 9 3 −2 1.2−2 1.9 0 U20734_s_at U20734 Human TF 10.2 Immediate early transcriptionfactor junB (junB) gene, 5′ region and complete cds. 3.5 3.1 1.8 8.4 1.3−1 0.2 −1 −2 −3 L38951_at L38951 H. sapiens importin RNA processing 5.6beta subunit mRNA, complete cds. 4.5 2.8 1 8.3 −2.6 −1 −3.9 2.5 −1 1.3D87071_at D87071 Human mRNA for ??? 5.7 No homology with KIAA0233 gene,complete cds. anything, large prot. 1.6 2.8 3.5 7.9 4.7 3.9 8.6 1.7 45.7 M72885_ma1_s_at M72885 Human Cell cycle 22.2 GOS2 gene, 5′ flank andcds. 1.4 2.8 3.6 7.8 1.2 −3 −1.7 −3 1.4 −1.4 M92843_s_at M92843 H.sapiens zinc TF 4.7 finger transcriptional regulator mRNA, complete cds.2.2 2.6 2.5 7.3 15 1.6 16.9 3.6 5.9 9.5 S81914_at S81914IEX-1=radiation- Apoptosis 33.7 Apoptosis inhibitor, inducibleimmediate-early gene [human, NFkB-regulated placenta, mRNA Partial, 11.7 2.8 2.7 7.2 −1.3 −3 −4.1 −2 1.4 −0.4 U72649_at U72649 Human BTG2Cell cycle 2.7 antiproliferative p53- (BTG2) mRNA, complete cds. 2 2.82.2 7 1.1 −1 0.1 1.5 1.8 3.3 D86988_at D86988 Human mRNA for RNAprocessing 10.4 mRNA decay trans-acting KIAA0221 gene, complete cds.factor!! 1.6 2.3 3.1 7 3.3 3.4 6.7 5.1 4.6 9.7 L19779_at L19779 H.sapiens histone Cell cycle 23.4 H2A.2 mRNA, complete cds. 3.1 2.1 1.76.9 1 −1 −0.2 1.4 1 2.4 U62317_rna3_at U62317 Chromosome ??? 9.1 Cholinephosphorylase-like 22q13 BAC Clone CIT987SK-384D8 complete sequence. 31.9 1.2 6.1 1 −2 −0.5 2 −1 0.7 X04412_at X04412 Human mRNA for cytoskel.6.3 plasma gelsolin. 2.5 1.7 1.7 5.9 1.5 −1 0.3 2.2 1.2 3.4 L27706_atL27706 Human chaperonin Chaperon 9.6 protein (Tcp20) gene complete cds.1.2 1.8 2.7 5.7 2.8 −1 1.4 1 2.3 3.3 X61123_at X61123 Human BTG1 GF/cyt10.4 mRNA. 1.6 1.5 2.6 5.7 3.1 1.6 4.7 1.5 2.5 4 M60974_s_at M60974Human growth DNA rep. 14.4 arrest and DNA-damage-inducible protein(gadd45) mRNA, complete cds 2.5 1.6 1.5 5.6 1.1 −1 0.1 1.9 1 2.9L19437_at L19437 Human transaldolase DNA rep. 8.6 glucolysis, pentosephosphate mRNA containing transposable element, complete cds. 1 1 3.15.1 3.1 4.4 7.5 5.9 4.8 10.7 X57985_rna2_at X57985 H. sapiens Cell cycle23.3 genes for histones H2B.1 and H2A. 2.5 −1 −1 0.5 1.7 −1 0.3 −2 −1−2.7 D90086_at D90086 Human pyruvate Energy −1.9 dehydrogenase (EC1.2.4.1) beta subunit gene, exons 1-10. −1.2 −3 −1 −5 1.2 −1 0.2 −2 −1−2.6 M34182_at M34182 Human testis- signaling −7.4 specific proteinkinase gamma-subunit mRNA, complete cds. −1.4 −3 −1 −5.2 1.1 −1 −0.1 −11.5 0.5 L16862_at L16862 H. sapiens G protein- signaling −4.8 coupledreceptor kinase (GRK6) mRNA, complete cds. −2.6 −2 −1 −5.3 −1.2 −1 −2.2−1 1 −0.3 D13705_s_at D13705 Human mRNA for detox −7.8 fatty acidsomega-hydroxylase (cytochrome P-450HKV), complete cds −1.3 −3 −2 −5.3−1.1 −3 −3.8 −1 −2 −3.6 U37122_at U37122 Human adducin cytoskel. −12.7gamma subunit mRNA, complete cds. −1.4 −1 −3 −5.4 −1.1 −1 −2.4 −2 −2−3.9 D45906_at D45906 H. sapiens mRNA for signaling −11.7 LIMK-2,complete cds. −1.8 −3 −2 −5.9 1 −1 −0.2 −3 1.2 −1.6 U07664_at U07664Human HB9 TF −7.7 homeobox gene, exons 2 and 3 and complete cds. −1.4 −2−3 −6 −1 −2 −2.6 −2 −2 −4 D87438_at D87438 Human mRNA for ??? −12.6KIAA0251 gene, partial cds. −1.3 −2 −3 −6 −1 −2 −3.3 −2 −1 −3.3L37042_at L37042 H. sapiens casein signaling −12.6 kinase I alphaisoform (CSNK1 A1) mRNA, complete cds. −1.1 −3 −2 −6 1.3 −2 −0.2 −2 −2−3.4 D14043_at D14043 Human mRNA for ??? −9.6 agglutinin binding MGC-24,complete cds. −1.6 −3 −2 −6.2 −1.2 −1 −2.2 −2 −1 −2.9 D13988_at D13988Human rab GDI signaling −11.3 mRNA, complete cds. −1.8 −3 −2 −6.3 −1.5−1 −2.8 −1 −3 −3.7 HG3492-HT3686_at U28480 Uncoupling Mit. −12.8thermogenic Protein Ucp −1.5 −2 −3 −6.4 −1.6 −3 −4.4 −2 6.8 4.8D50840_at D50840 H. sapiens mRNA for signaling −6 ceramideglucosyltransferase, complete −1.5 −2 −3 −6.4 −1.4 −2 −3 −2 −1 −3.6M55265_at M55265 Human casein kinase signaling II alpha subunit mRNA,complete cds. −1.7 −3 −2 −6.5 −1.5 −2 −3 −2 −2 −4.2 M96803_at M96803Human general beta- cytoskel. −13.7 spectrin (SPTBN1) mRNA, completecds. −2.2 −2 −2 −6.6 −2.6 −1 −3.7 −2 1 −1.3 U89336_cds4_at U89336 HumanHLA integral membrane −11.6 class III region containing NOTCH4 proteingene, partial sequence, homeobox PB −1.8 −3 −3 −6.9 −1.1 −1 −2.2 −1 −1−2.5 D87442_at D87442 Human mRNA for ?!? −11.6 No homology withanything, KIAA0253 gene, partial cds. −1.6 −3 −3 −6.9 −1.3 −2 −3.6 −1 −1−2.5 J03161_at J03161 Human serum response signaling −13 factor (SRF)mRNA, complete cds. −2.6 −3 −2 −7 −1.2 −1 −2.3 −3 −2 −5.3 D86965_atD86965 Human mRNA for signaling −14.6 KIAA0210 gene, complete cds. −2.8−3 −2 −7.2 −1 −1 −2.4 −2 1 −0.5 U17327_at U17327 Human neuronal NO −10.1nitric oxide synthase (NOS1) mRNA, complete cds. −2.5 −3 −3 −7.5 −1 1.30.3 −2 1 −0.7 D86966_at D86966 Human mRNA for TF −7.9 ZFY KIAA0211 gene,complete cds. −2.8 −2 −3 −7.6 −1.9 −2 −4 −2 1 −0.8 D85527_at D85527 H.sapiens mRNA for signaling −12.4 LIM domain, partial cds. −2.2 −3 −3 −8−2.6 −3 −5.5 −5 −3 −8 U42031_at U42031 Human 54 kD signaling −21.5progesterone receptor-associated immunophilin FKBP54 mRNA partial −3 −3−3 −8.3 −1.1 −1 −2.3 −1 −2 −2.9 X59434_at X59434 Human rohu mRNA Mit.−13.5 for rhodanese. −3.1 −3 −2 −8.4 −2.3 −5 −7.3 −4 −3 −7.2 M13929_s_atM13929 Human c-myc-P64 TF −22.9 mRNA, initiating from promoter PO,(HLmyc2.5) partial cds. −1.8 −3 −4 −8.5 −2.6 −4 −6.7 −3 −2 −5HG174-HT174_at J05211 Desmoplakin I cytoskel. −20.2 Second Response GeneSet 1 1.2 2.1 4.3 20 8.7 28.3 1.9 3 4.9 M57731_s_at M57731 Humangro-beta GF/cyt 37.5 mRNA, complete cds. 2.2 2.6 2.5 7.3 15 1.6 16.9 3.65.9 9.5 S81914_at S81914 IEX-1=radiation- Apoptosis 33.7 Apoptosisinhibitor, inducible immediate-early gene [human, placenta, mRNAPartial, 1 1 1 1 3 6.7 5.9 12.6 4 6.8 10.8 Y00787_s_at Y00787 Human mRNAfor GF/cyt 26.4 MDNCF (monocyte-derived neutrophil chemotactic factor).1 1 1 3 3.9 5.7 9.6 2.7 4.4 7.1 X54489_rna1_at X54489 Human gene forGF/cyt 19.7 melanoma growth stimulatory activity (MGSA). 1.6 2.8 3.5 7.94.7 3.9 8.6 1.7 4 5.7 M72885_rna1_s_at M72885 Human Cell cycle 22.2 GOS2gene, 5′ flank and cds. 4.6 5.7 5.8 16.1 9.4 −1 8.1 1 2 3 M62831_atM62831 Human transcription TF 27.2 Immediate only factor ETR101 mRNA,complete cds. 1 1 1 3 4 3.7 7.7 2.4 3.1 5.5 M28130_rna1_s_at M28130Human GF/cyt 16.2 interleukin 8 (IL8) gene, complete cds. 1 1 3.1 5.13.1 4.4 7.5 5.9 4.8 10.7 X57985_rna2_at X57985 H. sapiens Cell cycle23.3 genes for histones H2B.1 and H2A. 1 1 1 3 3.4 3.8 7.2 1 2.7 3.7X53800_s_at X53800 Human mRNA for GF/cyt 13.9 macrophage inflammatoryprotein-2beta (MIP2beta). 1.6 2.3 3.1 7 3.3 3.4 6.7 5.1 4.6 9.7L19779_at L19779 H. sapiens histone Cell cycle 23.4 H2A.2 mRNA, completecds. 1.3 1.5 1.5 4.3 3.9 2.7 6.6 3.5 3.7 7.2 AF001294_at AF001294 H.sapiens IPL Apoptosis 18.1 imprinted, possibly in (IPL) mRNA, completecds. apoptosis, PH dom. 2 3 4.6 9.6 3.2 2.9 6.1 1.2 1 2.2 X56681_s_atX56681 Human junD TF 17.9 Immediate early mRNA. 1 1 1 3 5.1 1 6.1 −3 −4−7.6 HG2724-HT2820_at S75762 Oncogene signaling 1.5 Tis/Chop, FusionActivated 1 1.3 −1 1.3 1.2 4.8 6 1 1.3 2.3 M84739_at M84739 Humanautoantigen ER/vesicles/ 9.6 Ca binding protein, ER calreticulin mRNA,complete cds. −1.1 −1.1 1 −1.2 2.4 3.5 5.9 3.3 7.6 10.9 M21302_at M21302Human small proline differentiation 15.6 rich protein (sprII) mRNA,clone 174N. 2 1.9 1.7 5.6 2.7 3 5.7 3.4 3.6 7 HG4322-HT4592_at V00599Tubulin, cytoskel. 15.6 Beta 1.4 1.3 1.7 4.4 2.6 2.7 5.3 3.5 6.5 10HG1612-HT1612_at X70326 Macmarcks cytoskel. 19.7 1 1 1 3 2.8 2.2 5 1.51.3 2.8 D10923_at D10923 Human mRNA for signaling 10.8 HM74. 1.5 1.4 1.34.2 2.6 2.3 4.9 1.6 1.4 3 D64142_at D64142 Human mRNA for Cell cycle12.1 histone H1x, complete cds. −1.2 1 1.2 1 2 2.8 4.8 3.7 2.1 5.8D86974_at D86974 Human mRNA for ??? 11.6 KIAA0220 gene, partial cds. 1.61.5 2.6 5.7 3.1 1.6 4.7 1.5 2.5 4 M60974_s_at M60974 Human growth DNArep. 14.4 arrest and DNA-damage-inducible protein (gadd4s) mRNA,complete cds 2.3 4.9 6.6 13.8 6.2 −2 4.6 −1 1 0 X68277_at X68277 H.sapiens CL 100 Signaling 18.4 mRNA for protein tyrosine phosphatase. 1 11 3 3.2 1 4.2 1 1 2 L13391_at L13391 Human helix-loop- TF 9.2 helixbasic phosphoprotein (GOS8) gene, complete cds. −1.1 −1.1 1 −1.2 2.6 1.54.1 −3 −2 −5.1 M31627_at M31627 Human X box TF −2.2 binding protein-1(XBP-1) mRNA, complete cds. 1.9 1.7 1.8 5.4 2.5 1.3 3.8 2.3 2 4.3U40369_rna1_at U40369 Human DNA rep. 13.5 spermidine/spermineN1-acetyltransferase (SSAT) gene, complete cds. 1.7 1.7 2 5.4 2.9 −1 1.8−1 1 −0.1 HG3494-HT3688_at X52560 Nuclear TF 7.1 Factor Nf-I16 1.2 1.82.7 5.7 2.8 −1 1.4 1 2.3 3.3 X61123_at X61123 Human BTG1 GF/cyt 10.4mRNA. 1.9 3.2 3.9 9 3 −2 1.2 −2 1.9 0 U20734_s_at U20734 Human TF 10.2Immediate only transcription factor junB (juoB) gene, 5′ region andcomplete cds. 1.8 1.3 1.6 4.7 2.7 −2 0.9 −2 1.4 −0.5 U35048_at U35048Human TSC-22 TF 5.1 protein mRNA, complete cds. 1.4 1.4 1.6 4.4 2.5 −20.8 1.4 1.7 3.1 M69043_at M69043 H. sapiens MAD-3 TF 8.3 mRNA encodingIkB-like activity, complete cds. 1.5 2.1 2 5.6 2.7 −2 0.3 −1 2 0.7X51345_at X51345 Human jun-B mRNA TF 6.6 Immediate only for JUN-Bprotein. −1.1 −1 −1 −3.5 1.6 −3 −0.9 1.8 1 2.8 S68616_at S68616 Na+/H+exchanger Integral membrane −1.6 integral membrane NHE-1 isoform [human,heart, mRNA, protein protein 4516 nt]. −1 −1.3 −1 −3.7 1.5 −3 −1 −4 −1−5 X89750_at X89750 H. sapiens mRNA for TF −9.7 homeobox TGIF protein.1.5 0.6 2 4.08 1.5 −3 −1.3 −6 −5 −11.3 X69111_at X69111 H. sapiens HLHTF −8.52 1R21 mRNA for helix-loop-helix protein. 1.1 −1.3 −2 −1.7 1.1 −3−1.4 −2 −3 −4.8 U14603_at U14603 Human protein- Signaling −7.9 tyrosinephosphatase (HU-PP-1) mRNA, partial sequence. 1.5 1.4 1 3.9 2.2 −4 −1.6−2 −2 −4.2 X52541_at X52541 Human mRNA for Signaling −1.9 GAP earlygrowth response protein 1 (hEGR1). 1.2 −1.4 −2 −2 1.1 −3 −1.6 −2 −1 −2.9D50683_at D50683 H. sapiens mRNA for Signaling −6.5 TGF-betaIIR alpha,complete cds. 1.4 2.8 3.6 7.8 1.2 −3 −1.7 −3 1.4 −1.4 M92843_s_at M92843H. sapiens zinc TF 4.7 finger transcriptional regulator mRNA, completecds. −1 −1 −1 −3 1 −3 −1.9 −3 −1 −3.5 X91247_at X91247 H. sapiens mRNAfor Detox −8.4 thioredoxin reductase. 1.3 −1.1 −1 −1.1 1.3 −3 −2 −2 −1−3.3 U05875_at U05875 Human clone pSK1 Signaling −6.4 IFN-induciblinterferon gamma receptor accessory factor-1 (AF-1) mRNA, compl 1.5 1.82.4 5.68 1.1 −3 −2 −2 −1 −3 L19314_at L19314 Human HRY gene, TF 0.68complete cds. 1.2 −1.3 −1 −1.1 1.6 −4 −2.2 −2 1.7 −0.3 M30703_s_atM30703 Human GF/cyt −3.6 amphiregulin (AR) gene, exon 6, cloneslambda-ARH(6,12). 1.6 1.5 1.5 4.6 1.5 −4 −2.3 1 −2 −0.7 U34252_at U34252Human gamma- Energy 1.6 aldehyde dehydrog. detox aminobutyraldehydedehydrogenase mRNA, complete cds. 2 2.2 1.5 5.7 1.1 −4 −2.5 −3 −2 −4.5HG3342-HT3519_s_at S78825 Id1 TF −1.3 −1 −1 1 −1 1 −4 −3.2 −3 −2 −5D85429_at D85429 H. sapiens gene for Signaling −9.2 heat shock protein40, complete cds. 1.6 1 1 3.6 −1 −3 −3.6 −1 1.2 0.2 U41766_s_at U41766Human Protease 0.2 metalloprotease/disintegrin/cysteine-rich proteinprecursor (MDC9) mRNA, c −2.2 −2.2 −2 −6.6 −2.6 −1 −3.7 −2 1 −1.3U89336_cds4_at U89336 Human HLA Integral membrane −11.6 class III regioncontaining NOTCH4 gene, partial sequence, homeobox PB −1 −1.1 −1 −3.1−2.6 −1 −3.7 −1 −2 −3.1 M69181_at M69181 Human nonmuscle Cytoskel.myosin heavy chain-B (MYH10) mRNA, partial cds. −1.4 −2 −2 −5.4 −1.2 −3−3.7 −1 1.4 0.3 D15050_at D15050 Human mRNA for TF −8.8 transcriptionfactor AREB6, complete cds. 1.7 1 1.1 3.8 −1.2 −3 −3.7 1 1.2 2.2U28386_at U28386 Human nuclear Nucler transport 2.3 localizationsequence receptor hSRP1alpha mRNA, complete cds. 1.3 1 −1 1.3 −1.2 −3−3.8 −2 −3 −4.9 L77886_at L77886 Human protein Signaling −7.4 tyrosinephosphatase mRNA, complete cds. 1.2 −1 −1 −0.9 −1.1 −3 −3.8 1.2 −1 0.2X64330_at X64330 H. sapiens mRNA for Lipid metabolism −4.5 lipidsynthesis ATP-citrate lyase. 1.3 −2.5 −2 −5.3 −1.1 −3 −3.8 −1 −2 −3.6U37122_at U37122 Human adducin Cytoskel. −12.7 gamma subunit mRNA,complete cds. 1.3 1.2 1.1 3.6 −1.1 −3 −3.9 −2 1 −1.3 X74008_at X74008 H.sapiens mRNA for Signaling −1.6 protein phosphatase 1 gamma. 1.1 −1 11.1 −1.1 −3 −3.9 1.2 −2 −0.7 U60205_at U60205 Human methyl sterol Lipidmetabolism −3.5 lipid metabolism oxidase (ERG25) mRNA, complete cds. 1 11 3 −1 −3 −3.9 −2 −5 −6.4 X76534_at X76534 H. sapiens NMB Integralmembrane −7.3 antimetastatic mRNA. protein transmembrane glycoprot. 4.52.8 1 8.3 −2.6 −1 −3.9 2.5 −1 1.3 D87071_at D87071 Human mRNA for ???5.7 No homology with KIAA0233 gene, complete cds. anything, large prot.1.3 1 1 3.3 −1.3 −3 −3.9 −1 −1 −2.7 U90716_at U90716 Human cell surfaceCell surface/ −3.3 virus receptors protein HCAR mRNA, complete cds. −1.4−1.3 −2 −4.4 −1.3 −3 −3.9 −2 −1 −3.2 M91083_at M91083 Human DNA- TF−11.5 binding protein (HRC1) mRNA, complete cds. −1.6 −2 −2 −5.7 −1.3 −3−3.9 −2 −2 −3.5 U29607_at U29607 Human methionine Translation −13.1Inhibitor aminopeptidase mRNA, complete cds. −1 −1.3 −1 −3.7 −1.5 −3 −4−3 −1 −4.2 M76482_at M76482 Human 130-kD Cytoskel. −11.9 pemphigusvulgaris antigen mRNA, complete cds. −1 −1.3 −2 −3.9 −1.2 −3 −4 −5 −3−7.7 U72066_at U72066 H. sapiens CtBP Signaling −15.6 Rb-bindinginteracting protein CtIP (CtIP) mRNA, complete cds. 1.3 1.3 1.2 3.8 −1.2−3 −4 −2 −4 −5.2 K03195_at K03195 Human (HepG2) Energy −5.4 glucosetransporter gene mRNA, complete cds. −1.4 −2.2 −2 −5.2 −1.6 −3 −4.1 −2−1 −3.7 X12953_at X12953 Human rab2 mRNA, Signaling −13 YPT1-related andmember of ras family. 1.2 −1.6 −1 −1.5 −1.4 −3 −4.1 −2 1.2 −0.7M60483_rna1_s_at M60483 Human Signaling −6.3 protein phosphatase 2Acatalytic subunit- alpha gene, complete cds. 1.7 2.8 2.7 7.2 −1.3 −3−4.1 −2 1.4 −0.4 U72649_at U72649 Human BTG2 Cell cycle 2.7antiproliferative (BTG2) mRNA, complete cds. p53-dependent −1.2 −1.8 −2−5.4 −1.4 −3 −4.2 −4 −2 −5.4 D14520_at D14520 Human mRNA for TF −15GC-Box binding protein BTEB2, complete cds. 1.3 −1 −1 −0.9 −1.7 −3 −4.31.8 5.9 7.7 L08069_at L08069 Human heat shock DNA rep. 2.5 protein, E.coli DnaJ homolog mRNA, complete cds. −1.5 −2 −3 −6.4 −1.6 −3 −4.4 −26.8 4.8 D50840_at D50840 H. sapiens mRNA for Signaling −6 ceramideglucosyltransferase, complete cds. −1.4 −1.9 −2 −5.5 −1.4 −3 −4.4 −2 −3−4.7 L31801_at L31801 H. sapiens Transporter −14.6 Lactate and pyruvatemonocarboxylate transporter 1 (SLC16A1) mRNA, complete cds. 1.5 1.4 1.14 −1.6 −3 −4.5 −2 −1 −3.1 S74017_at S74017 Nrf2=NF-E2-like TF −3.6 basicleucine zipper transcriptional activator [human, hemin-ind 1.7 1 1 3.7−1.3 −3 −4.5 −2 1 −0.8 X87241_at X87241 H. sapiens mRNA for Cellsurface/ −1.6 hFat protein. 1.4 1.1 −1 1.5 −1.9 −3 −4.8 −1 1.1 0X52425_at X52425 Human IL-4-R Signaling −3.3 mRNA for the interleukin 4receptor. −1.1 −1.8 −2 −5 −1.6 −3 4.8 −2 −2 −4 D79994_at D79994 HumanmRNA for ??? −13.8 ankyrin-related KIAA0172 gene, partial cds. −1.2 −1.2−1 −3.6 −1.6 −3 −4.9 −3 −1 −4.6 M58286_s_at M58286 H. sapiens tumorSignaling −13.1 necrosis factor receptor mRNA, complete cds. 1 1 1 3−2.8 −2 −5 1 −2 −0.7 M13829_s_at M13829 Human putative Signaling −2.7raf related protein (pks/a-rat) mRNA, partial cds. −1.2 −1.2 −2 −4.1−1.3 4 −5.2 −3 −1 −4.3 X78992_at X78992 H. sapiens ERF-2 TF −13.6 mRNA.−2.2 −2.8 −3 −8 −2.6 −3 −5.5 −5 −3 −8 U42031_at U42031 Human 54 kDSignaling −21.5 progesterone receptor-associated immunophilin FKBP54mRNA, partial −1.4 −1.8 −2 −4.9 −2.5 −3 −5.7 −3 −1 −4.5 U88629_at U88629Human RNA TF −15.1 polymerase II elongation factor ELL2, complete cds.−1.3 −1.2 −2 4.1 −2.4 −3 −5.8 −3 −3 −6.1 X52611_s_at XS2611 Human mRNAfor TF −16 transcription factor AP-2. 1.3 −1 −2 −1.7 −2.7 −3 −5.9 1 1.22.2 U28749_s_at U28749 Human high- DNA rep. −5.4 mobility groupphosphoprotein isoform I— C (HMGIC) mRNA, complete cds. 1.7 1.6 1.1 4.4−1.7 −4 −6 −2 −3 4.7 L00058_at L00058 Human (GH) TF −6.3 germline c-mycproto-oncogene, exon 3 and 3′ flank. 1.9 1.7 1.3 4.9 −1.3 −5 −6.1 −1 2.10.8 HG2855-HT2995_at L26336 Heat Shock signaling −0.4 Protein, 70 KD(Gb:Y00371) 1.6 1.2 −1 1.5 −1.5 −5 −6.4 −2 −1 −3.5 L08246_at L08246Human myeloid cell Apoptosis −8.4 Bcl2-like differentiation protein(MCL1) mRNA. 1.2 1.2 1.4 3.8 −1.5 −5 −6.4 −4 −3 −6.9 S73591_at S73591brain-expressed detox −9.5 Thioredoxin interacting HHCPA78 bomolog[human, HL-60 acute promyelocytic leukemia cells −1.8 −2.9 −4 −8.5 −2.6−4 −6.7 −3 −2 −5 HG174-HT174_at J05211 Desmoplakin I cytoskel. −20.2 1.61.3 1 3.9 −1.2 −6 −6.9 −1 −1 −2.5 L00352_at L00352 Human low densitysignaling −5.5 lipoprotein receptor gene, exon 18. −1.5 −1.6 −2 4.6 −3.14 −7.1 −2 −2 −3.9 HG3930-HT4201b_at Y13647 Stearoyl- lipid metabolism−15.6 lipogenic Coenzymea Desaturase 2.2 1.4 1.5 5.1 −2.4 −5 −7.1 −1 3.21.9 X77794_at X77794 H. sapiens mRNA for Cell cycle −0.1 cyclin G1. −1.3−1.8 −2 −5.5 −1.7 −5 −7.1 −6 −3 −9.4 M90656_at M90656 Human gamma- detox−22 glutathione biosynthesis glutamylcysteine synthetase (GCS) mRNA,complete cds. −3.1 −3 −2 −8.4 −2.3 −5 −7.3 −4 −3 −7.2 M13929_s_at M13929Human c-myc-P64 TF −22.9 mRNA, initiating from promoter P0, (HLmyc2.5)partial cds. 1 −1.3 −1 −1.5 −2 −6 −8.3 −3 −1 −4.6 D78129_at D78129 H.sapiens mRNA for lipid metabolism −14.4 lipogenic squalene epoxidase,partial cds. cholesterol synth. 1.7 1.4 1.1 4.2 −2.2 −7 −9.1 −3 −2 −5.5X80692_at X80692 H. sapiens ERK3 signaling −10.4 mRNA. −1.2 −1.9 −1 −4.5−3.9 −6 −9.7 −3 −1 −4.7 HG3523-HT4899_s_at J00120 Proto- TF −18.9Oncogene C-Myc, Alt. Splice 3, Orf 114 Third Response Gene Set 1.3 2.11.5 4.9 1.1 1.6 2.7 5.9 21 27 M20030_f_at M20030 Human smalldifferentiation 34.6 proline rich protein (sprII) mRNA, clone 930. 1.11.3 1.3 3.7 1.5 1.7 3.2 2.9 21 23.9 X53065_f_at X53065 differentiation30.8 1.2 −1.2 −2 −2.3 −1.1 −1 −2.2 5.8 14 19.3 M13903_at M13903 Humaninvolucrin differentiation 14.8 gene, exon 2. 1.1 −1.1 1.1 1.1 −1.1 −1−2.1 9.9 6.6 16.5 HG2815-HT2931_at M22918 Myosin, cytoskel. 15.5 LightChain, Alkali, Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice 1.2−1.1 −1 −1 1.5 1.2 2.7 3.4 10 13.4 L10343_at L10343 Huma elafin gene,differentiation 15.1 complete cds. 2.7 2 1.8 6.5 1 1.3 2.3 7.1 4.5 11.6M63573_at M63573 Human secreted GF/cyt 20.4 cyclophilin-like protein(SCYLP) mRNA, complete cds. −1.1 −1.1 1 −1.2 2.4 3.5 5.9 3.3 7.6 10.9M21302_at M21302 Human small proline differentation 15.6 rich protein(sprII) mRNA, clone 174N. 1 1 1 3 6.7 5.9 12.6 4 6.8 10.8 Y00787_s_atY00787 Human mRNA for GF/cyt 26.4 MDNCF (monocyte-derived neutrophilchemotactic factor). 1 1 3.1 5.1 3.1 4.4 7.5 5.9 4.8 10.7 X57985_rna2_atX57985 H. sapiens Cell cycle 23.3 genes for histones H2B.1 and H2A. −1 11.6 1.6 1.2 1.9 3.1 3.1 7.1 10.2 L05188_f_at L05188 H. sapiens smalldifferentiation 14.9 proline-rich protein 2 (SPRR2B) gene, complete cds.1.4 1.3 1.7 4.4 2.6 2.7 5.3 3.5 6.5 10 HG1612-HT1612_at X70326 Macmarckscytoskel. 19.7 3.1 2 1.7 6.8 1.7 1.2 2.9 6.1 3.9 10 X67325_at X67325 H.sapiens p27 IFN-inducible 19.7 mRNA. 1.6 2.3 3.1 7 3.3 3.4 6.7 5.1 4.69.7 L19779_at L19779 H. sapiens histone Cell cycle 23.4 H2A.2 mRNA,complete cds. 2.2 2.6 2.5 7.3 15 1.6 16.9 3.6 5.9 9.5 S81914_at S81914IEX-1=radiation- Apoptosis 33.7 Apoptosis inhibitor inducibleimmediate-early gene [human NFkB-regulated placenta, mRNA Partial, 1 2.11.3 1.2 4.6 1.5 1.5 3 6.5 3 9.5 D45248_at D45248 Human mRNA forIFN-inducible 17.1 proteasome activator hPA28 subunit beta, completecds. 2.6 2.4 2.4 7.4 1.1 1.1 2.2 7.5 2 9.5 Z22548_at Z22548 H. sapiensthiol- detox 19.1 specific antioxidant protein mRNA. 1.5 1 1.1 3.6 −1 −1−2.3 5.2 3.7 8.9 HG2815-HT2931_s_at M22918 Myosin cytoskel. 10.2 LightChain, Alkali, Smooth Muscle (Gh:U02629), Non-Muscle, Alt. Splice 2.21.3 1.9 5.4 −1.2 −1 −2.2 6.4 2.5 8.9 HG2259-HT2348_s_at X06956 Tubulin,cytoskel. 12.1 Alpha 1, Isoform 44 −2.1 −1.1 −1 −4.3 −1.2 1.5 0.3 4.93.7 8.6 V00594_at V00594 Human mRNA for detox 4.6 metallothionein fromcadmium-treated cells. −1.2 −1.2 −1 −3.6 2 1.7 3.7 2.5 5.9 8.4 M80254_atM80254 H. sapiens ??? 8.5 prolyl isomerase cyclophilin isoform (hCyP3)mRNA, complete cds. 1 1 1 3 1.5 2.4 3.9 4.5 3.9 8.4 U04636_rna1_atU04636 Human signaling 15.3 cyclooxygenase-2 (hCox-2) gene, completecds. 1.9 1.2 1.7 4.8 1.5 −2 −0.1 4.1 4.2 8.3 Z14244_at Z14244 H. sapienscox VIIb Mit. 13 mRNA for cytochrome c oxidase subunit VIIb. 1.9 1.7 1.65.2 1 1 2 4.3 3.6 7.9 X99920_at X99920 H. sapiens mRNA fordifferentation 15.1 S100 calcium-binding protein A13. 1 1 1 3 1.3 1.42.7 2 5.8 7.8 U62800_at U62800 Human cystatin M protease inhibitor 13.5protease inhibitor (CST6) mRNA, complete cds. 1.3 −1 −1 −0.9 −1.7 −3−4.3 1.8 5.9 7.7 L08069_at L08069 Human heat shock DNA rep. 2.5 protein,E. coli DnaJ homolog mRNA, complete cds. −1 −1 1 −1 1 1.6 2.6 3.8 3.97.7 L20688_at L20688 Human GDP- signaling 9.3 dissociation inhibitorprotein (Ly-GDI) mRNA, complete cds. 1.4 1.3 1.4 4.1 1.4 1.5 2.9 5.1 2.67.7 M13755_at M13755 Human interferon- IFN-inducible 14.7 induced17-kD/15-kD protein mRNA, complete cds. −1.2 −1.2 −1 −3.6 1 2.3 3.3 3.24.2 7.4 M60278_at M60278 Human heparin- GF/cyt 7.1 binding EGF-likegrowth factor mRNA, complete cds. 1.3 1.5 1.5 4.3 3.9 2.7 6.6 3.5 3.77.2 AF001294_at AF001294 H. sapiens IPL Apoptosis 18.1 imprinted,possibly in (IPL) mRNA, complete cds. approptosis, PH dom. 1 1 1 3 3.95.7 9.6 2.7 4.4 7.1 X54489_rna1_at X54489 Human gene for GF/cyt 19.7melanoma growth stimulatory activity (MGSA). 2 1.6 1.2 4.8 1.3 1.3 2.64.5 2.6 7.1 M21186_at M21186 Human neutrophil Mit. 14.5 cytochromeblight chain p22 phagocyte b-cytochrome mRNA, compl 1.3 1.6 1.3 4.2 −11.1 0.1 2.4 4.6 7 D42040_s_at D42040 Human mRNA for signaling 11.3 RING3domain KIAA9001 gene, complete cds. 2 1.9 1.7 5.6 2.7 3 5.7 3.4 3.6 7HG4322-HT4592_at V00599 Tubulin, cytoskel. 18.3 Beta 1.6 1.3 1.3 4.2 1.21.1 2.3 4.7 2.3 7 U37690_at U37690 Human RNA TF 13.5 polymerase IIsubunit (hsRPB10) mRNA, complete cds. 2.3 1.4 1.2 4.9 1.5 −1 0.5 3.3 3.66.9 M21005_at M21005 Human migration GF/cyt 12.3 inhibitoryfactor-related protein 8 (MRP8) gene, complete cds. 1.2 −1 1.1 1.3 1.41.2 2.6 3.4 3.4 6.8 M37583_at M37583 Human histone Cell cycle 10.7(H2A.Z) mRNA, complete cds. 1.5 1.2 1.1 3.8 1.2 1.9 3.1 1.8 4.9 6.7Z49989_at Z49989H, sapiens mRNA for cytoskel. 13.6 actin bindingsmoothelin. 1 1 1 3 1 1 2 1 5.5 6.5 L24564_at L24564 Human Rad mRNA,signaling 11.5 complete cds. 1.6 1.2 1.3 4.1 −1 1 0 3.2 3.3 6.5D49824s_at D49824 Human HLA-B integral membrane protein 10.6 null allelemRNA. 1.2 1 1 3.2 1.1 −1 0.1 1.4 5 6.4 M59465_at M59465 Human tumorsignaling 9.7 necrosis factor alpha inducible protein A20 mRNA, completecds. 1.5 1 1.2 3.7 1.1 −1 0.1 3 3.4 6.4 S54005_s_at S54005 thymosinbeta-10 cytoskel. 10.2 inhibition of actin [human, metastatic melanomacell line, polym. mRNA, 453 nt]. 3.1 2.1 2.7 7.9 1.2 1.2 2.4 4.2 2.1 6.3Z49254_at Z49254 H. sapiens L23- Mit. 16.6 related mRNA. 1.1 −1.2 1 0.9−1 1.1 0.1 2.5 3.7 6.2 HG2815-HT4023_s_at M22919 Myosin, cytoskel. 7.2Light Chain, Alkali, Smooth Muscle (Gb:U02629), Smooth Muscle, Alt. Spli1.3 1.3 1.3 3.9 1 1.4 2.4 4.1 2.1 6.2 U70660_at U70660 Human copperdetox 12.5 Antioxidant defense transport protein HAH1 (HAH1) mRNcomplete cds. 1.8 1.1 −1 1.7 1.3 1.2 2.5 4 2.1 6.1 AF006084_at AF006084H. sapiens cytoskel. 10.3 Arp2/3 protein complex subunit p41-Arc (ARC41)mRNA, complete cds. 1.8 1.1 1 3.9 1.7 −1 0.6 1.9 4 5.9 X62083_s_atX62083 H. sapiens mRNA signaling 10.4 for Drosophila female sterilehomeotic (FSH) homolog. −1.2 1 1.2 1 2 2.8 4.8 3.7 2.1 5.8 D86974_atD86974 Human mRNA for ??? 11.6 KIAA0220 gene, partial cds. 1.6 2.8 3.57.9 4.7 3.9 8.6 1.7 4 5.7 M72885_rna1_s_at M72885 Human Cell cycle 22.2GOS2 gene, 5′ flank and cds. 1.2 1.1 1 3.3 1 −1 0 3 2.7 5.7 S80437_s_atS80437 fatty acid synthase lipid metabolism 9 lipid synthesis {3′region} [human, breast and HepG2 cells, mRNA Partial, 22 2.1 1.4 1.3 4.81.2 −1 0.1 3.2 2.5 5.7 X04654_s_at X04654 Human mRNA for RNA processing10.6 RNA binding U1 RNA-associated 70 K protein. 1.8 1.5 1.4 4.7 1.1 −10.1 1.7 3.9 5.6 M26311_s_at M26311 Human cystic signaling 104 proteinkinase inhibitor fibrosis antigen mRNA, complete cds, 1.4 1.7 2 5.1 21.7 3.7 2.5 3.1 5.6 X14850_at X14850 Human H2A.X mRNA encoding histoneH2A.X. 1.7 1.3 1.5 4.5 −1.2 1.1 −0.1 3 2.6 5.6 M14328_s_at M14328 Humanalpha Energy 10 energy recruitment, enolase mRNA, complete cds. ATPsynth. 1.1 −1.5 −1 −1.7 −1.3 −1 −2.4 1.9 3.6 5.5 U07919_at U07919 Humanaldehyde detox 1.4 dehydrogenase 6 mRNA, complete cds. 1 1 1 3 4 3.7 7.72.4 3.1 5.5 M28130_rna1_s_at M28130 Human GF/cyt 16.2 interleukin 8(IL8) gene, complete cds. 5.2 2.4 4.7 12.3 2 1.6 3.6 3.6 1.9 5.5Z21507_at Z21507 H. sapiens EF-1 delta Translation 21.4 gene encodinghuman elongation factor delta. 1 1 1 3 1 1 2 1.1 4.3 5.4 M92934_atM92934 Human connective GF/cyt 10.4 tissue growth factor, complete cds.−1 −1.3 −2 −3.9 1.2 −2 −1.2 1.5 3.9 5.4 M27436_s_at M27436 Human tissueintegral membrane protein 0.3 interacts with the serine factor gene,complete eds, with a Alu protease repetitive sequence in the 3′ 1.7 1.41.5 4.6 −1.2 −1 −2.5 1.7 3.7 5.4 X74874_rna1_s_at X74874 H. sapiens TF7.5 gene for RNA pol II largest subunit, exon 1. 1.1 −1.1 −1 −1 −1.3 −1−2.3 2.6 2.8 5.4 X57351_at X57351 Human 1-8D gene IFN-inducible 2.1 frominterferon-inducible gene family. 1.6 1.2 1.2 4 1 −1 −0.2 2.6 2.7 5.3X52979_rna1_s_at X52979 Human gene RNA processing 9.1 for small nuclearribonucleoproteins SmB and SmB′. 1.4 1.1 1.3 3.8 1.3 1.2 2.5 3.9 1.4 5.3U41515_at U41515 Human deleted in ??? 11.6 split hand/split foot 1(DSS1) mRNA, complete cds. 1 1 1 3 1.6 2 3.6 2.5 2.6 5.1 D28235_s_atD28235 Human PTGS2 signaling 11.7 gene for prostaglandin endoperoxidesynthase-2, complete cds. 1.5 1.2 1.2 3.9 −1 −1 −2.3 2.9 2.1 5 Y00503_atY00503 Human mRNA for cytoskel. 6.6 keratin 19. 1 1.2 2.1 4.3 20 8.728.3 1.9 3 4.9 M57731_s_at M57731 Human gro-beta GF/cyt 37.5 mRNA,complete cds. −1.5 −2 −3 −6.4 −1.6 −3 −4.4 −2 6.8 4.8 D50840_at D50840H. sapiens mRNA for signaling −6 ceramide glucosyltransferase, completecds. 1 −1 −1 −1.2 1 1.1 2.1 1.7 3.1 4.8 U52101_at U52101 Human YMP mRNA,integral membrane protein 5.7 membrane glycoprotein complete cds. 1.71.6 1.8 5.1 −1.1 1 −0.1 2.9 1.9 4.8 D13413_rna1_s_at D13413 Human RNAprocessing 9.8 mRNA for tumor-associated 120 kD nuclear protein p120,partial cds(carbox 1.2 −1.1 −1 −1.2 1 1 2 2.9 1.9 4.8 L42379_at L42379H. sapiens bone- GF/cyt 5.6 derived growth factor (BPGF-1) mRNA completecds. −1.1 −1.1 1.2 −1 −1.1 −1 −2.3 −2 6.2 4.7 X52426_s_at X52426 H.sapiens mRNA cytoskel. 1.4 for cytokeratin 13. 1.3 1.1 1 3.4 1.2 1 2.22.5 2.2 4.7 J04456_at J04456 Human 14 kD lectin GF/cyt 10.3 mRNA,complete cds. 1.4 1.3 1.2 3.9 1.1 −1 0.1 1.4 3.3 4.7 S78771_s_at S78771NAT=CpG island- signaling 8.7 associated gene [human, mRNA, 1741 nt].1.8 1.7 2 5.5 −1 1.2 0.2 2.8 1.8 4.6 M26730_s_at M26730 Human Mit. 10.3mitochondrial ubiquinone-binding protein (QP) gene, exon 4. 2 1.4 1 4.4−1 1.1 0.1 3 1.6 4.6 U26727_at U26727 Human Cell cycle 9.1 Tumorsuppressor, p16INK4/MTS1 mRNA, complete cds. Cdk4/6 interacting 1.4 −1.9−2 −2.3 −1 −1 −2.1 3.2 1.4 4.6 X92896_at X92896 H. sapiens mRNA for ???0.2 ITBA2 protein. 1.3 1.4 1.4 4.1 1 1 2 1.8 2.7 4.5 Z69043_s_at Z69043H. sapiens mRNA ER/vesicles/lysosome 10.6 ER, translocon-translocon-associated protein delta associated protein subunitprecursor. 1.8 1.7 1.5 5 −1.2 −1 −2.6 2 2.5 4.5 L76568_xpt3_f_at L76568H. sapiens DNA rep. 6.9 excision and cross link repair protein (ERCC4)gene, complete genom 1.3 1 1.3 3.6 1.1 1.2 2.3 2.5 2 4.5 M12125_atM12125 Human fibroblast cytoskel. 10.4 muscle-type tropomyosin mRNA,complete cds. 1 −1.2 1.1 0.9 −1.1 1 −0.1 1.2 3.2 4.4 U09937_rna1_s_atU09937 Human signaling 5.2 urokinase-type plasminogen receptor, exon 7.1.8 1.4 1.9 5.1 1.1 1 2.1 2.6 1.8 4.4 X15822_at X15822 Human COX VIIa-LMit. 11.6 mRNA for liver-specific cytochrome c oxidase (EC 1.9.3.1.). 11 1.1 3.1 1 2.1 3.1 2.8 1.6 4.4 M34516_at M34516 Human omega light Cellsurface/adhesion 10.6 chain protein 14.1 (Ig lambda chain related) gene,exon 3. 1.1 1.4 1.1 3.6 2 2 4 2.9 1.5 4.4 U53830_at U53830 H. sapiensinterferon IFN-inducible 12 regulatory factor 7A mRNA, complete cds. 1.31.3 1.1 3.7 −1.4 −2 −3.4 3 1.4 4.4 X82693_at X82693 H. sapiens mRNA fordifferentation 4.7 Desmoglein III, PV E48 antigen. target 1.4 1.5 1.54.4 −1.1 −1 −2.1 3.2 1.1 4.3 M58026_at M58026 Human NB-1 ??? 6.6calmodulin-like mRNA, complete cds. 1 1 1 3 1.4 −2 −0.6 1 3.3 4.3M90657_at M90657 Human tumor Cell surface/adhesion 6.7 Glucoproteins,cell antigen (L6) mRNA, complete cds. −1.7 −1.5 −2 −5.3 1.2 −2 −0.5 1.82.5 4.3 X57579_s_at X57579 H. sapiens activin cytoskel. −1.5 beta-Asubunit (exon 2). 2.2 1.4 1 4.6 −1.1 −1 −2.2 2.6 1.7 4.3 D38251_s_atD38251 Human mRNA for TF 6.7 RPB5 (XAP4), complete cds. 1.8 1.1 1.1 41.6 1.4 3 2.8 1.5 4.3 D89667_at D89667 H. sapiens mRNA for signaling11.3 c-myc binding protein, complete cds. 1 1 1 3 1 1 2 1.1 3.1 4.2AB000584_at AB000584 H. sapiens GF/cyt 9.2 mRNA for TGF-beta superfamilyprotein complete cds. 2.4 1.4 1.3 5.1 1.5 1.1 2.6 2.6 1.6 4.2 L76200_atL76200 Human guanylate DNA rep. 11.9 kinase (GUK1) mRNA, complete cds.1.2 1 1 3.2 1.5 1.2 2.7 3.1 1.1 4.2 J04794_at J04794 Human aldehydedetox 10.1 reductase mRNA, complete cds. 1.4 1.1 1.1 3.6 1.4 −1 0.2 1.32.8 4.1 X52882_at X52882 Human t-complex Cell surface/adhesion 7.9polypeptide 1 gene. 1.5 1.8 2.1 5.4 −1 −1 −2 1.6 2.5 4.1 M79463_s_atM79463 Human PML-2 TF 7.5 mRNA, complete CDS. 1 −1.1 −1 −1.2 1.7 2 3.71.6 2.5 4.1 Y09022_at Y09022 H. sapiens mRNA for ER/vesicles/lysosome6.6 tenuous funtion!! Not56-like protein. 1.7 1.3 −1 2 1.7 −1 0.6 2.91.2 4.1 M12529_at M12529 Human GF/cyt 6.7 apolipoprotein E mRNA,complete cds. 1.2 1.1 −2 0.8 1.9 −1 0.5 2.9 1.2 4.1 X71129_at X71129 H.sapiens mRNA for Mit. 5.4 electron transfer flavoprotein beta subunit.1.2 1.2 1.9 4.3 −1.4 −1 −2.5 1.1 2.9 4 X83416_s_at X83416 H. sapiens PrPcytoskel. 5.8 prion protein gene, exon 2. −1 −2.6 −1 −4.7 1.4 2 3.4 1.42.6 4 D89052_at D89052 H. sapiens mRNA for Energy 2.7 proton-ATPase-likeprotein, complete cds. 1.6 1.5 2.6 5.7 3.1 1.6 4.7 1.5 2.5 4 M60974_s_atM60974 Human growth DNA rep. 14.4 arrest and DNA-damage-inducibleprotein (gadd45) mRNA, complete cds 1 1 1 3 1 1 2 3 1 4 M16364_s_atM16364 Human creatine Energy 9 energy recruitment, kinase-B mRNA,complete cds. ATP synth. 1.6 1.4 1.6 4.6 2 −1 0.8 1.2 2.7 3.9 D38305_atD38305 Human mRNA for signaling 9.3 Tob, complete cds. 1.4 1.5 1.3 4.2 1−1 0 1.2 2.7 3.9 HG2917-HT30611_at X87679 Major Cell surface/adhesion8.1 Histocompatibility Complex, Class I, E (Gb:M21533) 1.4 1.3 1.4 4.1−1.1 −1 −2.2 1.2 2.7 3.9 Z29505_at Z29505 H. sapiens mRNA for RNAprocessing 5.8 nucleic acid binding protein sub2.3. 1.1 1 −1 1 1.2 1.12.3 1.3 2.6 3.9 K02574_at K02574 ??? 7.3 1.5 1 1.1 3.6 1 −1 −0.2 2.6 1.33.9 U09813_at U09813 Human mitochondrial Mit. 7.3 ATP synthase subunit9, P3 gene copy, mRNA, nuclear gene enc 1.5 1.5 1.3 4.3 −1.1 −1 −2.1 2.61.3 3.9 X67951_at X67951 H. sapiens mRNA for detox 6.1 antioxidantprotein proliferation-associated gene (pag). 1.8 1.2 1 4 1.7 1.2 2.9 2.51.4 3.9 J04611_at J04611 Human lupus p70 (Ku) TF 10.8 autoantigenprotein mRNA, complete cds. 2.8 1.8 2 6.6 1.6 −1 0.6 2.8 1 3.8 U09578_atU09578 H. sapiens MAPKAP signaling 11 kinase (3pK) mRNA, complete cds. 11 1 3 3.4 3.8 7.2 1 2.7 3.7 X53800_s_at X53800 Human mRNA for GF/cyt13.9 macrophage inflammatory protein-2beta (MIP2beta). 1 1.3 1.4 3.7 11.3 2.3 1.1 2.6 3.7 HG1980-HT2023_at V00599 Tubulin, cytoskel. 9.7 Beta2 1.6 −0 1.6 3.18 −1 1.7 0.7 2.5 1.2 3.7 U69126_s_at U69126 Human FUSETF 7.58 binding protein 2 (FBP2) mRNA, partial cds. 1.6 1.5 1.5 4.6 1 −10 2.7 1 3.7 X53416_at XS3416 Human mRNA for cytoskel. 8.3 actin-bindingprotein (filamin) (ABP- 280). 1 1 1 3 1 1 2 1 2.6 3.6 U90546_r_at U90546Human integral membrane protein 8.6 membrane glycoprotein butyrophilin(BTF4) mRNA, complete cds. 2.6 1.9 1.8 6.3 1.3 1.1 2.4 4.2 −1 3.2M58459_at M58459 Human ribosomal Translation 11.9 protein (RPS4Y)isoform mRNA, complete cds. 2.6 1.7 1 5.3 1.2 1.3 2.5 3.1 −1 2.1M19961_at M19961 Human cytochrome Mit. 9.9 c oxidase subunit Vb (cox Vb)mRNA, complete cds. 2.8 2 2 6.8 1.4 1 2.4 3 −1 2 U65579_at U65579 Humanmitochondrial Mit. 11.2 NADH dehydrogenase-ubiquinone Fe—S protein 8, 23kD subunit 2.2 1.4 1.5 5.1 −2.4 −5 −7.1 −1 3.2 1.9 X77794_at X77794 H.sapiens mRNA for Cell cycle −0.1 cyclin G1. 1.8 1.5 1.2 4.5 1.4 −1 0.32.7 −1 1.7 M29064_at M29064 Human hnRNP B1 RNA processing 6.5 proteinmRNA. 1.3 1 −1 1.2 1 −1 −0.2 −1 2.7 1.6 D21853_at D21853 Human mRNA forTranslation 2.6 translation initiation KIAA0111 gene, complete cds. −1.1−1.4 −1 −3.9 1.4 1.7 3.1 −1 2.7 1.5 X78687_at X78687 H. sapiens G9 geneCell surface/adhesion 0.7 Glucoproteins, cell encoding sialidase.surface 1.6 −1.1 1.2 1.7 1.1 −2 −0.4 −1 2.6 1.5 X15729_s_at X15729 HumanmRNA for TF 2.8 nuclear p68 protein. 1.2 1 1.2 3.4 −1 −1 −2 3.1 −1.6 1.5X04828_at X04828 Human mRNA for signaling 2.9 G(i) protein alpha-subunit(adenylate cyclase inhibiting GTP-bind 1.1 1.2 −1 1.2 −1.3 −2 −2.8 2.6−1.3 1.3 L27943_at L27943 H. sapiens cytidine DNA rep. −0.3 deaminase(CDA) mRNA, complete cds. 1.4 −1.5 −2 −1.9 1.1 −1 −0.3 1.9 −2.8 −0.9L4039 _at L40391 H. sapiens (clone ??? −3.1 s153) mRNA fragment. 1.3 11.4 3.7 1.3 1.1 2.4 1.5 −2.5 −1 D42123_at D42123 H. sapiens mRNA forsignaling 5.1 cytoskel. LIM domain ESP1/CRP2, complete cds. 1 1.1 −1 1.11.1 −1 0 −3 1.4 −1.2 X74104_at X74104 H. sapiens mRNA forER/vesicles/lysosome −0.1 ER, translocon- TRAP beta subunit. associatedprotein 1.3 −1 1 1.3 −1.1 −2 −3.1 −3 1.4 −1.2 M84332_at M84332 HumanADP- signaling −3 ribosylation factor 1 gene, exons 2−5. 1 1 1 3 1.8 −2−0.1 1.9 −3.1 −1.2 L37127_at L37127 H. sapiens RNA TF 4.7 polymerase IImRNA, complete cds. 1.4 2.8 3.6 7.8 1.2 −3 −1.7 −3 1.4 −1.4 M92843_s_atM92843 H. sapiens zinc TF 4.7 finger transcriptional regulator mRNA,complete cds. −1.8 −2.5 −2 −5.9 1 −1 −0.2 −3 1.2 −1.6 U07664_at U07664Human HB9 TF −7.7 homeobox gene, exons 2 and 3 and complete cds. −1.6−2.2 −2 −5.3 1 1.7 2.7 1.4 −3 −1.6 L48546_at L48546 H. sapiens tuberinsignaling −4.2 GAP (TSC2) gene, exons 38, 39, 40 and 41. 1.8 1.4 1.4 4.6−1.4 −2 −3.4 1 −2.7 −1.7 X53586_rna1_at X53586 Human mRNA cytoskel. −0.5ECM for integrin alpha 6. 1.5 1 −1 1.2 1.4 1.1 2.5 1 −2.8 −1.8 D21852_atD21852 Human mRNA for ??? 1.9 KIAA0029 gene, partial cds. 1.1 1.1 1.13.3 −1.1 1.1 0 −3 1 −1.9 L11066_at L11066 Human mRNA signaling 1.4HSP-associated sequence. 4.3 2.9 1.6 8.8 1.6 1.3 2.9 1.7 −3.6 −1.9J04444_at J04444 Human cytochrome c-1 Mit. 9.8 gene, complete cds. 1.6 11 3.6 −1.6 −2 4 1.2 −3.7 −2.5 M95787_at M95787 Human 22kD cytoskel. −2.9transgelin smooth muscle protein (SM22) mRNA complete cds. −5.6 −4.5 −1−11.4 1.3 1 2.3 −5 1 −3.5 HG880-HT880_at L07517 Mucin 6, ??? −12.6Gastric (Gb:L07517) −1 −1 −1 −3 1 −3 −1.9 −3 −1 −3.5 X91247_at X91247 H.sapiens mRNA for detox −8.4 thioredoxin reductase. −1.4 −1.3 −2 −4.2−1.7 −2 −3.3 −3 −1 −3.5 L11672_at L11672 Human Kruppel TF −11 relatedzinc finger protein (HTF10) mRNA, complete cds. 1.1 −1.1 −2 −1.8 1.1 −1−0.1 −1 −2.6 −3.6 U30999_at U30999 Human (memc) ??? −5.5 mRNA, 3′UTR.1.2 −1.1 −1 −0.9 −1 −1 −2.2 −3 −1.1 −3.7 U01337_at U01337 Human Ser/Thrsignaling −6.8 protein kinase (A-RAF-1) gene, complete cds. −1.8 −2.7 −2−6.3 −1.5 −1 −2.8 −1 −2.6 −3.7 HG3492-HT3686_at U28480 Uncoupling Mit.−12.8 thermogenic Protein Ucp 1.2 1 1.3 3.5 −1.6 −2 −3.5 −3 −1.1 −3.9X12794_at X12794 Human v-erbA signaling −3.9 related ear-2 gene. 1.1 1.2−2 0.6 1.1 −2 −0.8 −3 −1.1 −3.9 L22005_at L22005 Human ubiquitinprotease −4.1 protease conjugating enzyme mRNA, partial cds −1.7 −1.7 −2−5.1 −1 −1 −2.3 −3 −1.2 −3.9 M12886_at M12886 Human T-cell signaling−11.3 receptor active beta-chain mRNA, complete cds. 1.5 1.7 1.4 4.6 1−1 −0.3 −1 −2.6 −4 Y08915_at Y08915 H. sapiens mRNA for signaling 0.3alpha 4 protein. 1.3 1.1 1.1 3.5 −1.4 −2 −3.2 −3 −1.3 4.1HG3638-HT3849_s_at M24547 Amyloid ECM −3.8 ECM Beta (A4) PrecursorProtein, Alt. Splice 2 A4(751) 1 1 −1 0.9 −1.3 −1 −2.4 −2 −2.5 −4.1X76717_at X76717 H. sapiens MT-11 detox. −5.6 mRNA. 1.6 1.4 1.3 4.3 1.1−2 −1 −1 −2.7 −4.1 M64347_at M64347 Human novel growth signaling −0.8factor receptor mRNA, 3′ cds. 1.4 1.2 1 3.6 1.2 −1 −0.1 −1 −2.8 −4.1X05409_at X05409 Human RNA for Mit. −0.6 mitochondrial aldehydedehydrogenase I ALDH I (EC 1.2.1.3). −1.1 −1.4 −2 −4.1 1.3 −1 −0.1 −1−2.8 −4.1 D87469_at D87469 Human mRNA for Cell surface/adhesion −8.3seven-pass KIAA0279 gene, partial cds. transmembrane cadherin −1.2 −1.3−1 −3.7 −1 −2 −2.5 −3 −1.3 −4.2 M58603_at M58603 Human nuclear TF −10.4factor kappa-B DNA binding subunit (NF-kappa-B) mRNA, complete cds −1−1.3 −1 −3.7 −1.5 −3 −4 −3 −1.3 −4.2 M76482_at M76482 Human 130-kDcytoskel. −11.9 pemphigus vulgaris antigen mRNA, complete cds. 1.3 −1 −1−1 1.4 −1 0.4 −3 −1.6 −4.2 X06323_at X06323 Human MRL3 Translation −4.8mRNA for ribosomal protein L3 homolog (MRL3 = mammalian ribosome L −1.2−1.2 −2 −4.1 −1.3 −4 −5.2 −3 −1 −4.3 X78992_at X78992 H. sapiens ERF-2TF −13.6 mRNA. 1.8 1 −1 1.7 1 −2 −1 −3 −1.2 −4.3 L41351_at L41351 H.sapiens prostasin protease −3.6 secreted protease mRNA, complete cds.1.1 1.1 1.3 3.5 −1.5 −2 −3 −3 −1.9 −4.4 X75342_at X75342 H. sapiens SHBsignaling −3.9 SH2 prot. mRNA. 1.1 1 1 3.1 −1.2 −2 −2.9 −1 −3.3 −4.4U83115_at U83115 Human non-lens beta cytoskel. −4.2 gamma-crystallinlike protein (AIM1) mRNA, partial cds. −1.4 −1.8 −2 −4.9 −2.5 −3 −5.7 −3−1.2 −4.5 U88629_at U88629 Human RNA TF −15.1 polymerase II elongationfactor ELL2, complete cds. 2 2.2 1.5 5.7 1.1 −4 −2.5 −3 −1.5 −4.5HG3342-HT3519_s_at S78825 Id1 TF −1.3 −1 −1.1 −1 −3.3 −1 −2 −3 −2 −2.9−4.5 U28811_at U28811 Human cysteine-rich signaling −10.8 fibroblastgrowth factor receptor (CFR-1) mRNA, complete cds −1.2 −1.2 −1 −3.6 −1.6−3 −4.9 −3 −1.2 −4.6 M58286_s_at M58286 H. sapiens tumor signaling −13.1necrosis factor receptor mRNA, complete cds. 1 −1.3 −1 −1.5 −2 −6 −8.3−3 −1.4 −4.6 D78129_at D78129 H. sapiens mRNA for lipid metabolism −14.4lipogenic, cholesterol squalene epoxidase, partial cds. synth. 1.6 1.61.6 4.8 −1 −2 −3.4 −3 −1.8 −4.6 D14874_at D14874 H. sapiens mRNA forGF/cyt −3.2 adrenomedullin precursor, complete cds. −1.4 −1.3 1 −1.7−1.3 −2 −3.3 −3 −2.1 −4.6 Z26317_at Z26317 H. sapiens mRNA for cytoskel.−9.6 desmoglein 2. −1.2 −1.1 −2 4.1 −1.8 −2 −3.7 −2 −2.8 −4.6 L19267_atL19267 H. sapiens 59 protein signaling −12.4 myotonic dystrophy mRNA, 3′end. −1.2 −1.9 −1 −4.5 −3.9 −6 −9.7 −3 −1.3 −4.7 HG3523-HT4899_s_atJ00120 Proto- TF −18.9 Oncogene C-Myc, Alt. Splice 3, Orf 114 1.4 −1.1−1 −0.7 1.2 −2 −0.4 −3 −1.7 −4.7 U33821_at U33821 Human taxi-bindingsignaling −5.8 protein TXBP151 mRNA, complete cds. 1.2 1 −1 1 −1 −2 −2.8−2 −2.7 −4.7 U52100_at U52100 Human XMP mRNA, Cell surface/adhesion −6.5membrane glycoprotein complete cds. −1.4 −1.9 −2 −5.5 −1.4 −3 −4.4 −2−2.9 −4.7 L31801_at L31801 H. sapiens transporter −14.6 Lactate andpyruvate monocarboxylate transporter 1 (SLC16A1) mRNA, complete cds. 1.71.6 1.1 4.4 −1.7 −4 −6 −2 −3 −4.7 L00058_at L00058 Human (GH) TF −6.3germline c-myc proto-oncogene, exon 3 and 3′ flank. −1 1.2 −1 −1.2 −1.1−2 −3.3 −2 −3.2 −4.7 U52426_at U52426 H. sapiens GOK ??? −9.2 secretedprotein (STIM1) mRNA, complete cds. 1.6 1.2 1.2 4 −1.1 −2 −2.8 −1 −3.5−4.7 M80244_at M80244 Human E16 mRNA, Translation −3.5 aa transportercomplete cds. −1.1 −2.2 −1 −4.3 −1.1 −2 −2.8 −4 −1.3 −4.8 U56418_atU56418 Human signaling −11.9 lysophosphatidic acid acyltransferase-betamRNA, complete cds. 1.5 1.7 2.2 5.4 −1.4 −2 −3.4 −3 −2.2 −4.8L38490_s_at L38490 H. sapiens ADP- signaling −2.8 ribosylation factormRNA, complete cds. 1.1 −1.3 −2 −1.7 1.1 −3 −1.4 −2 −2.6 −4.8 U14603_atU14603 Human protein- signaling −7.9 tyrosine phosphatase (HU-PP-1)mRNA, partial sequence. 1.3 1 −1 1.3 −1.2 −3 −3.8 −2 −2.6 −4.9 L77886_atL77886 Human protein −7.4 tyrosine phosphatase mRNA, complete cds. 1.31.2 −1 1.5 −1.7 −1 −3 −1 −3.6 −4.9 M38258_at M38258 Human retinoic acidTF −6.4 receptor gamma 1 mRNA, complete cds. −1 −1.3 −1 −3.7 1.5 −3 −1−4 −1.2 −5 X89750_at X89750 H. sapiens mRNA for TF −9.7 homeobox TGIFprotein. −1 −1 1 −1 1 −4 −3.2 −3 −1.8 −5 D85429_at D85429 H. sapiensgene for signaling −9.2 heat shock protein 40, complete cds. −1.8 −2.9−4 −8.5 −2.6 −4 −6.7 −3 −2.4 −5 HG174-HT174_at J05211 Desmoplakin Icytoskel. −20.2 −1.1 −1.1 1 −1.2 2.6 1.5 4.1 −3 −2.3 −5.1 M31627_atM31627 Human X box TF −2.2 binding protein-1 (XBP-1) mRNA, complete cds.1.2 1.2 1.4 3.8 −1.4 −1 −2.4 −1 −4.1 −5.1 X80695_at X80695 H. sapiensOXA1Hs Mit. −3.7 cytochrome oxydase mRNA. assembly −1 −1.9 −1 −4 1.2 −2−0.3 −4 −1.5 −5.2 M54915_s_at MS4915 Human h-pim-1 signaling −9.5 STkinase protein (h-pim-1) mRNA, complete cds −1 −1 −1 −3.4 1 1 2 −2 −3.4−5.2 D83777_at D83777 Human mRNA for ??? −6.6 KIAA0193 gene, completecds. 1.5 1.3 1 3.8 −1.1 −2 −2.7 −2 −3.5 −5.2 D31883_at D31883 Human mRNAfor cytoskel. −4.1 actin binding KIAA0059 gene, complete cds. 1.8 1.41.2 4.4 −1.2 −2 −3.5 −2 −3.7 −5.2 U00968_at U00968 Human SREBP-1 TF −4.3mRNA, complete cds. 1.3 1.3 1.2 3.8 −1.2 −3 −4 −2 −3.7 −5.2 K03195_atK03195 Human (HepG2) Energy −5.4 glucose transporter gene mRNA, completecds. −2.6 −2.6 −2 −7 −1.2 −1 −2.3 −3 −2 −5.3 D86965_at D86965 Human mRNAfor signaling −14.6 KIAA0210 gene, complete cds. −1.7 −1.3 −1 −4 −1.1 −2−3.5 −4 −1.4 −5.4 Z30643_at Z30643 H. sapiens mRNA for signaling −14.6chloride channel (putative) 2139bp. −1.2 −1.8 −2 −5.4 −1.4 −3 −4.2 −4−1.7 −5.4 D14520_at D14520 Human mRNA for TF −15 GC-Box binding proteinBTEB2, complete cds. 1.6 1.2 1.8 4.6 1.2 −1 −0.2 −3 −2.8 −5.4 D87462_atD87462 Human mRNA for ??? −1 BRCA1-associated KIAA0272 gene, partialcds. 1.7 1.4 1.1 4.2 −2.2 −7 −9.1 −3 −2.3 −5.5 X80692_at X80692 H.sapiens ERK3 signaling −10.4 mRNA. 1.3 1.1 1.1 3.5 1.6 −1 0.4 −3 −2.5−5.5 X90858_at X90858 H. sapiens mRNA for DNA rep. −1.6 uridinephosphorylase. −1.7 −2 −2 −5.6 −1 −2 −3.1 −4 −2.1 −5.9 M57763_at M57763Human ADP- signaling −14.6 ribosylation factor (hARF6) mRNA, completecds, 1.4 1.3 1.5 4.2 1.4 −1 0.1 −2 −3.8 −5.9 X92720_at X92720 H. sapiensmRNA for Energy −1.6 gluconeogenesys!! phosphoenolpyruvate carboxykinase−1.1 −1.3 −1 −3.8 −1.1 −2 −2.8 −3 −2.8 −6.1 M81601_at M81601 Humantranscription TF −12.7 elongation factor (SII) mRNA, complete cds. −1.3−1.2 −2 −4.1 −2.4 −3 −5.8 −3 −2.8 −6.1 X52611_s_at X52611 Human mRNA forTF −16 transcription factor AP-2. 1.3 1.2 −1 1.5 −1.4 −2 −3 −3 −3 −6.1U09587_at U09587 Human glycyl-tRNA Translation −7.6 synthetase mRNA,complete cds. 1.8 1 1 3.8 1.3 −1 −0.1 −2 −4.4 −6.1 U14550_at U14550Human Cell surface/adhesion −2.4 Glucoproteins, cell sialyltransferaseSThM (sthm) mRNA, surface complete cds. 1.6 1.6 1.7 4.9 2.4 1.3 3.7 −3−3.4 −6.2 D90209_at D90209 Human mRNA for TF 2.4 DNA binding proteinTAXREB67. 1.8 1.2 −1 1.9 −1 −2 −3.4 −3 −3.9 −6.4 X77366_at X77366 H.sapiens HBZ17 TF −7.9 mRNA. 1 1 1 3 −1 −3 −3.9 −2 −4.7 −6.4 X76534_atX76534 H. sapiens NMB integral membrane protein −7.3 antimetastaticmRNA. transmembrane glycoprot. −1.7 −1 −1 −4 −1.3 −2 −3.7 −1 −5.2 −6.5U37519_at U37519 Human aldehyde detox −14.2 dehydrogenase (ALDH8) mRNA,complete cds. 1.4 1.4 1.6 4.4 1.4 −2 −0.5 −4 −2.4 −6.6 M83667_rna1_s_atM83667 Human NF- TF −2.7 IL6-beta protein mRNA, complete cds. 1 1 −2 0.5−1.1 −1 −2.4 −3 −3.9 −6.6 U53347_at U53347 Human neutral amino AAmetabolism −8.5 AA metabolism acid transporter B mRNA, complete cds.−1.3 −1.4 −2 −4.2 −1.4 −2 −3.7 −2 −4.6 −6.6 L09229_s_at L09229 Humanlong-chain lipid metabolism −14.5 fatty acid synth. acyl-coenzyme Asynthetase (FACL1) mRNA, complete cds. 1.2 1.2 1.4 3.8 −1.5 −5 −6.4 −4−2.8 −6.9 S73591_at S73591 brain-expressed detox −9.5 Thiroedoxininteracting HHCPA78 homolog [human, HL-60 acute promyclocytic leukemiacells −3.1 −3 −2 −8.4 −2.3 −5 −7.3 −4 −2.9 −7.2 M13929_s_at M13929 Humanc-myc-P64 TF −22.9 mRNA, initiating from promoter P0, (HLmyc2.5) partialcds. 1.3 1.1 −1 1.2 −1.1 −2 −2.8 −3 4.7 −7.3 M55268_at M55268 Humancasein kinase signaling −8.9 II alpha′ subunit mRNA, complete cds. 1.21.1 1 3.3 1.2 1.7 2.9 −2 −5.4 −7.3 M77836_at M77836 Human pyrroline 5-Urea cycle −1.1 Urea cycle carboxylate reductase mRNA, complete cds. 1.31.2 −1 1.5 −1.4 −2 −3 −3 −3 −6.1 U09587_at U09587 Human glycyl-tRNATranslation −7.6 synthetase mRNA, complete cds. 1 1 1 3 5.1 1 6.1 −3−4.2 −7.6 HG2724-HT2820_at S75762 Oncongene signaling 1.5 Tls/Chop,Fusion Activated −1 −1.3 −2 −3.9 −1.2 −3 −4 −5 −3.2 −7.7 U72066_atU72066 H. sapiens CtBP signaling −15.6 Rb-binding interacting proteinCtIP (CtIP) mRNA, complete cds. −2.2 −2.8 −3 −8 −2.6 −3 −5.5 −5 −3.4 −8U42031_at U42031 Human 54 kD signaling −21.5 progesteronereceptor-associated immunophilin FKBP54 mRNA, partial 1.2 1 −1 1.2 −1.1−2 −2.7 −3 −4.8 −8.1 M27396_s_at M27396 Human asparagine Translation−9.6 synthetase mRNA, complete cds. 1.2 1.2 1.1 3.5 −1 −2 −2.6 −2 −6−8.1 X01630_at X01630 Human mRNA for Urea cycle −7.2 Urea cycleargininosuccinate synthetase. 1 −1.2 −1 −1.4 1.1 −1 0.1 −3 −5.8 −9.2D32050_at D32050 Human mRNA for Translation −10.5 alanyl-tRNAsynthetase, complete cds. −1.3 −1.8 −2 −5.5 −1.7 −5 −7.1 −6 −3.3 −9.4M90656_at M90656 Human gamma- detox −22 glutathione biosynthesisglutamylcysteine synthetase (GCS) mRNA, complete cds. −1.8 −1.8 −2 −5.4−1.7 −2 −3.9 −6 −4.1 −9.6 J04102_at J04102 Human TF −18.9erythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds.1.5 0.58 2 4.08 1.5 −3 −1.3 −6 −5.3 −11.3 X69111_at X69111 H. sapiensHLH TF −8.52 1R21 mRNA for helix-loop-helix protein.

[0144] and

[0145] Table 8 presents a list of genes the expression of which areinduced in response to ultraviolet radiation exposure. TABLE 8Ultraviolet Radiation-Regulated Induced Genes Set Induced Gene SetM20030_f_at M20030 Human small proline rich protein (sprII) mRNA, clone930. X53065_f_at X53065 M13903_at M13903 Human involucrin gene, exon 2.L10343_at L10343 Human elafin gene, complete cds. M21302_at M21302 Humansmall proline rich protein (sprII) mRNA, clone 174N. L05188_f_at L05188H. sapiens small proline-rich protein 2 (SPRR2B) gene, complete cds.Y00787_s_at Y00787 Human mRNA for MDNCF (monocyte-derived neutrophilchemotactic factor). D50840_at D50840 H. sapiens mRNA for ceramideglucosyltransferase, complete cds. HG2815-HT2931_at M22918 Myosin, LightChain, Alkali, Smooth Muscle (Gb:U02629), Non-Muscle, Alt. SpliceHG1612-HT1612_at X70326 Macmarcks X52426_s_at X52426 H. sapiens mRNA forcytokeratin 13. S81914_at S81914 IEX-1 = radiation-inducibleimmediate-early gene [human, placenta, mRNA Partial, 1 M80254_at M80254H. sapiens cyclophilin isoform (hCyP3) mRNA, complete cds. L08069_atL08069 Human heat shock protein, E. coli DnaJ homolog mRNA, completecds. U62800_at U62800 Human cystatin M (CST6) mRNA, complete cds.L24564_at L24564 Human Rad mRNA, complete cds. M59465_at M59465 Humantumor necrosis factor alpha inducible protein A20 mRNA, complete cds.Z49989_at Z49989 H. sapiens mRNA for smoothelin. X57985_rna2_at X57985H. sapiens genes for histones H2B.1 and H2A. L19779_at L19779 H. sapienshistone H2A.2 mRNA, complete cds. D42040_s_at D42040 Human mRNA forKIAA9001 gene, complete cds. M63573_at M63573 Human secretedcyclophilin-like protein (SCYLP) mRNA, complete cds. X54489_rna1_atX54489 Human gene for melanoma growth stimulatory activity (MGSA).M92934_at M92934 Human connective tissue growth factor, complete cds.Z14244_at Z14244 H. sapiens cox VIIb mRNA for cytochrome c oxidasesubunit VIIb. M60278_at M60278 Human heparin-binding EGF-like growthfactor mRNA, complete cds. M72885_rna1_s_at M72885 Human GOS2 gene, 5′flank and cds. X62083_s_at X62083 H. sapiens mRNA for Drosophila femalesterile homeotic (FSH) homolog. X67325_at X67325 H. sapiens p27 mRNA.U04636_rnal at U04636 Human cyclooxygenase-2 (hCox-2) gene, completecds. M26311_s_at M26311 Human cystic fibrosis antigen mRNA, completecds. L20688_at L20688 Human GDP-dissociation inhibitor protein (Ly-GDI)mRNA, complete cds. M27436_s_at M27436 Human tissue factor gene,complete cds, with a Alu repetitive sequence in the 3′ AF001294_atAF001294 H. sapiens IPL (IPL) mRNA, complete cds. HG2815-HT2931_s_atM22918 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629),Non-Muscle, Alt. Splice X74874_rna1_s_at X74874 H. sapiens gene for RNApol II largest subunit, exon 1. HG2815-HT4023_s_at M22919 Myosin, LightChain, Alkali, Smooth Muscle (Gb:U02629), Smooth Muscle, Alt. SpliV00594_at V00594 Human mRNA for metallothionein from cadmium- treatedcells. HG4322-HT4592_at V00599 Tubulin, Beta X99920_at X99920 H. sapiensmRNA for S100 calcium-binding protein A13. M21005_at M21005 Humanmigration inhibitory factor-related protein 8 (MRP8) gene, complete cds.U07919_at U07919 Human aldehyde dehydrogenase 6 mRNA, complete cds.M37583_at M37583 Human histone (H2A.Z) mRNA, complete cds. S54005_s_atS54005 thymosin beta-10 [human, metastatic melanoma cell line, mRNA, 453nt]. D49824_s_at D49824 Human HLA-B null allele mRNA. S78771_s_at S78771NAT = CpG island-associated gene [human, mRNA, 1741 nt]. M90657_atM90657 Human tumor antigen (L6) mRNA, complete cds. U09937_rna1_s_atU09937 Human urokinase-type plasminogen receptor, exon 7. X77794_atX77794 H. sapiens mRNA for cyclin G1. M28130_rna1_s_at M28130 Humaninterleukin 8 (IL8) gene, complete cds. X14850_at X14850 Human H2A.XmRNA encoding histone H2A.X. AB000584_at AB000584 H. sapiens mRNA forTGF-beta superfamily protein, complete cds. U52101_at U52101 Human YMPmRNA, complete cds. M57731_s_at M57731 Human gro-beta mRNA, completecds. D45248_at D45248 Human mRNA for proteasome activator hPA28 subunitbeta, complete cds. X83416_s_at X83416 H. sapiens PrP gene, exon 2.X52882_at X52882 Human t-complex potypeptide 1 gene. X57351_at X57351Human 1-8D gene from interferon-inducible gene family. X53800_s_atX53800 Human mRNA for macrophage inflammatory protein-2beta (MIP2beta).Z69043_s_at Z69043 H. sapiens mRNA translocon-associated protein deltasubunit precursor. D38305_at D38305 Human mRNA for Tob, complete cds.X52979_rna1_s_at X52979 Human gene for small nuclear ribonucleo-proteins SmB and SmB′. S80437_s_at S80437 fatty acid synthase {3′region} [human, breast and HepG2 cells, mRNA Partial, 22HG2917-HT3061_f_at X87679 Major Histocompatibility Complex, Class I, E(Gb:M21533) Z29505_at Z29505 H. sapiens mRNA for nucleic acid bindingprotein sub2.3. D21853_at D21853 Human mRNA for KIAA0111 gene, completecds. X78687_at X78687 H. sapiens G9 gene encoding sialidase. M13755_atM13755 Human interferon-induced 17-kD/15-kD protein mRNA, complete cds.M21186_at M21186 Human neutrophil cytochrome b light chain p22 phagocyteb-cytochrome mRNA, compl D28235_s_at D28235 Human PTGS2 gene forprostaglandin endo- peroxide synthase-2, complete cds. M14328_s_atM14328 Human alpha enolase mRNA, complete cds. HG1980-HT2023_at V00599Tubulin, Beta 2 U90546_r_at U90546 Human butyrophilin (BTF4) mRNA,complete cds. K02574_at K02574 X15729_s_at X15729 Human mRNA for nuclearp68 protein. D89052_at D89052 H. sapiens mRNA for proton-ATPase-likeprotein, complete cds. M60974_s_at M60974 Human growth arrest andDNA-damage- inducible protein (gadd45) mRNA, complete cds HG2259-HT2348s_at X06956 Tubulin, Alpha 1, Isoform 44 X04654_s_at X04654 Human mRNAfor U1 RNA-associated 70K protein. M79463_s_at M79463 Human PML-2 mRNA,complete CDS. L76568_xpt3_f_at L76568 H. sapiens excision and cross linkrepair protein (ERCC4) gene, complete genom Y09022_at Y09022 H. sapiensmRNA for Not56-like protein. X57579_s_at X57579 H. sapiens activinbeta-A subunit (exon 2). U37690_at U37690 Human RNA polymerase IIsubunit (hsRPB10) mRNA, complete cds. X61123_at X61123 Human BTG1 mRNA.J04456_at J04456 Human 14 kD lectin mRNA, complete cds. Z49254_at Z49254H. sapiens L23-related mRNA. U70660_at U70660 Human copper transportprotein HAH1 (HAH1) mRNA, complete cds. D86974_at D86974 Human mRNA forKIAA0220 gene, partial cds. AF006084_at AF006084 H. sapiens Arp2/3protein complex subunit p41-Arc (ARC41) mRNA, complete cds. Y00503_atY00503 Human mRNA for keratin 19. M62831_at M62831 Human transcriptionfactor ETR101 mRNA, complete cds. Z22548_at Z22548 H. sapiensthiol-specific antioxidant protein mRNA. U40369_rna1_at U40369 Humanspermidine/spermine N1- acetyltransferase (SSAT) gene, complete cds.M12125_at M12125 Human fibroblast muscle-type tropomyosin mRNA, completecds. X51345_at X51345 Human jun-B mRNA for JUN-B protein. Z21507_atZ21507 H. sapiens EF-1 delta gene encoding human elongationfactor-1-delta. U20734_s_at U20734 Human transcription factor junB(junB) gene, 5′ region and complete cds. D13413_rna1_s_at D13413 HumanmRNA for tumor-associated 120 kD nuclear protein p120, partialcds(carbox L42379_at L42379 H. sapiens bone-derived growth factor(BPGF-1) mRNA, complete cds. X15822_at X15822 Human COX VIIa-L mRNA forliver-specific cytochrome c oxidase (EC 1.9.3.1.). D86988_at D86988Human mRNA for KIAA0221 gene, complete cds. M26730_s_at M26730 Humanmitochondrial ubiquinone-binding protein (QP) gene, exon 4. M69043_atM69043 H. sapiens MAD-3 mRNA encoding IkB-like activity, complete cds.D38251_s_at D38251 Human mRNA for RPB5 (XAP4), complete cds. L76200_atL76200 Human guanylate kinase (GUK1) mRNA, complete cds. M34516_atM34516 Human omega light chain protein 14.1 (Ig lambda chain related)gene, exon 3. U26727_at U26727 Human p16INK4/MTS1 mRNA, complete cds.U53830_at U53830 H. sapiens interferon regulatory factor 7A mRNA,complete cds. M22960_at M22960 Human protective protein mRNA, completecds. D89667_at D89667 H. sapiens mRNA for c-myc binding protein,complete cds. M19309_s_at M19309 Human slow skeletal muscle troponin TmRNA, clone H22h. D64142_at D64142 Human mRNA for histone H1x, completecds. U41515_at U41515 Human deleted in split hand/split foot 1 (DSS1)mRNA, complete cds. J04611_at J04611 Human lupus p70 (Ku) autoantigenprotein mRNA, complete cds. U35048_at U35048 Human TSC-22 protein mRNA,complete cds. X82693_at X82693 H. sapiens mRNA for E48 antigen.M92843_s_at M92843 H. sapiens zinc finger transcriptional regulatormRNA, complete cds. U72649_at U72649 Human BTG2 (BTG2) mRNA, completecds. X92896_at X92896 H. sapiens mRNA for ITBA2 protein. D10923_atD10923 Human mRNA for HM74. M84739_at M84739 Human autoantigencalreticulin mRNA, complete cds. U09813_at U09813 Human mitochondrialATP synthase subunit 9, P3 gene copy, mRNA, nuclear gene enc X67951_atX67951 H. sapiens mRNA for proliferation-associated gene (pag).L27706_at L27706 Human chaperonin protein (Tcp20) gene complete cds.U69126_s_at U69126 Human FUSE binding protein 2 (FBP2) mRNA, partialcds. M12529_at M12529 Human apolipoprotein E mRNA, complete cds.X71129_at X71129 H. sapiens mRNA for electron transfer flavo- proteinbeta subunit. U13991_at U13991 Human TATA-binding protein associatedfactor 30 kD subunit (tafII30) mRNA, comp J04794_at J04794 Humanaldehyde reductase mRNA, complete cds. U51586_at U51586 Human siahbinding protein 1 (SiahBP1) mRNA, partial cds. M58026_at M58026 HumanNB-1 mRNA, complete cds. X68277_at X68277 H. sapiens CL 100 mRNA forprotein tyrosine phoshatase. X56681_s_at X56681 Human junD mRNA.V01512_rna1_at V01512 Human cellular oncogene c-fos (complete sequence).U09578_at U09578 H. sapiens MAPKAP kinase (3pK) mRNA, complete cds.L13391_at L13391 Human helix-loop-helix basic phosphoprotein (G0S8)gene, complete cds. U62317_rna3_at U62317 Chromosome 22q13 BAC CloneCIT987SK-384D8 complete sequence. M16364_s_at M16364 Human creatinekinase-B mRNA, complete cds. L19437_at L19437 Human transaldolase mRNAcontaining transposable element, complete cds. X53416_at X53416 HumanmRNA for actin-binding protein (filamin) (ABP-280). HG3494-HT3688_atX52560 Nuclear Factor Nf-I16 M58459_at M58459 Human ribosomal protein(RPS4Y) isoform mRNA, complete cds. U65579_at U65579 Human mitochondrialNADH dehydrogenase- ubiquinone Fe—S protein 8, 23 kD subunit M19961_atM19961 Human cytochrome c oxidase subunit Vb (cox Vb) mRNA, completecds. M29064_at M29064 Human hnRNP B1 protein mRNA. D90086_at D90086Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunit gene, exons 1-10.L04731_at L04731 H. sapiens translocation T(4:11) of ALL-1 gene tochromosome 4. D87071_at D87071 Human mRNA for KIAA0233 gene, completecds. X04412_at X04412 Human mRNA for plasma gelsolin. L27943_at L27943H. sapiens cytidine deaminase (CDA) mRNA, complete cds. U68142_at U68142Human RalGDS-like 2 (RGL2) mRNA, partial cds. U63825_at U63825 Humanhepatitis delta antigen interacting protein A (dipA) mRNA, complete cds.X04828_at X04828 Human mRNA for G(i) protein alpha-subunit (adenylatecyclase inhibiting GTP-bind L38951_at L38951 H. sapiens importin betasubunit mRNA, complete cds. M31627_at M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds. J04444_at J04444 Human cytochromec-1 gene, complete cds. HG2724-HT2820_at S75762 Oncogene Tls/Chop,Fusion Activated

[0146] and

[0147] Table 9 presents a list of genes the expression of which arerepressed in response to ultraviolet radiation exposure. TABLE 9Ultraviolet Radiation-Regulated Repressed Gene Set Repressed Gene SetD50840_at D50840 H. sapiens mRNA for ceramide glucosyltransferase,complete cds. L08069_at L08069 Human heat shock protein, E. coli DnaJhomolog mRNA, complete cds. X77794_at X77794 H. sapiens mRNA for cyclinG1. D89052_at D89052 H. sapiens mRNA for proton-ATPase-like protein,complete cds. HG2855-HT2995_at L26336 Heat Shock Protein, 70 KD(Gb:Y00371) M30703_s_at M30703 Human amphiregulin (AR) gene, exon 6,clones lambda-ARH(6,12). L16862_at L16862 H. sapiens G protein-coupledreceptor kinase (GRK6) mRNA, complete cds. M92843_s_at M92843 H. sapienszinc finger transcriptional regulator mRNA, complete cds. U72649_atU72649 Human BTG2 (BTG2) mRNA, complete cds. X74104_at X74104 H. sapiensmRNA for TRAP beta subunit. M84332_at M84332 Human ADP-ribosylationfactor 1 gene, exons 2-5. D15050_at D15050 Human mRNA for transcriptionfactor AREB6, complete cds. U28386_at U28386 Human nuclear localizationsequence receptor hSRP1alpha mRNA, complete cds. U41766_s_at U41766Human metalloprotease/disintegrin/cysteine- rich protein precursor(MDC9) mRNA, c AF006041_at AF006041 H. sapiens Fas-binding protein(DAXX) mRNA, partial cds. U28749_s_at U28749 Human high-mobility groupphosphoprotein isoform I-C (HMGIC) mRNA, complete cds. M60483_rna1_s_atM60483 Human protein phosphatase 2A catalytic subunit-alpha gene,complete cds. U07664_at U07664 Human HB9 homeobox gene, exons 2 and 3and complete cds. X52425_at X52425 Human IL-4-R mRNA for the interleukin4 receptor. X94563_xpt2_r_at X94563 H. sapiens dbi/acbp gene exon 1 & 2.L11066_at L11066 Human mRNA sequence. X74008_at X74008 H. sapiens mRNAfor protein phosphatase 1 gamma. X87241_at X87241 H. sapiens mRNA forhFat protein. S68616_at S68616 Na+/H+ exchanger NHE-1 isoform [human,heart, mRNA, 4516 nt]. D13705_s_at D13705 Human mRNA for fatty acidsomega-hydroxylase (cytochrome P-450HKV), complete cds D86966_at D86966Human mRNA for KIAA0211 gene, complete cds. U17327_at U17327 Humanneuronal nitric oxide synthase (NOS1) mRNA, complete cds. U89336_cds4_atU89336 Human HLA class III region containing NOTCH4 gene, partialsequence, homeobox PB D85527_at D85527 H. sapiens mRNA for LIM domain,partial cds. HG880-HT880_at L07517 Mucin 6, Gastric (Gb:L07517)X64330_at X64330 H. sapiens mRNA for ATP-citrate lyase. X89267_at X89267H. sapiens DNA for uroporphyrinogen decarboxylase gene. X91247_at X91247H. sapiens mRNA for thioredoxin reductase. L11672_at L11672 HumanKruppel related zinc finger protein (HTF10) mRNA, complete cds.X78992_at X78992 H. sapiens ERF-2 mRNA. L19314_at L19314 Human HRY gene,complete cds. X12794_at X12794 Human v-erbA related ear-2 gene.L22005_at L22005 Human ubiquitin conjugating enzyme mRNA, partial cds.U01337_at U01337 Human Ser/Thr protein kinase (A-RAF-1) gene, completecds. M34182_at M34182 Human testis-specific protein kinase gamma-subunitmRNA, complete cds. L08246_at L08246 Human myeloid cell differentiationprotein (MCL1) mRNA. L37042_at L37042 H. sapiens casein kinase I alphaisoform (CSNK1A1) mRNA, complete cds. D87071_at D87071 Human mRNA forKIAA0233 gene, complete cds. S74017_at S74017 Nrf2 = NF-E2-like basicleucine zipper transcriptional activator [human, hemin-ind L41351_atL41351 H. sapiens prostasin mRNA, complete cds. L00352_at_L00352 Humanlow density lipoprotein receptor gene, exon 18. D50683_at D50683 H.sapiens mRNA for TGF-betaIIR alpha, complete cds. X89750_at X89750 H.sapiens mRNA for TGIF protein. D13988_at D13988 Human rab GDI mRNA,complete cds. M12886_at M12886 Human T-cell receptor active beta-chainmRNA, complete cds. M55265_at M55265 Human casein kinase II alphasubunit mRNA, complete cds. J03161_at J03161 Human serum response factor(SRF) mRNA, complete cds. M58286_s_at M58286 H. sapiens tumor necrosisfactor receptor mRNA, complete cds. U88629_at U88629 Human RNApolymerase II elongation factor ELL2, complete cds. U90716_at U90716Human cell surface protein HCAR mRNA, complete cds. HG3638-HT3849_s_atM24547 Amyloid Beta (A4) Precursor Protein, Alt. Splice 2, A4(751)U05875_at U05875 Human clone pSK1 interferon gamma receptor accessoryfactor-1 (AF-1) mRNA, compl M58603_at M58603 Human nuclear factorkappa-B DNA binding subunit (NF-kappa-B) mRNA, complete cds D87442_atD87442 Human mRNA for KIAA0253 gene, partial cds. M76482_at M76482 Human130-kD pemphigus vulgaris antigen mRNA, complete cds. U56418_at U56418Human lysophosphatidic acid acyltransferase-beta mRNA, complete cds.HG3523-HT4899_s_at J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114U88898_r_at U88898 Human endogenous retroviral H protease/integrase-derived ORF1 mRNA, complete cds M91083_at M91083 HumanDNA-binding protein (HRC1) mRNA, complete cds. Z30643_at Z30643 H.sapiens mRNA for chloride channel (putative) 2139bp. X12953_at X12953Human rab2 mRNA, YPT1-related and member of ras family. D78129_at D78129H. sapiens mRNA for squalene epoxidase, partial cds. HG3342-HT3519_s_atS78825 Id1 M54915_s_at M54915 Human h-pim-1 protein (h-pim-1) mRNA,complete cds. X06323_at X06323 Human MRL3 mRNA for ribosomal protein L3homolog (MRL3 = mammalian ribosome L D14043_at D14043 Human mRNA forMGC-24, complete cds. U34252_at U34252 Human gamma-aminobutyraldehydedehydrogenase mRNA, complete cds. M13829_s_at M13829 Human putative rafrelated protein (pks/a-raf) mRNA, partial cds. U33821_at U33821 Humantax1-binding protein TXBP151 mRNA, complete cds. U66616_at U66616 HumanSWI/SNF complex 170 KD subunit (BAF170) mRNA, complete cds. U29607_atU29607 Human methionine aminopeptidase mRNA, complete cds. D14520_atD14520 Human mRNA for GC-Box binding protein BTEB2, complete cds.D14874_at D14874 H. sapiens mRNA for adrenomedullin precursor, completecds. D85429_at D85429 H. sapiens gene for heat shock protein 40,complete cds. M69181_at M69181 Human nonmuscle myosin heavy chain-B(MYH10) mRNA, partial cds. U60205_at U60205 Human methyl sterol oxidase(ERG25) mRNA, complete cds. X75342_at X75342 H. sapiens SHB mRNA.D45906_at D45906 H. sapiens mRNA for LIMK-2, complete cds. X59434_atX59434 Human rohu mRNA for rhodanese. M96803_at M96803 Human generalbeta-spectrin (SPTBN1) mRNA, complete cds. D79994_at D79994 Human mRNAfor KIAA0172 gene, partial cds. D86965_at D86965 Human mRNA for KIAA0210gene, complete cds. HG3930-HT4200_at Y13647 Stearoyl-CoenzymeaDesaturase X52541_at X52541 Human mRNA for early growth response protein1 (hEGR1). Z26317_at Z26317 H. sapiens mRNA for desmoglein 2. M57763_atM57763 Human ADP-ribosylation factor (hARF6) mRNA, complete cds.L38490_s_at L38490 H. sapiens ADP-ribosylation factor mRNA, completecds. D87438_at D87438 Human mRNA for KIAA0251 gene, partial cds.M31627_at M31627 Human X box binding protein-1 (XBP-1) mRNA, completecds. X80692_at X80692 H. sapiens ERK3 mRNA. U37122_at U37122 Humanadducin gamma subunit mRNA, complete cds. M83667_rna1_s_at M83667 HumanNF-IL6-beta protein mRNA, complete cds. HG174-HT174_at J05211Desmoplakin I D42123_at D42123 H. sapiens mRNA for ESP1/CRP2, completecds. X90858_at X90858 H. sapiens mRNA for uridine phosphorylase.X76717_at X76717 H. sapiens MT-11 mRNA. Y08915_at Y08915 H. sapiens mRNAfor alpha 4 protein. U30999_at U30999 Human (memc) mRNA, 3′UTR.L77886_at L77886 Human protein tyrosine phosphatase mRNA, complete cds.U14603_at U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA,partial sequence. HG3492-HT3686_at U28480 Uncoupling Protein UcpX53586_rna1_at X53586 Human mRNA for integrin alpha 6. M64347_at M64347Human novel growth factor receptor mRNA, 3′ cds. U52100_at U52100 HumanXMP mRNA, complete cds. D21852_at D21852 Human mRNA for KIAA0029 gene,partial cds. X05409_at X05409 Human RNA for mitochondrial aldehydedehydrogenase I ALDH I (EC 1.2.1.3). D87462_at D87462 Human mRNA forKIAA0272 gene, partial cds. L40391_at L40391 H. sapiens (clone s153)mRNA fragment. D87469_at D87469 Human mRNA for KIAA0279 gene, partialcds. S73591_at S73591 brain-expressed HHCPA78 homolog [human, HL-60acute promyelocytic leukemia cells L19267_at L19267 H. sapiens 59protein mRNA, 3′ end. M81601_at M81601 Human transcription elongationfactor (SII) mRNA, complete cds. X52611_s_at X52611 Human mRNA fortranscription factor AP-2. U28811_at U28811 Human cysteine-richfibroblast growth factor receptor (CFR-1) mRNA, complete cds L31801_atL31801 H. sapiens monocarboxylate transporter 1 (SLC16A1) mRNA, completecds. M13929_s_at M13929 Human c-myc-P64 mRNA, initiating from promoterP0, (HLmyc2.5) partial cds. L48546_at L48546 H. sapiens tuberin (TSC2)gene, exons 38, 39, 40 and 41. L00058_at L00058 Human (GH) germlinec-myc proto-oncogene, exon 3 and 3′ flank. U09587_at U09587 Humanglycyl-tRNA synthetase mRNA, complete cds. L37127_at L37127 H. sapiensRNA polymerase II mRNA, complete cds. U52426_at U52426 H. sapiens GOK(STIM1) mRNA, complete cds. U72066_at U72066 H. sapiens CtBP interactingprotein CtIP (CtIP) mRNA, complete cds. U83115_at U83115 Human non-lensbeta gamma-crystallin like protein (AIM1) mRNA, partial cds. M90656_atM90656 Human gamma-glutamylcysteine synthetase (GCS) mRNA, complete cds.D90209_at D90209 Human mRNA for DNA binding protein TAXREB67. D83777_atD83777 Human mRNA for KIAA0193 gene, complete cds. U42031_at U42031Human 54 kD progesterone receptor-associated immunophilin FKBP54 mRNA,partial M80244_at M80244 Human E16 mRNA, complete cds. D31883_at D31883Human mRNA for KIAA0059 gene, complete cds. J04444_at J04444 Humancytochrome c-1 gene, complete cds. M38258_at M38258 Human retinoic acidreceptor gamma 1 mRNA, complete cds. M95787_at M95787 Human 22 kD smoothmuscle protein (SM22) mRNA, complete cds. U00968_at U00968 Human SREBP-1mRNA, complete cds. K03195_at K03195 Human (HepG2) glucose transportergene mRNA, complete cds. X92720_at X92720 H. sapiens mRNA forphosphoenolpyruvate carboxykinase. X77366_at X77366 H. sapiens HBZ17mRNA. U53347_at U53347 Human neutral amino acid transporter B mRNA,complete cds. X80695_at X80695 H. sapiens OXA1Hs mRNA. J04102_at J04102Human erythroblastosis virus oncogene homolog 2 (ets-2) mRNA, completecds. HG2724-HT2820_at S75762 Oncogene Tls/Chop, Fusion ActivatedU14550_at U14550 Human sialyltransferase SThM (sthm) mRNA, complete cds.L09229_s_at L09229 Human long-chain acyl-coenzyme A synthetase (FACL1)mRNA, complete cds. X76534_at X76534 H. sapiens NMB mRNA. M55268_atM55268 Human casein kinase II alpha′ subunit mRNA, complete cds.M27396_s_at M27396 Human asparagine synthetase mRNA, complete cds.U37519_at U37519 Human aldehyde dehydrogenase (ALDH8) mRNA, completecds. X69111_at X69111 H. sapiens HLH 1R21 mRNA for helix-loop- helixprotein. M77836_at M77836 Human pyrroline 5-carboxylate reductase mRNA,complete cds. D32050_at D32050 Human mRNA for alanyl-tRNA synthetase,complete cds. X01630_at X01630 Human mRNA for argininosuccinatesynthetase.

I. Compositions of the Invention

[0148] The present invention exploits the discovery of a pattern of RNAand protein expression in a cell exposed to ultraviolet radiation.Compositions of matter of the invention include a plurality of specificnucleic acid and protein molecules identified by the invention asultraviolet radiation-regulated. In one aspect, the compositions of theinvention are directed to nucleic acid molecules that are at least 90%,91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identical at thenucleotide sequence level to the complete list group of ultravioletradiation-regulated nucleic acid molecules (Table 7). In another aspect,the compositions of the invention are directed to nucleic acid moleculesthat are at least 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or100% identical at the nucleotide sequence level to the complementarysequences of the complete list group (Table 7).

[0149] As used herein, the terms “nucleic acid” or “nucleic acidmolecule” refer to a deoxyribonucleotide or ribonucleotide polymer ineither single-or double-stranded form, and unless otherwise limited,would encompass analogs of natural nucleotides that can function in asimilar manner as the naturally occurring nucleotide. An“oligonucleotide” is a single-stranded nucleic acid of 12 bases plus Nbases, wherein N is a whole integer from 0 to 500. Nucleic acids may beisolated and purified, cloned, or synthesized using any techniques knownin the art. They may also include non-naturally occurring nucleotideanalogs, such as those which are modified to improve hybridization.

[0150] As known to those skilled in the art, the “percentage of sequenceidentity” or “sequence identity” may be determined by comparing twooptimally aligned sequences or subsequences over a comparison window orspan, wherein the portion of the polynucleotide sequence in thecomparison window may optionally comprise additions or deletions (i.e.,gaps) as compared to the reference sequence (which does not compriseadditions or deletions) for optimal alignment of the two sequences. Thepercentage is calculated by determining the number of positions at whichthe identical subunit (e.g., nucleic acid base or amino acid residue)occurs in both sequences to yield the number of matched positions,dividing the number of matched positions by the total number ofpositions in the window of comparison and multiplying the result by 100to yield the percentage of sequence identity. Percentage sequenceidentity when calculated using the programs GAP or BESTFIT (see above)is calculated using default gap weights.

[0151] Optimal alignment of sequences for comparison may be conducted bythe local homology algorithm of Smith and Waterman (Adv. Appl Math.(1981) 2:482); by the homology alignment algorithm of Needleman andWunsch (J. Mol. Biol. (1970) 48:443); by the search for similaritymethod of Pearson and Lipman (Proc. Natl. Acad. Sci. (USA) (1988)85:2444); by computerized implementations of these algorithms(including, but not limited to, CLUSTAL in the PC/Gene program byIntelligenetics (Mountain View, Calif.) GAP, BESTFIT, FASTA, and TFASTAin the Wisconsin Genetics Software Package, Genetics Computer Group(GCG) (Madison, Wis.); or by inspection. In particular, methods foraligning sequences using the CLUSTAL program are well described byHiggins and Sharp (Gene (1988) 73:237-244), (CABIOS (1989) 5:151-153),and both the BLAST and the PSI-BLAST programs (Altschul, et al (1997),Nucleic Acids Res. 25:3389-3402).

[0152] In one aspect, the invention provides a composition of mattercomprising a plurality of nucleic acid molecules, the expression ofwhich is altered by exposure to ultraviolet radiation. Nucleic acidmolecules of the composition are selected from at least one of thefollowing groups: the primary first response group, the primary secondresponse group, and the primary third response group. Alternatively, inanother embodiment, the composition comprises a plurality of nucleicacid molecules defined to be at least one, or at least two, or at leastthree, or at least four, or at least five, or at least six, or at leastseven, or at least eight, or at least nine, or at least ten nucleic acidmolecules selected from the complete list group described hereinabove.

[0153] In an alternative embodiment, the composition of matter comprisesa plurality of nucleic acid molecules, each one being at least 90%, atleast 91%, at least 92%, at least 93%, at least 94%, at least 95%, atleast 96%, at least 97%, at least 98%, at least 99%, or 100% identicalon a sequence level to a polynucleotide selected from at least one ofthe following: the secondary first response group, the secondary secondresponse group, and the secondary third response group. Alternatively,in another embodiment, the composition of matter comprises a pluralityof nucleic acid molecules, each one being at least 90%, at least 91%, atleast 92%, at least 93%, at least 94%, at least 95%, at least 96%, atleast 97%, at least 98%, at least 99% or 100% identical on a sequencelevel to a member of the group of polynucleotides consisting of leastone, or at least two, or at least three, or at least four, or at leastfive, or at least six, or at least seven, or at least eight, or at leastnine, or at least ten nucleic acid molecules selected from the completelist group described hereinabove.

[0154] The compositions of matter of the invention are useful for theproduction of DNA- or oligonucleotide arrays, referred to collectivelyherein as a “gene array.” Gene arrays comprise a plurality of different“probe” or “target” nucleic acids (or other compounds) attached to oneor more substrates or surfaces (e.g., solid, membrane, or gel). Genearrays may be constructed in a low or high density format. A highdensity gene array provides a rapid, essentially simultaneous,evaluation of a number of hybridizations in a single test. In apreferred embodiment, the plurality of nucleic acid molecules (or othermoieties) are attached to a single contiguous surface or to amultiplicity of surfaces juxtaposed to each other in an array format. Inthis way, a large number of different hybridization reactions can be runessentially “in parallel.” The method of performing hybridizationreactions in array based formats are well known to those of skill in theart (see, e.g., Pastinen (1997) Genome Res. 7:606-614; Jackson (1996)Nature Biotechnol. 14:1685; Chee (1995) Science 274:610; WO 96/17958;and Pinkel et al. (1998) Nature Genetics 20:207-211, which areincorporated herein by reference).

[0155] Different embodiments of the invention are directed to low andhigh density nucleic acid and oligonucleotide arrays. Depending on theintended application, arrays may be constructed using oligonucleotides,cDNAs, genomic clones, etc.; such a determination is well within theknowledge of one skilled in the art. Typically, oligonucleotide arraysare utilized in a high density format. Genomic clones, cDNAs and otherpolynucleotides greater than about 500 base pairs are easily utilized ina low density setting, but to obtain a high density array with thesepolynucleotides it is most easily accomplished by robotic application toa substrate. U.S. Pat. No. 5,143,854 and PCT Patent Publication Nos. WO90/15070 and WO 92/10092 teach the use of light-directed combinatorialsynthesis of high density oligonucleotide arrays, and the synthesis ofhigh density arrays is also described in U.S. Pat. Nos. 5,744,305,5,800,992 and 5,445,934.

[0156] Many methods for immobilizing nucleic acids on a variety ofsubstrates are known in the art. A wide variety of organic and inorganicpolymers, as well as other materials, both natural and synthetic, can beemployed as the material for the solid surface of a gene array.Illustrative solid surfaces include, e.g., nitrocellulose, nylon, glass,quartz, diazotized membranes (paper or nylon), silicones,polyformaldehyde, cellulose, and cellulose acetate. In addition,plastics such as polyethylene, polypropylene, polystyrene, and the likecan be used. Other materials which may be employed include, but are notlimited to, paper, ceramics, metals, metalloids, semiconductivematerials, and the like. In addition, substances that form gels can beused. Such materials include, e.g., proteins (e.g., gelatins),lipopolysaccharides, silicates, agarose and polyacrylamides. Where thesolid surface is porous, various pore sizes may be employed dependingupon the nature of the system.

[0157] The gene arrays of the invention may also be preparedcommercially. For example, a service provided by Affymetrix, Inc. (SantaClara, Calif.), producer of the GeneChip®, utilizes a proprietarysynthesis system to create on a glass substrate a nucleic acidexpression array. Construction of the Affymetrix array involves amultitude of gene sequences, each gene being represented on the probearray by multiple probe pairs, biased toward the 3′ end of the gene. Inaddition, each probe pair consists of a perfect match and a mismatcholigonucleotide. With the exception of a homo-mismatch at the centerbase position, the mismatch oligonucleotide is identical in sequence tothe perfect match, a pairing strategy which helps identify and subtractnon-specific hybridization and background signal.

[0158] In a particularly preferred embodiment, the composition of mattercomprises nucleic acid molecules that are oligonucleotides selected tohave a length of 12 bases plus N bases, wherein N is a whole integerfrom 0 to 500. In another particularly preferred embodiment, thecomposition of matter comprises oligonucleotides that are 21 bases inlength, and in a most preferred embodiment, the composition of matter ischaracterized as a gene array. The specific sequences of theoligonucleotides are selected from the nucleic acid sequences of thecomplete list group (Table 7) previously described herein, or from thesecondary first response group, the secondary second response group, thesecondary third response group, the induced group and/or the repressedgroup, all previously described herein and found in Tables 8 and 9,respectively.

[0159] In yet another embodiment, the composition of matter comprises aplurality of nucleic acid molecules, each one at least 90%, 91%, 92%,93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identical to the complementarynucleotide sequence of a member of the group of polynucleotidesconsisting of the secondary first response group, the secondary secondresponse group, the secondary third response group, the induced group,and/or the repressed group. The term “complementary nucleotide sequence”as used herein refers to a nucleic acid base sequence that can form adouble-stranded structure by matching base pairs; for example, thecomplementary sequence to G-T-A-C is C-A-T-G The term “base pairmatching” refers to the hydrogen bonding that occurs between certainnucleotides (adenine and thymine, guanine and cytosine) from oppositestrands of a double stranded nucleic acid (such as DNA or RNA).

[0160] Another aspect of the invention provides pharmaceuticalcompositions for modulating the response of a cell to ultravioletradiation exposure. The pharmaceutical compositions of the inventioncomprise a compound in sufficient quantity to modulate the response ofthe cell to exposure to ultraviolet radiation and a pharmaceuticallyacceptable carrier, the response being at least one of the following:the primary first response group, and the primary second response group,and the primary third response group. In various embodiments thereof,the response is the primary first response group, or the primary secondresponse group, or the primary third response group, or the primaryfirst response group and the primary second response group, or theprimary first response group and the primary third response group, orthe primary second response group and the primary third response group,or the primary first response group, the primary second response group,and the primary third response group.

[0161] The ultraviolet radiation to which the cell is exposed cancomprise ultraviolet radiation energy at a wavelength in the range ofabout 220 nm to about 440 nm. Preferably, the cell is exposed toultraviolet radiation energy at a wavelength of about 290 nm to about320 nm at a wavelength of about 320 to about 440 nm, or to a totalultraviolet radiation energy exposure in the range of about 0.2 mJ/cm²to about 40 mJ/cm² . The response of the cell thereto is at least one ofthe primary first response group, the primary second response groupand/or the primary third response group. The cell that provides theresponse(s) is a skin cell (epidermal or dermal) or a cell selected fromthe group consisting of a keratinocyte, a Langerhans cell, a melanocyte,and a fibroblast cell.

[0162] The term “about” is used herein to mean “approximately,” or“roughly,” or “around,” or “in the region of.” When the term “about” isused in conjunction with a numerical range, it modifies that range byextending the boundaries above and below the numerical values set forth.In general, the term “about” is used herein to modify a numerical valueabove and below the stated value by a variance of 20 percent. Thus, thephrase “about 320 nm” is construed to mean that a 20% variance in valueis placed on the numeral; for example, “about 320 nm” refers to allvalues between 320 nm minus (0.2)(320) and 320 nm plus (0.2)(320).

[0163] Exposure of a cell to a specific wavelength of ultravioletradiation to induce the response of the cell to ultraviolet radiationexposure is easily accomplished by those familiar with the art. Sourcesof ultraviolet radiation may be obtained commercially that have adefined output for a limited range or a specific wavelength ofultraviolet radiation. For example, the Stratagene 2000 illuminatorspecially equipped with FG15T light bulb is used which produces maximumoutput in the ultraviolet-B radiation wavelength range. In addition, oneskilled in the art has the requisite knowledge to determine the totalamount of ultraviolet radiation energy delivered to a cell in exposingit to ultraviolet radiation. For example, a luminometer UVB-500C fromthe National Biological Corp. (Twinsburg, Ohio) is useful for measuringthe total amount of ultraviolet radiation energy a cell receives uponexposure to ultraviolet radiation.

[0164] The invention also provides pharmaceutical compositions formodulating the response of a cell to ultraviolet radiation exposure.This pharmaceutical composition comprises a compound in sufficientquantity to modulate the response of the cell to ultraviolet radiationexposure and a pharmaceutically acceptable carrier, wherein the responseis characterized by a pattern of expression comprising the secondaryfirst response group, the secondary second response group, and/or thesecondary third response group.

[0165] In another embodiment thereof, the pharmaceutical composition isa compound in sufficient quantity to modulate the response of the cellto ultraviolet radiation exposure and a pharmaceutically acceptablecarrier. In this embodiment the response is the altered expression of atleast one, or at least two, or at least three, or at least four, or atleast five, or at least six, or at least seven, or at least eight, or atleast nine, or at least ten nucleic acid molecules, each of which is atleast 90%, at least 91%, at least 92%, at least 93%, at least 94%, atleast 95%, at least 96%, at least 97%, at least 98%, at least 99% or100% identical at the nucleotide sequence level to a polynucleotidesequence from the secondary first response group, the secondary secondresponse group, and/or the secondary third response group.

[0166] In other specific embodiments thereof, the invention providespharmaceutical compositions that modulate the response of a cell toultraviolet radiation. In this embodiment, the response is characterizedby either a pattern of expression that is induced or repressed byexposure to ultraviolet radiation. More specifically, in theseembodiments, the response is the induced response group (Table 8) or therepressed response group (Table 9).

[0167] The term “cell” as used herein is meant to include any skin cell(e.g., epidermal or dermal) or precursors thereof, in a culture, tissue,or organism. In specific cases, the cell is a keratinocyte, amelanocyte, a Langerhans cell, or a fibroblast cell.

[0168] By “a plurality of RNA molecules” is meant an RNA sample of highcomplexity; the term “complexity” being used here according to standardmeaning of the term as established by Britten et al. (Meth. Enzymol.(1974) 29:363). See, also, Cantor and Schimmel (Biophysical Chemistry:Part III pp. 1228-1230 (19______)) for further explanation of nucleicacid complexity.

[0169] The level of an RNA molecule or a plurality of RNA molecules maybe measured by any means known in the art. Methods of detecting and/orquantifying the transcript(s) of one or more gene(s) or EST(s) of thisinvention (e.g., mRNA or cDNA made therefrom) using nucleic acidhybridization techniques are known to those of skill in the art. Forexample, one method for evaluating the presence, absence, or quantity ofgene or EST reverse-transcribed cDNA involves a Southern blot transferand subsequent quantitation using nucleic acid hybridization technology.Alternatively, in a Northern blot, mRNA is directly quantitated. Inbrief, the mRNA is isolated from a given cell sample using, for example,an acid guanidinium-phenol-chloroform extraction method. The mRNA isthen electrophoresed to separate the mRNA species and the mRNA istransferred from the gel to a nitrocellulose membrane. As with theSouthern blots, labeled probes are used to identify and/or quantify thetarget mRNA.

[0170] The probes used herein for detection of the gene(s) and/or EST(s)of this invention can be full length or less than the full length of thegene or EST. Shorter probes are empirically tested for specificity.Preferably, nucleic acid probes are 20 bases or longer in length. (See,Sambrook et al., supra, for methods of selecting nucleic acid probesequences for use in nucleic acid hybridization). Visualization of thehybridized portions allows the qualitative determination of the presenceor absence of gene(s) and/or EST(s) of this invention.

[0171] Another aspect of the invention provides a pharmaceuticalcomposition for modulating the response of a cell to ultravioletradiation exposure comprising a compound in sufficient quantity tomodulate the response of the cell to ultraviolet radiation, wherein theresponse is a pattern of expression comprising a tertiary first responsegroup, and/or a tertiary second response group, and/or a tertiary thirdresponse, and an acceptable pharmaceutical carrier. The pattern ofexpression may be the tertiary first response group, the tertiary secondresponse group, and/or the tertiary third response group. In analternative embodiment thereof, the response is the quaternary firstresponse group, the quaternary second response group, and/or thequaternary third response group. The response may be modulation of atleast one, at least two, at least three, at least four, at least five,at least six, at least seven, at least eight, at least nine, or at leastten protein molecules encoded by the polynucleotides selected from theinduced group or selected from the repressed group.

[0172] It will be understood that, when administered to a human patient,the total daily usage of the pharmaceutical compositions of the presentinvention will be decided by the attending physician within the scope ofsound medical judgment. The specific therapeutically effective doselevel for any particular patient will depend upon a variety of factorsincluding: the type and degree of the response to be achieved; thespecific composition of another agent, if any, employed; the age, bodyweight, general health, sex and diet of the patient; the time ofadministration, route of administration, and rate of excretion of thecomposition; the duration of the treatment; drugs (such as achemotherapeutic agent) used in combination or coincidental with thespecific composition of the invention; and like factors well known inthe medical arts. Suitable formulations, known in the art, can be foundin Remington's Pharmaceutical Sciences ((latest edition), MackPublishing Company (Easton, Pa.)).

[0173] Moreover, the pharmaceutical compositions may be administered ina convenient manner such as by the topical, intradermal, subcutaneous,intravenous, intraperitoneal, intramuscular, or oral routes. Thepharmaceutical compositions are administered in an amount which iseffective for treatment and/or prophylaxis of the specific indication.By way of example, specific indications for the application of thepharmaceutical compositions include, but are not limited to, wrinklingof the skin, discoloration of the skin, benign keratinocytic tumors(keratoacanthoma and seborrheic keratosis), premalignant actinickeratosis (solar keratosis), malignant epidermal tumors such as basalcell carcinoma and squamous cell carcinomas, and malignant melanoma(which is classified into four types: (1) superficial spreadingmelanoma, (2) lentigo maligna melanoma, (3) acral-lentiginous melanoma,and (4) nodular melanoma).

[0174] Another aspect of the invention provides a pharmaceuticalcomposition for modulating a response of a cell to ultraviolet radiationexposure, comprising a compound in sufficient quantity to modulate theresponse of the cell to ultraviolet radiation exposure, the responsebeing an altered pattern of expression comprising at least one of thefollowing: the primary first response group, the primary second responsegroup and the primary third response group; and a pharmaceuticallyacceptable carrier. In embodiments thereof, modulation of the cellularresponse is an inhibition of the ultraviolet radiation exposure-inducedRNA expression or an inhibition of the ultraviolet radiationexposure-repressed RNA expression.

[0175] In yet another aspect, the invention provides a pharmaceuticalcomposition for modulating a response of a cell to ultraviolet radiationexposure, comprising a compound in sufficient quantity to modulate theresponse of the cell to ultraviolet radiation exposure, the responsebeing an altered pattern of expression comprising at least one of thefollowing: a secondary first response group, a secondary second responsegroup and a secondary third response group.

[0176] Another aspect of the invention provides a pharmaceuticalcomposition for modulating a response of a cell to ultraviolet radiationexposure, comprising a compound in sufficient quantity to modulate theresponse of the cell to ultraviolet radiation exposure, the responsebeing an altered pattern of expression comprising at least one of thefollowing: the tertiary first response group, the tertiary secondresponse group and the tertiary third response group; and apharmaceutically acceptable carrier. In embodiments thereof, modulationof the cellular response is an inhibition of the ultraviolet radiationexposure-induced protein expression or an inhibition of the ultravioletradiation exposure-repressed protein expression.

[0177] Another aspect of the invention provides a pharmaceuticalcomposition for modulating a response of a cell to ultraviolet radiationexposure, comprising a compound in sufficient quantity to modulate theresponse of the cell to ultraviolet radiation exposure, the responsebeing an altered pattern of expression comprising at least one of thefollowing: the quaternary first response group, the quaternary secondresponse group and the quaternary third response group; and apharmaceutically acceptable carrier. In embodiments thereof, modulationof the cellular response is an inhibition of the ultraviolet radiationexposure-induced protein expression or an inhibition of the ultravioletradiation exposure-repressed protein expression. In embodiments thereof,modulation of the cellular response is an inhibition of the ultravioletradiation exposure-induced protein expression or an inhibition of theultraviolet radiation exposure- repressed protein expression.

[0178] In a further aspect, the invention provides a pharmaceuticalcomposition for modulating the response of a cell to ultravioletradiation exposure, the response being an altered pattern of expressiondetermined by gene expression array analysis. The pharmaceuticalcomposition comprises a compound in sufficient quantity to modulate theresponse of the cell to ultraviolet radiation exposure; and apharmaceutically acceptable carrier.

II. Methods of the Invention A. Methods to Identify Cellular UltravioletRadiation Exposure

[0179] Another aspect of the invention provides methods for detectingexposure of a cell to ultraviolet radiation comprising measuring thelevels of a plurality of RNA or protein molecules in the cell, whereinthe response, i.e., a pattern of altered expression, of the cell toultraviolet radiation exposure is established and indicates that thecell was exposed to ultraviolet radiation. In various embodimentsthereof, the response of the cell comprises at least one of a firstresponse group, a second response, and/or a third response.

[0180] As used herein and as understood by those skilled in the art, theterm “altered expression” may refer to an increase or decrease in theexpression level of one or more nucleic acids, preferably one or moreRNA molecules. The term “altered expression” may also refer to arelative increase or decrease in the expression level of one or moreprotein molecules. Also, it will be understood by one skilled in the artthat an increase or decrease in an expression level may be effected bysynthesis rate, ie., transcription rate for RNA and translation rate forprotein, or a change in the stability of either the RNA or proteinmolecules affected. Thus, all of the “responses” described herein by acell exposed to ultraviolet radiation represent “altered expression”relative to nucleic acid molecules (e.g., RNAs) or proteins normallyexpressed in a cell that was not exposed to ultraviolet radiation.

[0181] The invention describes various responses of the cell toultraviolet radiation exposure. Through the use of gene array expressionanalysis, the invention provides a categorization and listing of genesand proteins the expression of which is altered in a cell exposed toultraviolet radiation. As disclosed in more detail in Example 1, below,of the 7,080 gene entries examined by gene array expression analysis,some 3,000 were scored as present in keratinocytes at at least one timepoint post-ultraviolet radiation exposure, and approximately 1,400 ofthese are present at all time points during the response of thekeratinocyte to ultraviolet radiation exposure. Among the entries, 308were differentially regulated at least two-and a half- fold at at leastone time point. Of these 308 gene sequences, specific attention was paidto genes represented by multiple probes on the gene (for example, genesequences for jun-B, c-Myc, Cox-2). Although the actual values of “foldregulation” varied, very similar patterns of regulation were found forthese multiple probe sets, which provided confidence in the fidelity ofthe hybridizations (Table 1). Of the 308 genes found to be regulated atsome point by 2.5 fold or more, 9 gene sequences were both induced andsuppressed 2.5 fold or more at different time points, while theremaining 299 gene sequences are approximately divided equally (152versus 147) between the induced and repressed group, respectively.

[0182] Using a clustering algorithm, seven time points after ultravioletradiation exposure (FIG. 2) were grouped according to the temporaloccurrence of the altered expression for each sequence. The most closelyrelated temporally were the 0.5, 1 and 2 hour time points, which formedthe first wave of regulated genes and proteins. Also very similar werethe 16 and 24 hour time points, forming the third wave of regulatedgenes and proteins. The four and eight hour time points were moresimilar to each other than to the other time points analyzed and,therefore, these were grouped together to form the second wave ofregulated genes and proteins. Thus, in addition to identifying the genesand proteins, the expression of which are altered by ultravioletradiation exposure, the invention also provides a temporal grouping ofthe responses in the first 24 hours after ultraviolet radiationexposure: the first response (from about 0.5 to about two hours), thesecond response (from about four to about eight hours), and the thirdresponse (from about 16 to about 24 hours). These first, second, andthird responses have been variously defined as detailed hereinabove.

[0183] In one embodiment, the invention provides a method to detectexposure of a cell to ultraviolet radiation wherein the responsecomprises at least one of the following: a primary first response group,a primary second response group, and a primary third response group. Thecell exposed to ultraviolet radiation may be a skin cell (epidermal ordermal) or a cell selected from the group consisting of a keratinocyte,a Langerhans cell, a melanocyte, or a fibroblast cell. The cell isexposed to ultraviolet radiation comprising: ultraviolet radiationenergy at a wavelength in the range of about 220 nm to about 440 nm,ultraviolet radiation energy at a wavelength in the range of about 290nm to about 320 nm, or ultraviolet radiation energy at a wavelength inthe range of about 320 to about 440 nm, or a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².

[0184] The method may further comprise a response characterized by: theprimary first response occurring from about 0.5 hours to about two hourspost-exposure to ultraviolet radiation, the primary second responseoccurring from about four hours to about eight hours post-exposure toultraviolet radiation, and/or the primary third response occurring fromabout 16 hours to about 24 hours post-exposure to ultraviolet radiation.The response comprises an increase or decrease in expression levelrelative to the expression in a control cell not exposed to ultravioletradiation. For these embodiments, the response is either the inducedgroup response or the repressed group response.

[0185] In yet another embodiment, the invention provides a method fordetecting exposure of a cell to ultraviolet radiation comprisingmeasuring the levels of a plurality of RNA molecules in the cell,wherein the response, i.e., a pattern of expression, is established andthe pattern indicates that the cell was exposed to ultravioletradiation. In this embodiment, the response is the altered expression ofat least one of the following: the secondary first response group, thesecondary second response group, and the secondary third response group.

[0186] In some embodiments thereof, the response comprises the modulatedexpression of at least one, or at least two, or at least three, or atleast four, or at least five, or at least six, or at least seven, or atleast eight, or at least nine, or at least ten nucleic acid molecules,each of which is at least 90%, at least 91%, at least 92%, at least 93%,at least 94%, at least 95%, at least 96%, at least 97%, at least 98%, atleast 99% or 100% identical at the nucleotide sequence level to apolynucleotide sequence from the secondary first response group, thesecondary second response group, and/or the secondary third responsegroup.

[0187] The invention also provides a method to detect exposure of a cellto ultraviolet radiation comprising measuring the levels of a pluralityof RNA molecules in the cell by expression array analysis. Expressionarray analysis comprises isolating RNA from the cell post-ultravioletradiation exposure, creating a test expression array through nucleicacid hybridization between a labeled probe that is complementary to theRNA, and an expression array substrate, analyzing the test expressionarray to create a test expression array data set, and comparing the testexpression array data set to a control expression array data set toidentity alterations in the expression level. The levels of theplurality of RNA molecules are then analyzed to establish a responsepattern of the cell, wherein exposure of the cell to ultravioletradiation is indicated by the response pattern comprising at least oneof the primary first response group, the primary second response group,and/or the primary third response group.

[0188] In this method, the cellular response is sometimes characterizedby the first response occurring from about 05 to about two hourspost-exposure to ultraviolet radiation, the second response occurringfrom about four to about eight hours post-exposure to ultravioletradiation, and the third response occurring from about 16 to about 24hours post-exposure to ultraviolet radiation. The response comprises anincrease in expression level or a decrease in expression level.

[0189] Another aspect of the invention provides methods for detectingexposure of a cell to ultraviolet radiation. The method comprisesmeasuring a plurality of protein molecules in the cell for at least onetime point, wherein a pattern of protein expression is established andthe pattern is indicative of ultraviolet radiation exposure. In variousembodiments thereof, this pattern of expression comprises a firstresponse, a second response, and/or a third response. In one embodimentthereof, the first response is the tertiary first response previouslydescribed above; the second response is the tertiary second responsepreviously described above; and the third response is the tertiary thirdresponse previously described above. The expression pattern is thetertiary first response, the tertiary second response group, or thetertiary third response group; the tertiary first response group and thetertiary second response group; the tertiary first response group andthe tertiary third response group; the tertiary second response groupand the tertiary third response group; or the tertiary first responsegroup, the tertiary second response group, and the tertiary thirdresponse group.

[0190] In another embodiment, the method for detecting exposure of acell to ultraviolet radiation comprises measuring the levels of aplurality of protein molecules in the cell for at least one time point,wherein a pattern of expression is established and the pattern isindicative of ultraviolet radiation exposure. In various embodimentsthereof, the first response is the quaternary first response previouslydescribed above; the second response is the quaternary second responsepreviously described above; and the third response is the tertiary thirdresponse previously described above. The pattern of expression is thequaternary first response group, the quaternary second response group,or the quaternary third response group; the quaternary first responsegroup and the quaternary second response group; the quaternary firstresponse group and the quaternary third response group; the quaternarysecond response group and the quaternary third response group; or thequaternary first response group, the quaternary second response group,and the quaternary third response group.

[0191] Preferably, the levels of a plurality of protein molecules aremeasured by enzyme-linked immunosorbent assays (ELISAs). In otherembodiments of the invention, the polypeptides encoded by the genesequences identified by the invention as ultraviolet radiation-regulatedmay be detected and quantified by any of a number of methods well knownto those skilled in the art. These may include analytic biochemicalmethods such as electrophoresis, capillary electrophoresis, highperformance liquid chromatography (HPLC), thin layer chromatography(TLC), hyperdiffusion chromatography, and the like, or variousimmunological methods such as fluid or gel precipitin reactions,immunodiffusion (single or double), immunoelectrophoresis,radioimmunoassay (RIA), immunofluorescent assays, Western blotting, andthe like.

[0192] As known by those skilled in the art, an ELISA assay (e.g.,Coligan, et al. (1991) Curr. Protocols Immunol. 1(2):Chapter 6) includespreparing an antibody (preferably a monoclonal antibody) specific to atarget protein. In addition, a reporter antibody is prepared against themonoclonal antibody. To the reporter antibody is attached a detectablereagent such as radioactive isotope, fluorescent tag or enzyme (e.g.,horseradish peroxidase). A sample is removed from a host and incubatedon a solid support (e.g. a polystyrene dish) that binds the proteins inthe sample. Any free protein binding sites on the dish are then coveredby incubating with a non-specific protein like bovine serum albumen.Next, the monoclonal antibodies attach to any target proteins attachedto the polystyrene dish. All unbound monoclonal antibody is washed awaywith buffer. The reporter antibody is then placed in the dish resultingin binding of the reporter antibody to any monoclonal antibody bound tothe target protein. Unattached reporter antibody is then washed out ofthe dish. The detectable reagent is then detected to identify theprotein of interest bound by the antibody specific for the targetprotein. For example, when horseradish peroxidase is used as adetectable label, peroxidase substrate is added to the dish, and theamount of color developed in a given time period is a measurement of theamount of target protein present in a given volume of sample whencompared against a standard curve.

[0193] Other assays useful for the measurement of protein levelsinclude: radioimmunoassays, competitive-binding assays, Western blotanalysis, and “sandwich” assays. In one representative sandwich assay,the target protein is passed over a solid support and binds totarget-specific antibody attached to the solid support. A secondantibody is then bound to the target protein. A third antibody which islabeled and specific to the second antibody is then passed over thesolid support and binds to the second antibody and an amount targetprotein can then be indirectly quantified. In a competition assay,antibodies specific to the target protein are attached to a solidsupport and labeled target protein and a sample derived from the hostare passed over the solid support. The amount of label detected, forexample, by liquid scintillation chromatography can be correlated to aquantity of target protein in the sample.

[0194] The term “quantifying” when used in the context of quantifyingtranscription levels of a gene can refer to absolute or relativequantification. Absolute quantification may be accomplished by inclusionof known concentration(s) of one or more target nucleic acids andreferencing the hybridization intensity of unknown nucleic acids withthe known target nucleic acids (e.g., through generation of a standardcurve). Alternatively, relative quantification can be accomplished bycomparison of hybridization signals between two or more genes, orbetween two or more treatments, to quantify the changes in hybridizationintensity and, by implication, the changes in the transcription level. Asimilar approach may be taken with protein quantification.

[0195] In a further aspect, the invention provides a method fordetecting exposure of a cell to ultraviolet radiation by screening for aresponse of the cell to ultraviolet radiation exposure, the responsebeing an altered pattern of expression determined by gene expressionarray analysis. The method comprises: (1) measuring the levels of aplurality of RNA molecules in the cell for at least one time point afterultraviolet radiation exposure to establish a test pattern ofexpression; and (2) comparing the test pattern of expression to theresponse of a cell to ultraviolet radiation exposure. If the pattern ofexpression for the cell is substantially similar to the normal responseof the cell to ultraviolet radiation, the cell was exposed toultraviolet radiation.

[0196] In a further aspect, the invention provides a method fordetecting exposure of a cell to ultraviolet radiation by screening for aresponse of the cell to ultraviolet radiation exposure, the responsebeing an altered pattern of expression determined by gene expressionarray analysis. The method comprises: (1) measuring the levels of aplurality of proteins in the cell for at least one time point afterultraviolet radiation exposure to establish a test pattern ofexpression; and (2) comparing the test pattern of expression to theresponse of a cell to ultraviolet radiation exposure. If the pattern ofexpression for the cell is substantially similar to the normal responseof the cell to ultraviolet radiation, the cell was exposed toultraviolet radiation.

B. Screening Methods for the Identification of Compounds that Modulate aResponse of a Cell to Ultraviolet Radiation Exposure

[0197] The invention includes a screening method for the detection of acompound that modulates a response of a cell to ultraviolet radiationexposure. This screening method comprises contacting a cell with acompound, exposing the cell to ultraviolet radiation that wouldotherwise induce a response of the cell to ultraviolet radiationexposure, and measuring the levels of a plurality of RNA molecules inthe cell after ultraviolet radiation exposure. Any change in the first,second, and/or third response to ultraviolet radiation indicates thatthe compound modulates the response of the cell to ultraviolet radiationexposure. Measurement of the levels of a plurality of RNA molecules maybe done at one or several time points post-ultraviolet radiationexposure.

[0198] The term “compound” includes both organic molecules and inorganicmolecules. The term compound also encompasses proteins, nucleic acidmolecules, carbohydrates, lipids, and combinations thereof.

[0199] As one skilled in the art recognizes, there are many ways inwhich a cell may be “contacted” with a compound. Contact may be in vivoor in vitro. For example, the compound may be placed in a carrier liquidmedium, such as phosphate buffered saline (PBS) or tissue culture media,and when cells are incubated in this media, the compound contacts ortouches the cell. Alternatively, contact may be through a cream or a gelwhich is applied topically.

[0200] The cell contacted with the compound is a cell in a culture, acell in an isolated tissue, or a cell in an organism, such as a skincell (epidermal or dermal). Alternatively, a cell may be selected fromthe group consisting of a keratinocyte, a Langerhans cell, a melanocyte,and a fibroblast cell. The cell is exposed to ultraviolet radiationconsisting of ultraviolet radiation energy at a wavelength in the rangeof about 220 nm to about 440 nm, ultraviolet radiation energy at awavelength of about 290 nm to about 320 nm, ultraviolet radiation energyat a wavelength of about 320 to about 440 nm, or a total ultravioletradiation energy exposure in the range of about 0.2 mJ/cm² to about 40mJ/cm².

[0201] The response of the cell is characterized by at least one of thefollowing: a primary first response occurring from about 0.5 hours toabout two hours post-exposure to ultraviolet radiation; a primary secondresponse occurring from about four to about eight hours post-exposure toultraviolet radiation; and a primary third response occurring from about16 to about 24 hours post-exposure to ultraviolet radiation. The patternof expression comprises an increase or decrease in expression level. Forthese embodiments, the response comprises either the induced response orthe repressed response, or both the induced and the repressed response.

[0202] Preferably, the screening method provides a compound thatmodulates the response of a cell to ultraviolet radiation in which theresponse is the altered expression of at least one, or at least two, orat least three, or at least four, or at least five, or at least six, orat least seven, or at least eight, or at least nine, or at least tennucleic acid molecules, each of which is at least 90%, or at least 91%,or at least 92%, or at least 93%, or at least 94%, or at least 95%, orat least 96%, or at least 97%, or at least 98%, or at least 99% or 100%identical at the nucleotide sequence level to a polynucleotide sequencefrom at least the secondary first response group, the secondary secondresponse group, and/or the secondary third response group.

[0203] Preferably, the screening method measures the levels of theplurality of RNAs by an expression array analysis. This analysisincludes isolating RNA from the cell for at least one time pointpost-ultraviolet radiation exposure, creating a test expression arraythrough nucleic acid hybridization between the labeled probe that iscomplementary to the isolated RNA and an expression array substrate, andanalyzing the test expression array to create a test expression arraydata set. The test and control data sets are then compared to identify amodulation of the response of the cell exposed to ultraviolet radiation.The modulation indicates that the compound modulates the response of acell exposed to ultraviolet radiation. The types of cells exposed to theradiation, as well as the ultraviolet radiation energy level of theradiation, are the same as those described above.

[0204] In some embodiments, the cellular response is characterized bythe secondary first response occurring from about 0.5 hours to about twohours post-exposure to ultraviolet radiation, the secondary secondresponse occurring from about four hours to about eight hourspost-exposure to ultraviolet radiation, and the secondary third responseoccurring from about 16 hours to about 24 hours post-exposure toultraviolet radiation. Other various embodiments of the method describedabove include methods wherein “altered expression” comprises an increasein expression level; or wherein “altered expression” comprises adecrease in expression level.

[0205] In an alternative aspect, the invention provides another methodfor detecting exposure of a cell to ultraviolet radiation. This methodcomprises measuring the levels of a plurality of RNA molecules in thecell for at least one time point, wherein an altered pattern ofexpression is established and is indicative of ultraviolet radiationexposure. This pattern comprises a first response comprising an alteredpattern of expression of at least one polynucleotide selected from thegroup consisting of a nucleic acid molecule encoding a transcriptionfactor protein, a nucleic acid molecule encoding a signal transducingprotein, and a nucleic acid molecule encoding a mitochondrial protein; asecond response comprising an altered pattern of expression of at leastone polynucleotide selected from the group consisting of a nucleic acidmolecule encoding a secreted growth factor, a nucleic acid moleculeencoding a cytokine, and a nucleic acid molecule encoding a chemokine;and a third response comprising an altered pattern of expression of atleast one polynucleotide selected from the group consisting of a nucleicacid molecule encoding an actin-binding protein, a nucleic acid moleculeencoding a desmosomal protein, and a nucleic acid molecule encoding atubulin protein.

[0206] In embodiments of the method thereof, the cell is a cell in aculture, tissue, or organism such as skin cell (epidermal or dermal).For example, the cell is a keratinocyte, a Langerhans cell, amelanocyte, or a fibroblast cell. Embodiments of the method also vary bythe wavelength of ultraviolet radiation and/or the total amount ofultraviolet radiation to which the cell is exposed. For example, invarious embodiments, the ultraviolet radiation exposure comprisesultraviolet radiation energy at a wavelength in the range of about 220nm to about 440 nm; or the ultraviolet radiation exposure comprisesultraviolet radiation energy at a wavelength of about 290 nm to about320 nm; or the ultraviolet radiation exposure comprises ultravioletradiation energy at a wavelength in the range of about 320 nm to about440 nm; or the ultraviolet radiation exposure comprises a totalultraviolet radiation energy exposure in the range of about 0.2 mJ/cm²to about 40 mu/cm².

[0207] Other embodiments of the method thereof vary according to thetime period post-ultraviolet radiation exposure defining the firstresponse, second response, and third response. In one embodiment, thefirst response is from about 0.5 hours to about two hours post-exposureto ultraviolet radiation. In another embodiment, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation. In another embodiment, the third response is from about 16hours to about 24 hours post-exposure to ultraviolet radiation. Inanother embodiment, the first response is from about 0.5 hours to abouttwo hours post-exposure to ultraviolet radiation, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation, and the third response is from about 16 hours to about 24hours post-exposure to ultraviolet radiation.

[0208] The invention also provides an embodiment of the method thereofwherein altered expression comprises an increase or decrease in RNAlevel. Thus, in one particular embodiment, the expression level of amember of the first response group, and/or second response group, and/orthird response group increases. In another embodiment thereof, theexpression level of a member of the first response group, and/or secondresponse group, and/or third response group decreases.

[0209] The invention also provides another method for detecting exposureof a cell to ultraviolet radiation. This method comprises measuring thelevels of a plurality of RNA molecules in the cell for at least one timepoint, wherein an altered pattern of expression is established and isindicative of ultraviolet radiation exposure. This pattern comprises afirst response comprising an altered pattern of expression of at leastone polynucleotide selected from the group consisting of the secondaryfirst response group; a second response comprising an altered pattern ofexpression of at least one polynucleotide selected from the groupconsisting of the secondary second response group; and a third responsecomprising an altered pattern of expression of at least onepolynucleotide selected from the group consisting of the secondary thirdresponse group.

[0210] In embodiments of the method thereof, the cell is a skin cell(epidermal or dermal) or the cell is selected from the group consistingof a keratinocyte, a Langerhans cell, a melanocyte, and a fibroblastcell. Embodiments of the method also vary by the wavelength ofultraviolet radiation and/or the total amount of ultraviolet radiationto which the cell is exposed. For example, in various embodiments, theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength in the range of about 220 nm to about 440 nm; or theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength of about 290 nm to about 320 nm; or the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 320 nm to about 440 nm; or theultraviolet radiation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².

[0211] Other embodiments of the method thereof vary according to thetime period post-ultraviolet radiation exposure defining the firstresponse, second response, and third response. In one embodiment, thefirst response is from about 0.5 hours to about two hours post-exposureto ultraviolet radiation. In another embodiment, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation. In another embodiment, the third response is from about 16hours to about 24 hours post-exposure to ultraviolet radiation. Inanother embodiment, the first response is from about 0.5 hours to abouttwo hours post-exposure to ultraviolet radiation, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation, and the third response is from about 16 hours to about 24hours post-exposure to ultraviolet radiation.

[0212] The invention also comprises an embodiment of the method thereofwherein altered expression comprises an increase or decrease in RNAlevel. Thus, in one particular embodiment, the expression level of amember of the first response group, and/or second response group, and/orthird response group increases. In another embodiment thereof, theexpression level of a member of the first response group, and/or secondresponse group, and/or third response group decreases.

[0213] In yet another aspect of the invention, a method is provided fordetecting exposure of a cell to ultraviolet radiation comprisingmeasuring the levels of a plurality of RNA molecules in the cell byexpression array analysis. This method comprises isolating RNA from thecell post ultraviolet radiation exposure, creating a test expressionarray through nucleic acid hybridization between a labeled probecomplementary to the RNA and an expression array substrate. An analysisof the levels of the plurality of RNA molecules in the cell establishesan expression response pattern of the cell. Exposure of the cell toultraviolet radiation is indicated by an altered pattern of expressioncomprising the following: (1) a first response comprising an alteredpattern of expression of at least one polynucleotide selected from thegroup consisting of a nucleic acid molecule encoding a transcriptionfactor protein, a nucleic acid molecule encoding a signal transducingprotein, and a nucleic acid molecule encoding a mitochondrial protein;(2) a second response comprising an altered pattern of expression of atleast one polynucleotide selected from the group consisting of a nucleicacid molecule encoding a secreted growth factor, a nucleic acid moleculeencoding a cytokine, and a nucleic acid molecule encoding a chemokine;and (3) a third response comprising an altered pattern of expression ofat least one polynucleotide selected from the group consisting of anucleic acid molecule encoding an actin-binding protein, a nucleic acidmolecule encoding a desmosomal protein, and a nucleic acid moleculeencoding a tubulin protein.

[0214] In embodiments of the method thereof, the cell is a cell in aculture, tissue, or organism such as skin cell (epidermal or dermal).For example, the cell is a keratinocyte, a Langerhans cell, amelanocyte, or a fibroblast cell. Embodiments of the method also vary bythe wavelength of ultraviolet radiation and/or the total amount ofultraviolet radiation to which the cell is exposed. For example, invarious embodiments, the ultraviolet radiation exposure comprisesultraviolet radiation energy at a wavelength in the range of about 220nm to about 440 nm; or the ultraviolet radiation exposure comprisesultraviolet radiation energy at a wavelength of about 290 nm to about320 nm; or the ultraviolet radiation exposure comprises ultravioletradiation energy at a wavelength in the range of about 320 nm to about440 nm; or the ultraviolet radiation exposure comprises a totalultraviolet radiation energy exposure in the range of about 0.2 mJ/cm²to about 40 mJ/cm².

[0215] Other embodiments of the method thereof vary according to thetime period post-ultraviolet radiation exposure defining the firstresponse, second response, and third response. In one embodiment, thefirst response is from about 0.5 hours to about two hours post-exposureto ultraviolet radiation. In another embodiment, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation. In another embodiment, the third response is from about 16hours to about 24 hours post-exposure to ultraviolet radiation. Inanother embodiment, the first response is from about 0.5 hours to abouttwo hours post-exposure to ultraviolet radiation, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation, and the third response is from about 16 hours to about 24hours post-exposure to ultraviolet radiation.

[0216] The invention also comprises an embodiment of the method thereofwherein altered expression comprises an increase or decrease in RNAlevel. Thus, in one particular embodiment, the expression level of amember of the first response group, and/or second response group, and/orthird response group increases. In another embodiment thereof, theexpression level of a member of the first response group, and/or secondresponse group, and/or third response group decreases.

[0217] In another embodiment, the method thereof comprises measuring thelevels of a plurality of RNA molecules in the cell for at least one timepoint, wherein an altered pattern of expression is established and isindicative of ultraviolet radiation exposure. This pattern comprises afirst response comprising an altered pattern of expression of at leastone polynucleotide selected from the group consisting of the secondaryfirst response group; a second response comprising an altered pattern ofexpression of at least one polynucleotide selected from the groupconsisting of the secondary second response group; and a third responsecomprising an altered pattern of expression of at least onepolynucleotide selected from the group consisting of the secondary thirdresponse group.

[0218] In an alternative aspect, the invention provides another methodfor detecting exposure of a cell to ultraviolet radiation. This methodcomprises measuring the levels of a plurality of proteins in the cellfor at least one time point, wherein an altered pattern of expression isestablished and is indicative of ultraviolet radiation exposure. Thispattern comprises a first response comprising an altered pattern ofexpression of at least one protein selected from the group consisting ofa transcription factor protein, a signal transducing protein, and amitochondrial protein; a second response comprising an altered patternof expression of at least one protein selected from the group consistingof a secreted growth factor, a cytokine, and a chemokine; and a thirdresponse comprising an altered pattern of expression of at least oneprotein selected from the group consisting of an actin-binding protein,a desmosomal protein, a tubulin protein, and a cornified envelopeprotein.

[0219] In embodiments of the method thereof, the cell is a skin cell(epidermal or dermal) or the cell is selected from the group consistingof a keratinocyte, a Langerhans cell, a melanocyte, and a fibroblastcell. Embodiments of the method also vary by the wavelength ofultraviolet radiation and/or the total amount of ultraviolet radiationto which the cell is exposed. For example, in various embodiments, theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength in the range of about 220 nm to about 440 nm; or theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength of about 290 nm to about 320 nm; or the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 320 nm to about 440 nm; or theultraviolet radiation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².

[0220] Other embodiments of the method thereof vary according to thetime period post-ultraviolet radiation exposure defining the firstresponse, second response, and third response. In one embodiment, thefirst response is from about 0.5 hours to about two hours post-exposureto ultraviolet radiation. In another embodiment, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation. In another embodiment, the third response is from about 16hours to about 24 hours post-exposure to ultraviolet radiation. Inanother embodiment, the first response is from about 0.5 hours to abouttwo hours post-exposure to ultraviolet radiation, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation, and the third response is from about 16 hours to about 24hours post-exposure to ultraviolet radiation.

[0221] The invention also comprises an embodiment of the method thereofwherein altered expression comprises an increase or decrease in proteinlevel. Thus, in one particular embodiment, the expression level of amember of the first response group, and/or second response group, and/orthird response group increases. In another embodiment thereof, theexpression level of a member of the first response group, and/or secondresponse group, and/or third response group decreases.

[0222] In another embodiment, the invention provides another method fordetecting exposure of a cell to ultraviolet radiation. This methodcomprises measuring the levels of a plurality of protein molecules inthe cell for at least one time point, wherein an altered pattern ofexpression is established and is indicative of ultraviolet radiationexposure. This pattern comprises a first response comprising an alteredpattern of expression of at least one protein that is at least 90%identical to a polypeptide encoded by a polynucleotide selected from thegroup consisting of the secondary first response group; a secondresponse comprising an altered pattern of expression of at least onepolynucleotide selected from the group consisting of the secondarysecond response group; and a third response comprising an alteredpattern of expression of at least one polynucleotide selected from thegroup consisting of the secondary third response group.

[0223] In various embodiments related to creation of a proteinexpression profile of a cell exposed to ultraviolet radiation, ELISA isused to measure the levels of the plurality of proteins expressed in thepresumptively exposed cell.

[0224] Another aspect of the invention relates to a screening method forthe detection of a compound that modulates a response of a cell toultraviolet radiation exposure. The method comprises contacting the cellwith the compound and exposing the cell to ultraviolet radiation thatwould otherwise induce the response, the response being an alteredpattern of expression comprising the following: (1) a first responsecomprising the altered pattern of expression of at least onepolynucleotide selected from the group consisting of a nucleic acidmolecule encoding a transcription factor protein, a nucleic acidmolecule encoding a signal transducing protein, and a nucleic acidmolecule encoding a mitochondrial protein; (2) a second responsecomprising the altered pattern of expression of at least onepolynucleotide selected from the group consisting of a nucleic acidmolecule encoding a secreted growth factor, a nucleic acid moleculeencoding a cytokine, and a nucleic acid molecule encoding a chemokine;and (3) a third response comprising the altered pattern of expression ofat least one polynucleotide selected from the group consisting of anucleic acid molecule encoding an actin-binding protein, a nucleic acidmolecule encoding a desmosomal protein, a nucleic acid molecule encodinga tubulin protein, a nucleic acid molecule encoding a cornified envelopeprotein; and measuring the levels of a plurality of RNA molecules in thecell for at least one time point after ultraviolet radiation exposure. Achange in the altered pattern of expression of the first response, thesecond response, and/or the third response indicates that the compoundmodulates the response of the cell to ultraviolet radiation exposure.

[0225] In one embodiment of the method thereof, the cell is contactedwith the compound in vitro.

[0226] In another embodiment of the method thereof, the cell iscontacted with the compound in vivo. In other embodiments of the methodthereof, the cell is a skin cell (epidermal or dermal) or the cell isselected from the group consisting of a keratinocyte, a Langerhans cell,a melanocyte, and a fibroblast cell. Embodiments of the method also varyby the wavelength of ultraviolet radiation and/or the total amount ofultraviolet radiation to which the cell is exposed. For example, invarious embodiments, the ultraviolet radiation exposure comprisesultraviolet radiation energy at a wavelength in the range of about 220nm to about 440 nm; or the ultraviolet radiation exposure comprisesultraviolet radiation energy at a wavelength of about 290 nm to about320 nm; or the ultraviolet radiation exposure comprises ultravioletradiation energy at a wavelength in the range of about 320 nm to about440 nm; or the ultraviolet radiation exposure comprises a totalultraviolet radiation energy exposure in the range of about 0.2 mJ/cm²to about 40 mJ/ cm².

[0227] Other embodiments of the method thereof vary according to thetime period post-ultraviolet radiation exposure defining the firstresponse, second response, and third response. In one embodiment, thefirst response is from about 0.5 hours to about two hours post-exposureto ultraviolet radiation. In another embodiment, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation. In another embodiment, the third response is from about 16hours to about 24 hours post-exposure to ultraviolet radiation. Inanother embodiment, the first response is from about 0.5 hours to abouttwo hours post-exposure to ultraviolet radiation, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation, and the third response is from about 16 hours to about 24hours post-exposure to ultraviolet radiation.

[0228] The invention also comprises an embodiment of the method thereofwherein altered expression comprises an increase or decrease in RNAlevel. Thus, in one particular embodiment, the expression level of amember of the first response group, and/or second response group, and/orthird response group increases. In another embodiment thereof, theexpression level of a member of the first response group, and/or secondresponse group, and/or third response group decreases.

[0229] Another aspect of the invention relates to a screening method forthe detection of a compound that modulates a response of a cell toultraviolet radiation exposure. The method comprises contacting the cellwith the compound and exposing the cell to ultraviolet radiation thatwould otherwise induce the response, the response being an alteredpattern of expression. This pattern comprises a first responsecomprising an altered pattern of expression of at least onepolynucleotide selected from the group consisting of the secondary firstresponse group; a second response comprising an altered pattern ofexpression of at least one polynucleotide selected from the groupconsisting of the secondary second response group; and a third responsecomprising an altered pattern of expression of at least onepolynucleotide selected from the group consisting of the secondary thirdresponse group. The levels of a plurality of RNA molecules in the cellare measured for at least one time point after ultraviolet radiationexposure, and a change in the altered pattern of expression of the firstresponse group, the second response group, and/or the third responsegroup indicates that the compound modulates the response of the cell toultraviolet radiation exposure.

[0230] In embodiments of the method thereof, the cell is a skin cell(epidermal or dermal) or the cell is selected from the group consistingof a keratinocyte, a Langerhans cell, a melanocyte, and a fibroblastcell. Embodiments of the method also vary by the wavelength ofultraviolet radiation and/or the total amount of ultraviolet radiationto which the cell is exposed. For example, in various embodiments, theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength in the range of about 220 nm to about 440 nm; or theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength of about 290 nm to about 320 nm; or the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 320 nm to about 440 nm; or theultraviolet radiation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².

[0231] Other embodiments of the method thereof vary according to thetime period post-ultraviolet radiation exposure defining the firstresponse, second response, and third response. In one embodiment, thefirst response is from about 0.5 hours to about two hours post-exposureto ultraviolet radiation. In another embodiment, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation. In another embodiment, the third response is from about 16hours to about 24 hours post-exposure to ultraviolet radiation. Inanother embodiment, the first response is from about 0.5 hours to abouttwo hours post-exposure to ultraviolet radiation, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation, and the third response is from about 16 hours to about 24hours post-exposure to ultraviolet radiation.

[0232] In yet another aspect of the invention, a screening method forthe detection of a compound that modulates a response of a cell toultraviolet radiation exposure. The method comprises contacting the cellwith the compound and exposing the cell to ultraviolet radiation thatwould otherwise induce the response; the response being an alteredpattern of expression. This method comprises isolating RNA from the cellpost ultraviolet radiation exposure; creating a test expression arraythrough nucleic acid hybridization between a labeled probe complimentaryto the RNA and an expression array substrate; analyzing the testexpression array to create a test expression array data set; andcomparing the test expression array data set to the response of the cellexposed to ultraviolet radiation in the absence of the drug, theresponse being an altered pattern of expression comprising the followinga primary first response group, a primary second response group, and aprimary third response group. A change in the altered pattern ofexpression of the primary first response, the primary second response,and/or the primary third response indicates that the compound modulatesthe response of the cell to ultraviolet radiation exposure.

[0233] In embodiments of the method thereof, the cell is a skin cell(epidermal or dermal) or the cell is selected from the group consistingof a keratinocyte, a Langerhans cell, a melanocyte, and a fibroblastcell. Embodiments of the method also vary by the wavelength ofultraviolet radiation and/or the total amount of ultraviolet radiationto which the cell is exposed. For example, in various embodiments, theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength in the range of about 220 nm to about 440 nm; or theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength of about 290 nm to about 320 nm; or the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 320 nm to about 440 nm; or theultraviolet radiation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².

[0234] Other embodiments of the method thereof vary according to thetime period post-ultraviolet radiation exposure defining the firstresponse, second response, and third response. In one embodiment, thefirst response is from about 0.5 hours to about two hours post-exposureto ultraviolet radiation. In another embodiment, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation. In another embodiment, the third response is from about 16hours to about 24 hours post-exposure to ultraviolet radiation. Inanother embodiment, the first response is from about 0.5 hours to abouttwo hours post-exposure to ultraviolet radiation, the second response isfrom about four hours to about eight hours post-exposure to ultravioletradiation, and the third response is from about 16 hours to about 24hours post-exposure to ultraviolet radiation.

[0235] Other embodiments of the method thereof are included in theinvention. For example, in one embodiment, cell contact with thecompound is topical contact, or in another embodiment, the compoundmodulates the cellular response by inhibiting ultravioletradiation-induced RNA expression, or in another embodiment, the compoundinhibits the ultraviolet radiation-repressed expression. In these lattertwo embodiments, ultraviolet radiation-induced expression is the“induced response group” and ultraviolet radiation-repressed expressionis the “repressed response group.”

[0236] Another aspect of the invention relates to a screening method forthe detection of a compound that modulates a response of a cell toultraviolet radiation exposure. The screening method comprisescontacting the cell with the compound and exposing the cell toultraviolet radiation that would otherwise induce the response, theresponse being an altered pattern of expression comprising thefollowing: (1) a tertiary first response group, (2) a tertiary secondresponse group, and (3) a tertiary third response group; and measuringthe levels of a plurality of RNA molecules in the cell for at least onetime point after ultraviolet radiation exposure. A change in the alteredpattern of expression of the tertiary first response, the tertiarysecond response, and/or the tertiary third response indicates that thecompound modulates the response of the cell to ultraviolet radiationexposure.

[0237] In various embodiments of the screening method thereof, the cellis contacted with the compound in vitro or in vivo. In other embodimentsof the screening method thereof, the cell is a skin cell (epidermal ordermal) or the cell is selected from the group consisting of akeratinocyte, a Langerhans cell, a melanocyte, and a fibroblast cell.Embodiments of the method also vary by the wavelength of ultravioletradiation and/or the total amount of ultraviolet radiation to which thecell is exposed. For example, in various embodiments, the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 220 nm to about 440 nm; or theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength of about 290 nm to about 320 nm; or the ultravioletradiation exposure comprises ultraviolet radiation energy at awavelength in the range of about 320 nm to about 440 nm; or theultraviolet radiation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².

[0238] Other embodiments of the screening method thereof vary accordingto the time period post-ultraviolet radiation exposure defining thefirst response, second response, and third response. In one embodiment,the first response is from about 0.5 hours to about two hourspost-exposure to ultraviolet radiation. In another embodiment, thesecond response is from about four hours to about eight hourspost-exposure to ultraviolet radiation. In another embodiment, the thirdresponse is from about 16 hours to about 24 hours post-exposure toultraviolet radiation. In another embodiment, the first response is fromabout 0.5 hours to about two hours post-exposure to ultravioletradiation, the second response is from about four hours to about eighthours post-exposure to ultraviolet radiation, and the third response isfrom about 16 hours to about 24 hours post-exposure to ultravioletradiation.

[0239] In various embodiments related to screening method thereof, ELISAis used to measure the levels of the plurality of proteins in a cell indetermining the response of the cell to ultraviolet radiation in thepresence and absence of the compound.

[0240] Another aspect of the invention relates to a screening method forthe detection of a compound that modulates a response of a cell toultraviolet radiation exposure. The screening method comprisescontacting the cell with the compound and exposing the cell toultraviolet radiation that would otherwise induce the response, theresponse being an altered pattern of expression comprising thefollowing: (1) a quaternary first response group; (2) a quaternarysecond response group; and (3) a quaternary third response group; andmeasuring the levels of a plurality of RNA molecules in the cell for atleast one time point after ultraviolet radiation exposure. A change inthe altered pattern of expression of the quaternary first response, thequaternary second response, and/or the quaternary third responseindicates that the compound modulates the response of the cell toultraviolet radiation exposure.

[0241] In various embodiments of the screening method, the cell iscontacted with the compound in vitro or in vivo. The cell is a cell in aculture, tissue, or organism, such as skin cell (epidermal or dermal).The cell may be a keratinocyte, a Langerhans cell, a melanocyte, and afibroblast cell. Embodiments of the method also vary by the wavelengthof ultraviolet radiation and/or the total amount of ultravioletradiation to which the cell is exposed. For example, in variousembodiments, the ultraviolet radiation exposure comprises ultravioletradiation energy at a wavelength in the range of about 220 nm to about440 nm; or the ultraviolet radiation exposure comprises ultravioletradiation energy at a wavelength of about 290 nm to about 320 nm; or theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength in the range of about 320 nm to about 440 nm; or theultraviolet radiation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².

[0242] Other embodiments of the screening method thereof vary accordingto the time period post-ultraviolet radiation exposure defining thefirst response, second response, and third response. In one embodiment,the first response is from about 0.5 hours to about two hourspost-exposure to ultraviolet radiation. In another embodiment, thesecond response is from about four hours to about eight hourspost-exposure to ultraviolet radiation. In another embodiment, the thirdresponse is from about 16 hours to about 24 hours post-exposure toultraviolet radiation. In another embodiment, the first response is fromabout 0.5 hours to about two hours post-exposure to ultravioletradiation, the second response is from about four hours to about eighthours post-exposure to ultraviolet radiation, and the third response isfrom about 16 hours to about 24 hours post-exposure to ultravioletradiation.

[0243] In various embodiments related to screening method thereof, ELISAis used to measure the levels of the plurality of proteins in a cell indetermining the response of the cell to ultraviolet radiation in thepresence and absence of the compound.

[0244] Another aspect of the invention provides a screening method forthe detection of a compound that simulates the response of a cell toultraviolet radiation exposure, comprising: contacting the cell with thecompound; measuring a level of at least one RNA molecule in thecontacted cell; and determining that the level of at least one RNAmolecule in the cell after exposure to the compound is substantiallysimilar to the level of the RNA found in the cell in response toultraviolet radiation exposure, the response of the cell to ultravioletradiation exposure being characterized by altered expression of thefollowing: a primary first response group, a primary second responsegroup, and a primary third response group. A determination that thelevel of expression of at least one RNA molecule is substantiallysimilar to the altered expression found for the RNA molecule in theprimary first response, the primary second response, or the primarythird response indicates that the compound simulates exposure of thecell to ultraviolet radiation.

[0245] Another aspect of the invention provides a screening method forthe detection of a compound that simulates the response of a cell toultraviolet radiation exposure, comprising: contacting the cell with thecompound; measuring a level of at least one RNA molecule in thecontacted cell; and determining that the level of at least one RNAmolecule in the cell after exposure to the compound is substantiallysimilar to the level of the RNA found in the cell in response toultraviolet radiation exposure, the response of the cell to ultravioletradiation exposure being characterized by altered expression of thefollowing: a secondary first response group, a secondary second responsegroup, and a secondary third response group. A determination that thelevel of expression of at least one RNA molecule is substantiallysimilar to the altered expression found for the RNA molecule in thesecondary first response, the secondary second response, or thesecondary third response indicates that the compound simulates exposureof the cell to ultraviolet radiation.

[0246] Another aspect of the invention provides a screening method forthe detection of a compound that simulates the response of a cell toultraviolet radiation exposure, comprising: contacting the cell with thecompound; measuring a level of at least one protein in the contactedcell; and determining that the level of at least one protein in the cellafter exposure to the compound is substantially similar to the level ofthe protein found in the cell in response to ultraviolet radiationexposure, the response of the cell to ultraviolet radiation exposurebeing characterized by altered expression of the following: a tertiaryfirst response group, a tertiary second response group, and a tertiarythird response group. A determination that the level of expression of atleast one protein is substantially similar to the altered expressionfound for the protein in the tertiary first response group, the tertiarysecond response group, or the tertiary third response group indicatesthat the compound simulates exposure of the cell to ultravioletradiation.

[0247] Another aspect of the invention provides a screening method forthe detection of a compound that simulates the response of a cell toultraviolet radiation exposure, comprising: contacting the cell with thecompound; measuring a level of at least one protein in the contactedcell; and determining that the level of at least one protein in the cellafter exposure to the compound is substantially similar to the level ofthe protein found in the cell in response to ultraviolet radiationexposure, the response of the cell to ultraviolet radiation exposurebeing characterized by altered expression of the following: a quaternaryfirst response group, a quaternary second response group, and aquaternary third response group. A determination that the level ofexpression of at least one protein is substantially similar to thealtered expression found for the protein in the quaternary firstresponse group, the quaternary second response group, or the quaternarythird response group indicates that the compound simulates exposure ofthe cell to ultraviolet radiation.

[0248] In a further aspect, the invention provides a screening methodfor the detection of a compound that modulates a response of a cell toultraviolet radiation exposure, the response being an altered pattern ofexpression determined by gene expression array analysis. The methodcomprises contacting the cell with the compound; exposing the cell toultraviolet radiation that would otherwise induce the response; andmeasuring the levels of a plurality of RNA molecules in the cell for atleast one time point after ultraviolet radiation exposure by gene arrayexpression analysis. A change in the response of the cell to ultravioletradiation exposure indicates that the compound modulates the response ofthe cell to ultraviolet radiation exposure.

[0249] In a further aspect, the invention provides a screening methodfor the detection of a compound that modulates a response of a cell toultraviolet radiation exposure, the response being an altered pattern ofexpression determined by gene expression array analysis. The methodcomprises contacting the cell with the compound; exposing the cell toultraviolet radiation that would otherwise induce the response; andmeasuring the levels of a plurality of proteins in the cell for at leastone time point after ultraviolet radiation exposure by gene arrayexpression analysis. A change in the response of the cell to ultravioletradiation exposure indicates that the compound modulates the response ofthe cell to ultraviolet radiation exposure.

C. Therapeutic Methods

[0250] The invention provides therapeutic methods for the treatment orprevention of premature aging of the skin and of skin cancers and otherdisorders of an individual. The ultraviolet radiation-regulated nucleicacid molecules and proteins, according to the invention, may be used inthe design of such therapeutics for an individual. As used herein, theterm “individual” refers to a mammal, and more preferably refers to ahuman.

[0251] In one embodiment of the invention, therapeutic treatment isaccomplished through known gene therapy techniques. Gene deliveryvehicles suitable for gene therapy applications are well known to thoseskilled in the art. For example, a gene delivery vehicle may preferablybe a viral vector and, more preferably, a retroviral, an adenoviral, anadeno-associated viral (AAV), a herpes viral, or an alphavirus vector.The viral vector can also be an astrovirus, a coronavirus, aorthomyxovirus, a papovavirus, a paramyxovirus, a parvovirus, apicornavirus, a poxvirus, or a togavirus viral vector (Jolly (1994)Cancer Gene Ther. 1:51-64; Kimura (1994) Hum. Gene Ther 5:845-852;Connelly (1995) Hum. Gene Ther. 6:185-193; and Kaplitt (1994) Nat.Genet. 6:148-153).

[0252] Delivery of the gene therapy constructs of this invention intocells is not limited to the above-mentioned viral vectors. Otherdelivery methods and media may be employed such as, for example, nucleicacid expression vectors, polycationic condensed DNA linked or unlinkedto killed adenovirus alone (e.g., see Curiel (1992) Hum. Gene Ther3:147-154); ligand linked DNA (e.g., see, Wu (1989) J. Biol. Chem.264:16985-16987); deposition of photopolymerized hydrogel materials,hand-held gene transfer particle gun (e.g., U.S. Pat. No. 5,149,655);ionizing radiation (e.g., U.S. Pat. No. 5,206,152 and PCT PatentPublication No. WO 92/11033); or nucleic charge neutralization or fusionwith cell membranes. Additional approaches are described in Philip((1994) Mol. Cell. Biol. 14:2411-2418) and in Woffendin ((1994) Proc.Natl. Acad. Sci. (USA) 91:1581-1585).

[0253] Briefly, the sequence of interest can be inserted intoconventional vectors that contain conventional control sequences forhigh level expression, and then be incubated with synthetic genetransfer molecules such as polymeric DNA-binding cations likepolylysine, protamine, and albumin, linked to cell targeting ligandssuch as asialoorosomucoid, as described in Wu et al (J. Biol. Chem.(1987) 262:4429-4432), insulin as described in Hucked (Biochem.Pharmacol. (1990) 40:253-263), galactose as described in Plank(Bioconjugate Chem. (1992) 3:533-539), lactose, or transferrin. NakedDNA may also be employed. Exemplary naked DNA introduction methods aredescribed in PCT Patent Publication No. WO 90/11092 and U.S. Pat. No.5,580,859. Uptake efficiency may be improved using biodegradable latexbeads. DNA coated latex beads are efficiently transported into cellsafter endocytosis initiation by the beads. The method may be improvedfurther by treatment of the beads to increase hydrophobicity and therebyfacilitate disruption of the endosome and release of the DNA into thecytoplasm. Liposomes that can act as gene delivery vehicles aredescribed in U.S. Pat. No. 5,422,120, PCT Patent Publication Nos. WO95/13796, WO 94/23697, and WO 91/144445, and EP Patent No. 524,968.

[0254] Potential target cells for gene therapy include skin cells(epidermal and dermal) and, more specifically, keratinocytes, Langerhanscells, melanocytes, and/or fibroblast cells. Gene therapy methodsspecific for epidermal cells and fibroblasts are known in the art (seeOhsawa et al. (2000) J. Dermatol. 27(4):244-251; Ina et al. (2000) Acta.Denn. Venereol. 80(1):10-13; Bevan et al. (1999) Biotechnol. Genet. Eng.Rev. 16:231-256; and Pellegrini et al. (1998) Med. Biol. Eng. Comput.36(6):778-790).

[0255] The invention provides herein the identification of many nucleicacid and protein molecules regulated by ultraviolet radiation exposure.Any one or more of these molecules may be targeted for use in genetherapy protocols.

[0256] Among the nucleic acids regulated by ultraviolet exposure aregenes which may be grouped into several distinct and clearly demarcatedfunctional categories: 1) induced DNA metabolism and repair genes; 2)signal transducing proteins and transcription factors induced and/orsuppressed at all experimental time points; 3) secreted growth factors,chemokines and cytokines at the intermediate time points; 4) induced andsurpressed structural proteins; and 5) mitochondrial proteins, which areamong the first induced in response to ultraviolet radiation exposure.In addition, ultraviolet radiation regulates genes for proteins involvedin the translation machinery, RNA processing, lipid, amino acid and ureametabolism, integral membrane and cell surface proteins, proteases andtheir inhibitors, and proteins that could not be classified into thosecategories, as well as several unidentified ESTs.

1) Proteins Involved in DNA Metabolism and Repair

[0257] One of the most notorious effects of ultraviolet radiation is DNAdamage and the resulting mutagenesis as a result thereof. In mammaliancells, different DNA damaging agents activate different repair processes(e.g., Wang, et al. (1998) Curr. Opin. Cell Biol. 10(3):416); and Wanget al. (1998) Curr. Opin. Cell Biol. 10:240-7)). Ultravioletradiation-caused DNA lesions are repaired primarily by the nucleotideexcision repair system (NER) (Lowndes, et al. (2000) Curr. Opin. Genet.Dev. 10:17-25; Batty et al. (2000) Gene 241:193-204). Ultravioletradiation induces the expression of ERCC4, a protein essential forrepair of DNA interstrand cross-links (Table 2). Several other repairenzymes are present in keratinocytes, but not further induced byultraviolet radiation, including excision repair protein ERCC1, mismatchrepair protein hmlh1, as well as XP-C, XP-G, XP-E and XRCC1. Ultravioletradiation also induces genes for several enzymes that produce buildingblocks for DNA synthesis, including guanylate kinase,nucleoside-diphosphate kinase, cytidine deaminase and transaldolase.Similarly, ultraviolet radiation-induces the expression of the histonesH2A.2, H2B.1, H2A.X, H1x, and H2A.Z, which may play a role in protectingnascent DNA from damage. Most of the DNA repair proteins are present insufficient amounts in keratinocytes even before the ultravioletradiation treatment, but cells produce more of the dNTPs and histones tobuild and protect the newly repaired DNA after ultraviolet radiationexposure.

[0258] Ultraviolet radiation regulates the expression of DNAdamage-inducible proteins gadd45, cyclin G1 and BTG2. These proteinsplay a role in cell cycle arrest, which allows keratinocytes to repairtheir DNA, together with spermidine/spermine ni-acetyltransferase, andseveral growth controlling oncogenes (Jin, et al. (2000) J. Biol. Chem.275:16602-16608; Cortes, et al. (2000) Mol. Carcinog. 27:57-64; vanLookeren Campagne, et al. (1998) J. Neurosci. Res. 53:279-296; andAlhonen et al. (1999) Mol. Phannacol. 55:693-698). As expected, theregulation of these proteins is often complex. For example, cyclin G1expression is suppressed at four and eight hours, but induced at 24hours after ultraviolet radiation exposure (Table 2). Presumably, theseproteins coordinate the DNA repair process with the cell cycle.

2) Signal Transducers and Transcription Factors

[0259] Signaling proteins regulated by ultraviolet radiation inkeratinocytes have very complex patterns of regulation. Some signalingproteins are induced, others are suppressed, some are first induced andthen suppressed, and for some just the opposite is the case. Reflectingthe variety of processes affected by ultraviolet radiation, they may begrouped into several categories.

[0260] Cell surface receptors (Table 3), with the exception of theurokinase-type plasminogen receptor, are suppressed by ultravioletradiation. These include IL-4-R, TNFαR, TGF-βIIR, T-cell receptor activeβ-chain, LDL receptor, the v-erbA related ear-2 receptor, cysteine-richfibroblast growth factor receptor (CFR-1) and novel growth factorreceptor. Receptor associated proteins are also generally suppressed.These include Fas-binding protein (DAXX), HM74, pSK1 interferon gammareceptor accessory factor-1, and SHB, which is an SH2 containingprotein. An EGFR associated protein, BTG1 (Tob), is induced byultraviolet radiation, while a close relative (BTG2 Job2, TIS21, PC3) issuppressed, although both are anti proliferative. In contrast, ligandsto various receptors, growth factors and cytokines, are induced four andeight hours after illumination (see below).

[0261] Importantly, ultraviolet radiation regulates about a dozen of thesmall GTP-binding proteins and their associated factors (Table 3). Rad,a member of ras family, Ly-GDI, RGL2 and G(i) protein α subunit areinduced by ultraviolet radiation at various time points, whileADP-ribosylation factors hARF1 and hARF6, Rab GDI, rab2 YPTI-relatedmember of ras family (all involved in vesicular transport) and tuberinTSC2, which is a GAP factor, are all suppressed at various time points.Ultraviolet radiation also suppresses, at various time points, severalless easily classified signaling proteins, including the progesteronereceptor-associated ihmunophilin FKBP54 and α-4, a rapamycin-sensitivepathway protein, as well as two heat shock proteins, heat shock protein40 and heat shock protein 70, and an HSP-associated protein (Table 3).

[0262] Most intracellular signaling processes involve proteinphosphorylation and, therefore, protein kinases and phosphatases areamong the regulated genes (Table 3). The dual specificity phosphataseCL100, which is the human homolog of murine MKPI that plays a role inshutting down the ultraviolet radiation-mediated signal transduction, isalso induced by ultraviolet radiation (Hirsch et aL (1997) J. Biol.Chem. 272:4568-4575). Ultraviolet radiation induces at various timepoints three RING3 family proteins, MAPKAP kinase (3pK) and cysticfibrosis antigen, which is a protein kinase inhibitor. On the otherhand, the following kinases are suppressed at various time points: Gprotein-coupled receptor kinase GRK6, Ser/Thr protein kinase (A-Raf-1),casein kinases CKI-α and CKII-α, ERK3, LIMK-2, testis-specific proteinkinase α-subunit, H-pim-1 and a raf related protein pks/a-raf. Alsosuppressed are the phosphatases PP2A,-Cα, PP1γ and PTP1.

[0263] Among the genes induced at early time points are severaltranscription factors (Table 3). The most highly induced in the firsttwo hours are immediate early genes junb, junD, and c-fos, ETR101, A20and GOS24 (a/k/a TTP, Nup475, Zfp36 and TIS11 (Heximer SP, ForsdykeDRI)). Their induction is short-lived and by four hours most and, by 16hours, all are either expressed to background levels, or evensuppressed. junB, junD, and c-fos are genes encoding the AP1 family ofproteins. These are accountable for inducing many of the knownultraviolet radiation-activated genes, such as matrix metalloproteases.AP1 proteins are activated by ultraviolet radiation in epidermis in vivoand may be responsible for the sun damage in humans. Their function isinhibited by retinoids. The skin-specific isoform of the retinoic acidreceptor, RARy is suppressed by ultraviolet radiation. Fourtranscription factors are first induced and then suppressed byultraviolet radiation, Nup475 (a/k/a TTP, Zfp36 and TIS11), HRY, XBP-1and in EGR 1 (a/k/a Krox-24), another immediate early gene.

[0264] The motif of increasing one and suppressing another member of anantagonistically coupled transcription pair, similar to AP1-RARγ,NFκB-IκB and C/EBPp-CHOP, is of note in the induction of MMI aninhibitor of c-Myc and strong and persistent suppression of c-Mycitself. This is consistent with the role of c-Myc in deregulating cellgrowth, promoting genomic instability, sensitizing to apoptosis, andinhibiting gadd34, gadd45 and gadd153, DNA damage induced growth arrestproteins (Amundson et al. (1998) Oncogene, 17:2149-54); Felsher et aL(1999) Proc. Natl. Acad. Sci (USA), 96:3940-4; Pelengaris, et al. (2000)Curr: Opin. Genet. Dev., 10:100-5). Epidermis-targeted over-expressionof c-Myc causes benign but pre-malignant and extensive epidermalproliferation, which is not beneficial in the context of ultravioletradiation induced DNA damage.

[0265] Ultraviolet radiation suppresses NFκB, while inducing theIκB-like protein. This is particularly interesting because NFκBtranscription factor is activated by ultraviolet radiation. Thesuppression of its synthesis and induction of its inhibitor may serve toattenuate the initial ultraviolet radiation signal. This is similar tothe induction of MKP1, a dual specificity kinase that attenuates the JNKpathway. Similarly, C/EBPβ is induced, while its inhibitors CHOP(GADD153) and C/EBPε are suppressed.

[0266] At the late time points, prominently induced are three of thecomponents of RNA pol 11, namely the largest subunit, RP135 and RPB10,as well as taf1130 a TATA-box binding protein associated factor, primingthe cells for enhanced transcription. On the other hand, transcriptionelongation factors ELL2 and SII are suppressed by ultraviolet radiation.Ultraviolet radiation also induces ALL-1 and PML-2, two transcriptionfactors made oncogenic by translocations. Conversely, two homeoboxproteins, TGIF and HB9 are suppressed.

[0267] Several additional transcription factors are suppressed byultraviolet radiation, including ets-2, BTEB2, SRF, ZFY, ERF-2,HLH-1R21, HTF10, AREB6 and others. AP2, a transcription factorresponsible for synthesis of keratinocyte basal cell markers, issuppressed by the ultraviolet radiation. Apparently, when responding toultraviolet radiation, the keratinocytes abandon the basal cellphenotype and instead switch to an activated phenotype, more similar towound-healing or psoriatic keratinocytes.

3) Secreted Polypeptides, Growth Factors, Cytokines and Chemokines

[0268] In the intermediate response the most prominent group ofregulated genes are secreted proteins, growth factors, cytokines andchemokines (Table 5). In particular, members of the IL-8 family areinduced: IL-8, gro-a, gro-0, and MIP2-0 (Geiser et aL (1993) J. Biol.Chem. 268:15419-24; Kemeny et al. (1995) Int. Arch. Allergy Immunol.106:351-6). These peptides are chemotactic and activating forneutrophils, basophils and macrophages and, presumably, play a roleinviting inflammatory cells into ultraviolet radiation-damaged tissue.Importantly, they also activate melanocytes, which may initiate tanningin response to ultraviolet radiation.

[0269] Heparin binding growth factor (HB-EGF) is induced, whileamphiregulin (AR) is suppressed. Both are activators of the EGF receptorand, presumably, autocrine factors for keratinocyte activation.Additional secreted proteins, such as 14 kD lectin, apo-E and CTGF arealso induced. Also induced is SCYLP, a peptidyl-prolyl isomerase, whichmay play a role in maturation of collagens and other proline-richextracellular matrix proteins implicated in photoaging.

[0270] The secreted peptides serve to alert the surrounding tissue thatdamage has occurred. The effects are paracrine, activating melanocytes,endothelial cells, neutrophils and fibroblasts, as well as autocrine,alerting keratinocytes themselves.

[0271] Several of the ultraviolet radiation-induced genes, includingIL-8, have previously been shown to be inducible by interferon-γ(Fujisawa et al. (1997) J. Interferon Cytokine Res. 17:347-353; Araganeet al. (1997) Proc. Natl. Acad. Sci. (USA) 94:11490-11495). These genesare induced at later time points after ultraviolet irradiation andinclude p27, 17-kD/15-kD protein, IRF 7A, 1-81 gene, hPA28-β, interferongamma receptor accessory factor-1 and STAT 5. These results may indicatea nexus between ultraviolet radiation and interferon-7 signaling.

4) Structural Proteins

[0272] Among the structural proteins regulated by ultraviolet radiation,prominent are cytoskeletal proteins, in particular actin bindingproteins (ABPs), desmosomal components, and three tubulin subunits, aswell as components of the cornified envelope, markers of keratinocytedifferentiation (Table 4).

[0273] Actin affects the shape of the plasma membrane, allows cellularmotility and maintains cell shape and polarity. To accomplish thesetasks actin collaborates with approximately 60 different ABPs. Thevarious ABPs work cooperatively or competitively with one another to aidin actin activity (Kreis and Vale, Guidebook to the Cytoskeletal andMotor Proteins, 2nd ed., New York: Oxford University Press (1999)). TheABPs induced early by ultraviolet irradiation are the genes encodinggelsolin and troponin. Gelsolin nucleates actin polymerization, but athigh Ca²⁺ concentrations it severs actin filaments, and is then releasedto allow the free actin ends to polymerize. Accordingly, gelsolin causescytoplasmic streaming of large cells, a process that maintains an evendistribution of metabolites throughout the cytoplasm and changes thecell shape. Mouse cells lacking gelsolin exhibit a deficiency in cellmotility (Barkalow et al. (1996) J. Cell Biol. 134:389-399; Witke et al.(1995) Cell 81:41-51). Liquefaction of the cell cortex by severingproteins also allows for the proper membrane contact and fusion ofmembrane-bound vesicles within the cell. Troponin, which is alsoactivated by Ca²⁺ binding, is one of the proteins that cause theshortening of muscle fibers in muscle cells.

[0274] ABP genes induced at the later time points include MacMARCKS,myosin light chain, Arp ⅔, filamin, tropomyosin, thymosin andsmoothelin. MacMARCKS, induced four hours after illumination, is ahomolog of MARCKS, which binds and cross links filamentous actin.MacMARCKS regulates actin structure during cell movement, phagocytosis,membrane trafficking and cell-cell adhesion. The myosin light chain canregulate the ATPase activity of myosin's heavy chain and is thus able tocontrol the interaction of the myosin head with actin filaments. Theentire myosin I protein moves vesicles along the actin filament, whilemyosin 11 slides the actin filaments past one another. The proteincomplex Arp⅔ nucleates actin filament formation, cross-links filamentsinto networks, and protects filament ends from depolymerization. Filamincross-links actin filaments and causes them to form a gel. Tropomyosinbinds along the length of actin filaments, increasing their strength andchanging their affinity for other proteins. Thymosin binds to actinmonomers, inhibits actin polymerization, and may play a role inpreventing apoptosis (Niu et aL (2000) Cell Adhes. Commun. 7:311-320).

[0275] In contrast to the induced genes, the gene encoding B-spectrin issuppressed by ultraviolet radiation in the early stages afterillumination. B-spectrin is a component of spectrin, which providesrigidity and stability to the cell membrane by controlling thedistribution of integral membrane proteins, and binds actin to hold itin place. Adducin expression is suppressed by ultraviolet radiation.Adducin caps and bundles actin and forms contacts between spectrin andactin.

[0276] The overall picture of the regulation of the cytoskeletalproteins by ultraviolet radiation shows an initial de-polymerization,softening of the actin cytoskeleton in the first two hours, which isfollowed by a re-polymerization of the actin filaments andreconstitution of the cytoskeletal network (Maekawa et al. (1996) Clin.Exp. Immunol. 105:389-396; Malorni, et aL (1994) J. Photochem.Photobiol. 26:265-270). Ultraviolet radiation also suppresses theexpression of transgelin, a LIM protein and myosin heavy chain. Inaddition, tubulins A1, B and B2 and keratins K13 and K19 are induced,all at the later time points after illumination. K17 is alreadyexpressed at high levels in cultured keratinocytes, and furtherinduction by ultraviolet radiation was not observed. Ultravioletradiation, under the conditions used herein, does not appear tosignificantly regulate any other keratin.

[0277] The most strongly induced genes overall are keratinocytedifferentiation markers, components of the cornified envelope. Theseinclude four of the small proline rich proteins SPRR1, 2A, 2B and 21, aswell as involucrin, desmoglein III and S100 calcium-binding proteins A13and A12. Only the small proline rich proteins were shown to be inducedby ultraviolet radiation previously (Kartasova et al. (1988) Mol. CellBiol. 8:2195-2203; Gibbs et al. (1990) Nucleic Acids Res. 18:4401-4407).Of the epidermal differentiation markers, only the cornified envelopecomponents are induced, while keratins and filaggrin are not. Theseproteins are all encoded in the epidermal marker locus on humanchromosome 1, and are induced at later time points, i.e., 16 and 24hours post-illumination. None of the differentiation markers appear tobe suppressed by ultraviolet radiation. Apparently, one of the epidermalresponses to ultraviolet radiation is enhancement of the stratum corneumproduction, which augments the dead, protective layer of skin.

5) Mitochondrial Proteins

[0278] Among the genes that are strongly induced immediately afterultraviolet radiation exposure are several mitochondrial proteins (Table6). Specifically, cytochrome c-1 is induced in the first hour. At the 24hour time point, its synthesis returns to the background levels, and iseven suppressed. Cytochrome c oxidase subunits Vb, Vila-L, Vilb, andcytochrome b light chain are also induced early after the illumination.In contrast, OXA1 Hs, a cytochrome oxidase assembly protein, issuppressed. Several other mitochondrial proteins, includingmitochondrial NADH dehydrogenase, mitochondrial ubiquinone-bindingprotein, mitochondrial ATP synthase, a mitochondrial ribosomal protein,and an electron transfer flavoprotein, are strongly induced. It appearsthat cells, upon illumination, sense a need for additional energy andinduce mitochondrial proteins to address this need.

[0279] A further indication that ultraviolet radiation illuminationleads to a requirement for additional energy comes from the fact thatultraviolet radiation induces several of the energy producing enzymes.These include α-enolase, creatine kinase-B, pyruvate dehydrogenase and aproton-ATPase-like protein. Conversely, gluconeogenic enzymes,phosphoenolpyruvate carboxykinase and gamma-aminobutyraldehydedehydrogenase, as well as transporters for lactate and pyruvate and forglucose are suppressed. Moreover, enzymes for lipid synthesis aresuppressed, including ATP-citrate lyase, squalene epoxidase,acyl-coenzyme A synthetase, stearoyl-coenzyme-A desaturase and methylsterol oxidase. Additionally, fatty acids omega-hydroxylase, cytochromeP-450HKV, is also suppressed at the earliest time point. Stronginhibition of lipid neogenesis seems in discrepancy with the inductionof the cornified envelope proteins because both the lipid and theproteinaceous components contribute to the formation of stratum corneum.

[0280] The response of keratinocyte mitochondrial genes to ultravioletradiation is quite different from the response of the mitochondrialgenes in lymphoma cells to ionizing radiation (Voehringer, et al. (2000)Proc. Natl. Acad. Sci. (USA) 97:2680-2685). Comparing two cell linesthat differ only in their responses to ionizing radiation, Voehringer etaL found that the resistant cell line expressed high levels ofmitochondrial proteins fructose-1, 6-biphosphatase, VDAC, fatty acidbinding proteins and uncoupling proteins. These are increased evenfurther by the ionizing radiation treatment. While the highly expressedproteins seem to protect the resistant cells from apoptosis, thesensitive cells lacking these proteins are not protected and die. In theassays described herein, these proteins do not change significantly inresponse to ultraviolet radiation in keratinocytes. The keratinocytes,based on the ultraviolet radiation dose, may either survive or apoptoseand increasing these proteins would predispose them to survive, which isa potentially dangerous response.

[0281] Mitochondrial proteins suppressed by ultraviolet radiationinclude aldehyde dehydrogenase 1, rhodanese (thiosulfate: cyanidesulfurtransferase), and UCP, a thermogenic uncoupling protein. Theseproteins are not immediately involved in energy production.Uroporphyrinogen synthetase is induced by LIV, while uroporphyrinogendecarboxylase, the enzyme degrading uroporphyrinogen, is suppressed,indicating that the mitochondria may require elevated levels ofuroporphyrinogen and perhaps other Fe-binding proteins.

[0282] The changes in mitochondrial proteins are very important inepidermal response to ultraviolet radiation and probably have severalfunctions. These include a burst of respiration proteins to provideadditional energy needed to cope with the ultraviolet radiation-causeddamage, and an increase of enzymes that remove reactive oxygen speciesas a detoxifying process. In addition, given the mitochondrial role incontrolling apoptosis, irradiated keratinocytes may prepare theirmitochondria to initiate apoptosis.

[0283] Ultraviolet radiation elicits induction of severalantioxidant-detoxifying proteins. Specifically, metallothionein andcopper transport protein HAH1, two thiol-specific antioxidant proteins,as well as aldehyde reductase and aldehyde dehydrogenase 6 are induced(Hanada et al. (1998) J. Invest. Dermatol. 111:582-585). On the otherhand, isoforms of MT, metallothionein 1 L and aldehyde dehydrogenase,ALDI-18 are specifically suppressed. HHCPA78 homolog, a thioredoxininteracting protein, is suppressed with thioredoxin reductase andgamma-glutamylcysteine synthetase.

[0284] The following examples illustrate the preferred modes of makingand practicing the present invention but are not meant to limit thescope of the invention since alternative methods may be utilized toobtain similar results.

EXAMPLES Example 1 Identification of Gene and Protein SequencesRegulated by Exposure to Ultraviolet-B Radiation A. Keratinocyte Cultureand Ultraviolet-B Radiation

[0285] Cultures of epidermal keratinocytes from human foreskin wereinitiated using 3T3 feeder layers as described (Simon, et al. (1984)Cell 36:827-834) and then stored frozen in liquid N₂. Once thawed, thekeratinocytes were grown without feeder cells in defined serum-freekeratinocyte growth medium (KGM) supplemented with 0.05 g/l bovinepituitary extract, 5 ng/ml epidermal growth factor, and 1%penicillin/streptomycin (KGM from Gibco-BRL (Rockville, Md.). Thekeratinocytes were maintained at 37° C., in 5% CO₂. The medium wasreplaced every two days. The cells were expanded through three passagesfor the experiments. They were trypsinized with 0.025% trypsin, whichwas neutralized with 0.5 mg/ml trypsin inhibitor. Serum was avoidedbecause it can promote keratinocyte differentiation. For allexperiments, third-passage keratinocytes were used one day afterreaching confluence.

[0286] For ultraviolet-B radiation, the Stratagene 2000 illuminatorspecially equipped with FG15T light bulb was used (Strategene, LaJolla,Calif.). This light produces maximum output in the ultraviolet-Bradiation wavelength range. The medium was removed from the cellcultures, and keratinocytes were irradiated in open dishes with eightmJ/cm². Immediately after the ultraviolet-B radiation exposure, the samemedium was replaced to the cultures. Control cells were subjected to theidentical procedure but were only sham-irradiated.

[0287] The protocol was chosen for two reasons: first, confluentkeratinocytes more closely resemble skin than sub-confluent ones; andsecond, nearly identical conditions from culture to culture werereliably and reproducibly achieved. The dose of ultraviolet-B radiationexposure was optimized by treating keratinocyte cultures with increasingamounts of radiation, replacing the medium and determining the cellviability 24 hours after the treatment. A dose of ultraviolet-Bradiation was chosen so that at least 10%, but less that 20%, of cellswere killed by ultraviolet-B radiation exposure; specifically, 8 J/M²was determined to be optimal.

[0288] Keratinocyte cultures were irradiated with a single 8 J/M² doseof ultraviolet-B radiation and the cells were harvested 0.5, 1, 2, 4, 8,16, and 24 hours later. As controls, mock-irradiated cells wereharvested 1, 4, 8, 16, and 24 hours after the treatment. The one hourmock-irradiated culture was then used as control for the 0.5, 1 and 2hour time points, while all the later time points had cognate controls.

B. Isolation of Total RNA and Probe Synthesis

[0289] Cells were harvested by scraping the culture dish. Kits fromQiagen (Chatsworth, Calif.) were used to prepare the RNA according tothe manufacturer's protocols. Qiashredders were used to homogenize celllysates with centrifugation at 1800 g for two minutes. RNA was extractedusing RNeasy Midi Kit. DNA was removed with on-column DNAse digestionusing Qiagen RNAses-free DNAse Set.

[0290] After the RNAs were prepared, but before they were used for genearray hybridization, the RNAs were tested in Northern blothybridizations with a probe corresponding to the c-fos gene.

[0291] For Northern blotting, 10 μg RNA was loaded on a 1.0%agarose-formaldehyde gel and run at 100 V for three to four hours. TheRNA was transferred overnight to a nylon membrane (Amersham LifeScience, Piscataway, N.J.) and cross-linked with the Stratalinker(Stratagene, LaJolla, Calif.). The probes for c-fos and IL-6 weresynthesized using reverse transcription-PCR from keratinocyte RNA andthe RT-PCR kit from Ambion (Austin, Tex.). Additional probes werederived from cDNA clones obtained from the American Type CultureCollection (ATCC, Manassas, Va.). Each clone was sequenced from both 5′and 3′ ends to confirm its identity. The ³²P labeled probes weregenerated using [³²P] dCTP (3000 Ci/mmol Dupont (NEN, Boston, Mass.) andthe Multiprime DNA labeling system (Amersham Pharmacia Biotech,Piscataway, N.J.) and purified using D-Salt Excellulose PlasticDesalting Columns (Pierce, Rockford, Ill.).

[0292] Hybridizations were performed using ExpressHyb solution(Clontech, Palo Alto, Calif.) at 68° C. for one hour. Membranes werewashed with 2× SSC, 0.05% SDS solution, with continuous shaking threetimes for 30 minutes at room temperature, and with 0.× SSC, 0.1% SDS at50° C. for 40 minutes. The membrane was exposed to Kodak (Toronto,Canada) BIOMAX MS film at −80° C., and radiographs were scanned andanalyzed with Multilmagine Light Cabinet Alphalmagine 2000 documentationand analysis system (Alpha Innotech Corporation, San Leandro, Calif.).The RNA levels were normalized to glyceraldehyde-3-phosphatedehydrogenase (GAPDH) mRNA.

[0293] As shown in FIG. 1A, appropriate induction of expression of c-fosgene was observed, which provided justification for using the RNAsamples in expression array hybridization studies. Subsequently, toconfirm the results from the arrays, Northern blots were used to examinethe expression of the regulated genes (Figure 1B). A strong correlationbetween the array data and the blots for the genes shown was found.

[0294] For the synthesis of probe for use with the gene array, eightmicrograms of total RNA were reverse transcribed, amplified and labeledas previously described (Mahadevappa et al. (1999) J.A. NatureBiotechnol. 17:1134-1136). As a result of the sequence of the primersused for reverse transcription, the resultant cDNA product contained anRNA polymerase promoter for use in the synthesis of cRNA probe to screenthe gene array.

C. Gene Array Hybridization

[0295] Labeled cRNA was hybridized to the HU6800 array (Affymetrix Inc.,Santa Clara, Calif.) under conditions recommended by the manufacturer.Arrays were washed, stained with anti-biotinstreptavidin-phycoerythourin labeled antibody and scanned using theGeneChip system (Hewlett-Packard, Miami, Fla.). GeneChip 3.0 software todetermine the expression of each gene. Intensity values were scaled bycalculating the overall signal for each array type.

[0296] Differential expression was determined by calculating the ratiobetween signal intensity value from ultraviolet radiation exposed cellsand control cells. To eliminate genes exhibiting potential falsepositive differential expression, only those genes that possessed asignal intensity of greater than 100 in any pair-wise comparison wereselected.

[0297] For data interpretation, the Cluster and Tree View software(available at http://rana.standford.edu/software) were used. First, thedata were imported into the cluster and tree view software intab-delimited format. A data set containing the expression patterns of311 regulated genes was clustered in two ways, based on the similarityof gene expression over the time course of 24 hours and based on thesimilarity between different time points. The clusters were observedusing Tree View program.

D. Northern Blot Analyses

[0298] For Northern blotting, 10 μg RNA was loaded on a 1.0%agarose-formaldehyde gel and run at 100 V for three to four hours. TheRNA was overnight transferred to a nylon membrane (Amersham LifeScience, Piscataway, N.J.) and cross-linked with a ultraviolet-Cradiation Stratalinker (Stratagene, LaJolla, Calif.). The probes forc-fos and IL-6 were synthesized using reverse transcription-PCR fromkeratinocyte RNA and the RT-PCR kit from Ambion, Austin, Tex. Additionalprobes were derived from cDNA clones obtained from ATCC. Each clone wassequenced from both 5′ and 3′ ends to confirm its identity. The ³²Plabeled probes were generated using [³²P] dCTP (3000 Ci/mmol Dupont NENand the Multiprime DNA labeling system (Amersham Pharmacia Biotech,Piscataway, N.J.) and purified using D-Salt Excellulose PlasticDesalting Columns (Pierce, Rockford, Ill.).

[0299] Hybridizations were performed using ExpressHyb solution(Clontech, Palo Alto, Calif.) at 68° C. for one hour. Membranes werewashed with 2× SSC, 0.05% SDS solution, with continuous shaking threetimes for 30 minutes at room temperature and with 0.1× SSC, 0.1% SDS at50° C. for 40 minutes. The membrane was exposed to Kodak (Toronto,Canada) BIOMAX MS film at −80° C., and radiographs were scanned andanalyzed with Multilmagine Light Cabinet Alphalmagine 2000 documentationand analysis system (Alpha Innotech Corp., San Leandro, Calif.). The RNAlevels were normalized to GAPDH mRNA.

E. Western Blot Analyses

[0300] For preparation of the whole cell lysates, cells were washed withcold phosphate buffered saline (PBS) and lysed in IPP buffer containing50 mM HEPES, pH 7.5, 150 mM NaCL, 1 mM EDTA, 1 mM EGTA, 10% glycerol, 1%triton X-100, 25 mM NaF, 10 mM ZnC12, 1 mM PMSF and 10 mg/ml leupeptin.The lysates were centrifuged at 1000× g, for three minutes at 4° C. Theprotein concentration of each sample was determined with Bio-Rad Proteinassay reagent. 50 μg of protein was loaded and separated on 10% or 20%SDS-polyacrylamide gel, transferred to Immobilon-P (polyvinylidenedifluoride) membrane using a semi-dry transfer cell (BioRad, Hercules,Calif.) and blocked in 5% BSA in TBST (50 mM Tris, pH 7.5, 150 mM NaCl,0.05% Tween 20). The membrane was incubated with primary antibodyovernight at 4° C. in 2.0% BSA in TBST, and then washed extensively withTBST, and incubated with 1:5000 anti-rabbit or anti-mouse horseradishperoxidase (HRP)-conjugated secondary antibodies (Amersham PharmaciaBiotech, Piscataway, N.J.). Proteins were visualized with the ECLdetection kit (Amersham Pharmacia Biotech, Piscataway, N.J.). Theequivalent loading of proteins in each well was ascertained usingPonceau staining of the membrane.

[0301] The primary antibody specific for Cox-2 protein was purchasedfrom Transduction Labs (Lexington, Ky.), for GRO-beta from LeincoTechnologies (St. Louis, Mo.), for Jun-D from Abcam (Cambridge, UK), forIL-8, C-MYC, MCL-1 and Cytochrome C from Research Diagnostics (Flanders,N.J.). The primary antibodies specific for Amphiregulin Ab-2, HDJ-2,Involucrin and AB-1 antibodies were purchased from NeoMarkers (Fremont,Calif.).

[0302] As demonstrated in FIG. 3, protein extracts were prepared fromirradiated keratinocytes and harvested at 0.5, 1, 2, 4, 8, 16, 24 hoursafter ultraviolet irradiation. These samples were screened withantibodies specific for the proteins c-Myc, c-jun, COX-2, involucrin,gro-β, and the LDL receptor. Antibody specific for JNK1 protein was usedas a control for gel loading. As demonstrated in FIG. 3, the expressionlevels for ultraviolet radiation-regulated proteins as identified byWestern blot analysis closely correlates with the results of theexpression analaysis provided herein.

[0303] Confirmation that the ultraviolet radiation-regulated genesidentified in the keratinocyte culture model system correlate with thein vivo response to ultraviolet radiation was obtained by examining theprotein expression level in a skin organ culture system. Organ cultureexplants of normal human skin were maintained in culture as previouslydescribed (Fisher, G J., et al., (1996) Nature 379, 335-339; and Varani,J., et al., (1993) American Journal of Pathology 142, 189-198). Briefly,pieces of normal human skin were obtained immediately after surgery, cutinto pieces approximately 5 mm3, and incubated in keratinocyte basalmedium (KBM) (Keratinocyte-SFM, Gibco-BRL, Gaithersburg, Md.) in ahumidified incubator at 37 oC. for 24 hours. Approximately 5 pieces oftissue were used per well (24-well culture dish) and enough medium wasadded to the well to just cover the explants. For ultraviolet radiationexposure, the media was removed from the well, and the explants wereexposed to 100 mJ/cm2 ultraviolet-B radiation. After exposure, theexplanted tissue was re-immersed in culture media.

[0304] In order to determine the level of protein expression betweencontrol non-ultraviolet radiation exposed and ultraviolet radiationexposed samples, the protein in the explanted tissue samples wasvisualized in situ by immunofluorescent staining. Briefly, at thedesired time point after ultraviolet radiation exposure, the explantedtissue samples were mounted in tissue Tec OCT compound (Sakura Finetek,Japan), frozen, and cut into sections 4 to 6 μm thick. The samplesmounted on slides and fixed with methanol/acetone for 10 min. Thesectioned samples were incubated overnight with mouse anti-involucrinantibody (NeoMarkers, Lab Vision Corporation, Fremont, Calif.) at 4 oC.,treated with peroxidase-conjugated anti-mouse IgG secondary antibody(Vecstatin ABC-mouse IgG kit from Vector Laboratories, Burlingame,Calif.) at room temperature for 1 hour, incubated with ABC complex(Vector Laboratories, Burlingame, Calif.) at room temperature for 1 hourand treated with 3,3′ -Diaminobenzidine-tetrahydrochloride (DojindoCorp., Japan) and 0.01% H202 in Tris pH 7.6 for 2 minutes. The sectionswere observed and photographed under the light microscope(Microphot-FXA, Nikon, Japan).

[0305] As demonstrated in FIG. 4, immunohistological stainingdemonstrates that ultraviolet radiation exposure enhances the expressionof involucrin in human skin organ culture at 2, 8 and 16 hours afterultraviolet radiation. Note that the suprabasal staining of theepidermis with the involucrin antibody is greatly augmented 16 hoursafter ultraviolet irradiation.

F. Array Data Analysis

[0306] Of the 7,080 entries, some 3,000 are scored as present inkeratinocytes at at least one time point, and approximately 1,400 arepresent at all time points. Among the entries, 308 are differentiallyregulated at least two-and one-half-fold at at least one time point.Judging 2.5-fold regulation to be significant, attention was focused onthese 308 genes. Specific attention was paid to genes represented bymultiple probes on the array, such as Jun-D, Tob, Cox-2 etc. Verysimilar patterns of regulation were observed for these multiple probesets, which provided further confidence in the fidelity of the resultinghybridizations (Table 1). Of the 308 genes, nine are both induced andsuppressed 2.5 fold or more at different time points. The remainderdivides about equally (152 versus 147) between the induced andsuppressed groups.

[0307] Using a clustering algorithm, data from seven time points weregrouped into three waves after ultraviolet radiation exposure (FIG. 2).Only a small portion of the genes analyzed is presented in this figure.The most closely related were the 0.5, one and two hour time points.These form the early wave of regulated genes. Also very similar were the16 and 24 hour time points, forming the late wave. The four and eighthour time points were more similar to each other than to the other timepoints and these formed the middle wave. Thus, the modification in geneexpression in the first 24 hours after ultraviolet radiation exposurecan conveniently be grouped into three “waves” of changes, the early orfirst response, from about 0.5 to about two hours, the intermediate orsecond response, from about four to about eight hours, and the late orthird response, from about 16 to about 24 hours.

[0308] Most of the regulated genes can be grouped by their function intoseveral distinct and clearly demarcated functional categories,including: (1) induced DNA metabolism and repair genes induced; (2)signal transducing proteins and transcription factors (the two largestcategories, which contain both induced and suppressed members at allexperimental time points); (3) structural proteins (most cytoskeletal,containing both induced and suppressed members); (4) secreted growthfactors, chemokines and cytokines (most strongly induced at intermediatetime points); and (5) mitochondrial proteins (a significant category ofproteins that are among the first induced). In addition, it was foundthat ultraviolet radiation regulates genes for proteins involved in thetranslation machinery, RNA processing, lipid, amino acid and ureametabolism, integral membrane, and cell surface proteins, proteases andtheir inhibitors, and proteins that could not be classified into thosecategories, as well as several unidentified ESTs.

Example 2 Identification of Gene and Protein Sequences Regulated byExposure to Ultraviolet-A Radiation A. Keratinocyte Culture andUltraviolet-A Radiation

[0309] Cultures of epidermal keratinocytes from human foreskin areinitiated using 3T3 feeder layers as described (Simon, et aL, (1984)Cell 36:827-834) and then stored frozen in liquid N₂. Once thawed, thekeratinocytes are grown without feeder cells in defined serum-freekeratinocyte growth medium (KGM) supplemented with 0.05 g/l bovinepituitary extract, 5 ng/ml epidermal growth factor, and 1%penicillin/streptomycin (KGM from Gibco-BRL, Rockville, Md.). Thekeratinocytes are maintained at 37° C., in 5% CO₂. The medium isreplaced every two days. The cells are expanded through three passagesfor the experiments. They are trypsinized with 0.025% trypsin, which isneutralized with 0.5 mg/ml trypsin inhibitor. Serum is avoided becauseit can promote keratinocyte differentiation. For all experiments,third-passage keratinocytes are used one day after reaching confluence.

[0310] For ultraviolet-A radiation, an illuminator specially equipped toproduce light output in the ultraviolet-A radiation wavelength range isused. For example, a Mutzhas Supersun 5000-type solar simulator(Mutzhas, Munich, Germany) is used by filtering for the emission ofultraviolet-A radiation (315 nm to 390 nm). The medium is removed fromthe cell cultures, and keratinocytes are irradiated in open dishes.Immediately after the ultraviolet-A radiation exposure, the same mediumis replaced to the cultures. Control cells are subjected to theidentical procedure but are only sham-irradiated.

[0311] The protocol is chosen for two reasons: first, confluentkeratinocytes more closely resemble skin than sub confluent ones; andsecond, nearly identical conditions from culture to culture are reliablyand reproducibly achieved. The dose of ultraviolet-A radiation exposureis optimized by treating keratinocyte cultures with increasing amountsof radiation, replacing the medium and determining the cell viability 24hours after the treatment. A dose of ultraviolet-A radiation is chosenso that at least 10%, but less that 20% of cells are killed byultraviolet-A radiation exposure.

[0312] Keratinocyte cultures are irradiated with a a single dose ofultraviolet-A radiation and harvested the cells 0.5, 1, 2, 4, 8, 16, and24 hours later. The specific wavelength of ultraviolet-A radiation isfrom about 315 nm to about 390 nm. As controls, mock-irradiated cellsare harvested 1, 4, 8, 16, and 24 hours after the treatment. The onehour mock-irradiated culture is then used as control for the 0.5, 1 and2 hour time points, while all the later time points have cognatecontrols.

B. Isolation of Total RNA and Probe Synthesis

[0313] Cells are harvested by scraping the culture dish. Kits fromQiagen, (Chatsworth, Calif.) are used to prepare the RNA according tothe manufacturer's protocols. Qiashredders are used to homogenize celllysates with centrifugation at 1800 g for 2 minutes. RNA is extractedusing RNeasy Midi Kit. DNA is removed with on-column DNAse digestionusing Qiagen RNAses-free DNAse Set.

[0314] After the total RNAs are prepared, but before they are used forgene array hybridization, the RNAs are tested in Northern blothybridizations with a probe corresponding to the c-fos gene.

[0315] For Northern blotting, 10 μg RNA is loaded on a 1.0%agarose-formaldehyde gel and run at 100 V for 3-4 hours. The RNA istransferred overnight to a nylon membrane (Amersham Life Science,Piscataway, N.J.) and cross-linked using a Stratalinker (Stratagene, LaJolla, Calif.). The probes for c-fos and IL-6 are synthesized usingreverse transcription-PCR from keratinocyte RNA and the RT-PCR kit fromAmbion (Austin, Tex.). Additional probes are derived from cDNA clonesobtained from the American Type Culture Collection (ATCC, Manassas,Va.). Each clone is sequenced from both 5′ and 3′ ends to confirm itsidentity. The ³²P labeled probes are generated using [³²P, dCTP (3000Ci/mmol) (Dupont NEN, Boston, Mass.) and the Multiprime DNA labelingsystem (Amersham Pharmacia Biotech, Piscataway, N.J.) and purified usingD-Salt Excellulose Plastic Desalting Columns (Pierce, Rockford, Ill.).

[0316] Hybridizations are performed using ExpressHyb solution (Clontech,Palo Alto, Calif.) at 68° C. for 1 hour. Membranes are ished with 2×SSC,0.05% SDS solution, with continuous shaking thouree times for 30 minutesat room temperature and with 0.1×SSC, 0.1% SDS at 50° C. for 40 minutes.The membrane is exposed to Kodak (Toronto, Canada) BIOMAX MS film at−80° C., and radiographs are scanned and analyzed with MultilmagineLight Cabinet Alphalmagine 2000 documentation and analysis system (AlphaInnotech Corporation, San Leandro, Calif.). The RNA levels arenormalized to glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA.

[0317] For the synthesis of probe for use with the gene array, eightmicrograms of total RNA are reverse transcribed, amplified and labeledas previously described (Mahadevappa et al. (1999) J.A. NatureBiotechnol. 17:1134-1136). As a result of the sequence of the primersused for reverse transcription, the resultant cDNA product contains anRNA polymerase promoter for use in the synthesis of cRNA probe to screenthe gene array.

C. Gene Array Hybridization

[0318] Labeled cRNA is hybridized to the HU6800 array (Affymetrix Inc.,Santa Clara, Calif.) under conditions recommended by the manufacturer.Arrays are ished, stained with anti-biotin streptavidin-phycoerythourinlabeled antibody and scanned using the GeneChip system (Hewlett-Packard,Miami, Fla.). GeneChip 3.0 software to determine the expression of eachgene. Intensity values are scaled by calculating the overall signal foreach array type.

[0319] Differential expression is determined by calculating the ratiobetween signal intensity value from ultraviolet radiation exposed cellsand control cells. To eliminate genes exhibiting potential falsepositive differential expression, only those genes that possessed asignal intensity of greater than 100 in any pair-wise comparison areselected.

[0320] For data interpretation, the Cluster and Tree View software(available at http://rana.standford.edu/software) are used. First, thedata are imported into the cluster and tree view software intab-delimited format. A data set containing the expression patterns of311 regulated genes is clustered in two ways, based on the similarity ofgene expression over the time course of 24 hours and based on thesimilarity between different time points. The clusters are observedusing Tree View program.

Equivalents

[0321] Those skilled in the art will recognize, or be able to ascertain,using no more than routine experimentation, many equivalents to thespecific embodiments of the invention described herein. Such equivalentsare intended to be encompasssed by the following claims.

What is claimed is:
 1. A screening method for the detection of acompound that modulates a response of a cell to ultraviolet radiationexposure, comprising: (a) contacting the cell with the compound; (b)exposing the cell to ultraviolet radiation that would otherwise inducethe response, the response being a pattern of expression comprising atleast one of the following: (i) a first response comprising alteredexpression of at least one nucleic acid molecule encoding atranscription factor protein, at least one nucleic acid moleculeencoding a signal transducing protein, and at least one nucleic acidmolecule encoding a mitochondrial protein; (ii) a second responsecomprising altered expression of at least one nucleic acid moleculeencoding a secreted growth factor, at least one nucleic acid moleculeencoding a cytokine, and at least one nucleic acid molecule encoding achemokine; and (iii) a third response comprising altered expression ofat least one nucleic acid molecule encoding an actin-binding protein, adesmosomal protein, and at least one nucleic acid molecule encoding atubulin protein; and (c) measuring the levels of a plurality of RNAmolecules in the cell for at least one time point after ultravioletradiation exposure, wherein a change in the altered expression of thefirst response, the second response and/or the third response indicatesthat the compound modulates the response of the cell to ultravioletradiation exposure.
 2. The method according to claim 1, wherein thepattern consists of the first response.
 3. The method according to claim1, wherein the pattern consists of the second response.
 4. The methodaccording to claim 1, wherein the pattern consists of the thirdresponse.
 5. The method according to claim 1, wherein in the patternconsists of the first and the second response.
 6. The method accordingto claim 1, wherein the pattern consists of the first response and thethird response.
 7. The method according to claim 1, wherein the patternconsists of the second response and the third response.
 8. The methodaccording to claim 1, wherein the pattern consists of the firstresponse, the second response, and the third response.
 9. The methodaccording to claim 1, wherein the cell is contacted with the compound invitro.
 10. The method according to claim 1, wherein the cell iscontacted with the compound in vivo.
 11. The method according to claim1, wherein the ultraviolet irradation exposure comprises energy at awavelength in the range of about 220 nm to about 440 nm.
 12. The methodaccording to claim 1, wherein the ultraviolet radiation exposurecomprises energy at a wavelength of about 290 nm to about 320 nm. 13.The method according to claim 11, wherein the ultraviolet radiationexposure comprises energy at a wavelength of about 320 nm to about 440nm.
 14. The method according to claim 1, wherein the ultravioletirradation exposure comprises a total energy exposure in the range ofabout 0.2 mJ/cm² to about 40 mJ/cm².
 15. The method according to claim1, wherein: (a) the nucleic acid molecule expressed in the firstresponse further comprises a nucleic acid molecule that is at least 90%identical to a nucleic acid molecule selected from the group consistingof: (i) M62831 Human transcription factor ETR101 mRNA, complete cds,(ii) X68277 H. sapiens CL 100 mRNA for protein tyrosine phosphatase,(iii) L04731 H. sapiens translocation T(4:11) of ALL-1 gene tochromosome 4, (iv) X56681 Human junD mRNA, (v) U20734 Humantranscription factor junB (junB) gene, 5′ region and complete cds, (vi)L38951 H. sapiens importin beta subunit mRNA, complete cds, (vii) D87071Human mRNA for KIAA0233 gene, complete cds, (viii) M72885 Human GOS2gene, 5′ flank and cds, (ix) M92843 H. sapiens zinc fingertranscriptional regulator mRNA, complete cds, (x) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, (xi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (xii) D86988Human mRNA for KIAA0221 gene, complete cds, (xiii) L19779 H. sapienshistone H2A.2 mRNA, complete cds, (xiv) U62317 Chromosome 22q13 BACClone CIT987SK-384D8 complete sequence, (xv) X04412 Human mRNA forplasma gelsolin, (xvi) L27706 Human chaperonin protein (Tcp20) genecomplete cds, (xvii) X61123 Human BTG1 mRNA, (xviii) M60974growth arrestand DNA-damage-inducible protein (gadd45) mRNA, complete cds, (xix)L19437 Human transaldolase mRNA containing transposable element,complete cds, (xx) X57985 H. sapiens genes for histones H2B.1 and H2A,(xxi) D90086 Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunitgene, exons 1-10, (xxii) M34182 Human testis-specific protein kinasegamma-subunit mRNA, complete cds, (xxiii) L16862 H. sapiens Gprotein-coupled receptor kinase (GRK6) mRNA, complete cds, (xxiv) D13705Human mRNA for fatty acids omega-hydroxylase (cytochrome P-450HKV),complete cd, (xxv) U37122 Human adducin gamma subunit mRNA, completecds, (xxvi) D45906 H. sapiens mRNA for LIMK-2, complete cds, (xxvii)U07664 Human HB9 homeobox gene, exons 2 and 3 and complete cds, (xxviii)D87438 Human mRNA for KIAA0251 gene, partial cds, (xxix) L37042 H.sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds,(xxx) D14043 Human mRNA for MGC-24, complete cds, (xxxi) D13988 Humanrab GDI mRNA, complete cds, (xxxii) U28480 Uncoupling Protein Uc,(xxxiii) D50840 H. sapiens mRNA for ceramide glucosyltransferase,complete cds, (xxxiv) M55265 Human casein kinase II alpha subunit mRNA,complete cds, (xxxv) M96803 Human general beta-spectrin (SPTBN1) mRNA,complete cds, (xxxvi) U89336 Human HLA class III region containingNOTCH4 gene, partial sequence, homeobox P, (xxxvii) D87442 Human mRNAfor KIAA0253 gene, partial cds, (xxxviii) J03161 Human serum responsefactor (SRF) mRNA, complete cds, (xxxix) D86965 Human mRNA for KIAA0210gene, complete cds, (xl) U17327 Human neuronal nitric oxide synthase(NOS1) mRNA, complete cds, (xli) D86966 Human mRNA for KIAA0211 gene,complete cds, (xlii) D85527 H. sapiens mRNA for LIM domain, partial cds,(xliii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (xliv) X59434 Human rohu mRNA forrhodanese, (xlv) M13929 Human c-myc-P64 mRNA, initiating from promoterP0, (HLmyc2.5) partial cds, and (xlvi) J05211 Desmoplakin; (b) thenucleic acid molecule expressed in the second response further comprisesa nucleic acid molecule that is at least 90% identical to a nucleic acidmolecule selected from the group consisting of: (i) M57731 Humangro-beta mRNA, complete cds, (ii) S81914 IEX-1=radiation-inducibleimmediate-early gene [human, placenta, mRNA Partial, 1, (iii) Y00787Human mRNA for MDNCF (monocyte-derived neutrophil chemotactic factor),(iv) X54489 Human gene for melanoma growth stimulatory activity (MGSA),(v) M72885 Human GOS2 gene, 5′ flank and cds, (vi) M62831 Humantranscription factor ETR101 mRNA, complete cds, (vii) M28130 Humaninterleukin 8 (IL8) gene, complete cds, (viii) X57985 H. sapiens genesfor histones H2B.1 and H2A, (ix) X53800 Human mRNA for macrophageinflammatory protein-2beta (MIP2beta), (x) L19779 H. sapiens histoneH2A.2 mRNA, complete cds, (xi) AF001294 H. sapiens IPL (IPL) mRNA,complete cds, (xii) X56681 Human junD mRNA, (xiii) S75762 OncogeneTls/Chop, Fusion Activate, (xiv) M84739 Human autoantigen calreticulinmRNA, complete cds, (xv) M21302 Human small proline rich protein (sprII)mRNA, clone 174N, (xvi) V00599 Tubulin, Bet, (xvii) X70326 Macmarck,(xviii) D10923 Human mRNA for HM74, (xix) D64142 Human mRNA for histoneH1x, complete cds, (xx) D86974 Human mRNA for KIAA0220 gene, partialcds, (xxi) M60974 Human growth arrest and DNA-damage-inducible protein(gadd45) mRNA, complete cds, (xxii) X68277 H. sapiens CL 100 mRNA forprotein tyrosine phosphatase, (xxiii) L13391 Human helix-loop-helixbasic phosphoprotein (GOS8) gene, complete cds, (xxiv) M31627 Human Xbox binding protein-1 (XBP-1) mRNA, complete cds, (xxv) U40369 Humanspermidine/spermine N1-acetyltransferase (SSAT) gene, complete cds,(xxvi) X52560 Nuclear Factor Nf-Il, (xxvii) X61123 Human BTG1 mRNA,(xxviii) U20734 Human transcription factor junB (junB) gene, 5′ regionand complete cds, (xxix) U35048 Human TSC-22 protein mRNA, complete cds,(xxx) M69043 H. sapiens MAD-3 mRNA encoding IkB-like activity, completecds, (xxxi) X51345 Human jun-B mRNA for JUN-B protein, (xxxii) S68616Na+/H+ exchanger NHE-1 isoform [human, heart, mRNA, 4516 nt], (xxxiii)X89750 H. sapiens mRNA for TGIF protein, (xxxiv) X69111 H. sapiens HLH1R21 mRNA for helix-loop-helix protein, (xxxv) U14603 Humanprotein-tyrosine phosphatase (HU-PP-1) mRNA, partial sequence, (xxxvi)X52541 Human mRNA for early growth response protein 1 (hEGR1), (xxxvii)D50683 H. sapiens mRNA for TGF-betaIIR alpha, complete cds, (xxxviii)M92843 H. sapiens zinc finger transcriptional regulator mRNA, completecds, (xxxix) X91247 H. sapiens mRNA for thioredoxin reductase, (xl)U05875 Human clone pSK1 interferon gamma receptor accessory factor-1(AF-1) mRNA, comp, (xli) L19314 Human HRY gene, complete cds, (xlii)M30703 Human amphiregulin (AR) gene, exon 6, clones lambda-ARH(6,12),(xliii) U34252 Human gamma-aminobutyraldehyde dehydrogenase mRNA,complete cds, (xliv) S78825 Id1, (xlv) D85429 H. sapiens gene for heatshock protein 40, complete cds, (xlvi) U41766 Humanmetalloprotease/disintegrin/cysteine-rich protein precursor (MDC9) mRNA,(xlvii) U89336 Human HLA class III region containing NOTCH4 gene,partial sequence, homeobox PB, (xlviii) M69181 Human nonmuscle myosinheavy chain-B (MYH10) mRNA, partial cds, (xlix) D15050 Human mRNA fortranscription factor AREB6, complete cds, (l) U28386 Human nuclearlocalization sequence receptor hSRP1alpha mRNA, complete cds, (li)L77886 Human protein tyrosine phosphatase mRNA, complete cds, (lii)X64330 H. sapiens mRNA for ATP-citrate lyase, (liii) U37122 Humanadducin gamma subunit mRNA, complete cds, (liv) X74008 H. sapiens mRNAfor protein phosphatase 1 gamma, (lv) U60205 Human methyl sterol oxidase(ERG25) mRNA, complete cds, (lvi) X76534 H. sapiens NMB mRNA, (lvii)D87071 Human mRNA for KIAA0233 gene, complete cds, (lviii) U90716 Humancell surface protein HCAR mRNA, complete cds, (lix) M91083 HumanDNA-binding protein (HRC1) mRNA, complete cds, (lx) U29607 Humanmethionine aminopeptidase mRNA, complete cds, (lxi) M76482 Human 130-kDpemphigus vulgaris antigen mRNA, complete cds, (lxii) U72066 H. sapiensCtBP interacting protein CtIP (CtIP) mRNA, complete cds, (lxiii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (lxiv) X12953Human rab2 mRNA, YPT1-related and member of ras family, (lxv) M60483Human protein phosphatase 2A catalytic subunit-alpha gene, complete cds,(lxvi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (lxvii) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (lxviii) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(lxix) D50840 H. sapiens mRNA for ceramide glucosyltransferase, completecds, (lxx) L31801 H. sapiens monocarboxylate transporter 1 (SLC16A1)mRNA, complete cds, (lxxi) S74017 Nrf2=NF-E2-like basic leucine zippertranscriptional activator [human, hemin-in, (lxxii) X87241 H. sapiensmRNA for hFat protein, (lxxiii) X52425 Human IL-4-R mRNA for theinterleukin 4 receptor, (lxxiv) D79994 Human mRNA for KIAA0172 gene,partial cds, (lxxv) M58286 H. sapiens tumor necrosis factor receptormRNA, complete cds, (lxxvi) M13829 Human putative raf related protein(pks/a-raf) mRNA, partial cds, (lxxvii) X78992 H. sapiens ERF-2 mRNA,(lxxviii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (lxxix) U88629 Human RNA polymeraseII elongation factor ELL2, complete cds, (lxxx) X52611 Human mRNA fortranscription factor AP-2, (lxxxi) U28749 Human high-mobility groupphosphoprotein isoform I-C (HMGIC) mRNA, complete cds, (lxxxii) L00058Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank, (lxxxiii)L26336 Heat Shock Protein, 70 Kda (Gb:Y00371, (lxxxiv) L08246 Humanmyeloid cell differentiation protein (MCL1) mRNA, (lxxxv) S73591brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic,leukemia cells (lxxxvi) J05211 Desmoplakin, (lxxxvii)L00352 Human low density lipoprotein receptor gene, exon 18, (lxxxviii)Y13647 Stearoyl-Coenzymea Desaturase, (lxxxix) X77794 H. sapiens mRNAfor cyclin G1, (xc) M90656 Human gamma-glutamylcysteine synthetase (GCS)mRNA, complete cds, (xci) M13929 Human c-myc-P64 mRNA, initiating frompromoter P0, (HLmyc2.5) partial cds, (xcii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (xciii) X80692 H. sapiens ERK3 mRNA,and (xciv) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114; and (c)the nucleic acid molecule expressed in the third response furthercomprises a nucleic acid molecule that is at least 90% identical to anucleic acid molecule selected from the group consisting of: (i) M20030Human small proline rich protein (sprII) mRNA, clone 930, (ii) X53065,(iii) M13903 Human involucrin gene, exon 2, (iv) M22918 Myosin, LightChain, Alkali, Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice, (v)L10343 Huma elafin gene, complete cds, (vi) M63573 Human secretedcyclophilin-like protein (SCYLP) mRNA, complete cds, (vii) M21302 Humansmall proline rich protein (sprII) mRNA, clone 174N, (viii) Y00787 HumanmRNA for MDNCF (monocyte-derived neutrophil chemotactic factor), (ix)X57985 H. sapiens genes for histones H2B.1 and H2A, (x) L05188 H.sapiens small proline-rich protein 2 (SPRR2B) gene, complete cds, (xi)X70326 Macmarcks, (xii) X67325 H. sapiens p27 mRNA, (xiii) L19779 H.sapiens histone H2A.2 mRNA, complete cds, (xiv) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, (xv) D45248 Human mRNA for proteasome activator hPA28subunit beta, complete cds, (xvi) Z22548 H. sapiens thiol-specificantioxidant protein mRNA, (xvii) M22918 Myosin, Light Chain, Alkali,Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice, (xviii) X06956Tubulin, Alpha 1, Isoform 44, (xix) V00594 Human mRNA formetallothionein from cadmium-treated cells, (xx) M80254 H. sapienscyclophilin isoform (hCyP3) mRNA, complete cds, (xxi) U04636 Humancyclooxygenase-2 (hCox-2) gene, complete cds, (xxii) Z14244 H. sapienscoxVIIb mRNA for cytochrome c oxidase subunit VIIb, (xxiii) X99920 H.sapiens mRNA for S100 calcium-binding protein A13, (xxiv) U62800 Humancystatin M (CST6) mRNA, complete cds, (xxv) L08069 Human heat shockprotein, E. coliDnaJ homologue mRNA, complete cds, (xxvi) L20688 HumanGDP-dissociation inhibitor protein (Ly-GDI) mRNA, complete cds, (xxvii)M13755 Human interferon-induced 17-kDa/15-kDa protein mRNA, completecds, (xxviii) M60278 Human heparin-binding EGF-like growth factor mRNA,complete cds, (xxix) AF001294 H. sapiens IPL (IPL) mRNA, complete cds,(xxx) X54489 Human gene for melanoma growth stimulatory activity (MGSA),(xxxi) M21186 Human neutrophil cytochrome b light chain p22 phagocyteb-cytochrome mRNA, compl, (xxxii) D42040 Human mRNA for KIAA9001 gene,complete cds, (xxxiii) V00599 Tubulin, Beta, (xxxiv) U37690 Human RNApolymerase II subunit (hsRPB10) mRNA, complete cds, (xxxv) M21005 Humanmigration inhibitory factor-related protein 8 (MRP8) gene, complete cds,(xxxvi) M37583 Human histone (H2A.Z) mRNA, complete cds, (xxxvii) Z49989H. sapiens mRNA for smoothelin, (xxxviii) L24564 Human Rad mRNA,complete cds, (xxxix) D49824 Human HLA-B null allele mRNA, (xl) M59465Human tumor necrosis factor alpha inducible protein A20 mRNA, completecds, (xli) S54005 thymosin beta-10 [human, metastatic melanoma cellline, mRNA, 453 nt], (xlii) Z49254 H. sapiens L23-related mRNA, (xliii)M22919 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629), SmoothMuscle, Alt. Spli, (xliv) U70660 Human copper transport protein HAH1(HAH1) mRNA, complete cds, (xlv) AF006084 H. sapiens Arp⅔ proteincomplex subunit p41-Arc (ARC41) mRNA, complete cds, (xlvi) X62083 H.sapiens mRNA for Drosophila female sterile homeotic (FSH) homologue,(xlvii) D86974 Human mRNA for KIAA0220 gene, partial cds, (xlviii)M72885 Human GOS2 gene, 5′ flank and cds, (xlix) S80437 fatty acidsynthase {3′ region} [human, breast and HepG2 cells, mRNA Partial, 22,(l) X04654 Human mRNA for U1 RNA-associated 70K protein, (li) t M26311Human cystic fibrosis antigen mRNA, complete cds, (lii) X14850 HumanH2A.X mRNA encoding histone H2A.X, (liii) M14328 Human alpha enolasemRNA, complete cds, (liv) U07919 Human aldehyde dehydrogenase 6 mRNA,complete cds, (lv) M28130 Human interleukin 8 (IL8) gene, complete cds,(lvi) Z21507 H. sapiens EF-1 delta gene encoding human elongationfactor-1-delta, (lvii) M92934 Human connective tissue growth factor,complete cds, (lviii) M27436 Human tissue factor gene, complete cds,with a Alu repetitive sequence in the 3′, (lix) X74874 H. sapiens genefor RNA pol II largest subunit, exon 1, (lx) X57351 Human 1-8D gene frominterferon-inducible gene family, (lxi) X52979 Human gene for smallnuclear ribonucleoproteins SmB and SmB′, (lxii) U41515 Human deleted insplit hand/split foot 1 (DSS1) mRNA, complete cds, (lxiii) D28235 HumanPTGS2 gene for prostaglandin endoperoxide synthase-2, complete cds,(lxiv) Y00503 Human mRNA for keratin
 19. (lxv) M57731 Human gro-betamRNA, complete cds, (lxvi) D50840 H. sapiens mRNA for ceramideglucosyltransferase, complete cds, (lxvii) U52101 Human YMP mRNA,complete cds. (lxviii) D13413 Human mRNA for tumor-associated 120 kDanuclear protein p120, partial cds(carbox, (lxix) L42379 H. sapiensbone-derived growth factor (BPGF-1) mRNA, complete cds, (lxx) X52426 H.sapiens mRNA for cytokeratin 13, (lxxi) J04456 Human 14 kd lectin mRNA,complete cds, (lxxii) S78771 NAT=CpG island-associated gene [human,mRNA, 1741 nt], (lxxiii) M26730 Human mitochondrial ubiquinone-bindingprotein (QP) gene, exon 4, (lxxiv) U26727 Human p16INK4/MTS1 mRNA,complete cds, (lxxv) X92896 H. sapiens mRNA for ITBA2 protein, (lxxvi)Z69043 H. sapiens mRNA translocon-associated protein delta subunitprecursor, (lxxvii) L76568 H. sapiens excision and cross link repairprotein (ERCC4) gene, complete genom, (lxxviii) M12125 Human fibroblastmuscle-type tropomyosin mRNA, complete cds, (lxxix) U09937 Humanurokinase-type plasminogen receptor, exon 7, (lxxx) X15822 Human COXVIIa-L mRNA for liver-specific cytochrome c oxidase (EC 1.9.3.1.),(lxxxi) M34516 Human omega light chain protein 14.1 (Ig lambda chainrelated) gene, exon 3, (lxxxii) U53830 H. sapiens interferon regulatoryfactor 7A mRNA, complete cds, (lxxxiii) X82693 H. sapiens mRNA for E48antigen, (lxxxiv) M58026 Human NB-1 mRNA, complete cds, (lxxxv) M90657Human tumor antigen (L6) mRNA, complete cds, (lxxxvi) X57579 H. sapiensactivin beta-A subunit (exon 2), (lxxxvii) D38251 Human mRNA for RPB5(XAP4), complete cds, (lxxxviii) D89667 H. sapiens mRNA for c-mycbinding protein, complete cds, (lxxxix) AB000584 H. sapiens mRNA forTGF-beta superfamily protein, complete cds, (xc) L76200 Human guanylatekinase (GUK1) mRNA, complete cds, (xci) J04794 Human aldehyde reductasemRNA, complete cds, (xcii) X52882 Human t-complex polypeptide 1 gene,(xciii) M79463 Human PML-2 mRNA, complete CDS, (xciv) Y09022 H. sapiensmRNA for Not56-like protein, (xcv) M12529 Human apolipoprotein E mRNA,complete cds, (xcvi) X71129 H. sapiens mRNA for electron transferflavoprotein beta subunit, (xcvii) X83416 H. sapiens PrP gene, exon 2,(xcviii) D89052 H. sapiens mRNA for proton-ATPase-like protein, completecds, (xcix) M60974 Human growth arrest and DNA-damage-inducible protein(gadd45) mRNA, complete cds, (c) M16364 Human creatine kinase-B mRNA,complete cds, (ci) D38305 Human mRNA for Tob, complete cds, (cii) X87679Major Histocompatibility Complex, Class I, E (Gb:M21533), (ciii) Z29505H. sapiens mRNA for nucleic acid binding protein sub2.3, (civ) K02574,(cv) U09813 Human mitochondrial ATP synthase subunit 9, P3 gene copy,mRNA, nuclear gene enc, (cvi) X67951 H. sapiens mRNA forproliferation-associated gene (pag), (cvii) J04611 Human lupus p70 (Ku)autoantigen protein mRNA, complete cds, (cviii) U09578 H. sapiens MAPKAPkinase (3pK) mRNA, complete cds, (cix) X53800 Human mRNA for macrophageinflammatory protein-2beta (MIP2beta), (cx) V00599 Tubulin, Beta 2,(cxi) U69126 Human FUSE binding protein 2 (FBP2) mRNA, partial cds,(cxii) X53416 Human mRNA for actin-binding protein (filamin) (ABP-280),(cxiii) U90546 Human butyrophilin (BTF4) mRNA, complete cds, (cxiv)M58459 Human ribosomal protein (RPS4Y) isoform mRNA, complete cds, (cxv)M19961 Human cytochrome c oxidase subunit Vb (coxVb) mRNA, complete cds,(cxvi) U65579 Human mitochondrial NADH dehydrogenase-ubiquinone Fe-Sprotein 8, 23 kDa subunit, (cxvii) X77794 H. sapiens mRNA for cyclin G1,(cxviii) M29064 Human hnRNP B1 protein mRNA, (cxix) D21853 Human mRNAfor KIAA0111 gene, complete cds, (cxx) X78687 H. sapiens G9 geneencoding sialidase, (cxxi) X15729 Human mRNA for nuclear p68 protein,(cxxii) X04828 Human mRNA for G(i) protein alpha-subunit (adenylatecyclase inhibiting GTP-bind, (cxxiii) L27943 H. sapiens cytidinedeaminase (CDA) mRNA, complete cds, (cxxiv) L40391 H. sapiens (clones153) mRNA fragment, (cxxv) D42123 H. sapiens mRNA for ESP1/CRP2,complete cds, (cxxvi) X74104 H. sapiens mRNA for TRAP beta subunit,(cxxvii) M84332 Human ADP-ribosylation factor 1 gene, exons 2-5,(cxxviii) L37127 H. sapiens RNA polymerase II mRNA, complete cds,(cxxix) M92843 H. sapiens zinc finger transcriptional regulator mRNA,complete cds, (cxxx) U07664 Human HB9 homeobox gene, exons 2 and 3 andcomplete cds, (cxxxi) JA8546 H. sapiens tuberin (TSC2) gene, exons 38,39, 40 and 41, (cxxxii) X53586 Human mRNA for integrin alpha 6,(cxxxiii) t D21852 Human mRNA for KIAA0029 gene, partial cds, (cxxxiv)L11066 Human mRNA sequence, (cxxxv) J04444 Human cytochrome c-1 gene,complete cds, (cxxxvi) M95787 Human 22 kDa smooth muscle protein (SM22)mRNA, complete cds, (cxxxvii) L07517 Mucin 6, Gastric (Gb:L07517),(cxxxviii) X91247 H. sapiens mRNA for thioredoxin reductase, (cxxxix)L11672 Human Kruppel related zinc finger protein (HTF10) mRNA, completecds, (cxl) U30999 Human (memc) mRNA, 3′UTR, (cxli) U01337 Human Ser/Thrprotein kinase (A-RAF- 1) gene, complete cds, (cxlii) U28480 UncouplingProtein Ucp, (cxliii) X12794 Human v-erbA related ear-2 gene, (cxliv)L22005 Human ubiquitin conjugating enzyme mRNA, partial cds, (cxlv)M12886 Human T-cell receptor active beta-chain mRNA, complete cds,(cxlvi) Y08915 H. sapiens mRNA for alpha 4 protein, (cxlvii) M24547Amyloid Beta (A4) Precursor Protein, Alt. Splice 2, A4(751), (cxlviii)X76717 H. sapiens MT-11 mRNA, (cxlix) M64347 Human novel growth factorreceptor mRNA, 3′ cds, (cl) X05409 Human RNA for mitochondrial aldehydedehydrogenase I ALDH I (EC 1.2.1.3), (cli) D87469 Human mRNA forKIAA0279 gene, partial cds, (clii) M58603 Human nuclear factor kappa-BDNA binding subunit (NF-kappa-B) mRNA, complete cds, (cliii) M76482Human 130-kD pemphigus vulgaris antigen mRNA, complete cds, (cliv)X06323 Human MRL3 mRNA for ribosomal protein L3 homologue (MRL3=mammalian ribosome L, (clv) X78992 H. sapiens ERF-2 mRNA, (clvi)L41351 H. sapiens prostasin mRNA, complete cds, (clvii) X75342 H.sapiens SHB mRNA, (clviii) U83115 Human non-lens beta gamma-crystallinlike protein (AIM1) mRNA, partial cds, (clix) U88629 Human RNApolymerase II elongation factor ELL2, complete cds, (clx) S78825 Id1,(clxi) U28811 Human cysteine-rich fibroblast growth factor receptor(CFR-1) mRNA, complete cds, (clxii) M58286 H. sapiens tumor necrosisfactor receptor mRNA, complete cds, (clxiii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (clxiv) D14874 H. sapiens mRNA foradrenomedullin precursor, complete cds, (clxv) Z26317 H. sapiens mRNAfor desmoglein 2, (clxvi) L19267 H. sapiens 59 protein mRNA, 3′ end,(clxvii) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114, (clxviii)U33821 Human tax1-binding protein TXBP151 mRNA, complete cds, (clxix)U52100 Human XMP mRNA, complete cds, (clxx) L31801 H. sapiensmonocarboxylate transporter 1 (SLC16A1) mRNA, complete cds, (clxxi)L00058 Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank,(clxxii) U52426 H. sapiens GOK (STIM1) mRNA, complete cds, (clxxiii)M80244 Human E16 mRNA, complete cds, (clxxiv) U56418 Humanlysophosphatidic acid acyltransferase-beta mRNA, complete cds, (clxxv)L38490 H. sapiens ADP-ribosylation factor mRNA, complete cds, (clxxvi)U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (clxxvii) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (clxxviii) M38258 Human retinoic acid receptor gamma 1mRNA, complete cds, (clxxix) X89750 H. sapiens mRNA for TGIF protein,(clxxx) D85429 H. sapiens gene for heat shock protein 40, complete cds,(clxxxi) J05211 Desmoplakin I, (clxxxii) M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds, (clxxxiii) X80695 H. sapiensOXA1Hs mRNA, (clxxxiv) M54915 Human h-pim-1 protein (h-pim-1) mRNA,complete cds, (clxxxv) D83777 Human mRNA for KIAA0193 gene, completecds, (clxxxvi) D31883 Human mRNA for KIAA0059 gene, complete cds,(clxxxvii) U00968 Human SREBP-1 mRNA, complete cds, (clxxxviii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (clxxxix)D86965 Human mRNA for KIAA0210 gene, complete cds, (cxc) Z30643 H.sapiens mRNA for chloride channel (putative) 2139 bp, (cxci) D14520Human mRNA for GC-Box binding protein BTEB2, complete cds, (cxcii)D87462 Human mRNA for KIAA0272 gene, partial cds, (cxciii) X80692 H.sapiens ERK3 mRNA, (cxciv) X90858 H. sapiens mRNA for uridinephosphorylase, (cxcv) M57763 Human ADP-ribosylation factor (hARF6) mRNA,complete cds, (cxcvi) X92720 H. sapiens mRNA for phosphoenolpyruvatecarboxykinase, (cxcvii) M81601 Human transcription elongation factor(SII) mRNA, complete cds, (cxcviii) X52611 Human mRNA for transcriptionfactor AP-2, (cxcix) U09587 Human glycyl-tRNA synthetase mRNA, completecds, (cc) U14550 Human sialyltransferase SThM (sthm) mRNA, complete cds,(cci) D90209 Human mRNA for DNA binding protein TAXREB67, (ccii) X77366H. sapiens HBZ17 mRNA, (cciii) X76534 H. sapiens NMB mRNA, (cciv) U37519Human aldehyde dehydrogenase (ALDH8) mRNA, complete cds, (ccv) M83667Human NF-IL6-beta protein mRNA, complete cds, (ccvi) U53347 Humanneutral amino acid transporter B mRNA, complete cds, (ccvii) L09229Human long-chain acyl-coenzyme A synthetase (FACL1) mRNA, complete cds,(ccviii) S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, (ccix) M13929 Human c-myc-P64 mRNA,initiating from promoter P0, (HLmyc2.5) partial cds, (ccx) M55268 Humancasein kinase II alpha′ subunit mRNA, complete cds, (ccxi) M77836 Humanpyrroline 5-carboxylate reductase mRNA, complete cds, (ccxii)HG2724-HT2820_at S75762 Oncogene Tls/Chop, Fusion Activated, (ccxiii)U72066 H. sapiens CtBP interacting protein CtIP (CtIP) mRNA, completecds, (ccxiv) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (ccxv) M27396 Human asparaginesynthetase mRNA, complete cds, (ccxvi) X01630 Human mRNA forargininosuccinate synthetase, (ccxvii) D32050 Human mRNA for alanyl-tRNAsynthetase, complete cds, (ccxviii) M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, (ccxix) J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,and (ccxx) X69111 H. sapiens HLH 1R21 mRNA.
 16. The method according toclaim 1, wherein the cell is an epidermal cell.
 17. The method accordingto claim 1, wherein the cell is selected from the group consisting of akeratinocyte, a Langerhans cell, a melanocyte, and a fibroblast cell.18. The method according to claim 1, wherein the RNA is isolated at atime point between about 0.5 to about 2 hours post-ultraviolet radiationexposure.
 19. The method according to claim 1, wherein the RNA isisolated at a time point between about 4 to about 8 hourspost-ultraviolet radiation exposure.
 20. The method according to claim1, wherein the RNA is isolated at a time point between about 16 to about24 hours post-ultraviolet radiation exposure.
 21. The method accordingto claim 1, wherein the levels of the plurality of RNAs are measured byan expression array analysis comprising: (a) isolating RNA from the cellat a time point between about 0.5 hours to about 24 hourspost-ultraviolet radiation exposure, (b) creating a test expressionarray through nucleic acid hybridization between a labeled probecomplementary to the RNA and an expression array substrate; (c)analyzing the test expression array to create a test expression arraydata set; and (d) comparing the test expression array data set to acontrol expression array data set to identity alterations in theexpression level.
 22. The method according to claim 10, wherein thecontact is topical contact.
 23. The screening method according to claim1, wherein the compound modulates the response by inhibiting ultravioletradiation-induced RNA expression.
 24. The method according to claim 23,wherein the compound inhibits at least one nucleic acid molecule inducedin the first response, the second response, or the third response thatis at least 90% identical to a polynucleotide selected from the groupconsisting of: (i) M20030 Human small proline rich protein (sprII) mRNA,clone 930, (ii) X53065, (iii) M13903 Human involucrin gene, exon 2, (iv)L10343 Huma elafin gene, complete cds, (v) M21302 Human small prolinerich protein (sprII) mRNA, clone 174N, (vi) L05188 H. sapiens smallproline-rich protein 2 (SPRR2B) gene, complete cds, (vii) Y00787 HumanmRNA for MDNCF (monocyte-derived neutrophil chemotactic factor), (viii)D50840 H. sapiens mRNA for ceramide glucosyltransferase, complete cds,(ix) M22918 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629),Non-Muscle, Alt. Splice, (x) X70326 Macmarcks, (xi) X52426 H. sapiensmRNA for cytokeratin 13, (xii) S81914 IEX-1=radiation-inducibleimmediate-early gene [human, placenta, mRNA Partial, 1, (xiii) M80254 H.sapiens cyclophilin isoform (hCyP3) mRNA, complete cds, (xiv) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(xv) U62800 Human cystatin M (CST6) mRNA, complete cds, (xvi) L24564Human Rad mRNA, complete cds, (xvii) M59465 Human tumor necrosis factoralpha inducible protein A20 mRNA, complete cds, (xviii) Z49989 H.sapiens mRNA for smoothelin, (xix) X57985 H. sapiens genes for histonesH2B.1 and H2A, (xx) L19779 H. sapiens histone H2A.2 mRNA, complete cds,(xxi) D42040 Human mRNA for KIAA9001 gene, complete cds, (xxii) M63573Human secreted cyclophilin-like protein (SCYLP) mRNA, complete cds,(xxiii) X54489 Human gene for melanoma growth stimulatory activity(MGSA), (xxiv) M92934 Human connective tissue growth factor, completecds, (xxv) Z14244 H. sapiens coxVIIb mRNA for cytochrome c oxidasesubunit VIIb, (xxvi) M60278 Human heparin-binding EGF-like growth factormRNA, complete cds, (xxvii) M72885 Human GOS2 gene, 5′ flank and cds,(xxviii) X62083 H. sapiens mRNA for Drosophila female sterile homeotic(FSH) homologue, (xxix) X67325 H. sapiens p27 mRNA, (xxx) U04636 Humancyclooxygenase-2 (hCox-2) gene, complete cds, (xxxi) M26311 Human cysticfibrosis antigen mRNA, complete cds, (xxxii) L20688 HumanGDP-dissociation inhibitor protein (Ly-GDI) mRNA, complete cds, (xxxiii)M27436 Human tissue factor gene, complete cds, with a Alu repetitivesequence in the 3′, (xxxiv) AF001294 H. sapiens IPL (IPL) mRNA, completecds, (xxxv) M22918 Myosin, Light Chain, Alkali, Smooth Muscle(Gb:U02629), Non-Muscle, Alt. Splice, (xxxvi) X74874 H. sapiens gene forRNA pol II largest subunit, exon 1, (xxxvii) M22919 Myosin, Light Chain,Alkali, Smooth Muscle (Gb:U02629), Smooth Muscle, Alt. Spli, (xxxviii)V00594 Human mRNA for metallothionein from cadmium-treated cells,(xxxix) V00599 Tubulin, Beta, (xl) X99920 H. sapiens mRNA for S100calcium-binding protein A13, (xli) M21005 Human migration inhibitoryfactor-related protein 8 (MRP8) gene, complete cds, (xlii) U07919 Humanaldehyde dehydrogenase 6 mRNA, complete cds, (xliii) M37583 Humanhistone (H2A.Z) mRNA, complete cds, (xliv) S54005 thymosin beta-10[human, metastatic melanoma cell line, mRNA, 453 nt], (xlv) D49824 HumanHLA-B null allele mRNA, (xlvi) S78771 NAT=CpG island-associated gene[human, mRNA, 1741 nt], (xlvii) M90657 Human tumor antigen (L6) mRNA,complete cds, (xlviii) U09937 Human urokinase-type plasminogen receptor,exon 7, (xlix) X77794 H. sapiens mRNA for cyclin G1, (l) M28130 Humaninterleukin 8 (IL8) gene, complete cds, (li) X14850 Human H2A.X mRNAencoding histone H2A.X, (lii) AB000584 H. sapiens mRNA for TGF-betasuperfamily protein, complete cds, (liii) U52101 Human YMP mRNA,complete cds, (liv) M57731 Human gro-beta mRNA, complete cds, (lv)D45248 Human mRNA for proteasome activator hPA28 subunit beta, completecds, (lvi) X83416 H. sapiens PrP gene, exon 2, (lvii) X52882 Humant-complex polypeptide 1 gene, (lviii) X57351 Human 1-8D gene frominterferon-inducible gene family, (lix) X53800 Human mRNA for macrophageinflammatory protein-2beta (MIP2beta), (lx) Z69043 H. sapiens mRNAtranslocon-associated protein delta subunit precursor, (lxi) D38305Human mRNA for Tob, complete cds, (lxii) t X52979 Human gene for smallnuclear ribonucleoproteins SmB and SmB′, (lxiii) S80437 fatty acidsynthase {3′ region} [human, breast and HepG2 cells, mRNA Partial, 22,(lxiv) X87679 Major Histocompatibility Complex, Class I, E (Gb:M21533),(lxv) Z29505 H. sapiens mRNA for nucleic acid binding protein sub2.3,(lxvi) D21853 Human mRNA for KIAA0111 gene, complete cds, (lxvii) X78687H. sapiens G9 gene encoding sialidase, (lxviii) M13755 Humaninterferon-induced 17-kDa/15-kDa protein mRNA, complete cds, (lxix)M21186 Human neutrophil cytochrome b light chain p22 phagocyteb-cytochrome mRNA, compl, (lxx) 8235_s_at D28235 Human PTGS2 gene forprostaglandin endoperoxide synthase-2, complete cds, (Lxxi) M14328 Humanalpha enolase mRNA, complete cds, (lxxii) V00599 Tubulin, Beta 2,(lxxiii) U90546 Human butyrophilin (BTF4) mRNA, complete cds, (lxxiv)K02574, (lxxv) X15729 Human mRNA for nuclear p68 protein, (lxxvi) D89052H. sapiens mRNA for proton-ATPase-like protein, complete cds, (lxxvii)M60974 Human growth arrest and DNA-damage-inducible protein (gadd45)mRNA, complete cds, (lxxviii) X06956 Tubulin, Alpha 1, Isoform 44,(lxxix) X04654 Human mRNA for U1 RNA-associated 70K protein, (lxxx)M79463 Human PML-2 mRNA, complete CDS, (lxxxi) L76568 H. sapiensexcision and cross link repair protein (ERCC4) gene, complete genom,(lxxxii) Y09022 H. sapiens mRNA for Not56-like protein, (lxxxiii) X57579H. sapiens activin beta-A subunit (exon 2), (lxxxiv) 37690 Human RNApolymerase II subunit (hsRPB10) mRNA, complete cds, (lxxxv) X61123 HumanBTG1 mRNA, (lxxxvi) J04456 Human 14 kd lectin mRNA, complete cds,(lxxxvii) Z49254 H. sapiens L23-related mRNA, (lxxxviii) U70660 Humancopper transport protein HAH1 (HAH1) mRNA, complete cds, (lxxxix) D86974Human mRNA for KIAA0220 gene, partial cds, (xc) AF006084 H. sapiens Arp⅔protein complex subunit p41-Arc (ARC41) mRNA, complete cds, (xci) Y00503Human mRNA for keratin 19, (xcii) M62831 Human transcription factorETR101 mRNA, complete cds, (xciii) Z22548 H. sapiens thiol-specificantioxidant protein mRNA, (xciv) U40369 Human spermidine/spermineN1-acetyltransferase (SSAT) gene, complete cds, (xcv) M12125 Humanfibroblast muscle-type tropomyosin mRNA, complete cds, (xcvi) X51345Human jun-B mRNA for JUN-B protein, (xcvii) Z21507 H. sapiens EF-1deltagene encoding human elongation factor-1-delta, (xcviii) U20734 Humantranscription factor junB (junB) gene, 5′ region and complete cds,(xcix) D13413 Human mRNA for tumor-associated 120 kDa nuclear proteinp120, partial cds(carbox, (c) L42379 H. sapiens bone-derived growthfactor (BPGF-1) mRNA, complete cds, (ci) X15822 Human COX VIIa-L mRNAfor liver-specific cytochrome c oxidase (EC 1.9.3.1.), (cii) D86988Human mRNA for KIAA0221 gene, complete cds. (ciii) M26730 Humanmitochondrial ubiquinone-binding protein (QP) gene, exon 4, (civ) M69043H. sapiens MAD-3 mRNA encoding IkB-like activity, complete cds, (cv)D38251 Human mRNA for RPB5 (XAP4), complete cds, (cvi) L76200 Humanguanylate kinase (GUK1) mRNA, complete cds, (cvii) M34516 Human omegalight chain protein 14.1 (Ig lambda chain related) gene, exon 3, (cviii)U26727 Human p16INK4/MTS1 mRNA, complete cds, (cix) U53830 H. sapiensinterferon regulatory factor 7A mRNA, complete cds, (cx) M22960 Humanprotective protein mRNA, complete cds, (cxi) D89667 H. sapiens mRNA forc-myc binding protein, complete cds, (cxii) M19309 Human slow skeletalmuscle troponin T mRNA, clone H22h, (cxiii) D64142 Human mRNA forhistone H1x, complete cds, (cxiv) U41515 Human deleted in splithand/split foot 1 (DSS1) mRNA, complete cds, (cxv) J04611 Human lupusp70 (Ku) autoantigen protein mRNA, complete cds, (cxvi) U35048 HumanTSC-22 protein mRNA, complete cds, (cxvii) X82693 H. sapiens mRNA forE48 antigen, (cxviii) M92843 H. sapiens zinc finger transcriptionalregulator mRNA, complete cds, (cxix) U72649 Human BTG2 (BTG2) mRNA,complete cds, (cxx) X92896 H. sapiens mRNA for ITBA2 protein. (cxxi)D10923 Human mRNA for HM74, (cxxii) M84739 Human autoantigencalreticulin mRNA, complete cds, (cxxiii) U09813 Human mitochondrial ATPsynthase subunit 9, P3 gene copy, mRNA, nuclear gene enc, (cxxiv) X67951H. sapiens mRNA for proliferation-associated gene (pag), (cxxv) L27706Human chaperonin protein (Tcp20) gene complete cds, (cxxvi) U69126 HumanFUSE binding protein 2 (FBP2) mRNA, partial cds, (cxxvii) M12529 Humanapolipoprotein E mRNA, complete cds, (cxxviii) X71129 H. sapiens mRNAfor electron transfer flavoprotein beta subunit, (cxxix) U13991 HumanTATA-binding protein associated factor 30 kDa subunit (tafII30) mRNA,comp, (cxxx) J04794 Human aldehyde reductase mRNA, complete cds, (cxxxi)U51586 Human siah binding protein 1 (SiahBP1) mRNA, partial cds,(cxxxii) M58026 Human NB-1 mRNA, complete cds, (cxxxiii) X68277 H.sapiens CL 100 mRNA for protein tyrosine phosphatase, (cxxxiv) X56681Human junD mRNA, (cxxxv) V01512 Human cellular oncogene c-fos (completesequence), (cxxxvi) U09578 H. sapiens MAPKAP kinase (3pK) mRNA, completecds, (cxxxvii) L13391 Human helix-loop-helix basic phosphoprotein (GOS8)gene, complete cds, (cxxxviii) U62317 Chromosome 22q13 BAC CloneCIT987SK-384D8 complete sequence, (cxxxix) M16364 Human creatinekinase-B mRNA, complete cds, (cxl) L19437 Human transaldolase mRNAcontaining transposable element, complete cds, (cxli) X53416 Human mRNAfor actin-binding protein (filamin) (ABP-280), (cxlii) X52560 NuclearFactor Nf-I16, (cxliii) M58459 Human ribosomal protein (RPS4Y) isoformmRNA, complete cds, (cxliv) U65579 Human mitochondrial NADHdehydrogenase-ubiquinone Fe-S protein 8, 23 kDa subunit, (cxlv) M19961Human cytochrome c oxidase subunit Vb (cox Vb) mRNA, complete cds,(cxlvi) M29064 Human hnRNP B1 protein mRNA, (cxlvii) D90086 Humanpyruvate dehydrogenase (EC 1.2.4.1) beta subunit gene, exons 1-10,(cxlviii) L04731 H. sapiens translocation T(4:11) of ALL-1 gene tochromosome 4, (cxlix) D87071 Human mRNA for KIAA0233 gene, complete cds,(cl) X04412 Human mRNA for plasma gelsolin, (cli) L27943 H. sapienscytidine deaminase (CDA) mRNA, complete cds, (clii) U68142 HumanRalGDS-like 2 (RGL2) mRNA, partial cds, (cliii) U63825 Human hepatitisdelta antigen interacting protein A (dipA) mRNA, complete cds, (cliv)X04828 Human mRNA for G(i) protein alpha-subunit (adenylate cyclaseinhibiting GTP-bind, (clv) L38951 H. sapiens importin beta subunit mRNA,complete cds, (clvi) M31627 Human X box binding protein-1 (XBP-1) mRNA,complete cds, (clvii) J04444 Human cytochrome c-1 gene, complete cds,(clviii) S75762 Oncogene Tls/Chop, Fusion Activated.
 25. The screeningmethod according to claim 1, wherein the compound modulates the responseby inhibiting ultraviolet radiation-repressed RNA expression.
 26. Themethod according to claim 25, wherein the compound inhibits at least onenucleic acid molecule repressed in the first response, the secondresponse, or the third response that is at least 90% identical to apolynucleotide selected from the group consisting of: (i) D50840 H.sapiens mRNA for ceramide glucosyltransferase, complete cds, (ii) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(iii) X77794 H. sapiens mRNA for cyclin G1, (iv) D89052 H. sapiens mRNAfor proton-ATPase-like protein, complete cds, (v) L26336 Heat ShockProtein, 70 Kda (Gb:Y00371), (vi) M30703 Human amphiregulin (AR) gene,exon 6, clones lambda-ARH(6,12), (vii) L16862 H. sapiens Gprotein-coupled receptor kinase (GRK6) mRNA, complete cds, (viii) M92843H. sapiens zinc finger transcriptional regulator mRNA, complete cds,(ix) U72649 Human BTG2 (BTG2) mRNA, complete cds, (x) X74104 H. sapiensmRNA for TRAP beta subunit, (xi) M84332 Human ADP-ribosylation factor 1gene, exons 2-5, (xii) D15050 Human mRNA for transcription factor AREB6,complete cds, (xiii) U28386 Human nuclear localization sequence receptorhSRP1alpha mRNA, complete cds, (xiv) U41766 Humanmetalloprotease/disintegrin/cysteine-rich protein- precursor (MDC9)mRNA, c, (xv) AF006041 H. sapiens Fas-binding protein (DAXX) mRNA,partial cds, (xvi) U28749 Human high-mobility group phosphoproteinisoform I-C (HMGIC) mRNA, complete cds, (xvii) M60483 Human proteinphosphatase 2A catalytic subunit-alpha gene, complete cds, (xviii)U07664 Human HB9 homeobox gene, exons 2 and 3 and complete cds, (xix)X52425 Human IL-4-R mRNA for the interleukin 4 receptor, (xx) X94563 H.sapiens dbi/acbp gene exon 1 &2, (xxi) L11066 Human mRNA sequence,(xxii) X74008 H. sapiens mRNA for protein phosphatase 1 gamma, (xxiii)X87241 H. sapiens mRNA for hFat protein, (xxiv) S68616 Na+/H+ exchangerNHE-1 isoform [human, heart, mRNA, 4516 nt], (xxv) D13705 Human mRNA forfatty acids omega-hydroxylase (cytochrome P-450HKV), complete cds,(xxvi) D86966 Human mRNA for KIAA0211 gene, complete cds, (xxvii) U17327Human neuronal nitric oxide synthase (NOS1) mRNA, complete cds, (xxviii)U89336 Human HLA class III region containing NOTCH4 gene, partialsequence, homeobox PB, (xxix) D85527 H. sapiens mRNA for LIM domain,partial cds, (xxx) L07517 Mucin 6, Gastric (Gb:L07517), (xxxi) X64330 H.sapiens mRNA for ATP-citrate lyase, (xxxii) X89267 H. sapiens DNA foruroporphyrinogen decarboxylase gene, (xxxiii) X91247 H. sapiens mRNA forthioredoxin reductase, (xxxiv) L11672 Human Kruppel related zinc fingerprotein (HTF10) mRNA, complete cds, (xxxv) X78992 H. sapiens ERF-2 mRNA,(xxxvi) L19314 Human HRY gene, complete cds, (xxxvii) X12794 Humanv-erbA related ear-2 gene, (xxxviii) L22005 Human ubiquitin conjugatingenzyme mRNA, partial cds, (xxxix) U01337 Human Ser/Thr protein kinase(A-RAF-1) gene, complete cds. (xl) M34182 Human testis-specific proteinkinase gamma-subunit mRNA, complete cds, (xli) L08246 Human myeloid celldifferentiation protein (MCL1) mRNA, (xlii) L37042 H. sapiens caseinkinase I alpha isoform (CSNK1A1) mRNA, complete cds, (xliii) D87071Human mRNA for KIAA0233 gene, complete cds, (xliv) S74017Nrf2=NF-E2-like basic leucine zipper transcriptional activator [human,hemin-ind, (xlv) L41351 H. sapiens prostasin mRNA, complete cds, (xlvi)L00352 Human low density lipoprotein receptor gene, exon 18, (xlvii)D50683 H. sapiens mRNA for TGF-betaIIR alpha, complete cds, (xlviii)X89750 H. sapiens mRNA for TGIF protein, (xlix) t D13988 Human rab GDImRNA, complete cds, (l) M12886 Human T-cell receptor active beta-chainmRNA, complete cds, (li) M55265 Human casein kinase II alpha subunitmRNA, complete cds, (lii) J03161 Human serum response factor (SRF) mRNA,complete cds, (liii) M58286 H. sapiens tumor necrosis factor receptormRNA, complete cds, (liv) U88629 Human RNA polymerase II elongationfactor ELL2, complete cds, (lv) U90716 Human cell surface protein HCARmRNA, complete cds, (lvi) M24547 Amyloid Beta (A4) Precursor Protein,Alt. Splice 2, A4(751), (lvii) U05875 Human clone pSK1 interferon gammareceptor accessory factor-1 (AF-1) mRNA, compl, (lviii) M58603 Humannuclear factor kappa-B DNA binding subunit (NF-kappa-B) mRNA, completecds, (lix) D87442 Human mRNA for KIAA0253 gene, partial cds, (lx) M76482Human 130-kD pemphigus vulgaris antigen mRNA, complete cds, (lxi) U56418Human lysophosphatidic acid acyltransferase-beta mRNA, complete cds,(lxii) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114, (lxiii)U88898 Human endogenous retroviral H protease/integrase-derived ORF1mRNA, complete cds, (lxiv) M91083 Human DNA-binding protein (HRC1) mRNA,complete cds, (lxv) Z30643 H. sapiens mRNA for chloride channel(putative) 2139 bp, (lxvi) X12953 Human rab2 mRNA, YPT1-related andmember of ras family, (lxvii) D78129 H. sapiens mRNA for squaleneepoxidase, partial cds, (lxviii) S78825 Id1, (lxix) M54915 Human h-pim-1protein (h-pim-1) mRNA, complete cds, (lxx) X06323 Human MRL3 mRNA forribosomal protein L3 homologue (MRL3=mammalian ribosome L, (lxxi) D14043Human mRNA for MGC-24, complete cds, (lxxii) U34252 Humangamma-aminobutyraldehyde dehydrogenase mRNA, complete cds, (lxxiii)M13829 Human putative raf related protein (pks/a-raf) mRNA, partial cds,(lxxiv) U33821 Human tax1-binding protein TXBP151 mRNA, complete cds,(lxxv) U66616 Human SWI/SNF complex 170 KDa subunit (BAF170) mRNA,complete cds, (lxxvi) U29607 Human methionine aminopeptidase mRNA,complete cds, (lxxvii) D14520 Human mRNA for GC-Box binding proteinBTEB2, complete cds, (lxxviii) D14874 H. sapiens mRNA for adrenomedullinprecursor, complete cds, (lxxix) D85429 H. sapiens gene for heat shockprotein 40, complete cds, (lxxx) t M69181 Human nonmuscle myosin heavychain-B (MYH10) mRNA, partial cds, (lxxxi) U60205 Human methyl steroloxidase (ERG25) mRNA, complete cds, (lxxxii) X75342 H. sapiens SHB mRNA,(lxxxiii) t D45906 H. sapiens mRNA for LIMK-2, complete cds, (lxxxiv)X59434 Human rohu mRNA for rhodanese, (lxxxv) M96803 Human generalbeta-spectrin (SPTBN1) mRNA, complete cds, (lxxxvi) D79994 Human mRNAfor KIAA0172 gene, partial cds, (lxxxvii) D86965 Human mRNA for KIAA0210gene, complete cds, (lxxxviii) Y13647 Stearoyl-Coenzymea Desaturase,(lxxxix) X52541 Human mRNA for early growth response protein 1 (hEGR1),(xc) Z26317 H. sapiens mRNA for desmoglein 2, (xci) t M57763 HumanADP-ribosylation factor (hARF6) mRNA, complete cds, (xcii) L38490 H.sapiens ADP-ribosylation factor mRNA, complete cds, (xciii) D87438 HumanmRNA for KIAA0251 gene, partial cds, (xciv) M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds, (xcv) X80692 H. sapiens ERK3 mRNA,(xcvi) U37122 Human adducin gamma subunit mRNA, complete cds, (xcvii)M83667 Human NF-IL6-beta protein mRNA, complete cds, (xcviii) J05211Desmoplakin I, (xcix) D42123 H. sapiens mRNA for ESP1/CRP2, completecds, (c) X90858 H. sapiens mRNA for uridine phosphorylase, (ci) X76717H. sapiens MT-11 mRNA, (cii) Y08915 H. sapiens mRNA for alpha 4 protein,(ciii) U30999 Human (memc) mRNA, 3′UTR, (civ) L77886 Human proteintyrosine phosphatase mRNA, complete cds, (cv) U14603 Humanprotein-tyrosine phosphatase (HU-PP-1) mRNA, partial sequence, (cvi)U28480 Uncoupling Protein Ucp, (cvii) X53586 Human mRNA for integrinalpha6, (cviii) M64347 Human novel growth factor receptor mRNA, 3′ cds,(cix) U52100 Human XMP mRNA, complete cds, (cx) D21852 Human mRNA forKIAA0029 gene, partial cds, (cxi) X05409 Human RNA for mitochondrialaldehyde dehydrogenase I ALDH I (EC 1.2.1.3), (cxii) D87462 Human mRNAfor KIAA0272 gene, partial cds, (cxiii) L40391 H. sapiens (clone s153)mRNA fragment, (cxiv) D87469 Human mRNA for KIAA0279 gene, partial cds,(cxv) S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, (cxvi) L19267 H. sapiens 59 protein mRNA,3′ end, (cxvii) M81601 Human transcription elongation factor (SII) mRNA,complete cds, (cxviii) X52611 Human mRNA for transcription factor AP-2,(cxix) U28811 Human cysteine-rich fibroblast growth factor receptor(CFR-1) mRNA, complete cds, (cxx) L31801 H. sapiens monocarboxylatetransporter 1 (SLC16A1) mRNA, complete cds, (cxxi) M13929 Humanc-myc-P64 mRNA, initiating from promoter P0, (HLmyc2.5) partial cds,(cxxii) L48546 H. sapiens tuberin (TSC2) gene, exons 38, 39, 40 and 41,(cxxiii) L00058 Human (GH) germline c-myc proto-oncogene, exon 3 and 3′flank, (cxxiv) U09587 Human glycyl-tRNA synthetase mRNA, complete cds,(cxxv) L37127 H. sapiens RNA polymerase II mRNA, complete cds, (cxxvi)U52426 H. sapiens GOK (STIM1) mRNA, complete cds, (cxxvii) U72066 H.sapiens CtBP interacting protein CtIP (CtIP) mRNA, complete cds,(cxxviii) U83115 Human non-lens beta gamma-crystallin like protein(AIM1) mRNA, partial cds, (cxxix) M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, (cxxx) D90209 Human mRNA for DNAbinding protein TAXREB67, (cxxxi) D83777 Human mRNA for KIAA0193 gene,complete cds, (cxxxii) U42031 Human 54 kDa progesteronereceptor-associated immunophilin FKBP54 mRNA, partial, (cxxxiii) M80244Human E16 mRNA, complete cds, (cxxxiv) D31883 Human mRNA for KIAA0059gene, complete cds, (cxxxv) J04444 Human cytochrome c-1 gene, completecds, (cxxxvi) M38258 Human retinoic acid receptor gamma 1 mRNA, completecds, (cxxxvii) M95787 Human 22 kDa smooth muscle protein (SM22) mRNA,complete cds, (cxxxviii) U00968 Human SREBP-1 mRNA, complete cds,(cxxxix) K03195 Human (HepG2) glucose transporter gene mRNA, completecds, (cxl) X92720 H. sapiens mRNA for phosphoenolpyruvate carboxykinase,(cxli) X77366 H. sapiens HBZ17 mRNA, (cxlii) U53347 Human neutral aminoacid transporter B mRNA, complete cds, (cxliii) X80695 H. sapiens OXA1HsmRNA, (cxliv) J04102 Human erythroblastosis virus oncogene homolog 2(ets-2) mRNA, complete cds, (cxlv) S75762 Oncogene Tls/Chop, FusionActivated, (cxlvi) U14550 Human sialyltransferase SThM (sthm) mRNA,complete cds, (cxlvii) L09229 Human long-chain acyl-coenzyme Asynthetase (FACL1) mRNA, complete cds, (cxlviii) X76534 H. sapiens NMBmRNA, (cxlix) M55268 Human casein kinase II alpha′ subunit mRNA,complete cds, (cl) M27396 Human asparagine synthetase mRNA, completecds, (cli) U37519 Human aldehyde dehydrogenase (ALDH8) mRNA, completecds, (clii) X691 11 H. sapiens HLH 1R21 mRNA for helix-loop-helixprotein, (cliii) M77836 Human pyrroline 5-carboxylate reductase mRNA,complete cds, (cliv) D32050 Human mRNA for alanyl-tRNA synthetase,complete cds, (clv) X01630 Human mRNA for argininosuccinate synthetase.27. A pharmaceutical composition for modulating the response of a cellto ultraviolet radiation exposure, comprising: (a) a compound insufficient quantity to modulate the response of the cell to ultravioletradiation exposure, the response being a pattern of expressioncomprising at least one of the following: (i) a first responsecomprising altered expression of at least one nucleic acid moleculeencoding a transcription factor protein, at least one nucleic acidmolecule encoding a signal transducing protein, and at least one nucleicacid molecule encoding a mitochondrial protein; (ii) a second responsecomprising altered expression of at least one nucleic acid moleculeencoding a secreted growth factor, at least one nucleic acid moleculeencoding a cytokine, and at least one nucleic acid molecule encoding achemokine; and/or (iii) a third response comprising altered expressionof at least one nucleic acid molecule encoding an actin-binding protein,at least one nucleic acid molecule encoding a desmosomal protein, and atleast one nucleic acid molecule encoding a tubulin protein; and (b) apharmaceutically acceptable carrier.
 28. The pharmaceutical compositionof claim 27, wherein the nucleic acid molecule expressed in the firstresponse further comprises a nucleic acid molecule that is at least 90%identical to a nucleic acid molecule selected from the group consistingof: (i) M62831 Human transcription factor ETR101 mRNA, complete cds,(ii) X68277 H. sapiens CL 100 mRNA for protein tyrosine phosphatase,(iii) L04731 H. sapiens translocation T(4:11) of ALL-1 gene tochromosome 4, (iv) X56681 Human junD mRNA, (v) U20734 Humantranscription factor junB (junB) gene, 5′ region and complete cds, (vi)L38951 H. sapiens importin beta subunit mRNA, complete cds, (vii) D87071Human mRNA for KIAA0233 gene, complete cds, (viii) M72885 Human GOS2gene, 5′ flank and cds, (ix) M92843 H. sapiens zinc fingertranscriptional regulator mRNA, complete cds, (x) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, (xi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (xii) D86988Human mRNA for KIAA0221 gene, complete cds, (xiii) L19779 H. sapienshistone H2A.2 mRNA, complete cds, (xiv) U62317 Chromosome 22q13 BACClone CIT987SK-384D8 complete sequence, (xv) X04412 Human mRNA forplasma gelsolin, (xvi) L27706 Human chaperonin protein (Tcp20) genecomplete cds, (xvii) X61123 Human BTG1 mRNA, (xviii) M60974growth arrestand DNA-damage-inducible protein (gadd45) mRNA, complete cds, (xix)L19437 Human transaldolase mRNA containing transposable element,complete cds, (xx) X57985 H. sapiens genes for histones H2B.1 and H2A,(xxi) D90086 Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunitgene, exons 1-10, (xxii) M34182 Human testis-specific protein kinasegamma-subunit mRNA, complete cds, (xxiii) L16862 H. sapiens Gprotein-coupled receptor kinase (GRK6) mRNA, complete cds, (xxiv) D13705Human mRNA for fatty acids omega-hydroxylase (cytochrome P-450HKV),complete cd, (xxv) U37122 Human adducin gamma subunit mRNA, completecds, (xxvi) D45906 H. sapiens mRNA for LIMK-2, complete cds, (xxvii)U07664 Human HB9 homeobox gene, exons 2 and 3 and complete cds, (xxviii)D87438 Human mRNA for KIAA0251 gene, partial cds, (xxix) L37042 H.sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds,(xxx) D14043 Human mRNA for MGC-24, complete cds, (xxxi) D13988 Humanrab GDI mRNA, complete cds, (xxxii) U28480 Uncoupling Protein Uc,(xxxiii) D50840 H. sapiens mRNA for ceramide glucosyltransferase,complete cds, (xxxiv) M55265 Human casein kinase II alpha subunit mRNA,complete cds, (xxxv) M96803 Human general beta-spectrin (SPTBN1) mRNA,complete cds, (xxxvi) U89336 Human HLA class III region containingNOTCH4 gene, partial sequence, homeobox P, (xxxvii) D87442 Human mRNAfor KIAA0253 gene, partial cds, (xxxviii) J03161 Human serum responsefactor (SRF) mRNA, complete cds, (xxxix) D86965 Human mRNA for KIAA0210gene, complete cds, (xl) U17327 Human neuronal nitric oxide synthase(NOS1) mRNA, complete cds, (xli) D86966 Human mRNA for KIAA0211 gene,complete cds, (xlii) D85527 H. sapiens mRNA for LIM domain, partial cds,(xliii) U4203 1 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (xliv) X59434 Human rohu mRNA forrhodanese, (xlv) M13929 Human c-myc-P64 mRNA, initiating from promoterP0, (HLmyc2.5) partial cds, and (xlvi) J05211 Desmoplakin.
 29. Thepharmaceutical composition of claim 27, wherein the nucleic acidmolecule expressed in the second response further comprises a nucleicacid molecule that is at least 90% identical to a nucleic acid moleculeselected from the group consisting of. (i) M57731 Human gro-beta mRNA,complete cds, (ii) S81914 IEX-1=radiation-inducible immediate-early gene[human, placenta, mRNA Partial, 1, (iii) Y00787 Human mRNA for MDNCF(monocyte-derived neutrophil chemotactic factor), (iv) X54489 Human genefor melanoma growth stimulatory activity (MGSA), (v) M72885 Human GOS2gene, 5′ flank and cds, (vi) M62831 Human transcription factor ETR101mRNA, complete cds, (vii) M28130 Human interleukin 8 (IL8) gene,complete cds, (viii) X57985 H. sapiens genes for histones H2B.1 and H2A,(ix) X53800 Human mRNA for macrophage inflammatory protein-2beta(MIP2beta), (x) L19779 H. sapiens histone H2A.2 mRNA, complete cds, (xi)AF001294 H. sapiens IPL (IPL) mRNA, complete cds, (xii) X56681 HumanjunD mRNA, (xiii) S75762 Oncogene Tls/Chop, Fusion Activate, (xiv)M84739 Human autoantigen calreticulin mRNA, complete cds, (xv) M21302Human small proline rich protein (sprII) mRNA, clone 174N, (xvi) V00599Tubulin, Bet, (xvii) X70326 Macmarck, (xviii) D10923 Human mRNA forHM74, (xix) D64142 Human mRNA for histone H1x, complete cds, (xx) D86974Human mRNA for KIAA0220 gene, partial cds, (xxi) M60974 Human growtharrest and DNA-damage-inducible protein (gadd45) mRNA, complete cds,(xxii) X68277 H. sapiens CL 100 mRNA for protein tyrosine phosphatase,(xxiii) L13391 Human helix-loop-helix basic phosphoprotein (G0S8) gene,complete cds, (xxiv) M31627 Human X box binding protein-1 (XBP-1) mRNA,complete cds, (xxv) U40369 Human spermidine/spermineN1-acetyltransferase (SSAT) gene, complete cds, (xxvi) X52560 NuclearFactor Nf-Il, (xxvii) X61123 Human BTG1 mRNA, (xxviii) U20734 Humantranscription factor junB (junB) gene, 5′ region and complete cds,(xxix) U35048 Human TSC-22 protein mRNA, complete cds, (xxx) M69043 H.sapiens MAD-3 mRNA encoding IkB-like activity, complete cds, (xxxi)X51345 Human jun-B mRNA for JUN-B protein, (xxxii) S68616 Na+/H+exchanger NHE-1 isoform [human, heart, mRNA, 4516 nt], (xxxiii) X89750H. sapiens mRNA for TGIF protein, (xxxiv) X69111 H. sapiens HLH 1R21mRNA for helix-loop-helix protein, (xxxv) U14603 Human protein-tyrosinephosphatase (HU-PP-1) mRNA, partial sequence, (xxxvi) X52541 Human mRNAfor early growth response protein 1 (hEGR1), (xxxvii) D50683 H. sapiensmRNA for TGF-betaIIR alpha, complete cds, (xxxviii) M92843 H. sapienszinc finger transcriptional regulator mRNA, complete cds, (xxxix) X91247H. sapiens mRNA for thioredoxin reductase, (xl) U05875 Human clone pSK1interferon gamma receptor accessory factor-1 (AF-1) mRNA, comp, (xli)L19314 Human HRY gene, complete cds, (xlii) M30703 Human amphiregulin(AR) gene, exon 6, clones lambda-ARH(6,12), (xliii) U34252 Humangamma-aminobutyraldehyde dehydrogenase mRNA, complete cds, (xliv) S78825Id1, (xlv) D85429 H. sapiens gene for heat shock protein 40, completecds, (xlvi) U41766 Human metalloprotease/disintegrin/cysteine-richprotein precursor (MDC9) mRNA, (xlvii) U89336 Human HLA class III regioncontaining NOTCH4 gene, partial sequence, homeobox PB, (xlviii) M69181Human nonmuscle myosin heavy chain-B (MYH10) mRNA, partial cds, (xlix)D15050 Human mRNA for transcription factor AREB6, complete cds, (l)U28386 Human nuclear localization sequence receptor hSRP1alpha mRNA,complete cds, (li) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (lii) X64330 H. sapiens mRNA for ATP-citrate lyase, (liii)U37122 Human adducin gamma subunit mRNA, complete cds, (liv) X74008 H.sapiens mRNA for protein phosphatase 1 gamma, (lv) U60205 Human methylsterol oxidase (ERG25) mRNA, complete cds, (lvi) X76534 H. sapiens NMBmRNA, (lvii) D87071 Human mRNA for KIAA0233 gene, complete cds, (lviii)U90716 Human cell surface protein HCAR mRNA, complete cds, (lix) M91083Human DNA-binding protein (HRC1) mRNA, complete cds, (lx) U29607 Humanmethionine aminopeptidase mRNA, complete cds, (lxi) M76482 Human 130-kDpemphigus vulgaris antigen mRNA, complete cds, (lxii) U72066 H. sapiensCtBP interacting protein CtIP (CtIP) mRNA, complete cds, (lxiii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (lxiv) X12953Human rab2 mRNA, YPT1-related and member of ras family, (lxv) M60483Human protein phosphatase 2A catalytic subunit-alpha gene, complete cds,(lxvi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (lxvii) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (lxviii) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(lxix) D50840 H. sapiens mRNA for ceramide glucosyltransferase, completecds, (lxx) L31801 H. sapiens monocarboxylate transporter 1 (SLC16A1)mRNA, complete cds, (lxxi) S74017 Nrf2=NF-E2-like basic leucine zippertranscriptional activator [human, hemin-in, (lxxii) X87241 H. sapiensmRNA for hFat protein, (lxxiii) X52425 Human IL-4-R mRNA for theinterleukin 4 receptor, (lxxiv) D79994 Human mRNA for KIAA0172 gene,partial cds, (lxxv) M58286 H. sapiens tumor necrosis factor receptormRNA, complete cds, (lxxvi) M13829 Human putative raf related protein(pks/a-raf) mRNA, partial cds, (lxxvii) X78992 H. sapiens ERF-2 mRNA,(lxxviii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (lxxix) U88629 Human RNA polymeraseII elongation factor ELL2, complete cds, (lxxx) X52611 Human mRNA fortranscription factor AP-2, (lxxxi) U28749 Human high-mobility groupphosphoprotein isoform I-C (HMGIC) mRNA, complete cds, (lxxxii) L00058Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank, (lxxxiii)L26336 Heat Shock Protein, 70 Kda (Gb:Y00371, (lxxxiv) L08246 Humanmyeloid cell differentiation protein (MCL1) mRNA, (lxxxv) S73591brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic,leukemia cells (lxxxvi) J05211 Desmoplakin, (lxxxvii)L00352 Human low density lipoprotein receptor gene, exon 18, (lxxxviii)Y13647 Stearoyl-Coenzymea Desaturase, (lxxxix) X77794 H. sapiens mRNAfor cyclin G1, (xc) M90656 Human gamma-glutamylcysteine synthetase (GCS)mRNA, complete cds, (xci) M13929 Human c-myc-P64 mRNA, initiating frompromoter P0, (HLmyc2.5) partial cds, (xcii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (xciii) X80692 H. sapiens ERK3 mRNA,and (xciv) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf
 114. 30. Thepharmaceutical composition of claim 27, wherein the nucleic acidmolecule expressed in the third response further comprises a nucleicacid molecule that is at least 90% identical to a nucleic acid moleculeselected from the group consisting of: (i) M20030 Human small prolinerich protein (sprII) mRNA, clone 930, (ii) X53065, (iii) M13903 Humaninvolucrin gene, exon 2, (iv) M22918 Myosin, Light Chain, Alkali, SmoothMuscle (Gb:U02629), Non-Muscle, Alt. Splice, (v) L10343 Huma elafingene, complete cds, (vi) M63573 Human secreted cyclophilin-like protein(SCYLP) mRNA, complete cds, (vii) M21302 Human small proline richprotein (sprII) mRNA, clone 174N, (viii) Y00787 Human mRNA for MDNCF(monocyte-derived neutrophil chemotactic factor), (ix) X57985 H. sapiensgenes for histones H2B.1 and H2A, (x) L05188 H. sapiens smallproline-rich protein 2 (SPRR2B) gene, complete cds, (xi) X70326Macmarcks, (xii) X67325 H. sapiens p27 mRNA, (xiii) L19779 H. sapienshistone H2A.2 mRNA, complete cds, (xiv) S81914 IEX-1=radiation-inducibleimmediate-early gene [human, placenta, mRNA Partial, 1, (xv) D45248Human mRNA for proteasome activator hPA28 subunit beta, complete cds,(xvi) Z22548 H. sapiens thiol-specific antioxidant protein mRNA, (xvii)M22918 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629),Non-Muscle, Alt. Splice, (xviii) X06956 Tubulin, Alpha 1, Isoform 44,(xix) V00594 Human mRNA for metallothionein from cadmium-treated cells,(xx) M80254 H. sapiens cyclophilin isoform (hCyP3) mRNA, complete cds,(xxi) U04636 Human cyclooxygenase-2 (hCox-2) gene, complete cds, (xxii)Z14244 H. sapiens coxVIIb mRNA for cytochrome c oxidase subunit VIIb,(xxiii) X99920 H. sapiens RNA for S100 calcium-binding protein A13,(xxiv) U62800 Human cystatin M (CST6) mRNA, complete cds, (xxv) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(xxvi) L20688 Human GDP-dissociation inhibitor protein (Ly-GDI) mRNA,complete cds, (xxvii) M13755 Human interferon-induced 17-kDa/15-kDaprotein mRNA, complete cds, (xxviii) M60278 Human heparin-bindingEGF-like growth factor mRNA, complete cds, (xxix) AF001294 H. sapiensIPL (IPL) mRNA, complete cds, (xxx) X54489 Human gene for melanomagrowth stimulatory activity (MGSA), (xxxi) M21186 Human neutrophilcytochrome b light chain p22 phagocyte b-cytochrome mRNA, compl, (xxxii)D42040 Human mRNA for KIAA9001 gene, complete cds, (xxxiii) V00599Tubulin, Beta, (xxxiv) U37690 Human RNA polymerase II subunit (hsRPB10)mRNA, complete cds, (xxxv) M21005 Human migration inhibitoryfactor-related protein 8 (MRP8) gene, complete cds, (xxxvi) M37583 Humanhistone (H2A.Z) mRNA, complete cds, (xxxvii) Z49989 H. sapiens mRNA forsmoothelin, (xxxviii) L24564 Human Rad mRNA, complete cds, (xxxix)D49824 Human HLA-B null allele mRNA, (xl) M59465 Human tumor necrosisfactor alpha inducible protein A20 mRNA, complete cds, (xli) S54005thymosin beta-10 [human, metastatic melanoma cell line, mRNA, 453 nt],(xlii) Z49254 H. sapiens L23-related mRNA, (xliii) M22919 Myosin, LightChain, Alkali, Smooth Muscle (Gb:U02629), Smooth Muscle, Alt. Spli,(xliv) U70660 Human copper transport protein HAH1 (HAH1) mRNA, completecds, (xlv) AF006084 H. sapiens Arp2/3 protein complex subunit p41-Arc(ARC41) mRNA, complete cds, (xlvi) X62083 H. sapiens mRNA for Drosophilafemale sterile homeotic (FSH) homologue, (xlvii) D86974 Human mRNA forKIAA0220 gene, partial cds, (xlviii) M72885 Human GOS2 gene, 5′ flankand cds, (xlix) S80437 fatty acid synthase {3′ region} [human, breastand HepG2 cells, mRNA Partial, 22, (l) X04654 Human mRNA for U1RNA-associated 70K protein, (li) t M26311 Human cystic fibrosis antigenmRNA, complete cds, (lii) X14850 Human H2A.X mRNA encoding histoneH2A.X, (liii) M14328 Human alpha enolase mRNA, complete cds, (liv)U07919 Human aldehyde dehydrogenase 6 mRNA, complete cds, (lv) M28130Human interleukin 8 (IL8) gene, complete cds, (lvi) Z21507 H. sapiensEF-1delta gene encoding human elongation factor-1-delta, (lvii) M92934Human connective tissue growth factor, complete cds, (lviii) M27436Human tissue factor gene, complete cds, with a Alu repetitive sequencein the 3′, (lix) X74874 H. sapiens gene for RNA pol II largest subunit,exon 1, (lx) X57351 Human 1-8D gene from interferon-inducible genefamily, (lxi) X52979 Human gene for small nuclear ribonucleoproteins SmBand SmB′, (lxii) U41515 Human deleted in split hand/split foot 1 (DSS1)mRNA, complete cds, (lxiii) D28235 Human PTGS2 gene for prostaglandinendoperoxide synthase-2, complete cds, (lxiv) Y00503 Human mRNA forkeratin
 19. (lxv) M57731 Human gro-beta mRNA, complete cds, (lxvi)D50840 H. sapiens mRNA for ceramide glucosyltransferase, complete cds,(lxvii) U52101 Human YMP mRNA, complete cds. (lxviii) D13413 Human mRNAfor tumor-associated 120 kDa nuclear protein p120, partial cds(carbox,(lxix) L42379 H. sapiens bone-derived growth factor (BPGF-1) mRNA,complete cds, (lxx) X52426 H. sapiens mRNA for cytokeratin 13, (lxxi)J04456 Human 14 kd lectin mRNA, complete cds, (lxxii) S78771 NAT=CpGisland-associated gene [human, mRNA, 1741 nt], (lxxiii) M26730 Humanmitochondrial ubiquinone-binding protein (QP) gene, exon 4, (lxxiv)U26727 Human p16INK4/MTS 1 mRNA, complete cds, (lxxv) X92896 H. sapiensmRNA for ITBA2 protein, (lxxvi) Z69043 H. sapiens mRNAtranslocon-associated protein delta subunit precursor, (lxxvii) L76568H. sapiens excision and cross link repair protein (ERCC4) gene, completegenom, (lxxviii) M12125 Human fibroblast muscle-type tropomyosin mRNA,complete cds, (lxxix) U09937 Human urokinase-type plasminogen receptor,exon 7, (lxxx) X15822 Human COX VIIa-L mRNA for liver-specificcytochrome c oxidase (EC 1.9.3.1.), (lxxxi) M34516 Human omega lightchain protein 14.1 (Ig lambda chain related) gene, exon 3, (lxxxii)U53830 H. sapiens interferon regulatory factor 7A mRNA, complete cds,(lxxxiii) X82693 H. sapiens mRNA for E48 antigen, (lxxxiv) M58026 HumanNB-1 mRNA, complete cds, (lxxxv) M90657 Human tumor antigen (L6) mRNA,complete cds, (lxxxvi) X57579 H. sapiens activin beta-A subunit (exon2), (lxxxvii) D38251 Human mRNA for RPB5 (XAP4), complete cds,(lxxxviii) D89667 H. sapiens mRNA for c-myc binding protein, completecds, (lxxxix) AB000584 H. sapiens mRNA for TGF-beta superfamily protein,complete cds, (xc) L76200 Human guanylate kinase (GUK1) mRNA, completecds, (xci) J04794 Human aldehyde reductase mRNA, complete cds, (xcii)X52882 Human t-complex polypeptide 1 gene, (xciii) M79463 Human PML-2mRNA, complete CDS, (xciv) Y09022 H. sapiens mRNA for Not56-likeprotein, (xcv) M12529 Human apolipoprotein E mRNA, complete cds, (xcvi)X71129 H. sapiens mRNA for electron transfer flavoprotein beta subunit,(xcvii) X83416 H. sapiens PrP gene, exon 2, (xcviii) D89052 H. sapiensmRNA for proton-ATPase-like protein, complete cds, (xcix) M60974 Humangrowth arrest and DNA-damage-inducible protein (gadd45) mRNA, completecds, (c) M16364 Human creatine kinase-B mRNA, complete cds, (ci) D38305Human mRNA for Tob, complete cds, (cii) X87679 Major HistocompatibilityComplex, Class I, E (Gb:M21533), (ciii) Z29505 H. sapiens mRNA fornucleic acid binding protein sub2.3, (civ) K02574, (cv) U09813 Humanmitochondrial ATP synthase subunit 9, P3 gene copy, mRNA, nuclear geneenc, (cvi) X67951 H. sapiens mRNA for proliferation-associated gene(pag), (cvii) J04611 Human lupus p70 (Ku) autoantigen protein mRNA,complete cds, (cviii) U09578 H. sapiens MAPKAP kinase (3pK) mRNA,complete cds, (cix) X53800 Human mRNA for macrophage inflammatoryprotein-2beta (MIP2beta), (cx) V00599 Tubulin, Beta 2, (cxi) U69126Human FUSE binding protein 2 (FBP2) mRNA, partial cds, (cxii) X53416Human mRNA for actin-binding protein (filamin) (ABP-280), (cxiii) U90546Human butyrophilin (BTF4) mRNA, complete cds, (cxiv) M58459 Humanribosomal protein (RPS4Y) isoform mRNA, complete cds, (cxv) M19961 Humancytochrome c oxidase subunit Vb (coxVb) mRNA, complete cds, (cxvi)U65579 Human mitochondrial NADH dehydrogenase-ubiquinone Fe-S protein 8,23 kDa subunit, (cxvii) X77794 H. sapiens mRNA for cyclin G1, (cxviii)M29064 Human hnRNP B 1 protein mRNA, (cxix) D21853 Human mRNA forKIAA0111 gene, complete cds, (cxx) X78687 H. sapiens G9 gene encodingsialidase, (cxxi) X15729 Human mRNA for nuclear p68 protein, (cxxii)X04828 Human mRNA for G(i) protein alpha-subunit (adenylate cyclaseinhibiting GTP-bind, (cxxiii) L27943 H. sapiens cytidine deaminase (CDA)mRNA, complete cds, (cxxiv) L40391 H. sapiens (clone s153) mRNAfragment, (cxxv) D42123 H. sapiens mRNA for ESP1/CRP2, complete cds,(cxxvi) X74104 H. sapiens mRNA for TRAP beta subunit, (cxxvii) M84332Human ADP-ribosylation factor 1 gene, exons 2-5, (cxxviii) L37127 H.sapiens RNA polymerase II mRNA, complete cds, (cxxix) M92843 H. sapienszinc finger transcriptional regulator mRNA, complete cds, (cxxx) U07664Human HB9 homeobox gene, exons 2 and 3 and complete cds, (cxxxi) L48546H. sapiens tuberin (TSC2) gene, exons 38, 39,40 and 41, (cxxxii) X53586Human mRNA for integrin alpha 6, (cxxxiii) t D21852 Human mRNA forKIAA0029 gene, partial cds, (cxxxiv) L11066 Human mRNA sequence, (cxxxv)J04444 Human cytochrome c-1 gene, complete cds, (cxxxvi) M95787 Human 22kDa smooth muscle protein (SM22) mRNA, complete cds, (cxxxvii) L07517Mucin 6, Gastric (Gb:L07517), (cxxxviii) X91247 H. sapiens mRNA forthioredoxin reductase, (cxxxix) L11672 Human Kruppel related zinc fingerprotein (HTF10) mRNA, complete cds, (cxl) U30999 Human (memc) mRNA,3′UTR, (cxli) U01337 Human Ser/Thr protein kinase (A-RAF-1) gene,complete cds, (cxlii) U28480 Uncoupling Protein Ucp, (cxliii) X12794Human v-erbA related ear-2 gene, (cxliv) L22005 Human ubiquitinconjugating enzyme mRNA, partial cds, (cxlv) M12886 Human T-cellreceptor active beta-chain mRNA, complete cds, (cxlvi) Y08915 H. sapiensmRNA for alpha 4 protein, (cxlvii) M24547 Amyloid Beta (A4) PrecursorProtein, Alt. Splice 2, A4(751), (cxlviii) X76717 H. sapiens MT-1l mRNA,(cxlix) M64347 Human novel growth factor receptor mRNA, 3′ cds, (cl)X05409 Human RNA for mitochondrial aldehyde dehydrogenase I ALDH I (EC1.2.1.3), (cli) D87469 Human mRNA for KIAA0279 gene, partial cds, (clii)M58603 Human nuclear factor kappa-B DNA binding subunit (NF-kappa-B)mRNA, complete cds, (cliii) M76482 Human 130-kD pemphigus vulgarisantigen mRNA, complete cds, (cliv) X06323 Human MRL3 mRNA for ribosomalprotein L3 homologue (MRL3=mammalian ribosome L, (clv) X78992 H. sapiensERF-2 mRNA, (clvi) L41351 H. sapiens prostasin mRNA, complete cds,(clvii) X75342 H. sapiens SHB mRNA, (clviii) U83115 Human non-lens betagamma-crystallin like protein (AIM1) mRNA, partial cds, (clix) U88629Human RNA polymerase II elongation factor ELL2, complete cds, (clx)S78825 Id1, (clxi) U28811 Human cysteine-rich fibroblast growth factorreceptor (CFR-1) mRNA, complete cds, (clxii) M58286 H. sapiens tumornecrosis factor receptor mRNA, complete cds, (clxiii) D78129 H. sapiensmRNA for squalene epoxidase, partial cds, (clxiv) D14874 H. sapiens mRNAfor adrenomedullin precursor, complete cds, (clxv) Z26317 H. sapiensmRNA for desmoglein 2, (clxvi) L19267 H. sapiens 59 protein mRNA, 3′end, (clxvii) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114,(clxviii) U33821 Human tax1-binding protein TXBP151 mRNA, complete cds,(clxix) U52100 Human XMP mRNA, complete cds, (clxx) L31801 H. sapiensmonocarboxylate transporter 1 (SLC16A1) mRNA, complete cds, (clxxi)L00058 Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank,(clxxii) U52426 H. sapiens GOK (STIM1) mRNA, complete cds, (clxxiii)M80244 Human E16 mRNA, complete cds, (clxxiv) U56418 Humanlysophosphatidic acid acyltransferase-beta mRNA, complete cds, (clxxv)L38490 H. sapiens ADP-ribosylation factor mRNA, complete cds, (clxxvi)U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (clxxvii) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (clxxviii) M38258 Human retinoic acid receptor gamma 1mRNA, complete cds, (clxxix) X89750 H. sapiens mRNA for TGIF protein,(clxxx) D85429 H. sapiens gene for heat shock protein 40, complete cds,(clxxxi) J05211 Desmoplakin I, (clxxxii) M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds, (clxxxiii) X80695 H. sapiensOXA1Hs mRNA, (clxxxiv) M54915 Human h-pim-1 protein (h-pim-1) mRNA,complete cds, (clxxxv) D83777 Human mRNA for KIAA0193 gene, completecds, (clxxxvi) D31883 Human mRNA for KIAA0059 gene, complete cds,(clxxxvii) U00968 Human SREBP-1 mRNA, complete cds, (clxxxviii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (clxxxix)D86965 Human mRNA for KIAA0210 gene, complete cds, (cxc) Z30643 H.sapiens RNA for chloride channel (putative) 2139 bp, (cxci) D14520 Humanm-RNA for GC-Box binding protein BTEB2, complete cds, (cxcii) D87462Human mRNA for KIAA0272 gene, partial cds, (cxciii) X80692 H. sapiensERK3 mRNA, (cxciv) X90858 H. sapiens mRNA for uridine phosphorylase,(cxcv) M57763 Human ADP-ribosylation factor (hARF6) RNA, complete cds,(cxcvi) X92720 H. sapiens mRNA for phosphoenolpyruvate carboxykinase,(cxcvii) M81601 Human transcription elongation factor (SII) mRNA,complete cds, (cxcviii) X52611 Human mRNA for transcription factor AP-2,(cxcix) U09587 Human glycyl-tRNA synthetase mRNA, complete cds, (cc)U14550 Human sialyltransferase SThM (sthm) mRNA, complete cds, (cci)D90209 Human mRNA for DNA binding protein TAXREB67, (ccii) X77366 H.sapiens HBZ17 mRNA, (cciii) X76534 H. sapiens NMB mRNA, (cciv) U37519Human aldehyde dehydrogenase (ALDH8) mRNA, complete cds, (ccv) M83667Human NF-IL6-beta protein mRNA, complete cds, (ccvi) U53347 Humanneutral amino acid transporter B mRNA, complete cds, (ccvii) L09229Human long-chain acyl-coenzyme A synthetase (FACL1) mRNA, complete cds,(ccviii) S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, (ccix) M13929 Human c-myc-P64 mRNA,initiating from promoter P0, (HLmyc2.5) partial cds, (ccx) M55268 Humancasein kinase II alpha′ subunit mRNA, complete cds, (ccxi) M77836 Humanpyrroline 5-carboxylate reductase mRNA, complete cds, (ccxii)HG2724-HT2820_at S75762 Oncogene Tls/Chop, Fusion Activated, (ccxiii)U72066 H. sapiens CtBP interacting protein CtIP (CtIP) mRNA, completecds, (ccxiv) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (ccxv) M27396 Human asparaginesynthetase mRNA, complete cds, (ccxvi) X01630 Human mRNA forargininosuccinate synthetase, (ccxvii) D32050 Human mRNA for alanyl-tRNAsynthetase, complete cds, (ccxviii) M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, (ccxix) J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,and (ccxx) X69111 H. sapiens HLH 1R21 mRNA for helix-loop-helix protein.31. The composition of claim 27, wherein modulation of the responseconstitutes an inhibition of the ultraviolet radiation exposure-inducedRNA expression.
 32. The composition of claim 27, wherein modulation ofthe response constitutes an inhibition of the ultraviolet radiationexposure-repressed RNA expression.
 33. A screening method for thedetection of a compound that modulates a response of a cell toultraviolet radiation exposure, comprising: (a) contacting the cell withthe compound; (b) exposing the cell to ultraviolet radiation that wouldotherwise induce the response to ultraviolet radiation exposure, theresponse being a pattern of expression comprising at least one of thefollowing: (i) a first response comprising altered expression of atleast one of a transcription factor protein, at least one of a signaltransducing protein, and at least one of a mitochondrial protein; (ii) asecond response comprising altered expression of at least one of asecreted growth factor protein, at least one of a cytokine protein, andat least one of a chemokine protein; and (iii) a third responsecomprising altered expression of at least one of anactin-bindingprotein, at least one of a desmosomal protein, and at least one of atubulin protein; and (c) measuring the levels of a plurality of proteinmolecules in the cell for at least one time point after ultravioletradiation exposure, wherein a change in the altered expression of thefirst response, the second response, and/or the third response indicatesthat the compound modulates the response of the cell to ultravioletradiation exposure.
 34. The method according to claim 33, wherein thecell is contacted with the compound in vitro.
 35. The method accordingto claim 33, wherein the cell is contacted with the compound in vivo.36. The method according to claim 33, wherein the ultraviolet irradationexposure comprises ultraviolet radiation energy at a wavelength in therange of about 220 nm to about 440 nm.
 37. The method according to claim36,wherein the ultraviolet radiation exposure comprises ultravioletradiation energy at a wavelength of about 290 nm to about320 nm.
 38. Themethod according to claim 36,wherein the ultraviolet radiation exposurecomprises ultraviolet radiation energy at a wavelength of about 320 nmto about 440 nm.
 39. The method according to claim 33, wherein theultraviolet irradation exposure comprises a total ultraviolet radiationenergy exposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm². 40.The screening method of claim 33, wherein: (a) the protein expressed inthe first response further comprises a protein that is encoded by apolynucleotide that is at least 90% identical to a nucleic acid moleculeselected from the group consisting of: (i) M62831 Human transcriptionfactor ETR101 mRNA, complete cds, (ii) X68277 H. sapiens CL 100 mRNA forprotein tyrosine phosphatase, (iii) L04731 H. sapiens translocationT(4:11) of ALL-1 gene to chromosome 4, (iv) X56681 Human junD mRNA, (v)U20734 Human transcription factor junB (junB) gene, 5′ region andcomplete cds, (vi) L38951 H. sapiens importin beta subunit mRNA,complete cds, (vii) D87071 Human mRNA for KIAA0233 gene, complete cds,(viii) M72885 Human GOS2 gene, 5′ flank and cds, (ix) M92843 H. sapienszinc finger transcriptional regulator mRNA, complete cds, (x) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, (xi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (xii) D86988Human mRNA for KIAA0221 gene, complete cds, (xiii) L19779 H. sapienshistone H2A.2 mRNA, complete cds, (xiv) U62317 Chromosome 22q13 BACClone CIT987SK-384D8 complete sequence, (xv) X04412 Human mRNA forplasma gelsolin, (xvi) L27706 Human chaperonin protein (Tcp20) genecomplete cds, (xvii) X61123 Human BTG1 mRNA, (xviii) M60974growth arrestand DNA-damage-inducible protein (gadd45) mRNA, complete cds, (xix)L19437 Human transaldolase mRNA containing transposable element,complete cds, (xx) X57985 H. sapiens genes for histones H2B.1 and H2A,(xxi) D90086 Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunitgene, exons 1-10, (xxii) M34182 Human testis-specific protein kinasegamma-subunit mRNA, complete cds, (xxiii) L16862 H. sapiens Gprotein-coupled receptor kinase (GRK6) mRNA, complete cds, (xxiv) D13705Human mRNA for fatty acids omega-hydroxylase (cytochrome P-450HKV),complete cd, (xxv) U37122 Human adducin gamma subunit mRNA, completecds, (xxvi) D45906 H. sapiens mRNA for LIMK-2, complete cds, (xxvii)U07664 Human HB9 homeobox gene, exons 2 and 3 and complete cds, (xxviii)D87438 Human mRNA for KIAA0251 gene, partial cds, (xxix) L37042 H.sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds,(xxx) D14043 Human mRNA for MGC-24, complete cds, (xxxi) D13988 Humanrab GDI mRNA, complete cds, (xxxii) U28480 Uncoupling Protein Uc,(xxxiii) D50840 H. sapiens mRNA for ceramide glucosyltransferase,complete cds, (xxxiv) M55265 Human casein kinase II alpha subunit mRNA,complete cds, (xxxv) M96803 Human general beta-spectrin (SPTBN1) mRNA,complete cds, (xxxvi) U89336 Human HLA class III region containingNOTCH4 gene, partial sequence, homeobox P, (xxxvii) D87442 Human mRNAfor KIAA0253 gene, partial cds, (xxxviii) J03161 Human serum responsefactor (SRF) mRNA, complete cds, (xxxix) D86965 Human mRNA for KIAA0210gene, complete cds, (xl) U17327 Human neuronal nitric oxide synthase(NOS1) mRNA, complete cds, (xli) D86966 Human mRNA for KIAA0211 gene,complete cds, (xlii) D85527 H. sapiens mRNA for LIM domain, partial cds,(xliii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (xliv) X59434 Human rohu mRNA forrhodanese, (xlv) M13929 Human c-myc-P64 mRNA, initiating from promoterP0, (HLmyc2.5) partial cds, and (xlvi) J05211 Desmoplakin; (b) theprotein expressed in the second response further comprises a proteinthat is encoded by a polynucleotide that is at least 90% identical to anucleic acid molecule selected from the group consisting of: (i) M57731Human gro-beta mRNA, complete cds, (ii) S81914 IEX-1=radiation-inducibleimmediate-early gene [human, placenta, mRNA Partial, 1, (iii) Y00787Human mRNA for MDNCF (monocyte-derived neutrophil chemotactic factor),(iv) X54489 Human gene for melanoma growth stimulatory activity (MGSA),(v) M72885 Human GOS2 gene, 5′ flank and cds, (vi) M62831 Humantranscription factor ETR101 mRNA, complete cds, (vii) M28130 Humaninterleukin 8 (IL8) gene, complete cds, (viii) X57985 H. sapiens genesfor histones H2B.1 and H2A, (ix) X53800 Human mRNA for macrophageinflammatory protein-2beta (MIP2beta), (x) L19779 H. sapiens histoneH2A.2 mRNA, complete cds, (xi) AF001294 H. sapiens IPL (IPL) mRNA,complete cds, (xii) X56681 Human junD mRNA, (xiii) S75762 OncogeneTls/Chop, Fusion Activate, (xiv) M84739 Human autoantigen calreticulinmRNA, complete cds, (xv) M21302 Human small proline rich protein (sprII)mRNA, clone 174N, (xvi) V00599 Tubulin, Bet, (xvii) X70326 Macmarck,(xviii) D10923 Human mRNA for HM74, (xix) D64142 Human mRNA for histoneH1x, complete cds, (xx) D86974 Human mRNA for KIAA0220 gene, partialcds, (xxi) M60974 Human growth arrest and DNA-damage-inducible protein(gadd45) mRNA, complete cds, (xxii) X68277 H. sapiens CL 100 mRNA forprotein tyrosine phosphatase, (xxiii) L13391 Human helix-loop-helixbasic phosphoprotein (G0S8) gene, complete cds, (xxiv) M31627 Human Xbox binding protein-1 (XBP-1) mRNA, complete cds, (xxv) U40369 Humanspermidine/spermine N1-acetyltransferase (SSAT) gene, complete cds,(xxvi) X52560 Nuclear Factor Nf-Il, (xxvii) X61123 Human BTG1 mRNA,(xxviii) U20734 Human transcription factor junB (junB) gene, 5′ regionand complete cds, (xxix) U35048 Human TSC-22 protein mRNA, complete cds,(xxx) M69043 H. sapiens MAD-3 mRNA encoding IkB-like activity, completecds, (xxxi) X51345 Human jun-B mRNA for JUN-B protein, (xxxii) S68616Na+/H+ exchanger NHE-1 isoform [human, heart, mRNA, 4516 nt], (xxxiii)X89750 H. sapiens mRNA for TGIF protein, (xxxiv) X69111 H. sapiens HLH1R21 mRNA for helix-loop-helix protein, (xxxv) U14603 Humanprotein-tyrosine phosphatase (HU-PP-1) mRNA, partial sequence, (xxxvi)X52541 Human mRNA for early growth response protein 1 (hEGR1), (xxxvii)D50683 H. sapiens mRNA for TGF-betaIIR alpha, complete cds, (xxxviii)M92843 H. sapiens zinc finger transcriptional regulator mRNA, completecds, (xxxix) X91247 H. sapiens mRNA for thioredoxin reductase, (xl)U05875 Human clone pSK1 interferon gamma receptor accessory factor-1(AF-1) mRNA, comp, (xli) L19314 Human HRY gene, complete cds, (xlii)M30703 Human amphiregulin (AR) gene, exon 6, clones lambda-ARH(6,12),(xliii) U34252 Human gamma-aminobutyraldehyde dehydrogenase mRNA,complete cds, (xliv) S78825 Id1, (xlv) D85429 H. sapiens gene for heatshock protein 40, complete cds, (xlvi) U41766 Humanmetalloprotease/disintegrin/cysteine-rich protein precursor (MDC9) mRNA,(xlvii) U89336 Human HLA class III region containing NOTCH4 gene,partial sequence, homeobox PB, (xlviii) M69181 Human nonmuscle myosinheavy chain-B (MYH10) mRNA, partial cds, (xlix) D15050 Human mRNA fortranscription factor AREB6, complete cds, (l) U28386 Human nuclearlocalization sequence receptor hSRP1alpha mRNA, complete cds, (li)L77886 Human protein tyrosine phosphatase mRNA, complete cds, (lii)X64330 H. sapiens mRNA for ATP-citrate lyase, (liii) U37122 Humanadducin gamma subunit mRNA, complete cds, (liv) X74008 H. sapiens mRNAfor protein phosphatase 1 gamma, (lv) U60205 Human methyl sterol oxidase(ERG25) mRNA, complete cds, (lvi) X76534 H. sapiens NMB mRNA, (lvii)D87071 Human mRNA for KIAA0233 gene, complete cds, (lviii) U90716 Humancell surface protein HCAR mRNA, complete cds, (lix) M91083 HumanDNA-binding protein (HRC1) mRNA, complete cds, (lx) U29607 Humanmethionine aminopeptidase mRNA, complete cds, (lxi) M76482 Human 130-kDpemphigus vulgaris antigen mRNA, complete cds, (lxii) U72066 H. sapiensCtBP interacting protein CtIP (CtIP) mRNA, complete cds, (lxiii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (lxiv) X12953Human rab2 mRNA, YPT1-related and member of ras family, (lxv) M60483Human protein phosphatase 2A catalytic subunit-alpha gene, complete cds,(lxvi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (lxvii) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (lxviii) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(lxix) D50840 H. sapiens mRNA for ceramide glucosyltransferase, completecds, (lxx) L31801 H. sapiens monocarboxylate transporter 1 (SLC16A1)mRNA, complete cds, (lxxi) S74017 Nrf2=NF-E2-like basic leucine zippertranscriptional activator [human, hemin-in, (lxxii) X87241 H. sapiensmRNA for hFat protein, (lxxiii) X52425 Human IL-4-R mRNA for theinterleukin 4 receptor, (lxxiv) D79994 Human mRNA for KIAA0172 gene,partial cds, (lxxv) M58286 H. sapiens tumor necrosis factor receptormRNA, complete cds, (lxxvi) M13829 Human putative raf related protein(pks/a-raf) mRNA, partial cds, (lxxvii) X78992 H. sapiens ERF-2 mRNA,(lxxviii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (Lxxix) U88629 Human RNA polymeraseII elongation factor ELL2, complete cds, (lxxx) X52611 Human mRNA fortranscription factor AP-2, (lxxxi) U28749 Human high-mobility groupphosphoprotein isoform I-C (HMGIC) mRNA, complete cds, (lxxxii) L00058Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank, (lxxxiii)L26336 Heat Shock Protein, 70 Kda (Gb:Y00371, (lxxxiv) L08246 Humanmyeloid cell differentiation protein (MCL1) mRNA, (lxxxv) S73591brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic,leukemia cells (lxxxvi) J0521 1 Desmoplakin, (lxxxvii)L00352 Human low density lipoprotein receptor gene, exon 18, (lxxxviii)Y13647 Stearoyl-Coenzymea Desaturase, (lxxxix) X77794 H. sapiens mRNAfor cyclin G1, (xc) M90656 Human gamma-glutamylcysteine synthetase (GCS)mRNA, complete cds, (xci) M13929 Human c-myc-P64 mRNA, initiating frompromoter P0, (HLmyc2.5) partial cds, (xcii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (xciii) X80692 H. sapiens ERK3 mRNA,and (xciv) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114; and (c)the protein expressed in the third response further comprises a proteinthat is encoded by a polynucleotide that is at least 90% identical to anucleic acid molecule selected from the group consisting of: (i) M20030Human small proline rich protein (sprII) mRNA, clone 930, (ii) X53065,(iii) M13903 Human involucrin gene, exon 2, (iv) M22918 Myosin, LightChain, Alkali, Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice, (v)L10343 Huma elafin gene, complete cds, (vi) M63573 Human secretedcyclophilin-like protein (SCYLP) mRNA, complete cds, (vii) M21302 Humansmall proline rich protein (sprII) mRNA, clone 174N, (viii) Y00787 HumanmRNA for MDNCF (monocyte-derived neutrophil chemotactic factor), (ix)X57985 H. sapiens genes for histones H2B.1 and H2A, (x) L05188 H.sapiens small proline-rich protein 2 (SPRR2B) gene, complete cds, (xi)X70326 Macmarcks, (xii) X67325 H. sapiens p27 mRNA, (xiii) L19779 H.sapiens histone H2A.2 mRNA, complete cds, (xiv) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, (xv) D45248 Human mRNA for proteasome activator hPA28subunit beta, complete cds, (xvi) Z22548 H. sapiens thiol-specificantioxidant protein mRNA, (xvii) M22918 Myosin, Light Chain, Alkali,Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice, (xviii) X06956Tubulin, Alpha 1, Isoform 44, (xix) V00594 Human mRNA formetallothionein from cadmium-treated cells, (xx) M80254 H. sapienscyclophilin isoform (hCyP3) mRNA, complete cds, (xxi) U04636 Humancyclooxygenase-2 (hCox-2) gene, complete cds, (xxii) Z14244 H. sapienscox VIIb mRNA for cytochrome c oxidase subunit VIIb, (xxiii) X99920 H.sapiens mRNA for S100 calcium-binding protein A13, (xxiv) U62800 Humancystatin M (CST6) mRNA, complete cds, (xxv) L08069 Human heat shockprotein, E. coli DnaJ homologue mRNA, complete cds, (xxvi) L20688 HumanGDP-dissociation inhibitor protein (Ly-GDI) mRNA, complete cds, (xxvii)M13755 Human interferon-induced 17-kDa/15-kDa protein mRNA, completecds, (xxviii) M60278 Human heparin-binding EGF-like growth factor mRNA,complete cds, (xxix) AF001294 H. sapiens IPL (IPL) mRNA, complete cds,(xxx) X54489 Human gene for melanoma growth stimulatory activity (MGSA),(xxxi) M21186 Human neutrophil cytochrome b light chain p22 phagocyteb-cytochrome mRNA, compl, (xxxii) D42040 Human mRNA for KIAA9001 gene,complete cds, (xxxiii) V00599 Tubulin, Beta, (xxxiv) U37690 Human RNApolymerase II subunit (hsRPB10) mRNA, complete cds, (xxxv) M21005 Humanmigration inhibitory factor-related protein 8 (MRP8) gene, complete cds,(xxxvi) M37583 Human histone (H2A.Z) mRNA, complete cds, (xxxvii) Z49989H. sapiens mRNA for smoothelin, (xxxviii) L24564 Human Rad mRNA,complete cds, (xxxix) D49824 Human HLA-B null allele mRNA, (xl) M59465Human tumor necrosis factor alpha inducible protein A20 mRNA, completecds, (xli) S54005 thymosin beta-10 [human, metastatic melanoma cellline, mRNA, 453 nt], (xlii) Z49254 H. sapiens L23-related mRNA, (xliii)M22919 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629), SmoothMuscle, Alt. Spli, (xliv) U70660 Human copper transport protein HAH1(HAH1) mRNA, complete cds, (xlv) AF006084 H. sapiens Arp2/3 proteincomplex subunit p41-Arc (ARC41) mRNA, complete cds, (xlvi) X62083 H.sapiens mRNA for Drosophila female sterile homeotic (FSH) homologue,(xlvii) D86974 Human mRNA for KIAA0220 gene, partial cds, (xlviii)M72885 Human GOS2 gene, 5′ flank and cds, (xlix) S80437 fatty acidsynthase {3′ region} [human, breast and HepG2 cells, mRNA Partial, 22,(l) X04654 Human mRNA for U1 RNA-associated 70K protein, (li) t M26311Human cystic fibrosis antigen mRNA, complete cds, (lii) X14850 HumanH2A.X mRNA encoding histone H2A.X, (liii) M14328 Human alpha enolasemRNA, complete cds, (liv) U07919 Human aldehyde dehydrogenase 6 mRNA,complete cds, (lv) M28130 Human interleukin 8 (IL8) gene, complete cds,(lvi) Z21507 H. sapiens EF-1delta gene encoding human elongationfactor-1-delta, (lvii) M92934 Human connective tissue growth factor,complete cds, (iviii) M27436 Human tissue factor gene, complete cds,with a Alu repetitive sequence in the 3′, (lix) X74874 H. sapiens genefor RNA pol II largest subunit, exon 1, (lx) X57351 Human 1-8D gene frominterferon-inducible gene family, (lxi) X52979 Human gene for smallnuclear ribonucleoproteins SmB and SmB′, (lxii) U41515 Human deleted insplit hand/split foot 1 (DSS1) mRNA, complete cds, (lxiii) D28235 HumanPTGS2 gene for prostaglandin endoperoxide synthase-2, complete cds,(lxiv) Y00503 Human mRNA for keratin
 19. (lxv) M57731 Human gro-betamRNA, complete cds, (lxvi) D50840 H. sapiens mRNA for ceramideglucosyltransferase, complete cds, (lxvii) U52101 Human YMP mRNA,complete cds. (lxviii) D13413 Human mRNA for tumor-associated 120 kDanuclear protein p120, partial cds(carbox, (lxix) L42379 H. sapiensbone-derived growth factor (BPGF-1) mRNA, complete cds, (lxx) X52426 H.sapiens mRNA for cytokeratin 13, (lxxi) J04456 Human 14 kd lectin mRNA,complete cds, (lxxii) S78771 NAT=CpG island-associated gene [human,mRNA, 1741 nt], (lxxiii) M26730 Human mitochondrial ubiquinone-bindingprotein (QP) gene, exon 4, (lxxiv) U26727 Human p16INK4/MTS1 mRNA,complete cds, (lxxv) X92896 H. sapiens mRNA for ITBA2 protein, (lxxvi)Z69043 H. sapiens mRNA translocon-associated protein delta subunitprecursor, (lxxvii) L76568 H. sapiens excision and cross link repairprotein (ERCC4) gene, complete genom, (lxxviii) M12125 Human fibroblastmuscle-type tropomyosin mRNA, complete cds, (lxxix) U09937 Humanurokinase-type plasminogen receptor, exon 7, (lxxx) X15822 Human COXVIIa-L mRNA for liver-specific cytochrome c oxidase (EC 1.9.3.1.),(lxxxi) M34516 Human omega light chain protein 14.1 (Ig lambda chainrelated) gene, exon 3, (lxxxii) U53830 H. sapiens interferon regulatoryfactor 7A mRNA, complete cds, (lxxxiii) X82693 H. sapiens mRNA for E48antigen, (lxxxiv) M58026 Human NB-1 mRNA, complete cds, (lxxxv) M90657Human tumor antigen (L6) mRNA, complete cds, (lxxxvi) X57579 H. sapiensactivin beta-A subunit (exon 2), (lxxxvii) D38251 Human mRNA for RPB5(XAP4), complete cds, (lxxxviii) D89667 H. sapiens mRNA for c-mycbinding protein, complete cds, (lxxxix) AB000584 H. sapiens mRNA forTGF-beta superfamily protein, complete cds, (xc) L76200 Human guanylatekinase (GUK1) mRNA, complete cds, (xci) J04794 Human aldehyde reductasemRNA, complete cds, (xcii) X52882 Human t-complex polypeptide 1 gene,(xciii) M79463 Human PML-2 mRNA, complete CDS, (xciv) Y09022 H. sapiensmRNA for Not56-like protein, (xcv) M12529 Human apolipoprotein E mRNA,complete cds, (xcvi) X71129 H. sapiens mRNA for electron transferflavoprotein beta subunit, (xcvii) X83416 H. sapiens PrP gene, exon 2,(xcviii) D89052 H. sapiens mRNA for proton-ATPase-like protein, completecds, (xcix) M60974 Human growth arrest and DNA-damage-inducible protein(gadd45) mRNA, complete cds, (c) M16364 Human creatine kinase-B mRNA,complete cds, (ci) D38305 Human mRNA for Tob, complete cds, (cii) X87679Major Histocompatibility Complex, Class I, E (Gb:M21533), (ciii) Z29505H. sapiens mRNA for nucleic acid binding protein sub2.3, (civ) K02574,(cv) U09813 Human mitochondrial ATP synthase subunit 9, P3 gene copy,mRNA, nuclear gene enc, (cvi) X67951 H. sapiens mRNA forproliferation-associated gene (pag), (cvii) J04611 Human lupus p70 (Ku)autoantigen protein mRNA, complete cds, (cviii) U09578 H. sapiens MAPKAPkinase (3pK) mRNA, complete cds, (cix) X53800 Human mRNA for macrophageinflammatory protein-2beta (MIP2beta), (cx) V00599 Tubulin, Beta 2,(cxi) U69126 Human FUSE binding protein 2 (FBP2) mRNA, partial cds,(cxii) X53416 Human mRNA for actin-binding protein (filamin) (ABP-280),(cxiii) U90546 Human butyrophilin (BTF4) mRNA, complete cds, (cxiv)M58459 Human ribosomal protein (RPS4Y) isoform mRNA, complete cds, (cxv)M19961 Human cytochrome c oxidase subunit Vb (coxVb) mRNA, complete cds,(cxvi) U65579 Human mitochondrial NADH dehydrogenase-ubiquinone Fe—Sprotein 8, 23 kDa subunit, (cxvii) X77794 H. sapiens mRNA for cyclin G1,(cxviii) M29064 Human hnRNP B1 protein mRNA, (cxix) D21853 Human mRNAfor KIAA0111 gene, complete cds, (cxx) X78687 H. sapiens G9 geneencoding sialidase, (cxxi) X15729 Human mRNA for nuclear p68 protein,(cxxii) X04828 Human mRNA for G(i) protein alpha-subunit (adenylatecyclase inhibiting GTP-bind, (cxxiii) L27943 H. sapiens cytidinedeaminase (CDA) mRNA, complete cds, (cxxiv) L40391 H. sapiens (clones153) mRNA fragment, (cxxv) D42123 H. sapiens mRNA for ESP1/CRP2,complete cds, (cxxvi) X74104 H. sapiens mRNA for TRAP beta subunit,(cxxvii) M84332 Human ADP-ribosylation factor 1 gene, exons 2-5,(cxxviii) L37127 H. sapiens RNA polymerase II mRNA, complete cds,(cxxix) M92843 H. sapiens zinc finger transcriptional regulator mRNA,complete cds, (cxxx) U07664 Human HB9 homeobox gene, exons 2 and 3 andcomplete cds, (cxxxi) L48546 H. sapiens tuberin (TSC2) gene, exons 38,39, 40 and 41, (cxxxii) X53586 Human mRNA for integrin alpha 6,(cxxxiii) t D21852 Human mRNA for KIAA0029 gene, partial cds, (cxxxiv)L11066 Human mRNA sequence, (cxxxv) J04444 Human cytochrome c-1 gene,complete cds, (cxxxvi) M95787 Human 22 kDa smooth muscle protein (SM22)mRNA, complete cds, (cxxxvii) L07517 Mucin 6, Gastric (Gb:L07517),(cxxxviii) X91247 H. sapiens mRNA for thioredoxin reductase, (cxxxix)L11672 Human Kruppel related zinc finger protein (HTF10) mRNA, completecds, (cxl) U30999 Human (memc) mRNA, 3′UTR, (cxli) U01337 Human Ser/Thrprotein kinase (A-RAF-1) gene, complete cds, (cxlii) U28480 UncouplingProtein Ucp, (cxliii) X12794 Human v-erbA related ear-2 gene, (cxliv)L22005 Human ubiquitin conjugating enzyme mRNA, partial cds, (cxlv)M12886 Human T-cell receptor active beta-chain mRNA, complete cds,(cxlvi) Y08915 H. sapiens mRNA for alpha 4 protein, (cxlvii) M24547Amyloid Beta (A4) Precursor Protein, Alt. Splice 2, A4(751), (cxlviii)X76717 H. sapiens MT-1l mRNA, (cxlix) M64347 Human novel growth factorreceptor mRNA, 3′ cds, (cl) X05409 Human RNA for mitochondrial aldehydedehydrogenase I ALDH I (EC 1.2.1.3), (cli) D87469 Human mRNA forKIAA0279 gene, partial cds, (clii) M58603 Human nuclear factor kappa-BDNA binding subunit (NF-kappa-B) mRNA, complete cds, (cliii) M76482Human 130-kD pemphigus vulgaris antigen mRNA, complete cds, (cliv)X06323 Human MRL3 mRNA for ribosomal protein L3 homologue (MRL3=mammalian ribosome L, (clv) X78992 H. sapiens ERF-2 mRNA, (clvi)L41351 H. sapiens prostasin mRNA, complete cds, (clvii) X75342 H.sapiens SHB mRNA, (clviii) U83115 Human non-lens beta gamma-crystallinlike protein (AIM1) mRNA, partial cds, (clix) U88629 Human RNApolymerase II elongation factor ELL2, complete cds, (clx) S78825 Id1,(clxi) U28811 Human cysteine-rich fibroblast growth factor receptor(CFR-1) mRNA, complete cds, (clxii) M58286 H. sapiens tumor necrosisfactor receptor mRNA, complete cds, (clxiii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (clxiv) D14874 H. sapiens mRNA foradrenomedullin precursor, complete cds, (clxv) Z26317 H. sapiens mRNAfor desmoglein 2, (clxvi) L19267 H. sapiens 59 protein mRNA, 3′ end,(clxvii) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114, (clxviii)U33821 Human tax1-binding protein TXBP151 mRNA, complete cds, (clxix)U52100 Human XMP mRNA, complete cds, (clxx) L31801 H. sapiensmonocarboxylate transporter 1 (SLC16A1) mRNA, complete cds, (clxxi)L00058 Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank,(clxxii) U52426 H. sapiens GOK (STIM1) mRNA, complete cds, (clxxiii)M80244 Human E16 mRNA, complete cds, (clxxiv) U56418 Humanlysophosphatidic acid acyltransferase-beta mRNA, complete cds, (clxxv)L38490 H. sapiens ADP-ribosylation factor mRNA, complete cds, (clxxvi)U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (clxxvii) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (clxxviii) M38258 Human retinoic acid receptor gamma 1mRNA, complete cds, (clxxix) X89750 H. sapiens mRNA for TGIF protein,(clxxx) D85429 H. sapiens gene for heat shock protein 40, complete cds,(clxxxi) J05211 Desmoplakin I, (clxxxii) M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds, (clxxxiii) X80695 H. sapiensOXA1Hs mRNA, (clxxxiv) M54915 Human h-pim-1 protein (h-pim-1) mRNA,complete cds, (clxxxv) D83777 Human mRNA for KIAA0193 gene, completecds, (clxxxvi) D31883 Human mRNA for KIAA0059 gene, complete cds,(clxxxvii) U00968 Human SREBP-1 mRNA, complete cds, (clxxxviii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (clxxxix)D86965 Human mRNA for KIAA0210 gene, complete cds, (cxc) Z30643 H.sapiens mRNA for chloride channel (putative) 2139 bp, (cxci) D14520Human mRNA for GC-Box binding protein BTEB2, complete cds, (cxcii)D87462 Human mRNA for KIAA0272 gene, partial cds, (cxciii) X80692 H.sapiens ERK3 mRNA, (cxciv) X90858 H. sapiens mRNA for uridinephosphorylase, (cxcv) M57763 Human ADP-ribosylation factor (hARF6) mRNA,complete cds, (cxcvi) X92720 H. sapiens mRNA for phosphoenolpyruvatecarboxykinase, (cxcvii) M81601 Human transcription elongation factor(SII) mRNA, complete cds, (cxcviii) X52611 Human mRNA for transcriptionfactor AP-2, (cxcix) U09587 Human glycyl-tRNA synthetase mRNA, completecds, (cc) U14550 Human sialyltransferase SThM (sthm) mRNA, complete cds,(cci) D90209 Human mRNA for DNA binding protein TAXREB67, (ccii) X77366H. sapiens HBZ17 mRNA, (cciii) X76534 H. sapiens NMB mRNA, (cciv) U37519Human aldehyde dehydrogenase (ALDH8) mRNA, complete cds, (ccv) M83667Human NF-IL6-beta protein mRNA, complete cds, (ccvi) U53347 Humanneutral amino acid transporter B mRNA, complete cds, (ccvii) L09229Human long-chain acyl-coenzyme A synthetase (FACL1) mRNA, complete cds,(ccviii) S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, (ccix) M13929 Human c-myc-P64 mRNA,initiating from promoter P0, (HLmyc2.5) partial cds, (ccx) M55268 Humancasein kinase II alpha′ subunit mRNA, complete cds, (ccxi) M77836 Humanpyrroline 5-carboxylate reductase mRNA, complete cds, (ccxii)HG2724-HT2820_at S75762 Oncogene Tls/Chop, Fusion Activated, (ccxiii)U72066 H. sapiens CtBP interacting protein CtIP (CtIP) mRNA, completecds, (ccxiv) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (ccxv) M27396 Human asparaginesynthetase mRNA, complete cds, (ccxvi) X01630 Human mRNA forargininosuccinate synthetase, (ccxvii) D32050 Human mRNA for alanyl-tRNAsynthetase, complete cds, (ccxviii) M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, (ccxix) J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,and (ccxx) X69111 H. sapiens HLH 1R21 mRNA for helix-loop-helix protein.41. The method according to claim 33, wherein the cell is an epidermalcell.
 42. The method according to claim 33 wherein the cell is selectedfrom the group consisting of a keratinocyte, a Langerhans cell, amelanocyte, and a fibroblast cell.
 43. The method according to claim 33,wherein the protein is isolated at a time point between about 0.5 toabout 2 hours post-ultraviolet radiation exposure.
 44. The methodaccording to claim 33, wherein the protein is isolated at a time pointbetween about 4 to about 8 hours post-ultraviolet radiation exposure.45. The method according to claim 33, wherein the protein is isolated ata time point between about 16 to about 24 hours post-ultravioletradiation exposure.
 46. The method according to claim 33, wherein thelevels of a plurality of protein molecules are measured by ELISA.
 47. Apharmaceutical composition for modulating the response of a cell toultraviolet radiation exposure comprising: (a) a compound in sufficientquantity to modulate the response of the cell to ultraviolet radiationexposure, the response being a pattern of expression comprising at leastone of the following: (i) a first response comprising altered expressionof at least one of a transcription factor protein, at least one of asignal transducing protein, and at least one of a mitochondrial protein;(ii) a second response comprising altered expression of at least one ofa of a secreted growth factor protein, at least one of a cytokineprotein, and at least one of a chemokine protein; and/or (iii) a thirdresponse comprising altered expression of at least one of anactin-binding protein, at least one of a desmosomal protein, and atleast one of a tubulin protein; and (b) a pharmaceutically acceptablecarrier.
 48. The pharmaceutical composition of claim 47, wherein the theprotein expressed in the first response further comprises a protein thatis encoded by a polynucleotide that is at least 90% identical to anucleic acid molecule selected from the group consisting of: (i) M62831Human transcription factor ETR101 mRNA, complete cds, (ii) X68277 H.sapiens CL 100 mRNA for protein tyrosine phosphatase, (iii) L04731 H.sapiens translocation T(4:11) of ALL-1 gene to chromosome 4, (iv) X56681Human junD mRNA, (v) U20734 Human transcription factor junB (junB) gene,5′ region and complete cds, (vi) L38951 H. sapiens importin beta subunitmRNA, complete cds, (vii) D87071 Human mRNA for KIAA0233 gene, completecds, (viii) M72885 Human GOS2 gene, 5′ flank and cds, (ix) M92843 H.sapiens zinc finger transcriptional regulator mRNA, complete cds, (x)S81914 IEX-1=radiation-inducible immediate-early gene [human, placenta,mRNA Partial, (xi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (xii)D86988 Human mRNA for KIAA0221 gene, complete cds, (xiii) L19779 H.sapiens histone H2A.2 mRNA, complete cds, (xiv) U62317 Chromosome 22q13BAC Clone CIT987SK-384D8 complete sequence, (xv) X04412 Human mRNA forplasma gelsolin, (xvi) L27706 Human chaperonin protein (Tcp20) genecomplete cds, (xvii) X61123 Human BTG1 mRNA, (xviii) M60974growth arrestand DNA-damage-inducible protein (gadd45) mRNA, complete cds, (xix)L19437 Human transaldolase mRNA containing transposable element,complete cds, (xx) X57985 H. sapiens genes for histones H2B.1 and H2A,(xxi) D90086 Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunitgene, exons 1-10, (xxii) M34182 Human testis-specific protein kinasegamma-subunit mRNA, complete cds, (xxiii) L16862 H. sapiens Gprotein-coupled receptor kinase (GRK6) mRNA, complete cds, (xxiv) D13705Human mRNA for fatty acids omega-hydroxylase (cytochrome P-450HKV),complete cd, (xxv) U37122 Human adducin gamma subunit mRNA, completecds, (xxvi) D45906 H. sapiens mRNA for LIMK-2, complete cds, (xxvii)U07664 Human HB9 homeobox gene, exons 2 and 3 and complete cds, (xxviii)D87438 Human mRNA for KIAA0251 gene, partial cds, (xxix) L37042 H.sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds,(xxx) D14043 Human mRNA for MGC-24, complete cds, (xxxi) D13988 Humanrab GDI mRNA, complete cds, (xxxii) U28480 Uncoupling Protein Uc,(xxxiii) D50840 H. sapiens mRNA for ceramide glucosyltransferase,complete cds, (xxxiv) M55265 Human casein kinase II alpha subunit mRNA,complete cds, (xxxv) M96803 Human general beta-spectrin (SPTBN1) mRNA,complete cds, (xxxvi) U89336 Human HLA class III region containingNOTCH4 gene, partial sequence, homeobox P, (xxxvii) D87442 Human mRNAfor KIAA0253 gene, partial cds, (xxxviii) J03161 Human serum responsefactor (SRF) mRNA, complete cds, (xxxix) D86965 Human mRNA for KIAA0210gene, complete cds, (xl) U17327 Human neuronal nitric oxide synthase(NOS1) mRNA, complete cds, (xli) D86966 Human mRNA for KIAAO211 gene,complete cds, (xlii) D85527 H. sapiens mRNA for LIM domain, partial cds,(xliii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (xliv) X59434 Human rohu mRNA forrhodanese, (xlv) M13929 Human c-myc-P64 mRNA, initiating from promoterP0, (HLmyc2.5) partial cds, and (xlvi) J05211 Desmoplakin.
 49. Thepharmaceutical composition of claim 47, wherein the protein expressed inthe second response further comprises a protein that is encoded by apolynucleotide that is at least 90% identical to a nucleic acid moleculeselected from the group consisting of: (i) M57731 Human gro-beta mRNA,complete cds, (ii) S81914 IEX-1=radiation-inducible immediate-early gene[human, placenta, mRNA Partial, 1, (iii) Y00787 Human mRNA for MDNCF(monocyte-derived neutrophil chemotactic factor), (iv) X54489 Human genefor melanoma growth stimulatory activity (MGSA), (v) M72885 Human GOS2gene, 5′ flank and cds, (vi) M62831 Human transcription factor ETR101mRNA, complete cds, (vii) M28130 Human interleukin 8 (IL8) gene,complete cds, (viii) X57985 H. sapiens genes for histones H2B.1 and H2A,(ix) X53800 Human mRNA for macrophage inflammatory protein-2beta(MIP2beta), (x) L19779 H. sapiens histone H2A.2 mRNA, complete cds, (xi)AF001294 H. sapiens IPL (IPL) mRNA, complete cds, (xii) X56681 HumanjunD mRNA, (xiii) S75762 Oncogene Tls/Chop, Fusion Activate, (xiv)M84739 Human autoantigen calreticulin mRNA, complete cds, (xv) M21302Human small proline rich protein (sprII) mRNA, clone 174N, (xvi) V00599Tubulin, Bet, (xvii) X70326 Macmarck, (xviii) D10923 Human mRNA forHM74, (xix) D64142 Human mRNA for histone H1x, complete cds, (xx) D86974Human mRNA for KIAA0220 gene, partial cds, (xxi) M60974 Human growtharrest and DNA-damage-inducible protein (gadd45) mRNA, complete cds,(xxii) X68277 H. sapiens CL 100 mRNA for protein tyrosine phosphatase,(xxiii) L13391 Human helix-loop-helix basic phosphoprotein (G0S8) gene,complete cds, (xxiv) M31627 Human X box binding protein-1 (XBP-1) mRNA,complete cds, (xxv) U40369 Human spermidine/spermineN1-acetyltransferase (SSAT) gene, complete cds, (xxvi) X52560 NuclearFactor Nf-Il, (xxvii) X61123 Human BTG1 mRNA, (xxviii) U20734 Humantranscription factor junB (junB) gene, 5′ region and complete cds,(xxix) U35048 Human TSC-22 protein mRNA, complete cds, (xxx) M69043 H.sapiens MAD-3 mRNA encoding IkB-like activity, complete cds, (xxxi)X51345 Human jun-B mRNA for JUN-B protein, (xxxii) S68616 Na+/H+exchanger NHE-1 isoform [human, heart, mRNA, 4516 nt], (xxxiii) X89750H. sapiens mRNA for TGIF protein, (xxxiv) X69111 H. sapiens HLH 1R21mRNA for helix-loop-helix protein, (xxxv) U14603 Human protein-tyrosinephosphatase (HU-PP-1) mRNA, partial sequence, (xxxvi) X52541 Human mRNAfor early growth response protein 1 (hEGR1), (xxxvii) D50683 H. sapiensmRNA for TGF-betaIIR alpha, complete cds, (xxxviii) M92843 H. sapienszinc finger transcriptional regulator mRNA, complete cds, (xxxix) X91247H. sapiens mRNA for thioredoxin reductase, (xl) U05875 Human clone pSK1interferon gamma receptor accessory factor-1 (AF-1) mRNA, comp, (xli)L19314 Human HRY gene, complete cds, (xlii) M30703 Human amphiregulin(AR) gene, exon 6, clones lambda-ARH(6,12), (xliii) U34252 Humangamma-aminobutyraldehyde dehydrogenase mRNA, complete cds, (xliv) S78825Id1, (xlv) D85429 H. sapiens gene for heat shock protein 40, completecds, (xlvi) U41766 Human metalloprotease/disintegrin/cysteine-richprotein precursor (MDC9) mRNA, (xlvii) U89336 Human HLA class III regioncontaining NOTCH4 gene, partial sequence, homeobox PB, (xlviii) M69181Human nonmuscle myosin heavy chain-B (MYH10) mRNA, partial cds, (xlix)D15050 Human mRNA for transcription factor AREB6, complete cds, (l)U28386 Human nuclear localization sequence receptor hSRP1alpha mRNA,complete cds, (li) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (lii) X64330 H. sapiens mRNA for ATP-citrate lyase, (liii)U37122 Human adducin gamma subunit mRNA, complete cds, (liv) X74008 H.sapiens mRNA for protein phosphatase 1 gamma, (lv) U60205 Human methylsterol oxidase (ERG25) mRNA, complete cds, (lvi) X76534 H. sapiens NMBmRNA, (lvii) D87071 Human mRNA for KIAA0233 gene, complete cds, (lviii)U90716 Human cell surface protein HCAR mRNA, complete cds, (lix) M91083Human DNA-binding protein (HRC1) mRNA, complete cds, (lx) U29607 Humanmethionine aminopeptidase mRNA, complete cds, (lxi) M76482 Human 130-kDpemphigus vulgaris antigen mRNA, complete cds, (lxii) U72066 H. sapiensCtBP interacting protein CtIP (CtIP) mRNA, complete cds, (lxiii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (lxiv) X12953Human rab2 mRNA, YPT1-related and member of ras family, (lxv) M60483Human protein phosphatase 2A catalytic subunit-alpha gene, complete cds,(lxvi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (lxvii) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (lxviii) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(lxix) D50840 H. sapiens mRNA for ceramide glucosyltransferase, completecds, (lxx) L31801 H. sapiens monocarboxylate transporter 1 (SLC16A1)mRNA, complete cds, (lxxi) S74017 Nrf2=NF-E2-like basic leucine zippertranscriptional activator [human, hemin-in, (lxxii) X87241 H. sapiensmRNA for hFat protein, (lxxiii) X52425 Human IL-4-R mRNA for theinterleukin 4 receptor, (lxxiv) D79994 Human mRNA for KIAA0172 gene,partial cds, (lxxv) M58286 H. sapiens tumor necrosis factor receptormRNA, complete cds, (lxxvi) Ml3829 Human putative raf related protein(pks/a-raf) mRNA, partial cds, (lxxvii) X78992 H. sapiens ERF-2 mRNA,(lxxviii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (lxxix) U88629 Human RNA polymeraseII elongation factor ELL2, complete cds, (lxxx) X52611 Human mRNA fortranscription factor AP-2, (lxxxi) U28749 Human high-mobility groupphosphoprotein isoform I-C (HMGIC) mRNA, complete cds, (lxxxii) L00058Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank, (lxxxiii)L26336 Heat Shock Protein, 70 Kda (Gb:Y00371, (lxxxiv) L08246 Humanmyeloid cell differentiation protein (MCL1) mRNA, (lxxxv) S73591brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic,leukemia cells (lxxxvi) J05211 Desmoplakin, (lxxxvii)L00352 Human low density lipoprotein receptor gene, exon 18, (lxxxviii)Y13647 Stearoyl-Coenzymea Desaturase, (lxxxix) X77794 H. sapiens mRNAfor cyclin G1, (xc) M90656 Human gamma-glutamylcysteine synthetase (GCS)mRNA, complete cds, (xci) M13929 Human c-myc-P64 mRNA, initiating frompromoter P0, (HLmyc2.5) partial cds, (xcii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (xciii) X80692 H. sapiens ERK3 mRNA,and (xciv) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf
 114. 50. Thepharmaceutical composition of claim 47, wherein the protein expressed inthe third response further comprises a protein that is encoded by apolynucleotide that is at least 90% identical to a nucleic acid moleculeselected from the group consisting of: (i) M20030 Human small prolinerich protein (sprII) mRNA, clone 930, (ii) X53065, (iii) M13903 Humaninvolucrin gene, exon 2, (iv) M22918 Myosin, Light Chain, Alkali, SmoothMuscle (Gb:U02629), Non-Muscle, Alt. Splice, (v) L10343 Huma elafingene, complete cds, (vi) M63573 Human secreted cyclophilin-like protein(SCYLP) mRNA, complete cds, (vii) M21302 Human small proline richprotein (sprII) mRNA, clone 174N, (viii) Y00787 Human mRNA for MDNCF(monocyte-derived neutrophil chemotactic factor), (ix) X57985 H. sapiensgenes for histones H2B.1 and H2A, (x) L05188 H. sapiens smallproline-rich protein 2 (SPRR2B) gene, complete cds, (xi) X70326Macmarcks, (xii) X67325 H. sapiens p27 mRNA, (xiii) L19779 H. sapienshistone H2A.2 mRNA, complete cds, (xiv) S81914 IEX-1=radiation-inducibleimmediate-early gene [human, placenta, mRNA Partial, 1, (xv) D45248Human mRNA for proteasome activator hPA28 subunit beta, complete cds,(xvi) Z22548 H. sapiens thiol-specific antioxidant protein mRNA, (xvii)M22918 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629),Non-Muscle, Alt. Splice, (xviii) X06956 Tubulin, Alpha 1, Isoform 44,(xix) V00594 Human mRNA for metallothionein from cadmium-treated cells,(xx) M80254 H. sapiens cyclophilin isoform (hCyP3) mRNA, complete cds,(xxi) U04636 Human cyclooxygenase-2 (hCox-2) gene, complete cds, (xxii)Z14244 H. sapiens coxVIIb mRNA for cytochrome c oxidase subunit VIIb,(xxiii) X99920 H. sapiens mRNA for S100 calcium-binding protein A13,(xxiv) U62800 Human cystatin M (CST6) mRNA, complete cds, (xxv) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(xxvi) L20688 Human GDP-dissociation inhibitor protein (Ly-GDI) mRNA,complete cds, (xxvii) M13755 Human interferon-induced 17-kDa/15-kDaprotein mRNA, complete cds, (xxviii) M60278 Human heparin-bindingEGF-like growth factor mRNA, complete cds, (xxix) AF001294 H. sapiensIPL (IPL) mRNA, complete cds, (xxx) X54489 Human gene for melanomagrowth stimulatory activity (MGSA), (xxxi) M21186 Human neutrophilcytochrome b light chain p22 phagocyte b-cytochrome mRNA, compl, (xxxii)D42040 Human mRNA for KIAA9001 gene, complete cds, (xxxiii) V00599Tubulin, Beta, (xxxiv) U37690 Human RNA polymerase II subunit (hsRPB10)mRNA, complete cds, (xxxv) M21005 Human migration inhibitoryfactor-related protein 8 (MRP8) gene, complete cds, (xxxvi) M37583 Humanhistone (H2A.Z) mRNA, complete cds, (xxxvii) Z49989 H. sapiens mRNA forsmoothelin, (xxxviii) L24564 Human Rad mRNA, complete cds, (xxxix)D49824 Human HLA-B null allele mRNA, (xl) M59465 Human tumor necrosisfactor alpha inducible protein A20 mRNA, complete cds, (xli) S54005thymosin beta-10 [human, metastatic melanoma cell line, mRNA, 453 nt],(xlii) Z49254 H. sapiens L23-related mRNA, (xliii) M22919 Myosin, LightChain, Alkali, Smooth Muscle (Gb:U02629), Smooth Muscle, Alt. Spli,(xliv) U70660 Human copper transport protein HAH1 (HAH1) mRNA, completecds, (xlv) AF006084 H. sapiens Arp2/3 protein complex subunit p41-Arc(ARC41) mRNA, complete cds, (xlvi) X62083 H. sapiens mRNA for Drosophilafemale sterile homeotic (FSH) homologue, (xlvii) D86974 Human mRNA forKIAA0220 gene, partial cds, (xlviii) M72885 Human GOS2 gene, 5′ flankand cds, (xlix) S80437 fatty acid synthase {3′ region} [human, breastand HepG2 cells, mRNA Partial, 22, (l) X04654 Human mRNA for U1RNA-associated 70K protein, (ii) t M26311 Human cystic fibrosis antigenmRNA, complete cds, (lii) X14850 Human H2A.X mRNA encoding histoneH2A.X, (liii) M14328 Human alpha enolase mRNA, complete cds, (liv)U07919 Human aldehyde dehydrogenase 6 RNA, complete cds, (lv) M28130Human interleukin 8 (IL8) gene, complete cds, (lvi) Z21507 H. sapiensEF-1delta gene encoding human elongation factor-1-delta, (lvii) M92934Human connective tissue growth factor, complete cds, (lviii) M27436Human tissue factor gene, complete cds, with a Alu repetitive sequencein the 3′, (lix) X74874 H. sapiens gene for RNA pol II largest subunit,exon 1, (lx) X57351 Human 1-8D gene from interferon-inducible genefamily, (lxi) X52979 Human gene for small nuclear ribonucleoproteins SmBand SmB′, (lxii) U41515 Human deleted in split hand/split foot 1 (DSS1)mRNA, complete cds, (lxiii) D28235 Human PTGS2 gene for prostaglandinendoperoxide synthase-2, complete cds, (lxiv) Y00503 Human mRNA forkeratin
 19. (lxv) M57731 Human gro-beta mRNA, complete cds, (lxvi)D50840 H. sapiens mRNA for ceramide glucosyltransferase, complete cds,(lxvii) U52101 Human YMP mRNA, complete cds. (lxviii) D13413 Human mRNAfor tumor-associated 120 kDa nuclear protein p120, partial cds(carbox,(lxix) L42379 H. sapiens bone-derived growth factor (BPGF-1) mRNA,complete cds, (lxx) X52426 H. sapiens mRNA for cytokeratin 13, (lxxi)J04456 Human 14 kd lectin mRNA, complete cds, (lxxii) S78771 NAT=CpGisland-associated gene [human, mRNA, 1741 nt], (lxxiii) M26730 Humanmitochondrial ubiquinone-binding protein (QP) gene, exon 4, (lxxiv)U26727 Human p16INK4/MTS1 mRNA, complete cds, (lxxv) X92896 H. sapiensmRNA for ITBA2 protein, (lxxvi) Z69043 H. sapiens mRNAtranslocon-associated protein delta subunit precursor, (lxxvii) L76568H. sapiens excision and cross link repair protein (ERCC4) gene, completegenom, (lxxviii) M12125 Human fibroblast muscle-type tropomyosin mRNA,complete cds, (lxxix) U09937 Human urokinase-type plasminogen receptor,exon 7, (lxxx) X15822 Human COX VIIa-L mRNA for liver-specificcytochrome c oxidase (EC 1.9.3.1.), (lxxxi) M34516 Human omega lightchain protein 14.1 (Ig lambda chain related) gene, exon 3, (lxxxii)U53830 H. sapiens interferon regulatory factor 7A mRNA, complete cds,(lxxxiii) X82693 H. sapiens mRNA for E48 antigen, (lxxxiv) M58026 HumanNB-1 mRNA, complete cds, (lxxxv) M90657 Human tumor antigen (L6) mRNA,complete cds, (lxxxvi) X57579 H. sapiens activin beta-A subunit (exon2), (lxxxvii) D38251 Human mRNA for RPB5 (XAP4), complete cds,(lxxxviii) D89667 H. sapiens mRNA for c-myc binding protein, completecds, (lxxxix) AB000584 H. sapiens mRNA for TGF-beta superfamily protein,complete cds, (xc) L76200 Human guanylate kinase (GUK1) mRNA, completecds, (xci) J04794 Human aldehyde reductase mRNA, complete cds, (xcii)X52882 Human t-complex polypeptide 1 gene, (xciii) M79463 Human PML-2mRNA, complete CDS, (xciv) Y09022 H. sapiens mRNA for Not56-likeprotein, (xcv) M12529 Human apolipoprotein E mRNA, complete cds, (xcvi)X71129 H. sapiens mRNA for electron transfer flavoprotein beta subunit,(xcvii) X83416 H. sapiens PrP gene, exon 2, (xcviii) D89052 H. sapiensmRNA for proton-ATPase-like protein, complete cds, (xcix) M60974 Humangrowth arrest and DNA-damage-inducible protein (gadd45) mRNA, completecds, (c) M16364 Human creatine kinase-B mRNA, complete cds, (ci) D38305Human mRNA for Tob, complete cds, (cii) X87679 Major HistocompatibilityComplex, Class I, E (Gb:M21533), (ciii) Z29505 H. sapiens mRNA fornucleic acid binding protein sub2.3, (civ) K02574, (cv) U09813 Humanmitochondrial ATP synthase subunit 9, P3 gene copy, mRNA, nuclear geneenc, (cvi) X67951 H. sapiens mRNA for proliferation-associated gene(pag), (cvii) J04611 Human lupus p70 (Ku) auto antigen protein mRNA,complete cds, (cviii) U09578 H. sapiens MAPKAP kinase (3pK) mRNA,complete cds, (cix) X53800 Human mRNA for macrophage inflammatoryprotein-2beta (MIP2beta), (cx) V00599 Tubulin, Beta 2, (cxi) U69126Human FUSE binding protein 2 (FBP2) mRNA, partial cds, (cxii) X53416Human mRNA for actin-binding protein (filamin) (ABP-280), (cxiii) U90546Human butyrophilin (BTF4) mRNA, complete cds, (cxiv) M58459 Humanribosomal protein (RPS4Y) isoform mRNA, complete cds, (cxv) M19961 Humancytochrome c oxidase subunit Vb (coxVb) mRNA, complete cds, (cxvi)U65579 Human mitochondrial NADH dehydrogenase-ubiquinone Fe—S protein 8,23 kDa subunit, (cxvii) X77794 H. sapiens mRNA for cyclin G1, (cxviii)M29064 Human hnRNP B1 protein mRNA, (cxix) D21853 Human mRNA forKIAA0111 gene, complete cds, (cxx) X78687 H. sapiens G9 gene encodingsialidase, (cxxi) X15729 Human mRNA for nuclear p68 protein, (cxxii)X04828 Human mRNA for G(i) protein alpha-subunit (adenylate cyclaseinhibiting GTP-bind, (cxxiii) L27943 H. sapiens cytidine deaminase (CDA)mRNA, complete cds, (cxxiv) L40391 H. sapiens (clone s153) mRNAfragment, (cxxv) D42123 H. sapiens mRNA for ESP1/CRP2, complete cds,(cxxvi) X74104 H. sapiens mRNA for TRAP beta subunit, (cxxvii) M84332Human ADP-ribosylation factor 1 gene, exons 2-5, (cxxviii) L37127 H.sapiens RNA polymerase II mRNA, complete cds, (cxxix) M92843 H. sapienszinc finger transcriptional regulator mRNA, complete cds, (cxxx) U07664Human HB9 homeobox gene, exons 2 and 3 and complete cds, (cxxxi) L48546H. sapiens tuberin (TSC2) gene, exons 38, 39, 40 and 41, (cxxxii) X53586Human mRNA for integrin alpha 6, (cxxxiii) t D21852 Human mRNA forKIAA0029 gene, partial cds, (cxxxiv) L11066 Human mRNA sequence, (cxxxv)J04444 Human cytochrome c-1 gene, complete cds, (cxxxvi) M95787 Human 22kDa smooth muscle protein (SM22) mRNA, complete cds, (cxxxvii) L07517Mucin 6, Gastric (Gb:L07517), (cxxxviii) X91247 H. sapiens mRNA forthioredoxin reductase, (cxxxix) L11672 Human Kruppel related zinc fingerprotein (HTF10) mRNA, complete cds, (cxl) U30999 Human (memc) mRNA,3′UTR, (cxli) U01337 Human Ser/Thr protein kinase (A-RAF-1) gene,complete cds, (cxlii) U28480 Uncoupling Protein Ucp, (cxliii) X12794Human v-erbA related ear-2 gene, (cxliv) L22005 Human ubiquitinconjugating enzyme mRNA, partial cds, (cxlv) M12886 Human T-cellreceptor active beta-chain mRNA, complete cds, (cxlvi) Y08915 H. sapiensmRNA for alpha 4 protein, (cxlvii) M24547 Amyloid Beta (A4) PrecursorProtein, Alt. Splice 2, A4(751), (cxlviii) X76717 H. sapiens MT-1l mRNA,(cxlix) M64347 Human novel growth factor receptor mRNA, 3′ cds, (cl)X05409 Human RNA for mitochondrial aldehyde dehydrogenase I ALDH I (EC1.2.1.3), (cli) D87469 Human mRNA for KIAA0279 gene, partial cds, (clii)M58603 Human nuclear factor kappa-B DNA binding subunit (NF-kappa-B)mRNA, complete cds, (cliii) M76482 Human 130-kD pemphigus vulgarisantigen mRNA, complete cds, (cliv) X06323 Human MRL3 mRNA for ribosomalprotein L3 homologue (MRL3=mammalian ribosome L, (clv) X78992 H. sapiensERF-2 mRNA, (clvi) L41351 H. sapiens prostasin mRNA, complete eds,(clvii) X75342 H. sapiens SHB mRNA, (clviii) U83115 Human non-lens betagamma-crystallin like protein (AIM1) mRNA, partial cds, (clix) U88629Human RNA polymerase II elongation factor ELL2, complete cds, (clx)S78825 Id1, (clxi) U28811 Human cysteine-rich fibroblast growth factorreceptor (CFR-1) mRNA, complete cds, (clxii) M58286 H. sapiens tumornecrosis factor receptor mRNA, complete cds, (clxiii) D78129 H. sapiensmRNA for squalene epoxidase, partial cds, (clxiv) D14874 H. sapiens mRNAfor adrenomedullin precursor, complete cds, (clxv) Z26317 H. sapiensmRNA for desmoglein 2, (clxvi) L19267 H. sapiens 59 protein mRNA, 3′end, (clxvii) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114,(clxviii) U33821 Human tax1-binding protein TXBP151 mRNA, complete cds,(clxix) U52100 Human XMP mRNA, complete cds, (clxx) L31801 H. sapiensmonocarboxylate transporter 1 (SLC16A1) mRNA, complete cds, (clxxi)L00058 Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank,(clxxii) U52426 H. sapiens GOK (STIM1) mRNA, complete cds, (clxxiii)M80244 Human E16 mRNA, complete cds, (clxxiv) U56418 Humanlysophosphatidic acid acyltransferase-beta mRNA, complete cds, (clxxv)L38490 H. sapiens ADP-ribosylation factor mRNA, complete cds, (clxxvi)U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (clxxvii) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (clxxviii) M38258 Human retinoic acid receptor gamma 1mRNA, complete cds, (clxxix) X89750 H. sapiens mRNA for TGIF protein,(clxxx) D85429 H. sapiens gene for heat shock protein 40, complete cds,(clxxxi) J05211 Desmoplakin I, (clxxxii) M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds, (clxxxiii) X80695 H. sapiensOXA1Hs mRNA, (clxxxiv) M54915 Human h-pim-1 protein (h-pim-1) mRNA,complete cds, (clxxxv) D83777 Human mRNA for KIAA0193 gene, completecds, (clxxxvi) D31883 Human mRNA for KIAA0059 gene, complete cds,(clxxxvii) U00968 Human SREBP-1 mRNA, complete cds, (clxxxviii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (clxxxix)D86965 Human mRNA for KIAA0210 gene, complete cds, (cxc) Z30643 H.sapiens mRNA for chloride channel (putative) 2139 bp, (cxci) D14520Human mRNA for GC-Box binding protein BTEB2, complete cds, (cxcii)D87462 Human mRNA for KIAA0272 gene, partial cds, (cxciii) X80692 H.sapiens ERK3 mRNA, (cxciv) X90858 H. sapiens mRNA for uridinephosphorylase, (cxcv) M57763 Human ADP-ribosylation factor (hARF6) mRNA,complete cds, (cxcvi) X92720 H. sapiens mRNA for phosphoenolpyruvatecarboxykinase, (cxcvii) M81601 Human transcription elongation factor(SII) mRNA, complete cds, (cxcviii) X52611 Human mRNA for transcriptionfactor AP-2, (cxcix) U09587 Human glycyl-tRNA synthetase mRNA, completecds, (cc) U14550 Human sialyltransferase SThM (sthm) mRNA, complete cds,(cci) D90209 Human mRNA for DNA binding protein TAXREB67, (ccii) X77366H. sapiens HBZ17 mRNA, (cciii) X76534 H. sapiens NMB mRNA, (cciv) U37519Human aldehyde dehydrogenase (ALDH8) mRNA, complete cds, (ccv) M83667Human NF-IL6-beta protein mRNA, complete cds, (ccvi) U53347 Humanneutral amino acid transporter B mRNA, complete cds, (ccvii) L09229Human long-chain acyl-coenzyme A synthetase (FACL1) mRNA, complete cds,(ccviii) S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, (ccix) M13929 Human c-myc-P64 mRNA,initiating from promoter P0, (HLmyc2.5) partial cds, (ccx) M55268 Humancasein kinase II alpha′ subunit mRNA, complete cds, (ccxi) M77836 Humanpyrroline 5-carboxylate reductase mRNA, complete cds, (ccxii)HG2724-HT2820_at S75762 Oncogene Tls/Chop, Fusion Activated, (ccxiii)U72066 H. sapiens CtBP interacting protein CtIP (CtIP) mRNA, completecds, (ccxiv) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (ccxv) M27396 Human asparaginesynthetase mRNA, complete cds, (ccxvi) X01630 Human mRNA forargininosuccinate synthetase, (ccxvii) D32050 Human mRNA for alanyl-tRNAsynthetase, complete cds, (ccxviii) M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, (ccxix) J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,and (ccxx) X691 11 H. sapiens HLH 1R21 mRNA for helix-loop-helixprotein.
 51. The composition of claim 47, wherein modulation ofexpression constitutes a reduction or elimination of ultravioletradiation exposure-induced protein expression.
 52. The composition ofclaim 47, wherein modulation of expression constitutes a reduction orelimination of ultraviolet radiation exposure-repressed proteinexpression.
 53. A screening method for the detection of a compound thatsimulates a response of a cell to ultraviolet radiation exposurecomprising: (a) contacting the cell with the compound; (b) measuring alevel of at least one RNA molecule in the contacted cell, and (c)determining whether the level of at least one RNA molecule issubstantially similar to that found in the response of the cell toultraviolet radiation exposure, wherein the response of the cellcharacterized by at least one of the following: (i) a first responsecomprising altered expression of at least one nucleic acid moleculeencoding a transcription factor protein, at least one nucleic acidmolecule encoding a signal transducing protein, and at least one nucleicacid molecule encoding a mitochondrial protein; (ii) a second responsecomprising altered expression of at least one nucleic acid moleculeencoding a secreted growth factor, at least one nucleic acid moleculeencoding a cytokine, and at least one nucleic acid molecule encoding achemokine; and (iii) a third response comprising altered expression ofat least one nucleic acid molecule encoding an actin-binding protein, adesmosomal protein, and a tubulin protein; and wherein a determinationthat the level of at least one RNA molecule is substantially similar tothe altered expression found in the first response, the second response,or the third response indicates that the compound simulates the responseof the cell to ultraviolet radiation exposure.
 54. The method accordingto claim 53, wherein: (a) the first response further comprises a nucleicacid molecule that is at least 90% identical to a polynucleotideselected from the group consisting of: (i) M62831 Human transcriptionfactor ETR101 mRNA, complete cds, (ii) X68277 H. sapiens CL 100 mRNA forprotein tyrosine phosphatase, (iii) L04731 H. sapiens translocationT(4:11) of ALL-1 gene to chromosome 4, (iv) X56681 Human junD mRNA, (v)U20734 Human transcription factor junB (junB) gene, 5′ region andcomplete cds, (vi) L38951 H. sapiens importin beta subunit mRNA,complete cds, (vii) D87071 Human mRNA for KIAA0233 gene, complete cds,(viii) M72885 Human GOS2 gene, 5′ flank and cds, (ix) M92843 H. sapienszinc finger transcriptional regulator mRNA, complete cds, (x) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, (xi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (xii) D86988Human mRNA for KIAA0221 gene, complete cds, (xiii) L19779 H. sapienshistone H2A.2 mRNA, complete cds, (xiv) U62317 Chromosome 22q13 BACClone CIT987SK-384D8 complete sequence, (xv) X04412 Human mRNA forplasma gelsolin, (xvi) L27706 Human chaperonin protein (Tcp20) genecomplete cds, (xvii) X61123 Human BTG1 mRNA, (xviii) M60974growth arrestand DNA-damage-inducible protein (gadd45) mRNA, complete cds, (xix)L19437 Human transaldolase mRNA containing transposable element,complete cds, (xx) X57985 H. sapiens genes for histones H2B.1 and H2A,(xxi) D90086 Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunitgene, exons 1-10, (xxii) M34182 Human testis-specific protein kinasegamma-subunit mRNA, complete cds, (xxiii) L16862 H. sapiens Gprotein-coupled receptor kinase (GRK6) mRNA, complete cds, (xxiv) D13705Human mRNA for fatty acids omega-hydroxylase (cytochrome P-450HKV),complete cd, (xxv) U37122 Human adducin gamma subunit mRNA, completecds, (xxvi) D45906 H. sapiens mRNA for LIMK-2, complete cds, (xxvii)U07664 Human HB9 homeobox gene, exons 2 and 3 and complete cds, (xxviii)D87438 Human mRNA for KIAA0251 gene, partial cds, (xxix) L37042 H.sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds,(xxx) D14043 Human mRNA for MGC-24, complete cds, (xxxi) D13988 Humanrab GDI mRNA, complete cds, (xxxii) U28480 Uncoupling Protein Uc,(xxxiii) D50840 H. sapiens mRNA for ceramide glucosyltransferase,complete cds, (xxxiv) M55265 Human casein kinase II alpha subunit mRNA,complete cds, (xxxv) M96803 Human general beta-spectrin (SPTBN1) mRNA,complete cds, (xxxvi) U89336 Human HLA class III region containingNOTCH4 gene, partial sequence, homeobox P, (xxxvii) D87442 Human mRNAfor KIAA0253 gene, partial cds, (xxxviii) J03161 Human serum responsefactor (SRF) mRNA, complete cds, (xxxix) D86965 Human mRNA for KIAA0210gene, complete cds, (xl) U17327 Human neuronal nitric oxide synthase(NOS1) mRNA, complete cds, (xli) D86966 Human mRNA for KIAA0211 gene,complete cds, (xlii) D85527 H. sapiens mRNA for LIM domain, partial cds,(xliii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (xliv) X59434 Human rohu mRNA forrhodanese, (xlv) M13929 Human c-myc-P64 mRNA, initiating from promoterP0, (HLmyc2.5) partialcds, and (xlvi) J05211 Desmoplakin; (b) the secondresponse further comprises a nucleic acid molecule that is at least 90%identical to a polynucleotide selected from the group consisting of: (i)M57731 Human gro-beta mRNA, complete cds, (ii) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, (iii) Y00787 Human mRNA for MDNCF (monocyte-derivedneutrophil chemotactic factor), (iv) X54489 Human gene for melanomagrowth stimulatory activity (MGSA), (v) M72885 Human GOS2 gene, 5′ flankand cds, (vi) M62831 Human transcription factor ETR101 mRNA, completecds, (vii) M28130 Human interleukin 8 (IL8) gene, complete cds, (viii)X57985 H. sapiens genes for histones H2B.1 and H2A, (ix) X53800 HumanmRNA for macrophage inflammatory protein-2beta (MIP2beta), (x) L19779 H.sapiens histone H2A.2 mRNA, complete cds, (xi) AF001294 H. sapiens IPL(IPL) mRNA, complete cds, (xii) X56681 Human junD mRNA, (xiii) S75762Oncogene Tls/Chop, Fusion Activate, (xiv) M84739 Human autoantigencalreticulin mRNA, complete cds, (xv) M21302 Human small proline richprotein (sprII) mRNA, clone 174N, (xvi) V00599 Tubulin, Bet, (xvii)X70326 Macmarck, (xviii) D10923 Human mRNA for HM74, (xix) D64142 HumanmRNA for histone H1x, complete cds, (xx) D86974 Human mRNA for KIAA0220gene, partial cds, (xxi) M60974 Human growth arrest andDNA-damage-inducible protein (gadd45) mRNA, complete cds, (xxii) X68277H. sapiens CL 100 mRNA for protein tyrosine phosphatase, (xxiii) L13391Human helix-loop-helix basic phosphoprotein (GOS8) gene, complete cds,(xxiv) M31627 Human X box binding protein-1 (XBP-1) mRNA, complete cds,(xxv) U40369 Human spermidine/spermine N1-acetyltransferase (SSAT) gene,complete cds, (xxvi) X52560 Nuclear Factor Nf-Il, (xxvii) X61123 HumanBTG1 mRNA, (xxviii) U20734 Human transcription factor junB (junB) gene,5′ region and complete cds, (xxix) U35048 Human TSC-22 protein mRNA,complete cds, (xxx) M69043 H. sapiens MAD-3 mRNA encoding IkB-likeactivity, complete cds, (xxxi) X51345 Human jun-B mRNA for JUN-Bprotein, (xxxii) S68616 Na+/H+ exchanger NHE-1 isoform [human, heart,mRNA, 4516 nt], (xxxiii) X89750 H. sapiens mRNA for TGIF protein,(xxxiv) X69111 H. sapiens HLH 1R21 mRNA for helix-loop-helix protein,(xxxv) U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (xxxvi) X52541 Human mRNA for early growth response protein 1(hEGR1), (xxxvii) D50683 H. sapiens mRNA for TGF-betaIIR alpha, completecds, (xxxviii) M92843 H. sapiens zinc finger transcriptional regulatormRNA, complete cds, (xxxix) X91247 H. sapiens mRNA for thioredoxinreductase, (xl) U05875 Human clone pSK1 interferon gamma receptoraccessory factor-1 (AF-1) mRNA, comp, (xli) L19314 Human HRY gene,complete cds, (xlii) M30703 Human amphiregulin (AR) gene, exon 6, cloneslambda-ARH(6,12), (xliii) U34252 Human gamma-aminobutyraldehydedehydrogenase mRNA, complete cds, (xliv) S78825 Id1, (xlv) D85429 H.sapiens gene for heat shock protein 40, complete cds, (xlvi) U41766Human metalloprotease/disintegrin/cysteine-rich protein precursor (MIC9)mRNA, (xlvii) U89336 Human HLA class III region containing NOTCH4 gene,partial sequence, homeobox PB, (xlviii) M69181 Human nonmuscle myosinheavy chain-B (MYH10) mRNA, partial cds, (xlix) D15050 Human mRNA fortranscription factor AREB6, complete cds, (l) U28386 Human nuclearlocalization sequence receptor hSRP1alpha mRNA, complete cds, (li)L77886 Human protein tyrosine phosphatase mRNA, complete cds, (lii)X64330 H. sapiens mRNA for ATP-citrate lyase, (liii) U37122 Humanadducin gamma subunit mRNA, complete cds, (liv) X74008 H. sapiens mRNAfor protein phosphatase 1 gamma, (lv) U60205 Human methyl sterol oxidase(ERG25) mRNA, complete cds, (lvi) X76534 H. sapiens NMB mRNA, (lvii)D87071 Human mRNA for KIAA0233 gene, complete cds, (lviii) U90716 Humancell surface protein HCAR mRNA, complete cds, (lix) M91083 HumanDNA-binding protein (HRC1) mRNA, complete cds, (lx) U29607 Humanmethionine aminopeptidase mRNA, complete cds, (lxi) M76482 Human 130-kDpemphigus vulgaris antigen mRNA, complete cds, (lxii) U72066 H. sapiensCtBP interacting protein CtIP (CtIP) mRNA, complete cds, (lxiii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (lxiv) X12953Human rab2 mRNA, YPT1-related and member of ras family, (lxv) M60483Human protein phosphatase 2A catalytic subunit-alpha gene, complete cds,(lxvi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (lxvii) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (lxviii) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(lxix) D50840 H. sapiens mRNA for ceramide glucosyltransferase, completecds, (lxx) L31801 H. sapiens monocarboxylate transporter 1 (SLC16A1)mRNA, complete cds, (lxxi) S74017 Nrf2=NF-E2-like basic leucine zippertranscriptional activator [human, hernin-in, (lxxii) X87241 H. sapiensmRNA for hFat protein, (lxxiii) X52425 Human IL-4-R mRNA for theinterleukin 4 receptor, (lxxiv) D79994 Human mRNA for KIAA0172 gene,partial cds, (lxxv) M58286 H. sapiens tumor necrosis factor receptormRNA, complete cds, (lxxvi) M13829 Human putative raf related protein(pks/a-raf) mRNA, partial cds, (lxxvii) X78992 H. sapiens ERF-2 mRNA,(lxxviii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (lxxix) U88629 Human RNA polymeraseII elongation factor ELL2, complete cds, (lxxx) X52611 Human mRNA fortranscription factor AP-2, (lxxxi) U28749 Human high-mobility groupphosphoprotein isoform I-C (HMGIC) mRNA, complete cds, (lxxxii) L00058Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank, (lxxxiii)L26336 Heat Shock Protein, 70 Kda (Gb:Y00371, (lxxxiv) L08246 Humanmyeloid cell differentiation protein (MCL1) mRNA, (lxxxv) S73591brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic,leukemia cells (lxxxvi) J05211 Desmoplakin, (lxxxvii)L00352 Human low density lipoprotein receptor gene, exon 18, (lxxxviii)Y13647 Stearoyl-Coenzymea Desaturase, (lxxxix) X77794 H. sapiens mRNAfor cyclin G1, (xc) M90656 Human gamma-glutamylcysteine synthetase (GCS)mRNA, complete cds, (xci) M13929 Human c-myc-P64 mRNA, initiating frompromoter P0, (HLmyc2.5) partial cds, (xcii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (xciii) X80692 H. sapiens ERK3 mRNA,and (xciv) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114; and (c)the second response further comprises a nucleic acid molecule that is atleast 90% identical to a polynucleotide selected from the groupconsisting of: (i) M20030 Human small proline rich protein (sprII) mRNA,clone 930, (ii) X53065, (iii) M13903 Human involucrin gene, exon 2, (iv)M22918 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629),Non-Muscle, Alt. Splice, (v) L10343 Huma elafin gene, complete cds, (vi)M63573 Human secreted cyclophilin-like protein (SCYLP) mRNA, completecds, (vii) M21302 Human small proline rich protein (sprII) mRNA, clone174N, (viii) Y00787 Human mRNA for MDNCF (monocyte-derived neutrophilchemotactic factor), (ix) X57985 H. sapiens genes for histones H2B.1 andH2A, (x) L05188 H. sapiens small proline-rich protein 2 (SPRR2B) gene,complete cds, (xi) X70326 Macmarcks, (xii) X67325 H. sapiens p27 mRNA,(xiii) L19779 H. sapiens histone H2A.2 mRNA, complete cds, (xiv) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, (xv) D45248 Human mRNA for proteasome activator hPA28subunit beta, complete cds, (xvi) Z22548 H. sapiens thiol-specificantioxidant protein mRNA, (xvii) M22918 Myosin, Light Chain, Alkali,Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice, (xviii) X06956Tubulin, Alpha 1, Isoform 44, (xix) V00594 Human mRNA formetallothionein from cadmium-treated cells, (xx) M80254 H. sapienscyclophilin isoform (hCyP3) mRNA, complete cds, (xxi) U04636 Humancyclooxygenase-2 (hCox-2) gene, complete cds, (xxii) Z14244 H. sapienscoxVIIb mRNA for cytochrome c oxidase subunit VIIb, (xxiii) X99920 H.sapiens mRNA for S100 calcium-binding protein A13, (xxiv) U62800 Humancystatin M (CST6) mRNA, complete cds, (xxv) L08069 Human heat shockprotein, E. coli DnaJ homologue mRNA, complete cds, (xxvi) L20688 HumanGDP-dissociation inhibitor protein (Ly-GDI) mRNA, complete cds, (xxvii)M13755 Human interferon-induced 17-kDa/15-kDa protein mRNA, completecds, (xxviii) M60278 Human heparin-binding EGF-like growth factor mRNA,complete cds, (xxix) AF001294 H. sapiens IPL (IPL) mRNA, complete cds,(xxx) X54489 Human gene for melanoma growth stimulatory activity (MGSA),(xxxi) M21186 Human neutrophil cytochrome b light chain p22 phagocyteb-cytochrome mRNA, compl, (xxxii) D42040 Human mRNA for KIAA9001 gene,complete cds, (xxxiii) V00599 Tubulin, Beta, (xxxiv) U37690 Human RNApolymerase II subunit (hsRPB10) mRNA, complete cds, (xxxv) M21005 Humanmigration inhibitory factor-related protein 8 (MRP8) gene, complete cds,(xxxvi) M37583 Human histone (H2A.Z) mRNA, complete cds, (xxxvii) Z49989H. sapiens mRNA for smoothelin, (xxxviii) L24564 Human Rad mRNA,complete cds, (xxxix) D49824 Human HLA-B null allele mRNA, (xl) M59465Human tumor necrosis factor alpha inducible protein A20 mRNA, completecds, (xli) S54005 thymosin beta-10[human, metastatic melanoma cell line,mRNA, 453 nt], (xlii) Z49254 H. sapiens L23-related mRNA, (xliii) M22919Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629), Smooth Muscle,Alt. Spli, (xliv) U70660 Human copper transport protein HAH1 (HAH1)mRNA, complete cds, (xlv) AF006084 H. sapiens Arp⅔ protein complexsubunit p41-Arc (ARC41) mRNA, complete cds, (xlvi) X62083 H. sapiensmRNA for Drosophila female sterile homeotic (FSH) homologue, (xlvii)D86974 Human mRNA for KIAA0220 gene, partial cds, (xlviii) M72885 HumanGOS2 gene, 5′ flank and cds, (xlix) S80437 fatty acid synthase {3′region} [human, breast and HepG2 cells, mRNA Partial, 22, (l) X04654Human mRNA for U1 RNA-associated 70K protein, (li) t M26311 Human cysticfibrosis antigen mRNA, complete cds, (lii) X14850 Human H2A.X mRNAencoding histone H2A.X, (liii) M14328 Human alpha enolase mRNA, completecds, (liv) U07919 Human aldehyde dehydrogenase 6 mRNA, complete cds,(lv) M28130 Human interleukin 8 (IL8) gene, complete cds, (lvi) Z21507H. sapiens EF-1 delta gene encoding human elongation factor-1-delta,(lvii) M92934 Human connective tissue growth factor, complete cds,(lviii) M27436 Human tissue factor gene, complete cds, with a Alurepetitive sequence in the 3′, (lix) X74874 H. sapiens gene for RNA polII largest subunit, exon 1, (lx) X57351 Human 1-8D gene frominterferon-inducible gene family, (lxi) X52979 Human gene for smallnuclear ribonucleoproteins SmB and SmB′, (lxii) U41515 Human deleted insplit hand/split foot 1 (DSS1) mRNA, complete cds, (lxiii) D28235 HumanPTGS2 gene for prostaglandin endoperoxide synthase-2, complete cds,(lxiv) Y00503 Human mRNA for keratin
 19. (lxv) M57731 Human gro-betamRNA, complete cds, (lxvi) D50840 H. sapiens mRNA for ceramideglucosyltransferase, complete cds, (lxvii) U52101 Human YMP mRNA,complete cds. (lxviii) D13413 Human mRNA for tumor-associated 120 kDanuclear protein p120, partial cds(carbox, (lxix) L42379 H. sapiensbone-derived growth factor (BPGF-1) mRNA, complete cds, (lxx) X52426 H.sapiens mRNA for cytokeratin 13, (lxxi) J04456 Human 14 kd lectin mRNA,complete cds, (lxxii) S78771 NAT=CpG island-associated gene [human,mRNA, 1741 nt], (lxxiii) M26730 Human mitochondrial ubiquinone-bindingprotein (QP) gene, exon 4, (lxxiv) U26727 Human pl6INK4/MTS1 mRNA,complete cds, (lxxv) X92896 H. sapiens mRNA for ITBA2 protein, (lxxvi)Z69043 H. sapiens mRNA translocon-associated protein delta subunitprecursor, (lxxvii) L76568 H. sapiens excision and cross link repairprotein (ERCC4) gene, complete genom, (lxxviii) M12125 Human fibroblastmuscle-type tropomyosin mRNA, complete cds, (lxxix) U09937 Humanurokinase-type plasminogen receptor, exon 7, (lxxx) X15822 Human COXVIIa-L mRNA for liver-specific cytochrome coxidase (EC 1.9.3.1.),(lxxxi) M34516 Human omega light chain protein 14.1 (Ig lambda chainrelated) gene, exon 3, (lxxxii) U53830 H. sapiens interferon regulatoryfactor 7A mRNA, complete cds, (lxxxiii) X82693 H. sapiens mRNA for E48antigen, (lxxxiv) M58026 Human NB-1 mRNA, complete cds, (lxxxv) M90657Human tumor antigen (L6) mRNA, complete cds, (lxxxvi) X57579 H. sapiensactivin beta-A subunit (exon 2), (lxxxvii) D38251 Human mRNA for RPB5(XAP4), complete cds, (lxxxviii) D89667 H. sapiens mRNA for c-mycbinding protein, complete cds, (lxxxix) AB000584 H. sapiens mRNA forTGF-beta superfamily protein, complete cds, (xc) L76200 Human guanylatekinase (GUK1) mRNA, complete cds, (xci) J04794 Human aldehyde reductasemRNA, complete cds, (xcii) X52882 Human t-complex polypeptide 1 gene,(xciii) M79463 Human PML-2 mRNA, complete CDS, (xciv) Y09022 H. sapiensmRNA for Not56-like protein, (xcv) M12529 Human apolipoprotein E mRNA,complete cds, (xcvi) X71129 H. sapiens mRNA for electron transferflavoprotein beta subunit, (xcvii) X83416 H. sapiens PrP gene, exon 2,(xcviii) D89052 H. sapiens mRNA for proton-ATPase-like protein, completecds, (xcix) M60974 Human growth arrest and DNA-damage-inducible protein(gadd45) mRNA, complete cds, (c) M16364 Human creatine kinase-B mRNA,complete cds, (ci) D38305 Human mRNA for Tob, complete cds, (cii) X87679Major Histocompatibility Complex, Class I, E (Gb:M21533), (ciii) Z29505H. sapiens mRNA for nucleic acid binding protein sub2.3, (civ) K02574,(cv) U09813 Human mitochondrial ATP synthase subunit 9, P3 gene copy,mRNA, nuclear gene enc, (cvi) X67951 H. sapiens mRNA forproliferation-associated gene (pag), (cvii) J04611 Human lupus p70 (Ku)autoantigen protein mRNA, complete cds, (cviii) U09578 H. sapiens MAPKAPkinase (3 pK) mRNA, complete cds, (cix) X53800 Human mRNA for macrophageinflammatory protein-2beta (MIP2beta), (cx) V00599 Tubulin, Beta 2,(cxi) U69126 Human FUSE binding protein 2 (FBP2) mRNA, partial cds,(cxii) X53416 Human mRNA for actin-binding protein (filamin) (ABP-280),(cxiii) U90546 Human butyrophilin (BTF4) mRNA, complete cds, (cxiv)M58459 Human ribosomal protein (RPS4Y) isoform mRNA, complete cds, (cxv)M19961 Human cytochrome c oxidase subunit Vb (coxVb) mRNA, complete cds,(cxvi) U65579 Human mitochondrial NADH dehydrogenase-ubiquinone Fe—Sprotein 8, 23 kDa subunit, (cxvii) X77794 H. sapiens mRNA for cyclin G1,(cxviii) M29064 Human mRNP B1 protein mRNA, (cxix) D21853 Human mRNA forKIAA0111 gene, complete cds, (cxx) X78687 H. sapiens G9 gene encodingsialidase, (cxxi) X15729 Human mRNA for nuclear p68 protein, (cxxii)X04828 Human mRNA for G(i) protein alpha-subunit (adenylate cyclaseinhibiting GTP-bind, (cxxiii) L27943 H. sapiens cytidine deaminase (CDA)mRNA, complete cds, (cxxiv) L40391 H. sapiens (clone s153) mRNAfragment, (cxxv) D42123 H. sapiens mRNA for ESP1/CRP2, complete cds,(cxxvi) X74104 H. sapiens mRNA for TRAP beta subunit, (cxxvii) M84332Human ADP-ribosylation factor 1 gene, exons 2-5, (cxxviii) L37127 H.sapiens RNA polymerase II mRNA, complete cds, (cxxix) M92843 H. sapienszinc finger transcriptional regulator mRNA, complete cds, (cxxx) U07664Human HB9 homeobox gene, exons 2 and 3 and complete cds, (cxxxi) L48546H. sapiens tuberin (TSC2) gene, exons 38, 39, 40 and 41, (cxxxii) X53586Human mRNA for integrin alpha 6, (cxxxiii) t D21852 Human mRNA forKIAA0029 gene, partial cds, (cxxxiv) L11066 Human mRNA sequence, (cxxxv)J04444 Human cytochrome c-1 gene, complete cds, (cxxxvi) M95787 Human 22kDa smooth muscle protein (SM22) mRNA, complete cds, (cxxxvii) L07517Mucin 6, Gastric (Gb:L07517), (cxxxviii) X91247 H. sapiens mRNA forthioredoxin reductase, (cxxxix) L11672 Human Kruppel related zinc fingerprotein (HTF10) mRNA, complete cds, (cxl) U30999 Human (memc) mRNA,3′UTR, (cxli) U01337 Human Ser/Thr protein kinase (A-RAF-1) gene,complete cds, (cxlii) U28480 Uncoupling Protein Ucp, (cxliii) X12794Human v-erbA related ear-2 gene, (cxliv) L22005 Human ubiquitinconjugating enzyme mRNA, partial cds, (cxlv) M12886 Human T-cellreceptor active beta-chain mRNA, complete cds, (cxlvi) Y08915 H. sapiensmRNA for alpha 4 protein, (cxlvii) M24547 Amyloid Beta (A4) PrecursorProtein, Alt. Splice 2, A4(751), (cxlviii) X76717 H. sapiens MT-1l mRNA,(cxlix) M64347 Human novel growth factor receptor mRNA, 3′ cds, (cl)X05409 Human RNA for mitochondrial aldehyde dehydrogenase I ALDH I (EC1.2.1.3), (cli) D87469 Human mRNA for KIAA0279 gene, partial cds, (clii)M58603 Human nuclear factor kappa-B DNA binding subunit (NF-kappa-B)mRNA, complete cds, (cliii) M76482 Human 130-kD pemphigus vulgarisantigen mRNA, complete cds, (cliv) X06323 Human MRL3 mRNA for ribosomalprotein L3 homologue ( MRL3=mammalian ribosome L, (clv) X78992 H.sapiens ERF-2 mRNA, (clvi) L41351 H. sapiens prostasin mRNA, completecds, (clvii) X75342 H. sapiens SHB mRNA, (clviii) U83115 Human non-lensbeta gamma-crystallin like protein (AIM1) mRNA, partial cds, (clix)U88629 Human RNA polymerase II elongation factor ELL2, complete cds,(clx) S78825 Id1, (clxi) U28811 Human cysteine-rich fibroblast growthfactor receptor (CFR-1) mRNA, complete cds, (clxii) M58286 H. sapienstumor necrosis factor receptor mRNA, complete cds, (clxiii) D78129 H.sapiens mRNA for squalene epoxidase, partial cds, (clxiv) D14874 H.sapiens mRNA for adrenomedullin precursor, complete cds, (clxv) Z26317H. sapiens mRNA for desmoglein 2, (clxvi) L19267 H. sapiens 59 proteinmRNA, 3′ end, (clxvii) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf114, (clxviii) U33821 Human taxl-binding protein TXBP151 mRNA, completecds, (clxix) U52100 Human XMP mRNA, complete cds, (clxx) L31801 H.sapiens monocarboxylate transporter 1 (SLC16A1) mRNA, complete cds,(clxxi) L00058 Human (GH) germline c-myc proto-oncogene, exon 3 and 3′flank, (clxxii) U52426 H. sapiens GOK (STIMI) mRNA, complete cds,(clxxiii) M80244 Human E16 mRNA, complete cds, (clxxiv) U56418 Humanlysophosphatidic acid acyltransferase-beta mRNA, complete cds, (clxxv)L38490 H. sapiens ADP-ribosylation factor mRNA, complete cds, (clxxvi)U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (clxxvii) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (clxxviii) M38258 Human retinoic acid receptor gamma 1mRNA, complete cds, (clxxix) X89750 H. sapiens mRNA for TGIF protein,(clxxx) D85429 H. sapiens gene for heat shock protein 40, complete cds,(clxxxi) J05211 Desmoplakin I, (clxxxii) M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds, (clxxxiii) X80695 H. sapiensOXA1Hs mRNA, (clxxxiv) M54915 Human h-pim-1 protein (h-pim-1) mRNA,complete cds, (clxxxv) D83777 Human mRNA for KIAA0193 gene, completecds, (clxxxvi) D31883 Human mRNA for KIAA0059 gene, complete cds,(clxxxvii) U00968 Human SREBP-1 mRNA, complete cds, (clxxxviii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (clxxxix)D86965 Human mRNA for KIAA0210 gene, complete cds, (cxc) Z30643 H.sapiens mRNA for chloride channel (putative) 2139bp, (cxci) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (cxcii) D87462Human mRNA for KIAA0272 gene, partial cds, (cxciii) X80692 H. sapiensERK3 mRNA, (cxciv) X90858 H. sapiens mRNA for uridine phosphorylase,(cxcv) M57763 Human ADP-ribosylation factor (hARF6) mRNA, complete cds,(cxcvi) X92720 H. sapiens mRNA for phosphoenolpyruvate carboxykinase,(cxcvii) M81601 Human transcription elongation factor (SII) mRNA,complete cds, (cxcviii) X52611 Human mRNA for transcription factor AP-2,(cxcix) U09587 Human glycyl-tRNA synthetase mRNA, complete cds, (cc)U14550 Human sialyltransferase SThM (sthm) mRNA, complete cds, (cci)D90209 Human mRNA for DNA binding protein TAXREB67, (ccii) X77366 H.sapiens HBZ17 mRNA, (cciii) X76534 H. sapiens NMB mRNA, (cciv) U37519Human aldehyde dehydrogenase (ALDH8) mRNA, complete cds, (ccv) M83667Human NF-IL6-beta protein mRNA, complete cds, (ccvi) U53347 Humanneutral amnino acid transporter B mRNA, complete cds, (ccvii) L09229Human long-chain acyl-coenzyme A synthetase (FACL1) mRNA, complete cds,(ccviii) S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, (ccix) M13929 Human c-myc-P64 mRNA,initiating from promoter P0, (HLmyc2.5) partial cds, (ccx) M55268 Humancasein kinase II alpha′ subunit mRNA, complete cds, (ccxi) M77836 Humanpyrroline 5-carboxylate reductase mRNA, complete cds, (ccxii)HG2724-HT2820_at S75762 Oncogene Tls/Chop, Fusion Activated, (ccxiii)U72066 H. sapiens CtBP interacting protein CtIP (CtIP) mRNA, completecds, (ccxiv) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (ccxv) M27396 Human asparaginesynthetase mRNA, complete cds, (ccxvi) X01630 Human mRNA forargininosuccinate synthetase, (ccxvii) D32050 Human mRNA for alanyl-tRNAsynthetase, complete cds, (ccxviii) M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, (ccxix) J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,and (ccxx) X69111 H. sapiens HLH 1R21 mRNA for helix-loop-helix protein.55. A screening method for the detection of a compound that simulates aresponse of a cell to ultraviolet radiation exposure comprising: (a)contacting the cell with the compound; (b) measuring a level of at leastone protein molecule in the contacted cell; and (c) determining whetherthe level of at least one protein molecule is substantially similar tothat found in the response of the cell to ultraviolet radiationexposure, wherein the response of the cell is characterized by at leastone of the following: (i) a first response comprising altered expressionof at least one nucleic acid molecule encoding a transcription factorprotein, at least one nucleic acid molecule encoding a signaltransducing protein, and at least one nucleic acid molecule encoding amitochondrial protein; (ii) a second response comprising alteredexpression of at least one nucleic acid molecule encoding a secretedgrowth factor, at least one nucleic acid molecule encoding a cytokine,and at least one nucleic acid molecule encoding a chemokine; and (iii) athird response comprising altered expression of at least one nucleicacid molecule encoding an actin-binding protein, a desmosomal protein,and a tubulin protein; and wherein a determination that the level of atleast one protein molecule is substantially similar to the alteredexpression found in the first response, the second response or the thirdresponse indicates that the compound simulates the response of the cellto ultraviolet radiation exposure.
 56. The method according to claim 55,wherein: (a) the first response further comprises a protein that isencoded by a polynucleotide that is at least 90% identical to a nucleicacid molecule selected from the group consisting of: (i) M62831 Humantranscription factor ETR101 mRNA, complete cds, (ii) X68277 H. sapiensCL 100 mRNA for protein tyrosine phosphatase, (iii) L04731 H. sapienstranslocation T(4:11) of ALL-1 gene to chromosome 4, (iv) X56681 HumanjunD mRNA, (v) U20734 Human transcription factor junB (junB) gene, 5′region and complete cds, (vi) L38951 H. sapiens importin beta subunitmRNA, complete cds, (vii) D87071 Human mRNA for KIAA0233 gene, completecds, (viii) M72885 Human GOS2 gene, 5′ flank and cds, (ix) M92843 H.sapiens zinc finger transcriptional regulator mRNA, complete cds, (x)S81914 IEX-1=radiation-inducible immediate-early gene [human, placenta,mRNA Partial, (xi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (xii)D86988 Human mRNA for KIAA0221 gene, complete cds, (xiii) L19779 H.sapiens histone H2A.2 mRNA, complete cds, (xiv) U62317 Chromosome 22q13BAC Clone CIT987SK-384D8 complete sequence, (xv) X04412 Human mRNA forplasma gelsolin, (xvi) L27706 Human chaperonin protein (Tcp20) genecomplete cds, (xvii) X61123 Human BTG1 mRNA, (xviii) M60974growth arrestand DNA-damage-inducible protein (gadd45) mRNA, complete cds, (xix)L19437 Human transaldolase mRNA containing transposable element,complete cds, (xx) X57985 H. sapiens genes for histones H2B.1 and H2A,(xxi) D90086 Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunitgene, exons 1-10, (xxii) M34182 Human testis-specific protein kinasegamma-subunit mRNA, complete cds, (xxiii) L16862 H. sapiens Gprotein-coupled receptor kinase (GRK6) mRNA, complete cds, (xxiv) D13705Human mRNA for fatty acids omega-hydroxylase (cytochrome P-450HKV),complete cd, (xxv) U37122 Human adducin gamma subunit mRNA, completecds, (xxvi) D45906 H. sapiens mRNA for LIMK-2, complete cds, (xxvii)U07664 Human HB9 homeobox gene, exons 2 and 3 and complete cds, (xxviii)D87438 Human mRNA for KIAA0251 gene, partial cds, (xxix) L37042 H.sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds,(xxx) D14043 Human mRNA for MGC-24, complete cds, (xxxi) D13988 Humanrab GDI mRNA, complete cds, (xxxii) U28480 Uncoupling Protein Uc,(xxxiii) D50840 H. sapiens mRNA for ceramide glucosyltransferase,complete cds, (xxxiv) M55265 Human casein kinase II alpha subunit mRNA,complete cds, (xxxv) M96803 Human general beta-spectrin (SPTBN1) mRNA,complete cds, (xxxvi) U89336 Human HLA class III region containingNOTCH4 gene, partial sequence, homeobox P, (xxxvii) D87442 Human mRNAfor KIAA0253 gene, partial cds, (xxxviii) J03161 Human serum responsefactor (SRF) mRNA, complete cds, (xxxix) D86965 Human mRNA for KIAA0210gene, complete cds, (xl) U17327 Human neuronal nitric oxide synthase(NOS 1) mRNA, complete cds, (xli) D86966 Human mRNA for KIAA0211 gene,complete cds, (xlii) D85527 H. sapiens mRNA for LIM domain, partial cds,(xliii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (xliv) X59434 Human rohu mRNA forrhodanese, (xlv) M13929 Human c-myc-P64 mRNA, initiating from promoterP0, (HLmyc2.5) partial cds, and (xlvi) J05211 Desmoplakin; (b) thesecond response further comprises a protein that is encoded by apolynucleotide that is at least 90% identical to a nucleic acid moleculeselected from the group consisting of: (i) M57731 Human gro-beta mRNA,complete cds, (ii) S81914 IEX-1=radiation-inducible immediate-early gene[human, placenta, mRNA Partial, 1, (iii) Y00787 Human mRNA for MDNCF(monocyte-derived neutrophil chemotactic factor), (iv) X54489 Human genefor melanoma growth stimulatory activity (MGSA), (v) M72885 Human GOS2gene, 5′ flank and cds, (vi) M62831 Human transcription factor ETR101mRNA, complete cds, (vii) M28130 Human interleukin 8 (IL8) gene,complete cds, (viii) X57985 H. sapiens genes for histones H2B.1 and H2A,(ix) X53800 Human mRNA for macrophage inflammatory protein-2beta(MIP2beta), (x) L19779 H. sapiens histone H2A.2 mRNA, complete cds, (xi)AF001294 H. sapiens IPL (IPL) mRNA, complete cds, (xii) X56681 HumanjunD mRNA, (xiii) S75762 Oncogene Tls/Chop, Fusion Activate, (xiv)M84739 Human autoantigen calreticulin mRNA, complete cds, (xv) M21302Human small proline rich protein (sprII) mRNA, clone 174N, (xvi) V00599Tubulin, Bet, (xvii) X70326 Macmarck, (xviii) D10923 Human mRNA forHM74, (xix) D64142 Human mRNA for histone H1x, complete cds, (xx) D86974Human mRNA for KIAA0220 gene, partial cds, (xxi) M60974 Human growtharrest and DNA-damage-inducible protein (gadd45) mRNA, complete cds,(xxii) X68277 H. sapiens CL 100 mRNA for protein tyrosine phosphatase,(xxiii) L13391 Human helix-loop-helix basic phosphoprotein (GOS8) gene,complete cds, (xxiv) M31627 Human X box binding protein-1 (XBP-1) mRNA,complete cds, (xxv) U40369 Human spermidine/spermineN1-acetyltransferase (SSAT) gene, complete cds, (xxvi) X52560 NuclearFactor Nf-Il, (xxvii) X61123 Human BTG1 mRNA, (xxviii) U20734 Humantranscription factor junB (junB) gene, 5′ region and complete cds,(xxix) U35048 Human TSC-22 protein mRNA, complete cds, (xxx) M69043 H.sapiens MAD-3 mRNA encoding IkB-like activity, complete cds, (xxxi)X51345 Human jun-B mRNA for JUN-B protein, (xxxii) S68616 Na+/H+exchanger NHE-1 isoform [human, heart, mRNA, 4516 nt], (xxxiii) X89750H. sapiens mRNA for TGIF protein, (xxxiv) X69111 H. sapiens HLH 1R21mRNA for helix-loop-helix protein, (xxxv) U14603 Human protein-tyrosinephosphatase (HU-PP-1) mRNA, partial sequence, (xxxvi) X52541 Human mRNAfor early growth response protein 1 (hEGR1), (xxxvii) D50683 H. sapiensmRNA for TGF-betaIIR alpha, complete cds, (xxxviii) M92843 H. sapienszinc finger transcriptional regulator mRNA, complete cds, (xxxix) X91247H. sapiens mRNA for thioredoxin reductase, (xl) U05875 Human clone pSK1interferon gamma receptor accessory factor-1(AF-1) mRNA, comp, (xli)L19314 Human HRY gene, complete cds, (xlii) M30703 Human amphiregulin(AR) gene, exon 6, clones lambda-ARH(6,12), (xliii) U34252 Humangamma-aminobutyraldehyde dehydrogenase mRNA, complete cds, (xliv) S78825Id1, (xlv) D85429 H. sapiens gene for heat shock protein 40, completecds, (xlvi) U41766 Human metalloprotease/disintegrin/cysteine-richprotein precursor (MDC9) mRNA, (xlvii) U89336 Human HLA class III regioncontaining NOTCH4 gene, partial sequence, homeobox PB, (xlviii) M69181Human nonmuscle myosin heavy chain-B (MYH10) mRNA, partial cds, (xlix)D15050 Human mRNA for transcription factor AREB6, complete cds, (l)U28386 Human nuclear localization sequence receptor hSRP1alpha mRNA,complete cds, (li) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (lii) X64330 H. sapiens mRNA for ATP-citrate lyase, (liii)U37122 Human adducin gamma subunit mRNA, complete cds, (liv) X74008 H.sapiens mRNA for protein phosphatase 1 gamma, (lv) U60205 Human methylsterol oxidase (ERG25) mRNA, complete cds, (lvi) X76534 H. sapiens NMBmRNA, (lvii) D87071 Human mRNA for KIAA0233 gene, complete cds, (lviii)U90716 Human cell surface protein HCAR mRNA, complete cds, (lix) M91083Human DNA-binding protein (HRC1) mRNA, complete cds, (lx) U29607 Humanmethionine aminopeptidase mRNA, complete cds, (lxi) M76482 Human 130-kDpemphigus vulgaris antigen mRNA, complete cds, (lxii) U72066 H. sapiensCtBP interacting protein CtIP (CtIP) mRNA, complete cds, (lxiii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (lxiv) X12953Human rab2 mRNA, YPT1-related and member of ras family, (lxv) M60483Human protein phosphatase 2A catalytic subunit-alpha gene, complete cds,(lxvi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (lxvii) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (lxviii) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(lxix) D50840 H. sapiens mRNA for ceramide glucosyltransferase, completecds, (lxx) L31801 H. sapiens monocarboxylate transporter 1 (SLC16A1)mRNA, complete cds, (lxxi) S74017 Nrf2=NF-E2-like basic leucine zippertranscriptional activator [human, hemin-in, (lxxii) X87241 H. sapiensmRNA for hFat protein, (lxxiii) X52425 Human IL-4-R mRNA for theinterleukin 4 receptor, (lxxiv) D79994 Human mRNA for KIAA0172 gene,partial cds, (lxxv) M58286 H. sapiens tumor necrosis factor receptormRNA, complete cds, (lxxvi) M13829 Human putative raf related protein(pks/a-raf) mRNA, partial cds, (lxxvii) X78992 H. sapiens ERF-2 mRNA,(lxxviii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (lxxix) U88629 Human RNA polymeraseII elongation factor ELL2, complete cds, (lxxx) X52611 Human mRNA fortranscription factor AP-2, (lxxxi) U28749 Human high-mobility groupphosphoprotein isoform I—C (HMGIC) mRNA, complete cds, (lxxxii) L00058Human (GH) gerrline c-myc proto-oncogene, exon 3 and 3′ flank, (lxxxiii)L26336 Heat Shock Protein, 70 Kda (Gb:Y00371, (lxxxiv) L08246 Humanmyeloid cell differentiation protein (MCL1) mRNA, (lxxxv) S73591brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic,leukemia cells (lxxxvi) J05211 Desmoplakin, (lxxxvii)L00352 Human low density lipoprotein receptor gene, exon 18, (lxxxviii)Y13647 Stearoyl-Coenzymea Desaturase, (lxxxix) X77794 H. sapiens mRNAfor cyclin G1, (xc) M90656 Human gamma-glutamylcysteine synthetase (GCS)mRNA, complete cds, (xci) M13929 Human c-myc-P64 mRNA, initiating frompromoter P0, (HLmyc2.5) partial cds, (xcii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (xciii) X80692 H. sapiens ERK3 mRNA,and (xciv) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114; and (c)the third response further comprises a protein that is encoded by apolynucleotide that is at least 90% identical to a nucleic acid moleculeselected from the group consisting of: (i) M20030 Human small prolinerich protein (sprII) mRNA, clone 930, (ii) X53065, (iii) M13903 Humaninvolucrin gene, exon 2, (iv) M22918 Myosin, Light Chain, Alkali, SmoothMuscle (Gb:U02629), Non-Muscle, Alt. Splice, (v) L10343 Huma elafingene, complete cds, (vi) M63573 Human secreted cyclophilin-like protein(SCYLP) mRNA, complete cds, (vii) M21302 Human small proline richprotein (sprII) mRNA, clone 174N, (viii) Y00787 Human mRNA for MDNCF(monocyte-derived neutrophil chemotactic factor), (ix) X57985 H. sapiensgenes for histones H2B.1 and H2A, (x) L05188 H. sapiens smallproline-rich protein 2 (SPRR2B) gene, complete cds, (xi) X70326Macmarcks, (xii) X67325 H. sapiens p27 mRNA, (xiii) L19779 H. sapienshistone H2A.2 mRNA, complete cds, (xiv) S81914 IEX-1=radiation-inducibleimmediate-early gene [human, placenta, mRNA Partial, 1, (xv) D45248Human mRNA for proteasome activator hPA28 subunit beta, complete cds,(xvi) Z22548 H. sapiens thiol-specific antioxidant protein mRNA, (xvii)M22918 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629),Non-Muscle, Alt. Splice, (xviii) X06956 Tubulin, Alpha 1, Isoform 44,(xix) V00594 Human mRNA for metallothionein from cadmium-treated cells,(xx) M80254 H. sapiens cyclophilin isoform (hCyP3) mRNA, complete cds,(xxi) U04636 Human cyclooxygenase-2 (hCox-2) gene, complete cds, (xxii)Z14244 H. sapiens coxVIIb mRNA for cytochrome c oxidase subunit VIIb,(xxiii) X99920 H. sapiens mRNA for S100 calcium-binding protein A13,(xxiv) U62800 Human cystatin M (CST6) mRNA, complete cds, (xxv) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(xxvi) L20688 Human GDP-dissociation inhibitor protein (Ly-GDI) mRNA,complete cds, (xxvii) M13755 Human interferon-induced 17-kDa/15-kDaprotein mRNA, complete cds, (xxviii) M60278 Human heparin-bindingEGF-like growth factor mRNA, complete cds, (xxix) AF001294 H. sapiensIPL (IPL) mRNA, complete cds, (xxx) X54489 Human gene for melanomagrowth stimulatory activity (MGSA), (xxxi) M21186 Human neutrophilcytochrome b light chain p22 phagocyte b-cytochrome mRNA, compl, (xxxii)D42040 Human mRNA for KIAA9001 gene, complete cds, (xxxiii) V00599Tubulin, Beta, (xxxiv) U37690 Human RNA polymerase II subunit (hsRPB10)mRNA, complete cds, (xxxv) M21005 Human migration inhibitoryfactor-related protein 8 (MRP8) gene, complete cds, (xxxvi) M37583 Humanhistone (H2A.Z) mRNA, complete cds, (xxxvii) Z49989 H. sapiens mRNA forsmoothelin, (xxxviii) L24564 Human Rad mRNA, complete cds, (xxxix)D49824 Human HLA-B null allele mRNA, (xl) M59465 Human tumor necrosisfactor alpha inducible protein A20 mRNA, complete cds, (xli) S54005thymosin beta-10 [human, metastatic melanoma cell line, mRNA, 453 nt],(xlii) Z49254 H. sapiens L23-related mRNA, (xliii) M22919 Myosin, LightChain, Alkali, Smooth Muscle (Gb:U02629), Smooth Muscle, Alt. Spli,(xliv) U70660 Human copper transport protein HAH1 (HAH1) mRNA, completecds, (xlv) AF006084 H. sapiens Arp⅔ protein complex subunit p41-Arc(ARC41) mRNA, complete cds, (xlvi) X62083 H. sapiens mRNA for Drosophilafemale sterile homeotic (FSH) homologue, (xlvii) D86974 Human mRNA forKIAA0220 gene, partial cds, (xlviii) M72885 Human GOS2 gene, 5′ flankand cds, (xlix) S80437 fatty acid synthase {3′ region} [human, breastand HepG2 cells, mRNA Partial, 22, (l) X04654 Human mRNA for U1RNA-associated 70K protein, (li) t M26311 Human cystic fibrosis antigenmRNA, complete cds, (lii) X14850 Human H2A.X mRNA encoding histoneH2A.X, (liii) M14328 Human alpha enolase mRNA, complete cds, (liv)U07919 Human aldehyde dehydrogenase 6 mRNA, complete cds, (lv) M28130Human interleukin 8 (IL8) gene, complete cds, (lvi) Z21507 H. sapiensEF-1delta gene encoding human elongation factor-1-delta, (lvii) M92934Human connective tissue growth factor, complete cds, (lviii) M27436Human tissue factor gene, complete cds, with a Alu repetitive sequencein the 3′, (lix) X74874 H. sapiens gene for RNA pol II largest subunit,exon 1, (lx) X57351 Human 1-8D gene from interferon-inducible genefamily, (lxi) X52979 Human gene for small nuclear ribonucleoproteins SmBand SmB′, (lxii) U41515 Human deleted in split hand/split foot 1 (DSSl)mRNA, complete cds, (lxiii) D28235 Human PTGS2 gene for prostaglandinendoperoxide synthase-2, complete cds, (lxiv) Y00503 Human mRNA forkeratin
 19. (lxv) M57731 Human gro-beta mRNA, complete cds, (lxvi)D50840 H. sapiens mRNA for ceramide glucosyltransferase, complete cds,(lxvii) U52101 Human YMP mRNA, complete cds. (lxviii) D13413 Human mRNAfor tumor-associated 120 kDa nuclear protein p120, partial cds(carbox,(lxix) L42379 H. sapiens bone-derived growth factor (BPGF-1) mRNA,complete cds, (lxx) X52426 H. sapiens mRNA for cytokeratin 13, (lxxi)J04456 Human 14 kd lectin mRNA, complete cds, (lxxii) S78771 NAT=CpGisland-associated gene [human, mRNA, 1741 nt], (lxxiii) M26730 Humanmitochondrial ubiquinone-binding protein (QP) gene, exon 4, (lxxiv)U26727 Human p1 6INK4/MTS 1 mRNA, complete cds, (lxxv) X92896 H. sapiensmRNA for ITBA2 protein, (lxxvi) Z69043 H. sapiens mRNAtranslocon-associated protein delta subunit precursor, (lxxvii) L76568H. sapiens excision and cross link repair protein (ERCC4) gene, completegenom, (lxxviii) M12125 Human fibroblast muscle-type tropomyosin mRNA,complete cds, (lxxix) U09937 Human urokinase-type plasminogen receptor,exon 7, (lxxx) X15822 Human COX VIIa-L mRNA for liver-specificcytochrome c oxidase (EC 1.9.3.1.), (lxxxi) M34516 Human omega lightchain protein 14.1 (Ig lambda chain related) gene, exon 3, (lxxxii)U53830 H. sapiens interferon regulatory factor 7A mRNA, complete cds,(lxxxiui) X82693 H. sapiens mRNA for E48 antigen, (lxxxiv) M58026 HumanNB-1 mRNA, complete cds, (lxxxv) M90657 Human tumor antigen (L6) mRNA,complete cds, (lxxxvi) X57579 H. sapiens activin beta-A subunit (exon2), (lxxxvii) D38251 Human mRNA for RPB5 (XAP4), complete cds,(lxxxviii) D89667 H. sapiens mRNA for c-myc binding protein, completecds, (lxxxix) AB000584 H. sapiens mRNA for TGF-beta superfamily protein,complete cds, (xc) L76200 Human guanylate kinase (GUK1) mRNA, completecds, (xci) J04794 Human aldehyde reductase mRNA, complete cds, (xcii)X52882 Human t-complex polypeptide 1 gene, (xciii) M79463 Human PML-2mRNA, complete CDS, (xciv) Y09022 H. sapiens mRNA for Not56-likeprotein, (xcv) M12529 Human apolipoprotein E mRNA, complete cds, (xcvi)X71129 H. sapiens mRNA for electron transfer flavoprotein beta subunit,(xcvii) X83416 H. sapiens PrP gene, exon 2, (xcviii) D89052 H. sapiensmRNA for proton-ATPase-like protein, complete cds, (xcix) M60974 Humangrowth arrest and DNA-damage-inducible protein (gadd45) mRNA, completecds, (c) M16364 Human creatine kinase-B mRNA, complete cds, (ci) D38305Human mRNA for Tob, complete cds, (cii) X87679 Major HistocompatibilityComplex, Class I, E (Gb:M21533), (ciii) Z29505 H. sapiens mRNA fornucleic acid binding protein sub2.3, (civ) K02574, (cv) U09813 Humanmitochondrial ATP synthase subunit 9, P3 gene copy, mRNA, nuclear geneenc, (cvi) X67951 H. sapiens mRNA for proliferation-associated gene(pag), (cvii) J04611 Human lupus p70 (Ku) autoantigen protein mRNA,complete cds, (cviii) U09578 H. sapiens MAPKAP kinase (3 pK) mRNA,complete cds, (cix) X53800 Human mRNA for macrophage inflammatoryprotein-2beta (MIP2beta), (cx) V00599 Tubulin, Beta 2, (cxi) U69126Human FUSE binding protein 2 (FBP2) mRNA, partial cds, (cxii) X53416Human mRNA for actin-binding protein (filamin) (ABP-280), (cxiii) U90546Human butyrophilin (BTF4) mRNA, complete cds, (cxiv) M58459 Humanribosomal protein (RPS4Y) isoform mRNA, complete cds, (cxv) M19961 Humancytochrome c oxidase subunit Vb (coxVb) mRNA, complete cds, (cxvi)U65579 Human mitochondrial NADH dehydrogenase-ubiquinone Fe—S protein 8,23 kDa subunit, (cxvii) X77794 H. sapiens mRNA for cyclin G1, (cxviii)M29064 Human hnRNP B1 protein mRNA, (cxix) D21853 Human mRNA forKIAA0111 gene, complete cds, (cxx) X78687 H. sapiens G9 gene encodingsialidase, (cxxi) X15729 Human mRNA for nuclear p68 protein, (cxxii)X04828 Human mRNA for G(i) protein alpha-subunit (adenylate cyclaseinhibiting GTP-bind, (cxxiii) L27943 H. sapiens cytidine deaminase (CDA)mRNA, complete cds, (cxxiv) L40391 H. sapiens (clone s153) mRNAfragment, (cxxv) D42123 H. sapiens mRNA for ESP1/CRP2, complete cds,(cxxvi) X74104 H. sapiens mRNA for TRAP beta subunit, (cxxvii) M84332Human ADP-ribosylation factor 1 gene, exons 2-5, (cxxviii) L37127 H.sapiens RNA polymerase II mRNA, complete cds, (cxxix) M92843 H. sapienszinc finger transcriptional regulator mRNA, complete cds, (cxxx) U07664Human HB9 homeobox gene, exons 2 and 3 and complete cds, (cxxxi) L48546H. sapiens tuberin (TSC2) gene, exons 38, 39, 40 and 41, (cxxxii) X53586Human mRNA for integrin alpha 6, (cxxxiii) t D21852 Human mRNA forKIAA0029 gene, partial cds, (cxxxiv) L11066 Human mRNA sequence, (cxxxv)J04444 Human cytochrome c-1 gene, complete cds, (cxxxvi) M95787 Human 22kDa smooth muscle protein (SM22) mRNA, complete cds, (cxxxvii) L07517Mucin 6, Gastric (Gb:L07517), (cxxxviii) X91247 H. sapiens mRNA forthioredoxin reductase, (cxxxix) L11672 Human Kruppel related zinc fingerprotein (HTF10) mRNA, complete cds, (cxl) U30999 Human (memc) mRNA,3′UTR, (cxli) U01337 Human Ser/Thr protein kinase (A-RAF-1) gene,complete cds, (cxlii) U28480 Uncoupling Protein Ucp, (cxliii) X12794Human v-erbA related ear-2 gene, (cxliv) L22005 Human ubiquitinconjugating enzyme mRNA, partial cds, (cxlv) M12886 Human T-cellreceptor active beta-chain mRNA, complete cds, (cxlvi) Y08915 H. sapiensmRNA for alpha 4 protein, (cxlvii) M24547 Amyloid Beta (A4) PrecursorProtein, Alt. Splice 2, A4(751), (cxlviii) X76717 H. sapiens MT-1l mRNA,(cxlix) M64347 Human novel growth factor receptor mRNA, 3′ cds, (cl)X05409 Human RNA for mitochondrial aldehyde dehydrogenase I ALDH I (EC1.2.1.3), (cli) D87469 Human mRNA for KIAA0279 gene, partial cds, (clii)M58603 Human nuclear factor kappa-B DNA binding subunit (NF-kappa-B)mRNA, complete cds, (cliii) M76482 Human 130-kD pemphigus vulgarisantigen mRNA, complete cds, (cliv) X06323 Human MRL3 mRNA for ribosomalprotein L3 homologue ( MRL3=mammalian ribosome L, (clv) X78992 H.sapiens ERF-2 mRNA, (clvi) L41351 H. sapiens prostasin mRNA, completecds, (clvii) X75342 H. sapiens SHB mRNA, (clviii) U83115 Human non-lensbeta gamma-crystallin like protein (AIM1) mRNA, partial cds, (clix)U88629 Human RNA polymerase II elongation factor ELL2, complete cds,(clx) S78825 Id1, (clxi) U28811 Human cysteine-rich fibroblast growthfactor receptor (CFR-1) mRNA, complete cds, (clxii) M58286 H. sapienstumor necrosis factor receptor mRNA, complete cds, (clxiii) D78129 H.sapiens mRNA for squalene epoxidase, partial cds, (clxiv) D14874 H.sapiens mRNA for adrenomedullin precursor, complete cds, (clxv) Z26317H. sapiens mRNA for desmoglein 2, (clxvi) L19267 H. sapiens 59 proteinmRNA, 3′ end, clxvii) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf114, (clxviii) U33821 Human taxl-binding protein TXBP151 mRNA, completecds, (clxix) U52100 Human XMP mRNA, complete cds, (clxx) L31801 H.sapiens monocarboxylate transporter 1 (SLC16A1) mRNA, complete cds,(clxxi) L00058 Human (GH) germline c-myc proto-oncogene, exon 3 and 3′flank, (clxxii) U52426 H. sapiens GOK (STIM1) mRNA, complete cds,(clxxiii) M80244 Human E16 mRNA, complete cds, (clxxiv) U56418 Humanlysophosphatidic acid acyltransferase-beta mRNA, complete cds, (clxxv)L38490 H. sapiens ADP-ribosylation factor mRNA, complete cds, (clxxvi)U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (clxxvii) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (clxxviii) M38258 Human retinoic acid receptor gamma 1mRNA, complete cds, (clxxix) X89750 H. sapiens mRNA for TGIF protein,(clxxx) D85429 H. sapiens gene for heat shock protein 40, complete cds,(clxxxi) J05211 Desmoplakin I, (clxxxii) M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds, (clxxxiii) X80695 H. sapiensOXA1Hs mRNA, (clxxxiv) M54915 Human h-pim-1 protein (h-pim-1) mRNA,complete cds, (clxxxv) D83777 Human mRNA for KIAA0193 gene, completecds, (clxxxvi) D31883 Human mRNA for KIAA0059 gene, complete cds,(clxxxvii) U00968 Human SREBP-1 mRNA, complete cds, (clxxxviii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (clxxxix)D86965 Human mRNA for KIAA0210 gene, complete cds, (cxc) Z30643 H.sapiens mRNA for chloride channel (putative) 2139bp, (cxci) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (cxcii) D87462Human mRNA for KIAA0272 gene, partial cds, (cxciii) X80692 H. sapiensERK3 mRNA, (cxciv) X90858 H. sapiens mRNA for uridine phosphorylase,(cxcv) M57763 Human ADP-ribosylation factor (hARF6) mRNA, complete cds,(cxcvi) X92720 H. sapiens mRNA for phosphoenolpyruvate carboxykinase,(cxcvii) M81601 Human transcription elongation factor (SII) mRNA,complete cds, (cxcviii) X52611 Human mRNA for transcription factor AP-2,(cxcix) U09587 Human glycyl-tRNA synthetase mRNA, complete cds, (cc)U14550 Human sialyltransferase SThM (sthm) mRNA, complete cds, (cci)D90209 Human mRNA for DNA binding protein TAXREB67, (ccii) X77366 H.sapiens HBZ17 mRNA, (cciii) X76534 H. sapiens NMB mRNA, (cciv) U37519Human aldehyde dehydrogenase (ALDH8) mRNA, complete cds, (ccv) M83667Human NF-IL6-beta protein mRNA, complete cds, (ccvi) U53347 Humanneutral amino acid transporter B mRNA, complete cds, (ccvii) L09229Human long-chain acyl-coenzyme A synthetase (FACL1) mRNA, complete cds,(ccviii) S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, (ccix) M13929 Human c-myc-P64 mRNA,initiating from promoter P0, (HLmyc2.5) partial cds, (ccx) M55268 Humancasein kinase II alpha′ subunit mRNA, complete cds, (ccxi) M77836 Humanpyrroline 5-carboxylate reductase mRNA, complete cds, (ccxii)HG2724-HT2820_at S75762 Oncogene Tls/Chop, Fusion Activated, (ccxiii)U72066 H. sapiens CtBP interacting protein CtIP (CtIP) mRNA, completecds, (ccxiv) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (ccxv) M27396 Human asparaginesynthetase mRNA, complete cds, (ccxvi) X01630 Human mRNA forargininosuccinate synthetase, (ccxvii) D32050 Human mRNA for alanyl-tRNAsynthetase, complete cds, (ccxviii) M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, (ccxix) J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,and (ccxx) X69111 H. sapiens HLH 1R21 mRNA for helix-loop-helix protein.57. A screening method for the detection of a compound that modulates aresponse of a cell to ultraviolet radiation exposure, comprising: (a)contacting the cell with the compound; (b) exposing the cell toultraviolet radiation that would otherwise induce the response, theresponse being an altered pattern of expression comprising thefollowing: (i) a first response comprising the altered pattern ofexpression of at least one polynucleotide selected from the groupconsisting of a nucleic acid molecule encoding a transcription factorprotein, a nucleic acid molecule encoding a signal transducing protein,and a nucleic acid molecule encoding a mitochondrial protein; (ii) asecond response comprising the altered pattern of expression of at leastone polynucleotide selected from the group consisting of a nucleic acidmolecule encoding a secreted growth factor, a nucleic acid moleculeencoding a cytokine, and a nucleic acid molecule encoding a chemokine;and (iii) a third response comprising the altered pattern of expressionof at least one polynucleotide selected from the group consisting of anucleic acid molecule encoding an actin-binding protein, a nucleic acidmolecule encoding a desmosomal protein, and a nucleic acid moleculeencoding a tubulin protein; and (c) isolating and measuring the levelsof a plurality of RNA molecules in the cell for at least one time pointafter ultraviolet radiation exposure, wherein a change in the alteredpattern of expression of the first response, the second response and/orthe third response indicates that the compound modulates the response ofthe cell to ultraviolet radiation exposure.
 58. The method according toclaim 57, wherein the cell is contacted with the compound in vitro. 59.The method according to claim 57, wherein the cell is contacted with thecompound in vivo.
 60. The method according to claim 57, wherein theultraviolet irradation exposure comprises ultraviolet radiation energyat a wavelength in the range of about 220 nm to about 440 nm.
 61. Themethod according to claim 57, wherein the ultraviolet radiation exposurecomprises ultraviolet radiation energy at a wavelength in the range ofabout 290 nm to about 320 nm.
 62. The method according to claim 57,wherein the ultraviolet radiation exposure comprises ultravioletradiation energy at a wavelength in the range of about 320 to about 440nm.
 63. The method according to claim 57, wherein the ultravioletirradation exposure comprises a total ultraviolet radiation energyexposure in the range of about 0.2 mJ/cm² to about 40 mJ/cm².
 64. Themethod according to claim 57, wherein: (a) the first response comprisesat least one nucleic acid molecule that is at least 90% identical to apolynucleotide selected from the group consisting of: (i) M62831 Humantranscription factor ETR101 mRNA, complete cds, (ii) X68277 H. sapiensCL 100 mRNA for protein tyrosine phosphatase, (iii) L04731 H. sapienstranslocation T(4:11) of ALL-1 gene to chromosome 4, (iv) X56681 HumanjunD mRNA, (v) U20734 Human transcription factor junB (junB) gene, 5′region and complete cds, (vi) L38951 H. sapiens importin beta subunitmRNA, complete cds, (vii) D87071 Human mRNA for KIAA0233 gene, completecds, (viii) M72885 Human GOS2 gene, 5′ flank and cds, (ix) M92843 H.sapiens zinc finger transcriptional regulator mRNA, complete cds, (x)S81914 IEX-1=radiation-inducible immediate-early gene [human, placenta,mRNA Partial, (xi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (xii)D86988 Human mRNA for KIAA0221 gene, complete cds, (xiii) L19779 H.sapiens histone H2A.2 mRNA, complete cds, (xiv) U62317 Chromosome 22q13BAC Clone CIT987SK-384D8 complete sequence, (xv) X04412 Human mRNA forplasma gelsolin, (xvi) L27706 Human chaperonin protein (Tcp20) genecomplete cds, (xvii) X61123 Human BTG1 mRNA, (xviii) M60974growth arrestand DNA-damage-inducible protein (gadd45) mRNA, complete cds, (xix)L19437 Human transaldolase mRNA containing transposable element,complete cds, (xx) X57985 H. sapiens genes for histones H2B.1 and H2A,(xxi) D90086 Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunitgene, exons 1-10, (xxii) M34182 Human testis-specific protein kinasegamma-subunit mRNA, complete cds, (xxiii) L16862 H. sapiens Gprotein-coupled receptor kinase (GRK6) mRNA, complete cds, (xxiv) D13705Human mRNA for fatty acids omega-hydroxylase (cytochrome P-450HKV),complete cd, (xxv) U37122 Human adducin gamma subunit mRNA, completecds, (xxvi) D45906 H. sapiens mRNA for LIMK-2, complete cds, (xxvii)U07664 Human HB9 homeobox gene, exons 2 and 3 and complete cds, (xxviii)D87438 Human mRNA for KIAA0251 gene, partial cds, (xxix) L37042 H.sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds,(xxx) D14043 Human mRNA for MGC-24, complete cds, (xxxi) D13988 Humanrab GDI mRNA, complete cds, (xxxii) U28480 Uncoupling Protein Uc,(xxxiii) D50840 H. sapiens mRNA for ceramide glucosyltransferase,complete cds, (xxxiv) M55265 Human casein kinase II alpha subunit mRNA,complete cds, (xxxv) M96803 Human general beta-spectrin (SPTBN1) mRNA,complete cds, (xxxvi) U89336 Human HLA class III region containingNOTCH4 gene, partial sequence, homeobox P, (xxxvii) D87442 Human mRNAfor KIAA0253 gene, partial cds, (xxxviii) J03161 Human serum responsefactor (SRF) mRNA, complete cds, (xxxix) D86965 Human mRNA for KIAA0210gene, complete cds, (xl) U17327 Human neuronal nitric oxide synthase(NOS 1) mRNA, complete cds, (xli) D86966 Human mRNA for KIAA0211 gene,complete cds, (xlii) D85527 H. sapiens mRNA for LIM domain, partial cds,(xliii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (xliv) X59434 Human rohu mRNA forrhodanese, (xlv) M13929 Human c-myc-P64 mRNA, initiating from promoterP0, (HLmyc2.5) partial cds, and (xlvi) J05211 Desmoplakin; (b) thesecond response comprises at least one nucleic acid molecule that is atleast 90% identical to a polynucleotide selected from the groupconsisting of; and (i) M57731 Human gro-beta mRNA, complete cds, (ii)S81914 IEX-1=radiation-inducible immediate-early gene [human, placenta,mRNA Partial, 1, (iii) Y00787 Human mRNA for MDNCF (monocyte-derivedneutrophil chemotactic factor), (iv) X54489 Human gene for melanomagrowth stimulatory activity (MGSA), (v) M72885 Human GOS2 gene, 5′ flankand cds, (vi) M62831 Human transcription factor ETR101 mRNA, completecds, (vii) M28130 Human interleukin 8 (IL8) gene, complete cds, (viii)X57985 H. sapiens genes for histones H2B.1 and H2A, (ix) X53800 HumanmRNA for macrophage inflammatory protein-2beta (MIP2beta), (x) L19779 H.sapiens histone H2A.2 mRNA, complete cds, (xi) AF001294 H. sapiens IPL(IPL) mRNA, complete cds, (xii) X56681 Human jund mRNA, (xiii) S75762Oncogene Tls/Chop, Fusion Activate, (xiv) M84739 Human autoantigencalreticulin mRNA, complete cds, (xv) M21302 Human small proline richprotein (sprII) mRNA, clone 174N, (xvi) V00599 Tubulin, Bet, (xvii)X70326 Macmarck, (xviii) D10923 Human mRNA for HM74, (xix) D64142 HumanmRNA for histone H1x, complete cds, (xx) D86974 Human mRNA for KIAA0220gene, partial cds, (xxi) M60974 Human growth arrest andDNA-damage-inducible protein (gadd45) mRNA, complete cds, (xxii) X68277H. sapiens CL 100 mRNA for protein tyrosine phosphatase, (xxiii) L13391Human helix-loop-helix basic phosphoprotein (GOS8) gene, complete cds,(xxiv) M31627 Human X box binding protein-1 (XBP-1) mRNA, complete cds,(xxv) U40369 Human spermidine/spermine N1-acetyltransferase (SSAT) gene,complete cds, (xxvi) X52560 Nuclear Factor Nf-Il, (xxvii) X61123 HumanBTG1 mRNA, (xxviii) U20734 Human transcription factor junB (junB) gene,5′ region and complete cds, (xxix) U35048 Human TSC-22 protein mRNA,complete cds, (xxx) M69043 H. sapiens MAD-3 mRNA encoding IkB-likeactivity, complete cds, (xxxi) X51345 Human jun-B mRNA for JUN-Bprotein, (xxxii) S68616 Na+/H+exchanger NHE-1 isoform [human, heart,mRNA, 4516 nt], (xxxiii) X89750 H. sapiens mRNA for TGIF protein,(xxxiv) X69111 H. sapiens HLH 1R21 mRNA for helix-loop-helix protein,(xxxv) U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (xxxvi) X52541 Human mRNA for early growth response protein 1(hEGR1), (xxxvii) D50683 H. sapiens mRNA for TGF-betaIIR alpha, completecds, (xxxviii) M92843 H. sapiens zinc finger transcriptional regulatormRNA, complete cds, (xxxix) X91247 H. sapiens mRNA for thioredoxinreductase, (xl) U05875 Human clone pSK1 interferon gamma receptoraccessory factor-1 (AF-1) mRNA, comp, (xli) L19314 Human HRY gene,complete cds, (xlii) M30703 Human amphiregulin (AR) gene, exon 6, cloneslambda-ARH(6,12), (xliii) U34252 Human gamma-aminobutyraldehydedehydrogenase mRNA, complete cds, (xliv) S78825 Id1, (xlv) D85429 H.sapiens gene for heat shock protein 40, complete cds, (xlvi) U41766Human metalloprotease/disintegrin/cysteine-rich protein precursor (MDC9)mRNA, (xlvii) U89336 Human HLA class III region containing NOTCH4 gene,partial sequence, homeobox PB, (xlviii) M69181 Human nonmuscle myosinheavy chain-B (MYH10) mRNA, partial cds, (xlix) D15050 Human mRNA fortranscription factor AREB6, complete cds, (l) U28386 Human nuclearlocalization sequence receptor hSRP1alpha mRNA, complete cds, (li)L77886 Human protein tyrosine phosphatase mRNA, complete cds, (lii)X64330 H. sapiens mRNA for ATP-citrate lyase, (liii) U37122 Humanadducin gamma subunit mRNA, complete cds, (liv) X74008 H. sapiens mRNAfor protein phosphatase 1 gamma, (lv) U60205 Human methyl sterol oxidase(ERG25) mRNA, complete cds, (lvi) X76534 H. sapiens NMB mRNA, (lvii)D87071 Human mRNA for KIAA0233 gene, complete cds, (lviii) U90716 Humancell surface protein HCAR mRNA, complete cds, (lix) M91083 HumanDNA-binding protein (HRC1) mRNA, complete cds, (lx) U29607 Humanmethionine aminopeptidase mRNA, complete cds, (lxi) M76482 Human 130-kDpemphigus vulgaris antigen mRNA, complete cds, (lxii) U72066 H. sapiensCtBP interacting protein CtIP (CtIP) mRNA, complete cds, (lxiii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (lxiv) X12953Human rab2 mRNA, YPT1-related and member of ras family, (lxv) M60483Human protein phosphatase 2A catalytic subunit-alpha gene, complete cds,(lxvi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (lxvii) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (lxviii) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(lxix) D50840 H. sapiens mRNA for ceramide glucosyltransferase, completecds, (lxx) L31801 H. sapiens monocarboxylate transporter 1 (SLC16A1)mRNA, complete cds, (lxxi) S74017 Nrf2=NF-E2-like basic leucine zippertranscriptional activator [human, hemin-in, (lxxii) X87241 H. sapiensmRNA for hFat protein, (lxxiii) X52425 Human IL-4-R mRNA for theinterleukin 4 receptor, (lxxiv) D79994 Human mRNA for KIAA0172 gene,partial cds, (lxxv) M58286 H. sapiens tumor necrosis factor receptormRNA, complete cds, (lxxvi) M13829 Human putative raf related protein(pks/a-raf) mRNA, partial cds, (lxxvii) X78992 H. sapiens ERF-2 mRNA,(lxxviii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (lxxix) U88629 Human RNA polymeraseII elongation factor ELL2, complete cds, (lxxx) X52611 Human mRNA fortranscription factor AP-2, (lxxxi) U28749 Human high-mobility groupphosphoprotein isoform I—C (HMGIC) mRNA, complete cds, (lxxxii) L00058Human (GH) gerrnline c-myc proto-oncogene, exon 3 and 3′ flank,(lxxxiii) L26336 Heat Shock Protein, 70 Kda (Gb:Y00371, (lxxxiv) L08246Human myeloid cell differentiation protein (MCL1) mRNA, (lxxxv) S73591brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic,leukemia cells (lxxxvi) J05211 Desmoplakin, (lxxxvii)L00352 Human low density lipoprotein receptor gene, exon 18, (lxxxviii)Y13647 Stearoyl-Coenzymea Desaturase, (lxxxix) X77794 H. sapiens mRNAfor cyclin G1, (xc) M90656 Human gamma-glutamylcysteine synthetase (GCS)mRNA, complete cds, (xci) M13929 Human c-myc-P64 mRNA, initiating frompromoter P0, (HLmyc2.5) partial cds, (xcii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (xciii) X80692 H. sapiens ERK3 mRNA,and (xciv) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114; and (c)the third response comprises at least one nucleic acid molecule that isat least 90% identical to a polynucleotide selected from the groupconsisting of: (i) M20030 Human small proline rich protein (sprII)MnRNA, clone 930, (ii) X53065, (iii) M13903 Human involucrin gene, exon2, (iv) M22918 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629),Non-Muscle, Alt. Splice, (v) L10343 Huma elafin gene, complete cds, (vi)M63573 Human secreted cyclophilin-like protein (SCYLP) mRNA, completecds, (vii) M21302 Human small proline rich protein (sprII) mRNA, clone174N, (viii) Y00787 Human mRNA for MDNCF (monocyte-derived neutrophilchemotactic factor), (ix) X57985 H. sapiens genes for histones H2B.1 andH2A, (x) L05188 H. sapiens small proline-rich protein 2 (SPRR2B) gene,complete cds, (xi) X70326 Macmarcks, (xii) X67325 H. sapiens p27 mRNA,(xiii) L19779 H. sapiens histone H2A.2 mRNA, complete cds, (xiv) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, (xv) D45248 Human mRNA for proteasome activator hPA28subunit beta, complete cds, (xvi) Z22548 H. sapiens thiol-specificantioxidant protein mRNA, (xvii) M22918 Myosin, Light Chain, Alkali,Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice, (xviii) X06956Tubulin, Alpha 1, Isoform 44, (xix) V00594 Human mRNA formetallothionein from cadmium-treated cells, (xx) M80254 H. sapienscyclophilin isoform (hCyP3) mRNA, complete cds, (xxi) U04636 Humancyclooxygenase-2 (hCox-2) gene, complete cds, (xxii) Z14244 H. sapienscoxVIIb mRNA for cytochrome c oxidase subunit VIIb, (xxiii) X99920 H.sapiens mRNA for S100 calcium-binding protein A13, (xxiv) U62800 Humancystatin M (CST6) mRNA, complete cds, (xxv) L08069 Human heat shockprotein, E. coli DnaJ homologue mRNA, complete cds, (xxvi) L20688 HumanGDP-dissociation inhibitor protein (Ly-GDI) mRNA, complete cds, (xxvii)M13755 Human interferon-induced 17-kDa/15-kDa protein mRNA, completecds, (xxviii) M60278 Human heparin-binding EGF-like growth factor mRNA,complete cds, (xxix) AF001294 H. sapiens IPL (IPL) mRNA, complete cds,(xxx) X54489 Human gene for melanoma growth stimulatory activity (MGSA),(xxxi) M21186 Human neutrophil cytochrome b light chain p22 phagocyteb-cytochrome mRNA, compl, (xxxii) D42040 Human mRNA for KIAA9001 gene,complete cds, xxxiii) V00599 Tubulin, Beta, (xxxiv) U37690 Human RNApolymerase II subunit (hsRPB10) mRNA, complete cds, (xxxv) M21005 Humanmigration inhibitory factor-related protein 8 (MRP8) gene, complete cds,(xxxvi) M37583 Human histone (H2A.Z) mRNA, complete cds, (xxxvii) Z49989H. sapiens mRNA for smoothelin, (xxxviii) L24564 Human Rad mRNA,complete cds, (xxxix) D49824 Human HLA-B null allele mRNA, (xl) M59465Human tumor necrosis factor alpha inducible protein A20 mRNA, completecds, (xli) S54005 thymosin beta-10 [human, metastatic melanoma cellline, mRNA, 453 nt], (xlii) Z49254 H. sapiens L23-related mRNA, (xliii)M22919 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629), SmoothMuscle, Alt. Spli, (xliv) U70660 Human copper transport protein HAH1(HAH1) mRNA, complete cds, (xlv) AF006084 H. sapiens Arp⅔ proteincomplex subunit p41-Arc (ARC41) mRNA, complete cds, (xlvi) X62083 H.sapiens mRNA for Drosophila female sterile homeotic (FSH) homologue,(xlvii) D86974 Human mRNA for KIAA0220 gene, partial cds, (xlviii)M72885 Human GOS2 gene, 5′ flank and cds, (xlix) S80437 fatty acidsynthase {3′ region} [human, breast and HepG2 cells, mRNA Partial, 22,(l) X04654 Human mRNA for U1 RNA-associated 70K protein, (li) t M26311Human cystic fibrosis antigen mRNA, complete cds, (lii) X14850 HumanH2A.X mRNA encoding histone H2A.X, (liii) M14328 Human alpha enolasemRNA, complete cds, (liv) U07919 Human aldehyde dehydrogenase 6 mRNA,complete cds, (lv) M28130 Human interleukin 8 (IL8) gene, complete cds,(lvi) Z21507 H. sapiens EF-1delta gene encoding human elongationfactor-1-delta, (lvii) M92934 Human connective tissue growth factor,complete cds, (lviii) M27436 Human tissue factor gene, complete cds,with a Alu repetitive sequence in the 3′, (lix) X74874 H. sapiens genefor RNA pol II largest subunit, exon 1, (lx) X57351 Human 1-8D gene frominterferon-inducible gene family, (lxi) X52979 Human gene for smallnuclear ribonucleoproteins SmB and SmB′, (lxii) U41515 Human deleted insplit hand/split foot 1 (DSS1) mRNA, complete cds, (lxiii) D28235 HumanPTGS2 gene for prostaglandin endoperoxide synthase-2, complete cds,(lxiv) Y00503 Human mRNA for keratin
 19. (lxv) M57731 Human gro-betamRNA, complete cds, (lxvi) D50840 H. sapiens mRNA for ceramideglucosyltransferase, complete cds, (lxvii) U52101 Human YMP mRNA,complete cds. (lxviii) D13413 Human mRNA for tumor-associated 120 kDanuclear protein p120, partial cds(carbox, (lxix) L42379 H. sapiensbone-derived growth factor (BPGF-1) mRNA, complete cds, (lxx) X52426 H.sapiens mRNA for cytokeratin 13, (lxxi) J04456 Human 14 kd lectin mRNA,complete cds, (lxxii) S78771 NAT=CpG island-associated gene [human,mRNA, 1741 nt], (lxxiii) M26730 Human mitochondrial ubiquinone-bindingprotein (QP) gene, exon 4, (lxxiv) U26727 Human p16INK4/MTS1 mRNA,complete cds, (lxxv) X92896 H. sapiens mRNA for ITBA2 protein, (lxxvi)Z69043 H. sapiens mRNA translocon-associated protein delta subunitprecursor, (lxxvii) L76568 H. sapiens excision and cross link repairprotein (ERCC4) gene, complete genom, (lxxviii) M12125 Human fibroblastmuscle-type tropomyosin mRNA, complete cds, (lxxix) U09937 Humanurokinase-type plasminogen receptor, exon 7, (lxxx) X15822 Human COXVIIa-L mRNA for liver-specific cytochrome c oxidase (EC 1.9.3.1.),(lxxxi) M34516 Human omega light chain protein 14.1 (Ig lambda chainrelated) gene, exon 3, (lxxxii) U53830 H. sapiens interferon regulatoryfactor 7A mRNA, complete cds, (lxxxiii) X82693 H. sapiens mRNA for E48antigen, (lxxxiv) M58026 Human NB-1 mRNA, complete cds, (lxxxv) M90657Human tumor antigen (L6) mRNA, complete cds, (lxxxvi) X57579 H. sapiensactivin beta-A subunit (exon 2), (lxxxvii) D38251 Human mRNA for RPB5(XAP4), complete cds, (lxxxviii) D89667 H. sapiens mRNA for c-mycbinding protein, complete cds, (lxxxix) AB000584 H. sapiens mRNA forTGF-beta superfamily protein, complete cds, (xc) L76200 Human guanylatekinase (GUKI) mRNA, complete cds, (xci) J04794 Human aldehyde reductasemRNA, complete cds, (xcii) X52882 Human t-complex polypeptide 1 gene,(xciii) M79463 Human PML-2 mRNA, complete CDS, (xciv) Y09022 H. sapiensmRNA for Not56-like protein, (xcv) M12529 Human apolipoprotein E mRNA,complete cds, (xcvi) X71129 H. sapiens mRNA for electron transferflavoprotein beta subunit, (xcvii) X83416 H. sapiens PrP gene, exon 2,(xcviii) D89052 H. sapiens mRNA for proton-ATPase-like protein, completecds, (xcix) M60974 Human growth arrest and DNA-damage-inducible protein(gadd45) mRNA, complete cds, (c) M16364 Human creatine kinase-B mRNA,complete cds, (ci) D38305 Human mRNA for Tob, complete cds, (cii) X87679Major Histocompatibility Complex, Class I, E (Gb:M21533), (ciii) Z29505H. sapiens mRNA for nucleic acid binding protein sub2.3, (civ) K02574,(cv) U09813 Human mitochondrial ATP synthase subunit 9, P3 gene copy,mRNA, nuclear gene enc, (cvi) X67951 H. sapiens mRNA forproliferation-associated gene (pag), (cvii) J04611 Human lupus p70 (Ku)autoantigen protein mRNA, complete cds, (cviii) U09578 H. sapiens MAPKAPkinase (3 pK) mRNA, complete cds, (cix) X53800 Human mRNA for macrophageinflammatory protein-2beta (MIP2beta), (cx) V00599 Tubulin, Beta 2,(cxi) U69126 Human FUSE binding protein 2 (FBP2) mRNA, partial cds,(cxii) X53416 Human mRNA for actin-binding protein (filamin) (ABP-280),(cxiii) U90546 Human butyrophilin (BTF4) mRNA, complete cds, (cxiv)M58459 Human ribosomal protein (RPS4Y) isoform mRNA, complete cds, (cxv)M19961 Human cytochrome c oxidase subunit Vb (coxVb) mRNA, complete cds,(cxvi) U65579 Human mitochondrial NADH dehydrogenase-ubiquinone Fe—Sprotein 8, 23 kDa subunit, (cxvii) X77794 H. sapiens mRNA for cyclin G1,(cxviii) M29064 Human hnRNP B1 protein mRNA, (cxix) D21853 Human mRNAfor KIAA0111 gene, complete cds, (cxx) X78687 H. sapiens G9 geneencoding sialidase, (cxxi) X15729 Human mRNA for nuclear p68 protein,(cxxii) X04828 Human mRNA for G(i) protein alpha-subunit (adenylatecyclase inhibiting GTP-bind, (cxxiii) L27943 H. sapiens cytidinedeaminase (CDA) mRNA, complete cds, (cxxiv) L40391 H. sapiens (clones153) mRNA fragment, (cxxv) D42123 H. sapiens mRNA for ESP1/CRP2,complete cds, (cxxvi) X74104 H. sapiens mRNA for TRAP beta subunit,(cxxvii) M84332 Human ADP-ribosylation factor 1 gene, exons 2-5,(cxxviii) L37127 H. sapiens RNA polymerase II mRNA, complete cds,(cxxix) M92843 H. sapiens zinc fmger transcriptional regulator mRNA,complete cds, (cxxx) U07664 Human HB9 homeobox gene, exons 2 and 3 andcomplete cds, (cxxxi) LA8546 H. sapiens tuberin (TSC2) gene, exons 38,39, 40 and 41, (cxxxii) X53586 Human mRNA for integrin alpha 6,(cxxxiii) t D21852 Human mRNA for KIAA0029 gene, partial cds, (cxxxiv)L11066 Human mRNA sequence, (cxxxv) J04444 Human cytochrome c-1 gene,complete cds, (cxxxvi) M95787 Human 22 kDa smooth muscle protein (SM22)mRNA, complete cds, (cxxxvii) L07517 Mucin 6, Gastric (Gb:L07517),(cxxxviii) X91247 H. sapiens mRNA for thioredoxin reductase, (cxxxix)L11672 Human Kruppel related zinc finger protein (HTF10) mRNA, completecds, (cxl) U30999 Human (memc) mRNA, 3′UTR, (cxli) U01337 Human Ser/Thrprotein kinase (A-RAF-1) gene, complete cds, (cxlii) U28480 UncouplingProtein Ucp, (cxliii) X12794 Human v-erbA related ear-2 gene, (cxliv)L22005 Human ubiquitin conjugating enzyme mRNA, partial cds, (cxlv)M12886 Human T-cell receptor active beta-chain mRNA, complete cds,(cxlvi) Y08915 H. sapiens mRNA for alpha 4 protein, (cxlvii) M24547Amyloid Beta (A4) Precursor Protein, Alt. Splice 2, A4(751), (cxlviii)X76717 H. sapiens MT-1l mRNA, (cxlix) M64347 Human novel growth factorreceptor mRNA, 3′ cds, (cl) X05409 Human RNA for mitochondrial aldehydedehydrogenase I ALDH I (EC 1.2.1.3), (cli) D87469 Human mRNA forKIAA0279 gene, partial cds, (clii) M58603 Human nuclear factor kappa-BDNA binding subunit (NF-kappa-B) mRNA, complete cds, (cliii) M76482Human 130-kD pemphigus vulgaris antigen mRNA, complete cds, (cliv)X06323 Human MRL3 mRNA for ribosomal protein L3 homologue(MRL3=mammalian ribosome L, (clv) X78992 H. sapiens ERF-2 mRNA, (clvi)LA1351 H. sapiens prostasin mRNA, complete cds, (clvii) X75342 H.sapiens SHB mRNA, (clviii) U83115 Human non-lens beta gamma-crystallinlike protein (AIM1) mRNA, partial cds, (clix) U88629 Human RNApolymerase II elongation factor ELL2, complete cds, (clx) S78825 Id1,(clxi) U28811 Human cysteine-rich fibroblast growth factor receptor(CFR-1) mRNA, complete cds, (clxii) M58286 H. sapiens tumor necrosisfactor receptor mRNA, complete cds, (clxiii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (clxiv) D14874 H. sapiens mRNA foradrenomedullin precursor, complete cds, (clxv) Z26317 H. sapiens mRNAfor desmoglein 2, (clxvi) L19267 H. sapiens 59 protein mRNA, 3′ end,(clxvii) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114, (clxviii)U33821 Human tax1-binding protein TXBP151 mRNA, complete cds, (clxix)U52100 Human XMP mRNA, complete cds, (clxx) L31801 H. sapiensmonocarboxylate transporter 1 (SLC16A1) mRNA, complete cds, (clxxi)L00058 Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank,(clxxii) U52426 H. sapiens GOK (STIM1) mRNA, complete cds, (clxxiii)M80244 Human E16 mRNA, complete cds, (clxxiv) U56418 Humanlysophosphatidic acid acyltransferase-beta mRNA, complete cds, (clxxv)L38490 H. sapiens ADP-ribosylation factor mRNA, complete cds, (clxxvi)U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (clxxvii) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (clxxviii) M38258 Human retinoic acid receptor gamma 1mRNA, complete cds, (clxxix) X89750 H. sapiens mRNA for TGIF protein,(clxxx) D85429 H. sapiens gene for heat shock protein 40, complete cds,(clxxxi) J05211 Desmoplakin I, (clxxxii) M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds, (clxxxiii) X80695 H. sapiensOXA1Hs mRNA, (clxxxiv) M54915 Human h-pim-1 protein (h-pim-1) mRNA,complete cds, (clxxxv) D83777 Human mRNA for KIAA0193 gene, completecds, (clxxxvi) D31883 Human mRNA for KIAA0059 gene, complete cds,(clxxxvii) U00968 Human SREBP-1 mRNA, complete cds, (clxxxviii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (clxxxix)D86965 Human mRNA for KIAA0210 gene, complete cds, (cxc) Z30643 H.sapiens mRNA for chloride channel (putative) 2139bp, (cxci) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (cxcii) D87462Human mRNA for KIAA0272 gene, partial cds, (cxciii) X80692 H. sapiensERK3 mRNA, (cxciv) X90858 H. sapiens mRNA for uridine phosphorylase,(cxcv) M57763 Human ADP-ribosylation factor (hARF6) mRNA, complete cds,(cxcvi) X92720 H. sapiens mRNA for phosphoenolpyruvate carboxykinase,(cxcvii) M81601 Human transcription elongation factor (SII) mRNA,complete cds, (cxcviii) X52611 Human mRNA for transcription factor AP-2,(cxcix) U09587 Human glycyl-tRNA synthetase mRNA, complete cds, (cc)U14550 Human sialyltransferase SThM (sthm) mRNA, complete cds, (cci)D90209 Human mRNA for DNA binding protein TAXREB67, (ccii) X77366 H.sapiens HBZ17 mRNA, (cciii) X76534 H. sapiens NMB mRNA, (cciv) U37519Human aldehyde dehydrogenase (ALDH8) mRNA, complete cds, (ccv) M83667Human NF-IL6-beta protein mRNA, complete cds, (ccvi) U53347 Humanneutral amino acid transporter B mRNA, complete cds, (ccvii) L09229Human long-chain acyl-coenzyme A synthetase (FACLI) mRNA, complete cds,(ccviii) S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, (ccix) M13929 Human c-myc-P64 mRNA,initiating from promoter P0, (HLmyc2.5) partial cds, (ccx) M55268 Humancasein kinase II alpha′ subunit mRNA, complete cds, (ccxi) M77836 Humanpyrroline 5-carboxylate reductase mRNA, complete cds, (ccxii)HG2724-HT2820_at S75762 Oncogene Tls/Chop, Fusion Activated, (ccxiii)U72066 H. sapiens CtBP interacting protein CtIP (CtIP) mRNA, completecds, (ccxiv) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (ccxv) M27396 Human asparaginesynthetase mRNA, complete cds, (ccxvi) X01630 Human mRNA forargininosuccinate synthetase, (ccxvii) D32050 Human mRNA for alanyl-tRNAsynthetase, complete cds, (ccxviii) M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, (ccxix) J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,and (ccxx) X69111 H. sapiens HLH 1R21 mRNA for helix-loop-helix protein.65. The method according to claim 57, wherein the cell is an epidermalcell.
 66. The method according to claim 57, wherein the cell is selectedfrom the group consisting of a keratinocyte, a Langerhans cell, amelanocyte, and a fibroblast cell.
 67. The method according to claim 57,wherein the RNA is isolated at a time point between about 0.5 hours toabout 2 hours post-ultraviolet radiation exposure.
 68. The methodaccording to claim 57, wherein the RNA is isolated at a time pointbetween about 4 hours to about 8 hours post-ultraviolet radiationexposure.
 69. The method according to claim 57, wherein the RNA isisolated at a time point between about 16 hours to about 24 hourspost-ultraviolet radiation exposure.
 70. The method according to claim57, wherein the levels of the plurality of RNAs are measured by genearray expression analysis, comprising: (a) isolating the RNA from thecell at a time between from about 0.5 hours to about 24 hourspost-ultraviolet radiation exposure; (b) creating a test expressionarray through nucleic acid hybridization between a labeled probecomplementary to the RNA and an expression array substrate; (c)analyzing the test expression array to create a test expression arraydata set; and (d) comparing the test expression array data set to acontrol expression array data set to identity alterations in theexpression level, the control set being created from the analysis of acontrol expression array obtained through nucleic acid hybridizationbetween the labeled probe complementary to RNA isolate from a like cellbefore exposure to ultraviolet radiation.
 71. The method according toclaim 57, wherein contact with the compound is topical contact.
 72. Thescreening method according to claim 57, wherein the compound modulatesthe cellular response by inhibiting ultraviolet radiation-induced RNAexpression.
 73. The method according to claim 57, wherein the compoundinhibits the ultraviolet radiation-induced expression of at least onenucleic acid molecule induced in the first response, the secondresponse, or the third response, the nucleic acid molecule being atleast 90% identical to a polynucleotide selected from the groupconsisting of: (i) M20030 Human small proline rich protein (sprII) mRNA,clone 930, (ii) X53065, (iii) M13903 Human involucrin gene, exon 2, (iv)L10343 Huma elafm gene, complete cds, (v) M21302 Human small prolinerich protein (sprII) mRNA, clone 174N, (vi) L05188 H. sapiens smallproline-rich protein 2 (SPRR2B) gene, complete cds, (vii) Y00787 HumanmRNA for MDNCF (monocyte-derived neutrophil chemotactic factor), (viii)D50840 H. sapiens mRNA for ceramide glucosyltransferase, complete cds,(ix) M22918 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629),Non-Muscle, Alt. Splice, (x) X70326 Macmarcks, (xi) X52426 H. sapiensmRNA for cytokeratin 13, (xii) S81914 IEX-1=radiation-inducibleimmediate-early gene [human, placenta, mRNA Partial, 1, (xiii) M80254 H.sapiens cyclophilin isoform (hCyP3) mRNA, complete cds, (xiv) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(xv) U62800 Human cystatin M (CST6) mRNA, complete cds, (xvi) L24564Human Rad mRNA, complete cds, (xvii) M59465 Human tumor necrosis factoralpha inducible protein A20 mRNA, complete cds, (xviii) Z49989 H.sapiens mRNA for smoothelin, (xviii) Z49989 H. sapiens mRNA forsmoothelin, (xix) X57985 H. sapiens genes for histones H2B.1 and H2A,(xx) L19779 H. sapiens histone H2A.2 mRNA, complete cds, (xxi) D42040Human mRNA for KIAA9001 gene, complete cds, (xxii) M63573 Human secretedcyclophilin-like protein (SCYLP) mRNA, complete cds, (xxiii) X54489Human gene for melanoma growth stimulatory activity (MGSA), (xxiv)M92934 Human connective tissue growth factor, complete cds, (xxv) Z14244H. sapiens coxVIIb mRNA for cytochrome c oxidase subunit VIIb, (xxvi)M60278 Human heparin-binding EGF-like growth factor mRNA, complete cds,(xxvii) M72885 Human GOS2 gene, 5′ flank and cds, (xxviii) X62083 H.sapiens mRNA for Drosophila female sterile homeotic (FSH) homologue,(xxix) X67325 H. sapiens p27 mRNA, (xxx) U04636 Human cyclooxygenase-2(hCox-2) gene, complete cds, (xxxi) M26311 Human cystic fibrosis antigenmRNA, complete cds, (xxxii) L20688 Human GDP-dissociation inhibitorprotein (Ly-GDI) mRNA, complete cds, (xxxiii) M27436 Human tissue factorgene, complete cds, with a Alu repetitive sequence in the 3′, (xxxiv)AF001294 H. sapiens IPL (IPL) mRNA, complete cds, (xxxv) M22918 Myosin,Light Chain, Alkali, Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice,(xxxvi) X74874 H. sapiens gene for RNA pol II largest subunit, exon 1,(xxxvii) M22919 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629),Smooth Muscle, Alt. Spli, (xxxviii) V00594 Human mRNA formetallothionein from cadmium-treated cells, (xxxix) V00599 Tubulin,Beta, (xl) X99920 H. sapiens mRNA for S100 calcium-binding protein A13,(xli) M21005 Human migration inhibitory factor-related protein 8 (MRP8)gene, complete cds, (xlii) U07919 Human aldehyde dehydrogenase 6 mRNA,complete cds, (xliii) M37583 Human histone (H2A.Z) mRNA, complete cds,(xliv) S54005 thymosin beta-10 [human, metastatic melanoma cell line,mRNA, 453 nt], (xlv) D49824 Human HLA-B null allele mRNA, (xlvi) S78771NAT=CpG island-associated gene [human, mRNA, 1741 nt], (xlvii) M90657Human tumor antigen (L6) mRNA, complete cds, (xlviii) U09937 Humanurokinase-type plasminogen receptor, exon 7, (xlix) X77794 H. sapiensmRNA for cyclin G1, (l) M28130 Human interleukin 8 (IL8) gene, completecds, (li) X14850 Human H2A.X mRNA encoding histone H2A.X, (lii) AB000584H. sapiens mRNA for TGF-beta superfamily protein, complete cds, (liii)U52101 Human YMP mRNA, complete cds, (liv) M57731 Human gro-beta mRNA,complete cds, (lv) D45248 Human mRNA for proteasome activator hPA28subunit beta, complete cds, (lvi) X83416 H. sapiens PrP gene, exon 2,(lvii) X52882 Human t-complex polypeptide 1 gene, (lviii) X57351 Human1-8D gene from interferon-inducible gene family, (lix) X53800 Human mRNAfor macrophage inflammatory protein-2beta (MIP2beta), (lx) Z69043 H.sapiens mRNA translocon-associated protein delta subunit precursor,(lxi) D38305 Human mRNA for Tob, complete cds, (lxii) t X52979 Humangene for small nuclear ribonucleoproteins SmB and SmB′, (lxiii) S80437fatty acid synthase {3′ region} [human, breast and HepG2 cells, mRNAPartial, 22, (lxiv) X87679 Major Histocompatibility Complex, Class I, E(Gb:M21533), (lxv) Z29505 H. sapiens mRNA for nucleic acid bindingprotein sub2.3, (lxvi) D21853 Human mRNA for KIAA0111 gene, completecds, (lxvii) X78687 H. sapiens G9 gene encoding sialidase, (lxviii)M13755 Human interferon-induced 17-kDa/15-kDa protein mRNA, completecds, (lxix) M21186 Human neutrophil cytochrome b light chain p22phagocyte b-cytochrome mRNA, compl, (lxx) 8235_s_at D28235 Human PTGS2gene for prostaglandin endoperoxide synthase-2, complete cds, (lxxi)M14328 Human alpha enolase mRNA, complete cds, (lxxii) V00599 Tubulin,Beta 2, (lxxiii) U90546 Human butyrophilin (BTF4) mRNA, complete cds,(lxxiv) K02574, (lxxv) X15729 Human mRNA for nuclear p68 protein,(lxxvi) D89052 H. sapiens mRNA for proton-ATPase-like protein, completecds, (lxxvii) M60974 Human growth arrest and DNA-damage-inducibleprotein (gadd45) mRNA, complete cds, (lxxviii) X06956 Tubulin, Alpha 1,Isoform 44, (lxxix) X04654 Human mRNA for U1 RNA-associated 70K protein,(lxxx) M79463 Human PML-2 mRNA, complete CDS, (lxxxi) L76568 H. sapiensexcision and cross link repair protein (ERCC4) gene, complete genom,(lxxxii) Y09022 H. sapiens mRNA for Not56-like protein, (lxxxiii) X57579H. sapiens activin beta-A subunit (exon 2), (lxxxiv) 37690 Human RNApolymerase II subunit (hsRPB10) mRNA, complete cds, (lxxxv) X61123 HumanBTG1 mRNA, (lxxxvi) J04456 Human 14 kd lectin mRNA, complete cds,(lxxxvii) Z49254 H. sapiens L23-related mRNA, (lxxxviii) U70660 Humancopper transport protein HAHI (HAH1) mRNA, complete cds, (lxxxix) D86974Human mRNA for KIAA0220 gene, partial cds, (xc) AF006084 H. sapiens Arp⅔protein complex subunit p41-Arc (ARC41) mRNA, complete cds, (xci) Y00503Human mRNA for keratin 19, (xcii) M62831 Human transcription factorETR101 mRNA, complete cds, (xciii) Z22548 H. sapiens thiol-specificantioxidant protein mRNA, (xciv) U40369 Human spermidine/spermineN1-acetyltransferase (SSAT) gene, complete cds, (xcv) M12125 Humanfibroblast muscle-type tropomyosin mRNA, complete cds, (xcvi) X51345Human jun-B mRNA for JUN-B protein, (xcvii) Z21507 H. sapiens EF-1deltagene encoding human elongation factor-1-delta, (xcviii) U20734 Humantranscription factor junB (junB) gene, 5′ region and complete cds,(xcix) D13413 Human mRNA for tumor-associated 120 kDa nuclear proteinp120, partial cds(carbox, (c) L42379 H. sapiens bone-derived growthfactor (BPGF-1) mRNA, complete cds, (ci) X15822 Human COX VIIa-L mRNAfor liver-specific cytochrome c oxidase (EC 1.9.3.1.), (cii) D86988Human mRNA for KIAA0221 gene, complete cds. (ciii) M26730 Humanmitochondrial ubiquinone-binding protein (QP) gene, exon 4, (civ) M69043H. sapiens MAD-3 mRNA encoding IkB-like activity, complete cds, (cv)D38251 Human mRNA for RPB5 (XAP4), complete cds, (cvi) L76200 Humanguanylate kinase (GUK1) mRNA, complete cds, (cvii) M34516 Human omegalight chain protein 14.1 (Ig lambda chain related) gene, exon 3, (cviii)U26727 Human p16INK4/MTS1 mRNA, complete cds, (cix) U53830 H. sapiensinterferon regulatory factor 7A mRNA, complete cds, (cx) M22960 Humanprotective protein mRNA, complete cds, (cxi) D89667 H. sapiens mRNA forc-myc binding protein, complete cds, (cxii) M19309 Human slow skeletalmuscle troponin T mRNA, clone H22h, (cxiii) D64142 Human mRNA forhistone H1x, complete cds, (cxiv) U41515 Human deleted in splithand/split foot 1 (DSS 1) mRNA, complete cds, (cxv) J04611 Human lupusp70 (Ku) autoantigen protein mRNA, complete cds, (cxvi) U35048 HumanTSC-22 protein mRNA, complete cds, (cxvii) X82693 H. sapiens mRNA forE48 antigen, (cxviii) M92843 H. sapiens zinc finger transcriptionalregulator mRNA, complete cds, (cxix) U72649 Human BTG2 (BTG2) mRNA,complete cds, (cxx) X92896 H. sapiens mRNA for ITBA2 protein. (cxxi)D10923 Human mRNA for HM74, (cxxii) M84739 Human autoantigencalreticulin mRNA, complete cds, (cxxiii) U09813 Human mitochondrial ATPsynthase subunit 9, P3 gene copy, mRNA, nuclear gene enc, (cxxiv) X67951H. sapiens mRNA for proliferation-associated gene (pag), (cxxv) L27706Human chaperonin protein (Tcp20) gene complete cds, (cxxvi) U69126 HumanFUSE binding protein 2 (FBP2) mRNA, partial cds, (cxxvii) M12529 Humanapolipoprotein E mRNA, complete cds, (cxxviii) X71129 H. sapiens mRNAfor electron transfer flavoprotein beta subunit, (cxxix) U13991 HumanTATA-binding protein associated factor 30 kDa subunit (tafII30) mRNA,comp, (cxxx) J04794 Human aldehyde reductase mRNA, complete cds, (cxxxi)U51586 Human siah binding protein 1 (SiabBP1) mRNA, partial cds,(cxxxii) M58026 Human NB-1 mRNA, complete cds, (cxxxiii) X68277 H.sapiens CL 100 mRNA for protein tyrosine phosphatase, (cxxxiv) X56681Human junD mRNA, (cxxxv) V01512 Human cellular oncogene c-fos (completesequence), (cxxxvi) U09578 H. sapiens MAPKAP kinase (3 pK) mRNA,complete cds, (cxxxvii) L13391 Human helix-loop-helix basicphosphoprotein (GOS8) gene, complete cds, (cxxxviii) U62317 Chromosome22q13 BAC Clone CIT987SK-384D8 complete sequence, (cxxxix) M16364 Humancreatine kinase-B mRNA, complete cds, (cxl) L19437 Human transaldolasemRNA containing transposable element, complete cds, (cxli) X53416 HumanmRNA for actin-binding protein (filamin) (ABP-280), (cxlii) X52560Nuclear Factor Nf-Il6, (cxliii) M58459 Human ribosomal protein (RPS4Y)isoform mRNA, complete cds, (cxliv) U65579 Human mitochondrial NADHdehydrogenase-ubiquinone Fe—S protein 8, 23 kDa subunit, (cxlv) M19961Human cytochrome c oxidase subunit Vb (coxVb) mRNA, complete cds,(cxlvi) M29064 Human hnRNP B1 protein mRNA, (cxlvii) D90086 Humanpyruvate dehydrogenase (EC 1.2.4.1) beta subunit gene, exons 1-10,(cxlviii) L04731 H. sapiens translocation T(4:11) of ALL-1 gene tochromosome 4, (cxlix) D87071 Human mRNA for KIAA0233 gene, complete cds,(cl) X04412 Human mRNA for plasma gelsolin, (cli) L27943 H. sapienscytidine deaminase (CDA) mRNA, complete cds, (clii) U68142 HumanRalGDS-like 2 (RGL2) mRNA, partial cds, (cliii) U63825 Human hepatitisdelta antigen interacting protein A (dipA) mRNA, complete cds, (cliv)X04828 Human mRNA for G(i) protein alpha-subunit (adenylate cyclaseinhibiting GTP-bind, (clv) L38951 H. sapiens importin beta subunit mRNA,complete cds, (clvi) M31627 Human X box binding protein-1 (XBP-1) mRNA,complete cds, (clvii) J04444 Human cytochrome c-1 gene, complete cds,(clviii) S75762 Oncogene Tls/Chop, Fusion Activated.
 74. The screeningmethod according to claim 1, wherein the compound modulates the responseby inhibiting ultraviolet radiation-repressed RNA expression.
 75. Themethod according to claim 25, wherein the compound inhibits at least onenucleic acid molecule repressed in the first response, the secondresponse, or the third response that is at least 90% identical to apolynucleotide selected from the group consisting of: (i) D50840 Homosapiens mRNA for ceramide glucosyltransferase, complete cds, (ii) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(iii) X77794 H.sapiens mRNA for cyclin G1, (iv) D89052 Homo sapiens mRNAfor proton-ATPase-like protein, complete cds, (v) L26336 Heat ShockProtein, 70 Kda (Gb:Y00371), (vi) M30703 Human amphiregulin (AR) gene,exon 6, clones lambda-ARH(6,12), (vii) L16862 Homo sapiens Gprotein-coupled receptor kinase (GRK6) mRNA, complete cds, (viii) M92843H.sapiens zinc finger transcriptional regulator mRNA, complete cds, (ix)U72649 Human BTG2 (BTG2) mRNA, complete cds, (x) X74104 H.sapiens mRNAfor TRAP beta subunit, (xi) M84332 Human ADP-ribosylation factor 1 gene,exons 2-5, (xii) D15050 Human mRNA for transcription factor AREB6,complete cds, (xiii) U28386 Human nuclear localization sequence receptorhSRP1alpha mRNA, complete cds, (xiv) U41766 Humanmetalloprotease/disintegrin/cysteine-rich protein precursor (MDC9) mRNA,c, (xv) AF006041 Homo sapiens Fas-binding protein (DAXX) mRNA, partialcds, (xvi) U28749 Human high-mobility group phosphoprotein isoform I—C(HMGIC) mRNA, complete cds, (xvii) M60483 Human protein phosphatase 2Acatalytic subunit-alpha gene, complete cds, (xviii) U07664 Human HB9homeobox gene, exons 2 and 3 and complete cds, (xix) X52425 Human IL-4-RmRNA for the interleukin 4 receptor, (xx) X94563 H.sapiens dbi/acbp geneexon 1 & 2 (xxi) L11066 Human mRNA sequence, (xxii) X74008 H.sapiensmRNA for protein phosphatase 1 gamma, (xxiii) X87241 H.sapiens mRNA forhFat protein, (xxiv) S68616 Na+/H+ exchanger NHE-1 isoform [human,heart, mRNA, 4516 nt], (xxv) D13705 Human mRNA for fatty acidsomega-hydroxylase (cytochrome P-45OHKV), complete cds, (xxvi) D86966Human mRNA for KIAA0211 gene, complete cds, (xxvii) U17327 Humanneuronal nitric oxide synthase (NOS1) mRNA, complete cds, (xxviii)U89336 Human HLA class III region containing NOTCH4 gene, partialsequence, homeobox PB, (xxix) D85527 Homo sapiens mRNA for LIM domain,partial cds, (xxx) L07517 Mucin 6, Gastric (Gb:L07517), (xxxi) X64330H.sapiens mRNA for ATP-citrate lyase, (xxxii) X89267 H.sapiens DNA foruroporphyrinogen decarboxylase gene, (xxxiii) X91247 H.sapiens mRNA forthioredoxin reductase, (xxxiv) L11672 Human Kruppel related zinc fingerprotein (HTF10) mRNA, complete cds, (xxxv) X78992 H.sapiens ERF-2 mRNA,(xxxvi) L19314 Human HRY gene, complete cds, (xxxvii) X12794 Humanv-erbA related ear-2 gene, (xxxviii) L22005 Human ubiquitin conjugatingenzyme mRNA, partial cds, (xxxix) U01337 Human Ser/Thr protein kinase(A-RAF-1) gene, complete cds. (xl) M34182 Human testis-specific proteinkinase gamma-subunit mRNA, complete cds, (xli) L08246 Human myeloid celldifferentiation protein (MCL1) mRNA, (xlii) L37042 Homo sapiens caseinkinase I alpha isoform (CSNK1A1) mRNA, complete cds, (xliii) D87071Human mRNA for KIAA0233 gene, complete cds, (xliv) S74017Nrf2=NF-E2-like basic leucine zipper transcriptional activator [human,hemin-ind, (xlv) LA1351 Homo sapiens prostasin mRNA, complete cds,(xlvi) L00352 Human low density lipoprotein receptor gene, exon 18,(xlvii) D50683 Homo sapiens mRNA for TGF-betaIIR alpha, complete cds,(xlviii) X89750 H.sapiens mRNA for TGIF protein, (xlix) t D13988 Humanrab GDI mRNA, complete cds, (l) M12886 Human T-cell receptor activebeta-chain mRNA, complete cds, (li) M55265 Human casein kinase II alphasubunit mRNA, complete cds, (lii) J03161 Human serum response factor(SRF) mRNA, complete cds, (liii) M58286 Homo sapiens tumor necrosisfactor receptor mRNA, complete cds, (liv) U88629 Human RNA polymerase IIelongation factor ELL2, complete cds, (lv) U90716 Human cell surfaceprotein HCAR mRNA, complete cds, (lvi) M24547 Amyloid Beta (A4)Precursor Protein, Alt. Splice 2, A4(751), (lvii) U05875 Human clonepSK1 interferon gamma receptor accessory factor-1 (AF-1) mRNA, compl,(lviii) M58603 Human nuclear factor kappa-B DNA binding subunit(NF-kappa-B) mRNA, complete cds, (lix) D87442 Human mRNA for KIAA0253gene, partial cds, (lx) M76482 Human 130-kD pemphigus vulgaris antigenmRNA, complete cds, (lxi) U56418 Human lysophosphatidic acidacyltransferase-beta mRNA, complete cds, (lxii) J00120 Proto-OncogeneC-Myc, Alt. Splice 3, Orf 114, (lxiii) U88898 Human endogenousretroviral H protease/integrase-derived ORF1 mRNA, complete cds, (lxiv)M91083 Human DNA-binding protein (HRC1) mRNA, complete cds, (lxv) Z30643H.sapiens mRNA for chloride channel (putative) 2139bp, (lxvi) X12953Human rab2 mRNA, YPT1-related and member of ras family, (lxvii) D78129Homo sapiens mRNA for squalene epoxidase, partial cds, (lxviii) S78825Id1, (lxix) M54915 Human h-pim-1 protein (h-pim-1) mRNA, complete cds,(lxx) X06323 Human MRL3 mRNA for ribosomal protein L3 homologue (MRL3=mammalian ribosome L, (lxxi) D14043 Human mRNA for MGC-24, completecds, (lxxii) U34252 Human gamma-aminobutyraldehyde dehydrogenase mRNA,complete cds, (lxxiii) M13829 Human putative raf related protein(pks/a-raf) mRNA, partial cds, (lxxiv) U33821 Human taxl-binding proteinTXBP151 mRNA, complete cds, (lxxv) U66616 Human SWI/SNF complex 170 KDasubunit (BAF170) mRNA, complete cds, (lxxvi) U29607 Human methionineaminopeptidase mRNA, complete cds, (lxxvii) D14520 Human mRNA for GC-Boxbinding protein BTEB2, complete cds, (lxxviii) D14874 Homo sapiens mRNAfor adrenomedullin precursor, complete cds, (lxxix) D85429 Homo sapiensgene for heat shock protein 40, complete cds, (lxxx) t M69181 Humannonmuscle myosin heavy chain-B (MYH10) mRNA, partial cds, (lxxxi) U60205Human methyl sterol oxidase (ERG25) mRNA, complete cds, (lxxxii) X75342H.sapiens SHB mRNA, (lxxxiii) t D45906 Homo sapiens mRNA for LIMK-2,complete cds, (lxxxiv) X59434 Human rohu mRNA for rhodanese, (lxxxv)M96803 Human general beta-spectrin (SPTBN1) mRNA, complete cds, (lxxxvi)D79994 Human mRNA for KIAA0172 gene, partial cds, (lxxxvii) D86965 HumanmRNA for KIAA0210 gene, complete cds, (lxxxviii) Y13647Stearoyl-Coenzymea Desaturase, (lxxxix) X52541 Human mRNA for earlygrowth response protein 1 (hEGR1), (xc) Z26317 H.sapiens mRNA fordesmoglein 2, (xci) t M57763 Human ADP-ribosylation factor (hARF6) mRNA,complete cds, (xcii) L38490 Homo sapiens ADP-ribosylation factor mRNA,complete cds, (xciii) D87438 Human mRNA for KIAA0251 gene, partial cds,(xciv) M31627 Human X box binding protein-1 (XBP-1) mRNA, complete cds,(xcv) X80692 H.sapiens ERK3 mRNA, (xcvi) U37122 Human adducin gammasubunit mRNA, complete cds, (xcvii) M83667 Human NF-IL6-beta proteinmRNA, complete cds, (xcviii) J05211 Desmoplakin I, (xcix) D42123 Homosapiens mRNA for ESP1/CRP2, complete cds, (c) X90858 H.sapiens mRNA foruridine phosphorylase, (ci) X76717 H.sapiens MT-1l mRNA, (cii) Y08915H.sapiens mRNA for alpha 4 protein, (ciii) U30999 Human (memc) mRNA,3′UTR, (civ) L77886 Human protein tyrosine phosphatase mRNA, completecds, (cv) U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA,partial sequence, (cvi) U28480 Uncoupling Protein Ucp, (cvii) X53586Human mRNA for integrin alpha 6, (cviii) M64347 Human novel growthfactor receptor mRNA, 3′ cds, (cix) U52100 Human XMP mRNA, complete cds,(cx) D21852 Human mRNA for KIAA0029 gene, partial cds, (cxi) X05409Human RNA for mitochondrial aldehyde dehydrogenase I ALDH I (EC1.2.1.3), (cxii) D87462 Human mRNA for KIAA0272 gene, partial cds,(cxiii) L40391 Homo sapiens (clone s153) mRNA fragment, (cxiv) D87469Human mRNA for KIAA0279 gene, partial cds, (cxv) S73591 brain-expressedHHCPA78 homolog [human, HL-60 acute promyelocytic leukemia cells, (cxvi)L19267 Homo sapiens 59 protein mRNA, 3′ end, (cxvii) M81601 Humantranscription elongation factor (SII) mRNA, complete cds, (cxviii)X52611 Human mRNA for transcription factor AP-2, (cxix) U28811 Humancysteine-rich fibroblast growth factor receptor (CFR-1) mRNA, completecds, (cxx) L31801 Homo sapiens monocarboxylate transporter 1 (SLC16A1)mRNA, complete cds, (cxxi) M13929 Human c-myc-P64 mRNA, initiating frompromoter P0, (HLmyc2.5) partial cds, (cxxii) L48546 Homo sapiens tuberin(TSC2) gene, exons 38, 39, 40 and 41, (cxxiii) L00058 Human (GH)germline c-myc proto-oncogene, exon 3 and 3′ flank, (cxxiv) U09587 Humanglycyl-tRNA synthetase mRNA, complete cds, (cxxv) L37127 Homo sapiensRNA polymerase II mRNA, complete cds, (cxxvi) U52426 Homo sapiens GOK(STIM1) mRNA, complete cds, (cxxvii) U72066 Homo sapiens CtBPinteracting protein CtIP (CtIP) mRNA, complete cds, (cxxviii) U83115Human non-lens beta gamma-crystallin like protein (AIM1) mRNA, partialcds, (cxxix) M90656 Human gamma-glutamylcysteine synthetase (GCS) mRNA,complete cds, (cxxx) D90209 Human mRNA for DNA binding protein TAXREB67,(cxxxi) D83777 Human mRNA for KIAA0193 gene, complete cds, (cxxxii)U42031 Human 54 kDa progesterone receptor-associated immunophilin FKBP54mRNA, partial, (cxxxiii) M80244 Human E16 mRNA, complete cds, (cxxxiv)D31883 Human mRNA for KIAA0059 gene, complete cds, (cxxxv) J04444 Humancytochrome c-1 gene, complete cds, (cxxxvi) M38258 Human retinoic acidreceptor gamma 1 mRNA, complete cds, (cxxxvii) M95787 Human 22 kDasmooth muscle protein (SM22) mRNA, complete cds, (cxxxviii) U00968 HumanSREBP-1 mRNA, complete cds, (cxxxix) K03195 Human (HepG2) glucosetransporter gene mRNA, complete cds, (cxl) X92720 H.sapiens mRNA forphosphoenolpyruvate carboxykinase, (cxli) X77366 H.sapiens HBZ17 mRNA,(cxlii) U53347 Human neutral amino acid transporter B mRNA, completecds, (cxliii) X80695 H.sapiens OXA1Hs mRNA, (cxliv) J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,(cxlv) S75762 Oncogene Tls/Chop, Fusion Activated, (cxlvi) U14550 Humansialyltransferase SThM (sthm) mRNA, complete cds, (cxlvii) L09229 Humanlong-chain acyl-coenzyme A synthetase (FACL1) mRNA, complete cds,(cxlviii) X76534 H.sapiens NMB mRNA, (cxlix) M55268 Human casein kinaseII alpha′ subunit mRNA, complete cds, (cl) M27396 Human asparaginesynthetase mRNA, complete cds, (cli) U37519 Human aldehyde dehydrogenase(ALDH8) mRNA, complete cds, (clii) X69111 H.sapiens HLH 1R21 mRNA forhelix-loop-helix protein, (cliii) M77836 Human pyrroline 5-carboxylatereductase mRNA, complete cds, (cliv) D32050 Human mRNA for alanyl-tRNAsynthetase, complete cds, (clv) X01630 Human mRNA for argininosuccinatesynthetase.
 76. A pharmaceutical composition for modulating a responseof a cell to ultraviolet radiation exposure, comprising: (a) a compoundin sufficient quantity to modulate the response of the cell toultraviolet radiation exposure, the response being an altered pattern ofexpression comprising at least one of the following: (i) a firstresponse comprising the altered pattern of expression of at least onepolynucleotide selected from the group consisting of: a nucleic acidmolecule encoding a transcription factor protein, a nucleic acidmolecule encoding a signal transducing protein, and a nucleic acidmolecule encoding a mitochondrial protein; (ii) a second responsecomprising the altered pattern of expression of at least onepolynucleotide selected from the group consisting of: a nucleic acidmolecule encoding a secreted growth factor, a nucleic acid moleculeencoding a cytokine, and a nucleic acid molecule encoding a chemokine;and (iii) a third response comprising the altered pattern of expressionof at least one polynucleotide selected from the group consisting of: anucleic acid molecule encoding an actin-binding protein, a nucleic acidmolecule encoding a desmosomal protein, and a nucleic acid moleculeencoding a tubulin protein; and (b) a pharmaceutically acceptablecarrier.
 77. The pharmaceutical composition of claim 76, wherein thefirst response comprises at least one nucleic acid molecule that is atleast 90% identical to a polynucleotide selected from the groupconsisting of: (i) M62831 Human transcription factor ETR101 mRNA,complete cds, (ii) X68277 H. sapiens CL 100 mRNA for protein tyrosinephosphatase, (iii) L04731 H. sapiens translocation T(4:11) of ALL-1 geneto chromosome 4, (iv) X56681 Human junD mRNA, (v) U20734 Humantranscription factor junB (junB) gene, 5′ region and complete cds, (vi)L38951 H. sapiens importin beta subunit mRNA, complete cds, (vii) D87071Human mRNA for KIAA0233 gene, complete cds, (viii) M72885 Human GOS2gene, 5′ flank and cds, (ix) M92843 H. sapiens zinc fingertranscriptional regulator mRNA, complete cds, (x) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, (xi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (xii) D86988Human mRNA for KIAA0221 gene, complete cds, (xiii) L19779 H. sapienshistone H2A.2 mRNA, complete cds, (xiv) U62317 Chromosome 22q13 BACClone CIT987SK-384D8 complete sequence, (xv) X04412 Human mRNA forplasma gelsolin, (xvi) L27706 Human chaperonin protein (Tcp20) genecomplete cds, (xvii) X61123 Human BTG1 mRNA, (xviii) M60974growth arrestand DNA-damage-inducible protein (gadd45) mRNA, complete cds, (xix)L19437 Human transaldolase mRNA containing transposable element,complete cds, (xx) X57985 H. sapiens genes for histones H2B.1 and H2A,(xxi) D90086 Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunitgene, exons 1-10, (xxii) M34182 Human testis-specific protein kinasegamma-subunit mRNA, complete cds, (xxiii) L16862 H. sapiens Gprotein-coupled receptor kinase (GRK6) mRNA, complete cds, (xxiv) DI3705 Human mRNA for fatty acids omega-hydroxylase (cytochrome P-450HKV),complete cd, (xxv) U37122 Human adducin gamma subunit mRNA, completecds, (xxvi) D45906 H. sapiens mRNA for LIMK-2, complete cds, (xxvii)U07664 Human HB9 homeobox gene, exons 2 and 3 and complete cds, (xxviii)D87438 Human mRNA for KIAA0251 gene, partial cds, (xxix) L37042 H.sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds,(xxx) D14043 Human mRNA for MGC-24, complete cds, (xxxi) D13988 Humanrab GDI mRNA, complete cds, (xxxii) U28480 Uncoupling Protein Uc,(xxxiii) D50840 H. sapiens mRNA for ceramide glucosyltransferase,complete cds, (xxxiv) M55265 Human casein kinase II alpha subunit mRNA,complete cds, (xxxv) M96803 Human general beta-spectrin (SPTBN1) mRNA,complete cds, (xxxvi) U89336 Human HLA class III region containingNOTCH4 gene, partial sequence, homeobox P, (xxxvii) D87442 Human mRNAfor KIAA0253 gene, partial cds, (xxxviii) J03161 Human serum responsefactor (SRF) mRNA, complete cds, (xxxix) D86965 Human mRNA for KIAA0210gene, complete cds, (xl) U17327 Human neuronal nitric oxide synthase(NOS 1) mRNA, complete cds, (xli) D86966 Human mRNA for KIAA0211 gene,complete cds, (xlii) D85527 H. sapiens mRNA for LIM domain, partial cds,(xliii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (xliv) X59434 Human rohu mRNA forrhodanese, (xlv) Ml 3929 Human c-myc-P64 mRNA, initiating from promoterP0, (HLmyc2.5) partial cds, and (xlvi) J05211 Desmoplakin.
 78. Thepharmaceutical composition of claim 76, wherein the second responsecomprises at least one nucleic acid molecule that is at least 90%identical to a polynucleotide selected from the group consisting of: (i)M57731 Human gro-beta mRNA, complete cds, (ii) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, (iii) Y00787 Human mRNA for MDNCF (monocyte-derivedneutrophil chemotactic factor), (iv) X54489 Human gene for melanomagrowth stimulatory activity (MGSA), (v) M72885 Human GOS2 gene, 5′ flankand cds, (vi) M62831 Human transcription factor ETR101 mRNA, completecds, (vii) M28130 Human interleukin 8 (IL8) gene, complete cds, (viii)X57985 H. sapiens genes for histones H2B.1 and H2A, (ix) X53800 HumanmRNA for macrophage inflammatory protein-2beta (MIP2beta), (x) L19779 H.sapiens histone H2A.2 mRNA, complete cds, (xi) AF001294 H. sapiens IPL(IPL) mRNA, complete cds, (xii) X56681 Human junD mRNA, (xiii) S75762Oncogene Tls/Chop, Fusion Activate, (xiv) M84739 Human autoantigencalreticulin mRNA, complete cds, (xv) M21302 Human small proline richprotein (sprII) mRNA, clone 174N, (xvi) V00599 Tubulin, Bet, (xvii)X70326 Macmarck, (xviii) D10923 Human mRNA for HM74, (xix) D64142 HumanmRNA for histone H1x, complete cds, (xx) D86974 Human mRNA for KIAA0220gene, partial cds, (xxi) M60974 Human growth arrest andDNA-damage-inducible protein (gadd45) mRNA, complete cds, (xxii) X68277H. sapiens CL 100 mRNA for protein tyrosine phosphatase, (xxiii) L13391Human helix-loop-helix basic phosphoprotein (GOS8) gene, complete cds,(xxiv) M31627 Human X box binding protein-1 (XBP-1) mRNA, complete cds,(xxv) U40369 Human spermidine/spermine N1-acetyltransferase (SSAT) gene,complete cds, (xxvi) X52560 Nuclear Factor Nf-Il, (xxvii) X61123 HumanBTGl mRNA, (xxviii) U20734 Human transcription factor junB (junB) gene,5′ region and complete cds, (xxix) U35048 Human TSC-22 protein mRNA,complete cds, (xxx) M69043 H. sapiens MAD-3 mRNA encoding IkB-likeactivity, complete cds, (xxxi) X51345 Human jun-B mRNA for JUN-Bprotein, (xxxii) S68616 Na+/H+ exchanger NHE-1 isoform [human, heart,mRNA, 4516 nt], (xxxiii) X89750 H. sapiens mRNA for TGIF protein,(xxxiv) X691 11 H. sapiens HLH 1R21 mRNA for helix-loop-helix protein,(xxxv) U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (xxxvi) X52541 Human mRNA for early growth response protein 1(hEGR1), (xxxvii) D50683 H. sapiens mRNA for TGF-betaIIR alpha, completecds, (xxxviii) M92843 H. sapiens zinc finger transcriptional regulatormRNA, complete cds, (xxxix) X91247 H. sapiens mRNA for thioredoxinreductase, (xl) U05875 Human clone pSK1 interferon gamma receptoraccessory factor-1 (AF-1) mRNA, comp, (xli) L19314 Human HRY gene,complete cds, (xlii) M30703 Human amphiregulin (AR) gene, exon 6, cloneslambda-ARH(6,12), (xliii) U34252 Human gamma-aminobutyraldehydedehydrogenase mRNA, complete cds, (xliv) S78825 Id1, (xlv) D85429 H.sapiens gene for heat shock protein 40, complete cds, (xlvi) U41766Human metalloprotease/disintegrin/cysteine-rich protein precursor (MDC9)mRNA, (xlvii) U89336 Human HLA class III region containing NOTCH4 gene,partial sequence, homeobox PB, (xlviii) M69181 Human nonmuscle myosinheavy chain-B (MYH1O) mRNA, partial cds, (xlix) D15050 Human mRNA fortranscription factor AREB6, complete cds, (l) U28386 Human nuclearlocalization sequence receptor hSRP1alpha mRNA, complete cds, (li)L77886 Human protein tyrosine phosphatase mRNA, complete cds, (lii)X64330 H. sapiens mRNA for ATP-citrate lyase, (liii) U37122 Humanadducin gamma subunit mRNA, complete cds, (liv) X74008 H. sapiens mRNAfor protein phosphatase 1 gamma, (lv) U60205 Human methyl sterol oxidase(ERG25) mRNA, complete cds, (lvi) X76534 H. sapiens NMB mRNA, (lvii)D87071 Human mRNA for KIAA0233 gene, complete cds, (lviii) U90716 Humancell surface protein HCAR mRNA, complete cds, (lix) M91083 HumanDNA-binding protein (HRC1) mRNA, complete cds, (lx) U29607 Humanmethionine aminopeptidase mRNA, complete cds, (lxi) M76482 Human 130-kDpemphigus vulgaris antigen mRNA, complete cds, (lxii) U72066 H. sapiensCtBP interacting protein CtIP (CtIP) mRNA, complete cds, (lxiii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (lxiv) X12953Human rab2 mRNA, YPT1-related and member of ras family, (lxv) M60483Human protein phosphatase 2A catalytic subunit-alpha gene, complete cds,(lxvi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (lxvii) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (lxvlii) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(lxix) D50840 H. sapiens mRNA for ceramide glucosyltransferase, completecds, (lxx) L31801 H. sapiens monocarboxylate transporter 1 (SLC16A1)mRNA, complete cds, (lxxi) S74017 Nrf2=NF—E2-like basic leucine zippertranscriptional activator [human, hemin-in, (lxxii) X87241 H. sapiensmRNA for hFat protein, (lxxiii) X52425 Human IL-4-R mRNA for theinterleukin 4 receptor, (lxxiv) D79994 Human mRNA for KIAA0172 gene,partial cds, (lxxv) M58286 H. sapiens tumor necrosis factor receptormRNA, complete cds, (lxxvi) M13829 Human putative raf related protein(pks/a-raf) mRNA, partial cds, (lxxvii) X78992 H. sapiens ERF-2 mRNA,(lxxviii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (lxxix) U88629 Human RNA polymeraseII elongation factor ELL2, complete cds, (lxxx) X52611 Human mRNA fortranscription factor AP-2, (lxxxi) U28749 Human high-mobility groupphosphoprotein isoform I—C (HMGIC) mRNA, complete cds, (lxxxii) L00058Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank, (lxxxiii)L26336 Heat Shock Protein, 70 Kda (Gb:Y00371, (lxxxiv) L08246 Humanmyeloid cell differentiation protein (MCL1) mRNA, (lxxxv) S73591brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic,leukemia cells (lxxxvi) J0521 1 Desmoplakin, (lxxxvii)L00352 Human low density lipoprotein receptor gene, exon 18, (lxxxviii)Y13647 Stearoyl-Coenzymea Desaturase, (lxxxix) X77794 H. sapiens mRNAfor cyclin G1, (xc) M90656 Human gamma-glutamylcysteine synthetase (GCS)mRNA, complete cds, (xci) M13929 Human c-myc-P64 mRNA, initiating frompromoter P0, (HLmyc2.5) partial cds, (xcii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (xciii) X80692 H. sapiens ERK3 mRNA,and (xciv) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf
 114. 79. Thepharmaceutical composition of claim 76, wherein the third responsecomprises at least one nucleic acid molecules at least 90% identical tothe polynucleotides of the group consisting of: (i) M20030 Human smallproline rich protein (sprII) mRNA, clone 930, (ii) X53065, (iii) M13903Human involucrin gene, exon 2, (iv) M22918 Myosin, Light Chain, Alkali,Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice, (v) L10343 Humaelafin gene, complete cds, (vi) M63573 Human secreted cyclophilin-likeprotein (SCYLP) mRNA, complete cds, (vii) M21302 Human small prolinerich protein (sprII) mRNA, clone 174N, (viii) Y00787 Human mRNA forMDNCF (monocyte-derived neutrophil chemotactic factor), (ix) X57985H.sapiens genes for histones H2B.1 and H2A, (x) L05188 Homo sapienssmall proline-rich protein 2 (SPRR2B) gene, complete cds, (xi) X70326Macmarcks, (xii) X67325 H.sapiens p27 mRNA, (xiii) L19779 Homo sapienshistone H2A.2 mRNA, complete cds, (xiv) S81914 IEX-1=radiation-inducibleimmediate-early gene [human, placenta, mRNA Partial, 1, (xv) lD45248Human mRNA for proteasome activator hPA28 subunit beta, complete cds,(xvi) Z22548 H.sapiens thiol-specific antioxidant protein mRNA, (xvii)M22918 Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629),Non-Muscle, Alt. Splice, (xviii) X06956 Tubulin, Alpha 1, Isoform 44,(xix) V00594 Human mRNA for metallothionein from cadmium-treated cells,(xx) M80254 H.sapiens cyclophilin isoform (hCyP3) mRNA, complete cds,(xxi) U04636 Human cyclooxygenase-2 (hCox-2) gene, complete cds, (xxii)Z14244 H.sapiens coxVIIb mRNA for cytochrome c oxidase subunit VIIb,(xxiii) X99920 H.sapiens mRNA for S100 calcium-binding protein A13,(xxiv) U62800 Human cystatin M (CST6) mRNA, complete cds, (xxv) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(xxvi) L20688 Human GDP-dissociation inhibitor protein (Ly-GDI) mRNA,complete cds, (xxvii) M13755 Human interferon-induced 17-kDa/15-kDaprotein mRNA, complete cds, (xxviii) M60278 Human heparin-bindingEGF-like growth factor mRNA, complete cds, (xxix) AF001294 Homo sapiensIPL (IPL) mRNA, complete cds, (xxx) X54489 Human gene for melanomagrowth stimulatory activity (MGSA), (xxxi) M21186 Human neutrophilcytochrome b light chain p22 phagocyte b-cytochrome mRNA, compl, (xxxii)D42040 Human mRNA for KIAA9001 gene, complete cds, (xxxiii) V00599Tubulin, Beta, (xxxiv) U37690 Human RNA polymerase II subunit (hsRPB10)mRNA, complete cds, (xxxv) M21005 Human migration inhibitoryfactor-related protein 8 (MRP8) gene, complete cds, (xxxvi) M37583 Humanhistone (H2A.Z) mRNA, complete cds, (xxxvii) Z49989 H.sapiens mRNA forsmoothelin, (xxxviii) L24564 Human Rad mRNA, complete cds, (xxxix)D49824 Human HLA-B null allele mRNA, (xl) M59465 Human tumor necrosisfactor alpha inducible protein A20 mRNA, complete cds, (xli) S54005thymosin beta-10 [human, metastatic melanoma cell line, mRNA, 453 nt],(xlii) Z49254 H.sapiens L23-related mRNA, (xliii) M22919 Myosin, LightChain, Alkali, Smooth Muscle (Gb:U02629), Smooth Muscle, Alt. Spli,(xliv) U70660 Human copper transport protein HAH1 (HAH1) mRNA, completecds, (xlv) AF006084 Homo sapiens Arp⅔ protein complex subunit p41-Arc(ARC41) mRNA, complete cds, (xlvi) X62083 H.sapiens mRNA for Drosophilafemale sterile homeotic (FSH) homologue, (xlvii) D86974 Human mRNA forKIAA0220 gene, partial cds, (xlviii) M72885 Human GOS2 gene, 5′ flankand cds, (xlix) S80437 fatty acid synthase {3′ region} [human, breastand HepG2 cells, mRNA Partial, 22, (l) X04654 Human mRNA for U1RNA-associated 70K protein, (li) t M26311 Human cystic fibrosis antigenmRNA, complete cds, (lii) X14850 Human H2A.X mRNA encoding histoneH2A.X, (liii) M14328 Human alpha enolase mRNA, complete cds, (liv)U07919 Human aldehyde dehydrogenase 6 mRNA, complete cds, (lv) M28130Human interleukin 8 (IL8) gene, complete cds, (lvi) Z21507 H.sapiensEF-1delta gene encoding human elongation factor-1-delta, (lvii) M92934Human connective tissue growth factor, complete cds, (lviii) M27436Human tissue factor gene, complete cds, with a Alu repetitive sequencein the 3′, (lix) X74874 H.sapiens gene for RNA pol II largest subunit,exon 1, (lx) X57351 Human 1-8D gene from interferon-inducible genefamily, (lxi) X52979 Human gene for small nuclear ribonucleoproteins SmBand SmB′, (lxii) U41515 Human deleted in split hand/split foot 1 (DSS1)mRNA, complete cds, (lxiii) D28235 Human PTGS2 gene for prostaglandinendoperoxide synthase-2, complete cds, (lxiv) Y00503 Human mRNA forkeratin
 19. (lxv) M57731 Human gro-beta mRNA, complete cds, (lxvi)D50840 Homo sapiens mRNA for ceramide glucosyltransferase, complete cds,(lxvii) U52101 Human YMP mRNA, complete cds. (lxviii) DI 3413 Human mRNAfor tumor-associated 120 kDa nuclear protein p120, partial cds(carbox,(lxix) L42379 Homo sapiens bone-derived growth factor (BPGF-1) mRNA,complete cds, (lxx) X52426 H.sapiens mRNA for cytokeratin 13, (lxxi)J04456 Human 14 kd lectin mRNA, complete cds, (lxxii) S78771 NAT=CpGisland-associated gene [human, mRNA, 1741 nt], (lxxiii) M26730 Humanmitochondrial ubiquinone-binding protein (QP) gene, exon 4, (lxxiv)U26727 Human p1 6INK4/MTS 1 mRNA, complete cds, (lxxv) X92896 H.sapiensmRNA for ITBA2 protein, (lxxvi) Z69043 H.sapiens mRNAtranslocon-associated protein delta subunit precursor, (lxxvii) L76568Homo sapiens excision and cross link repair protein (ERCC4) gene,complete genom, (lxxviii) M12125 Human fibroblast muscle-typetropomyosin mRNA, complete cds, (lxxix) U09937 Human urokinase-typeplasminogen receptor, exon 7, (lxxx) X15822 Human COX VIIa-L mRNA forliver-specific cytochrome c oxidase (EC 1.9.3.1.), (lxxxi) M34516 Humanomega light chain protein 14.1 (Ig lambda chain related) gene, exon 3,(lxxxii) U53830 Homo sapiens interferon regulatory factor 7A mRNA,complete cds, (lxxxiii) X82693 H.sapiens mRNA for E48 antigen, (lxxxiv)M58026 Human NB-1 mRNA, complete cds, (lxxxv) M90657 Human tumor antigen(L6) mRNA, complete cds, (lxxxvi) X57579 H.sapiens activin beta-Asubunit (exon 2), (lxxxvii) D38251 Human mRNA for RPB5 (XAP4), completecds, (lxxxviii) D89667 Homo sapiens mRNA for c-myc binding protein,complete cds, (lxxxix) AB000584 Homo sapiens mRNA for TGF-betasuperfamily protein, complete cds, (xc) L76200 Human guanylate kinase(GUK1) mRNA, complete cds, (xci) J04794 Human aldehyde reductase mRNA,complete cds, (xcii) X52882 Human t-complex polypeptide 1 gene, (xciii)M79463 Human PML-2 mRNA, complete CDS, (xciv) Y09022 H.sapiens mRNA forNot56-like protein, (xcv) M12529 Human apolipoprotein E mRNA, completecds, (xcvi) X71129 H.sapiens mRNA for electron transfer flavoproteinbeta subunit, (xcvii) X83416 H.sapiens PrP gene, exon 2, (xcviii) D89052Homo sapiens mRNA for proton-ATPase-like protein, complete cds, (xcix)M60974 Human growth arrest and DNA-damage-inducible protein (gadd45)mRNA, complete cds, (c) M16364 Human creatine kinase-B mRNA, completecds, (ci) D38305 Human mRNA for Tob, complete cds, (cii) X87679 MajorHistocompatibility Complex, Class I, E (Gb:M21533), (ciii) Z29505H.sapiens mRNA for nucleic acid binding protein sub2.3, (civ) K02574,(cv) U09813 Human mitochondrial ATP synthase subunit 9, P3 gene copy,mRNA, nuclear gene enc, (cvi) X67951 H.sapiens mRNA forproliferation-associated gene (pag), (cvii) J04611 Human lupus p70 (Ku)autoantigen protein mRNA, complete cds, (cviii) U09578 Homo sapiensMAPKAP kinase (3 pK) mRNA, complete cds, (cix) X53800 Human mRNA formacrophage inflammatory protein-2beta (MIP2beta), (cx) V00599 Tubulin,Beta 2, (cxi) U69126 Human FUSE binding protein 2 (FBP2) mRNA, partialcds, (cxii) X53416 Human mRNA for actin-binding protein (filamin)(ABP-280), (cxiii) U90546 Human butyrophilin (BTF4) mRNA, complete cds,(cxiv) M58459 Human ribosomal protein (RPS4Y) isoform mRNA, completecds, (cxv) M19961 Human cytochrome c oxidase subunit Vb (coxVb) mRNA,complete cds, (cxvi) U65579 Human mitochondrial NADHdehydrogenase-ubiquinone Fe-S protein 8, 23 kDa subunit, (cxvii) X77794H.sapiens mRNA for cyclin G1, (cxviii) M29064 Human hnRNP B1 proteinmRNA, (cxix) D21853 Human mRNA for KIAA0111 gene, complete cds, (cxx)X78687 H.sapiens G9 gene encoding sialidase, (cxxi) X15729 Human mRNAfor nuclear p68 protein, (cxxii) X04828 Human mRNA for G(i) proteinalpha-subunit (adenylate cyclase inhibiting GTP-bind, (cxxiii) L27943Homo sapiens cytidine deaminase (CDA) mRNA, complete cds, (cxxiv) L40391Homo sapiens (clone s153) mRNA fragment, (cxxv) D42123 Homo sapiens mRNAfor ESP1/CRP2, complete cds, (cxxvi) X74104 H.sapiens mRNA for TRAP betasubunit, (cxxvii) M84332 Human ADP-ribosylation factor 1 gene, exons2-5, (cxxviii) L37127 Homo sapiens RNA polymerase II mRNA, complete cds,(cxxix) M92843 H.sapiens zinc finger transcriptional regulator mRNA,complete cds, (cxxx) U07664 Human HB9 homeobox gene, exons 2 and 3 andcomplete cds, (cxxxi) L48546 Homo sapiens tuberin (TSC2) gene, exons 38,39, 40 and 41, (cxxxii) X53586 Human mRNA for integrin alpha 6,(cxxxiii) t D21852 Human mRNA for KIAA0029 gene, partial cds, (cxxxiv)L11066 Human mRNA sequence, (cxxxv) J04444 Human cytochrome c-1 gene,complete cds, (cxxxvi) M95787 Human 22 kDa smooth muscle protein (SM22)mRNA, complete cds, (cxxxvii) L07517 Mucin 6, Gastric (Gb:L07517),(cxxxviii) X91247 H.sapiens mRNA for thioredoxin reductase, (cxxxix)L11672 Human Kruppel related zinc finger protein (HTF10) mRNA, completecds, (cxl) U30999 Human (memc) mRNA, 3′UTR, (cxli) U01337 Human Ser/Thrprotein kinase (A-RAF-1) gene, complete cds, (cxlii) U28480 UncouplingProtein Ucp, (cxliii) X12794 Human v-erbA related ear-2 gene, (cxliv)L22005 Human ubiquitin conjugating enzyme mRNA, partial cds, (cxlv)M12886 Human T-cell receptor active beta-chain mRNA, complete cds,(cxlvi) Y08915 H. sapiens mRNA for alpha 4 protein, cxlvii) M24547Amyloid Beta (A4) Precursor Protein, Alt. Splice 2, A4(751), (cxlviii)X76717 H.sapiens MT-1l mRNA, (cxlix) M64347 Human novel growth factorreceptor mRNA, 3′ cds, (cl) X05409 Human RNA for mitochondrial aldehydedehydrogenase I ALDH I (EC 1.2.1.3), (cli) D87469 Human mRNA forKIAA0279 gene, partial cds, (clii) M58603 Human nuclear factor kappa-BDNA binding subunit (NF-kappa-B) mRNA, complete cds, (cliii) M76482Human 130-kD pemphigus vulgaris antigen mRNA, complete cds, (cliv)X06323 Human MRL3 mRNA for ribosomal protein L3 homologue (MRL3=mammalian ribosome L, (clv) X78992 H.sapiens ERF-2 mRNA, (clvi) L41351Homo sapiens prostasin mRNA, complete cds, (clvii) X75342 H.sapiens SHBmRNA, P1 (clviii) U83115 Human non-lens beta gamma-crystallin likeprotein (AIM1) mRNA, partial cds, (clix) U88629 Human RNA polymerase IIelongation factor ELL2, complete cds, (clx) S78825 Id1, (clxi) U28811Human cysteine-rich fibroblast growth factor receptor (CFR-1) mRNA,complete cds, (clxii) M58286 Homo sapiens tumor necrosis factor receptormRNA, complete cds, (clxiii) D78129 Homo sapiens mRNA for squaleneepoxidase, partial cds, (clxiv) D14874 Homo sapiens mRNA foradrenomedullin precursor, complete cds, (clxv) Z26317 H.sapiens mRNA fordesmoglein 2, (clxvi) L19267 Homo sapiens 59 protein mRNA, 3′ end,(clxvii) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114, (clxviii)U33821 Human tax1-binding protein TXBP151 mRNA, complete cds, (clxix)U52100 Human XMP mRNA, complete cds, (clxx) L31801 Homo sapiensmonocarboxylate transporter 1 (SLC16A1) mRNA, complete cds, (clxxi)L00058 Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank,(clxxii) U52426 Homo sapiens GOK (STIM1) mRNA, complete cds, (clxxiii)M80244 Human E16 mRNA, complete cds, (clxxiv) U56418 Humanlysophosphatidic acid acyltransferase-beta mRNA, complete cds, (clxxv)L38490 Homo sapiens ADP-ribosylation factor mRNA, complete cds, (clxxvi)U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (clxxvii) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (clxxviii) M38258 Human retinoic acid receptor gamma 1mRNA, complete cds, (clxxix) X89750 H.sapiens mRNA for TGIF protein,(clxxx) D85429 Homo sapiens gene for heat shock protein 40, completecds, (clxxxi) J05211 Desmoplakin I, (clxxxii) M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds, (clxxxiii) X80695 H.sapiens OXA1HsmRNA, (clxxxiv) M54915 Human h-pim-1 protein (h-pim-1) mRNA, completecds, (clxxxv) D83777 Human mRNA for KIAA0193 gene, complete cds,(clxxxvi) D31883 Human mRNA for KIAA0059 gene, complete cds, (clxxxvii)U00968 Human SREBP-1 mRNA, complete cds, (clxxxviii) K03195 Human(HepG2) glucose transporter gene mRNA, complete cds, (clxxxix) D86965Human mRNA for KIAA0210 gene, complete cds, (cxc) Z30643 H.sapiens mRNAfor chloride channel (putative) 2139bp, (cxci) D14520 Human mRNA forGC-Box binding protein BTEB2, complete cds, (cxcii) D87462 Human mRNAfor KIAA0272 gene, partial cds, (cxciii) X80692 H.sapiens ERK3 mRNA,(cxciv) X90858 H.sapiens mRNA for uridine phosphorylase, (cxcv) M57763Human ADP-ribosylation factor (hARF6) mRNA, complete cds, (cxcvi) X92720H. sapiens mRNA for phosphoenolpyruvate carboxykinase, (cxcvii) M81601Human transcription elongation factor (SII) mRNA, complete cds,(cxcviii) X52611 Human mRNA for transcription factor AP-2, (cxcix)U09587 Human glycyl-tRNA synthetase mRNA, complete cds, (cc) U14550Human sialyltransferase SThM (sthm) mRNA, complete cds, (cci) D90209Human mRNA for DNA binding protein TAXREB67, (ccii) X77366 H.sapiensHBZ17 mRNA, (cciii) X76534 H.sapiens NMB mRNA, (cciv) U37519 Humanaldehyde dehydrogenase (ALDH8) mRNA, complete cds, (ccv) M83667 HumanNF-IL6-beta protein mRNA, complete cds, (ccvi) U53347 Human neutralamino acid transporter B mRNA, complete cds, (ccvii) L09229 Humanlong-chain acyl-coenzyme A synthetase (FACL1) mRNA, complete cds,(ccviii) S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, (ccix) M13929 Human c-myc-P64 mRNA,initiating from promoter P0, (HLmyc2.5) partial cds, (ccx) M55268 Humancasein kinase II alpha′ subunit mRNA, complete cds, (ccxi) M77836 Humanpyrroline 5-carboxylate reductase mRNA, complete cds, (ccxii)HG2724-HT2820_at S75762 Oncogene Tls/Chop, Fusion Activated, (ccxiii)U72066 Homo sapiens CtBP interacting protein CtIP (CtIP) mRNA, completecds, (ccxiv) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (ccxv) M27396 Human asparaginesynthetase mRNA, complete cds, (ccxvi) X01630 Human mRNA forargininosuccinate synthetase, (ccxvii) D32050 Human mRNA for alanyl-tRNAsynthetase, complete cds, (ccxviii) M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, (ccxix) J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,and (ccxx) X69111 H.sapiens HLH 1R21 mRNA for helix-loop-helix protein.80. The composition of claim 76, wherein modulation of the cellularresponse is an inhibition of the ultraviolet radiation exposure-inducedRNA expression.
 81. The composition of claim 76, wherein modulation ofthe cellular response is an inhibition of the ultraviolet radiationexposure repressed RNA expression.
 82. A screening method for thedetection of a compound that modulates a response of a cell toultraviolet radiation exposure, comprising: (a) contacting the cell withthe compound; (b) exposing the contacted cell to ultraviolet radiationto induce the response to ultraviolet radiation exposure, the responsebeing an altered pattern of expression comprising the following: (i) afirst response comprising the altered pattern of expression of at leastone protein selected from the group consisting of a transcription factorprotein, a signal transduction protein, and a mitochondrial protein;(ii) a second response comprising the altered pattern of expression ofat least one protein selected from the group consisting of a secretedgrowth factor protein, a cytokine protein, and a chemokine protein; and(iii) a third response comprising the altered pattern of expression ofat least one protein selected from the group consisting of anactin-binding protein, a desmosomal protein, and a tubulin protein; and(c) measuring the levels of a plurality of proteins in the cell for atleast one time point after ultraviolet radiation exposure, wherein achange in the altered expression of the first response, the secondresponse, or the third response indicates that the compound modulatesthe response of the cell to ultraviolet radiation exposure.
 83. Themethod according to claim 82, wherein the cell is contacted with thecompound in vitro.
 84. The method according to claim 82, wherein thecell is contacted with the compound in vivo.
 85. The method according toclaim 82, wherein the ultraviolet radation exposure comprisesultraviolet radiation energy at a wavelength in the range of about 220nm to about 440 nm.
 86. The method according to claim 82,wherein theultraviolet radiation exposure comprises ultraviolet radiation energy ata wavelength in the range of about 290 nm to about 320 nm.
 87. Themethod according to claim 82,wherein the ultraviolet radiation exposurecomprises ultraviolet radiation energy at a wavelength in the range ofabout 320 to about 440 nm.
 88. The method according to claim 82, whereinthe ultraviolet irradation exposure comprises a total ultravioletradiation energy exposure in the range of about 0.2 mJ/cm² to about 40mJ/cm².
 89. The screening method of claim 82, wherein: (a) the firstresponse comprises the altered pattern of expression of at least oneprotein that is at least 90% identical to a polypeptide encoded by apolynucleotide selected from the group consisting of: (i) M62831 Humantranscription factor ETR101 mRNA, complete cds, (ii) X68277 H. sapiensCL 100 mRNA for protein tyrosine phosphatase, (iii) L04731 H. sapienstranslocation T(4:11) of ALL-1 gene to chromosome 4, (iv) X56681 HumanjunD mRNA, (v) U20734 Human transcription factor junB (junB) gene, 5′region and complete cds, (vi) L38951 H. sapiens importin beta subunitmRNA, complete cds, (vii) D87071 Human mRNA for KIAA0233 gene, completecds, (viii) M72885 Human GOS2 gene, 5′ flank and cds, (ix) M92843 H.sapiens zinc finger transcriptional regulator mRNA, complete cds, (x)S81914 IEX-1=radiation-inducible immediate-early gene [human, placenta,mRNA Partial, (xi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (xii)D86988 Human mRNA for KIAA0221 gene, complete cds, (xiii) L19779 H.sapiens histone H2A.2 mRNA, complete cds, (xiv) U62317 Chromosome 22 q13BAC Clone CIT987SK-384D8 complete sequence, (xv) X04412 Human mRNA forplasma gelsolin, (xvi) L27706 Human chaperonin protein (Tcp20) genecomplete cds, (xvii) X61123 Human BTG1 mRNA, (xviii) M60974growth arrestand DNA-damage-inducible protein (gadd45) mRNA, complete cds, (xix)L19437 Human transaldolase mRNA containing transposable element,complete cds, (xx) X57985 H. sapiens genes for histones H2B.1 and H2A,(xxi) D90086 Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunitgene, exons 1-10, (xxii) M34182 Human testis-specific protein kinasegamma-subunit mRNA, complete cds, (xxiii) L16862 H. sapiens Gprotein-coupled receptor kinase (GRK6) mRNA, complete cds, (xxiv) D13705Human mRNA for fatty acids omega-hydroxylase (cytochrome P-450HKV),complete cd, (xxv) U37122 Human adducin gamma subunit mRNA, completecds, (xxvi) D45906 H. sapiens mRNA for LIMK-2, complete cds, (xxvii)U07664 Human HB9 homeobox gene, exons 2 and 3 and complete cds, (xxviii)D87438 Human mRNA for KIAA0251 gene, partial cds, (xxix) L37042 H.sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds,(xxx) D14043 Human mRNA for MGC-24, complete cds, (xxxi) D13988 Humanrab GDI mRNA, complete cds, (xxxii) U28480 Uncoupling Protein Uc,(xxxiii) D50840 H. sapiens mRNA for ceramide glucosyltransferase,complete cds, (xxxiv) M55265 Human casein kinase II alpha subunit mRNA,complete cds, (xxxv) M96803 Human general beta-spectrin (SPTBN1) mRNA,complete cds, (xxxvi) U89336 Human HLA class III region containingNOTCH4 gene, partial sequence, homeobox P, (xxxvii) D87442 Human mRNAfor KIAA0253 gene, partial cds, (xxxviii) J03161 Human serum responsefactor (SRF) mRNA, complete cds, (xxxix) D86965 Human mRNA for KIAA0210gene, complete cds, (xl) U17327 Human neuronal nitric oxide synthase(NOS1) mRNA, complete cds, (xli) D86966 Human mRNA for KIAA0211 gene,complete cds, (xlii) D85527 H. sapiens mRNA for LIM domain, partial cds,(xliii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (xliv) X59434 Human rohu mRNA forrhodanese, (xlv) M13929 Human c-myc-P64 mRNA, initiating from promoterP0, (HLmyc2.5) partial cds, and (xlvi) J05211 Desmoplakin; (b) thesecond response comprises the altered pattern of expression of at leastone protein that is at least 90% identical to a polypeptide encoded by apolynucleotide selected from the group consisting of: (i) M57731 Humangro-beta mRNA, complete cds, (ii) S81914 IEX-1=radiation-inducibleimmediate-early gene [human, placenta, mRNA Partial, 1, (iii) Y00787Human mRNA for MDNCF (monocyte-derived neutrophil chemotactic factor),(iv) X54489 Human gene for melanoma growth stimulatory activity (MGSA),(v) M72885 Human GOS2 gene, 5′ flank and cds, (vi) M62831 Humantranscription factor ETR101 mRNA, complete cds, (vii) M28130 Humaninterleukin 8 (IL8) gene, complete cds, (viii) X57985 H. sapiens genesfor histones H2B.1 and H2A, (ix) X53800 Human mRNA for macrophageinflammatory protein-2beta (MIP2beta), (x) L19779 H. sapiens histoneH2A.2 mRNA, complete cds, (xi) AF001294 H. sapiens IPL (IPL) mRNA,complete cds, (xii) X56681 Human junD mRNA, (xiii) S75762 OncogeneTls/Chop, Fusion Activate, (xiv) M84739 Human autoantigen calreticulinmRNA, complete cds, (xv) M21302 Human small proline rich protein (sprlI)mRNA, clone 174N, (xvi) V00599 Tubulin, Bet, (xvii) X70326 Macmarck,(xviii) D10923 Human mRNA for HM74, (xix) D64142 Human mRNA for histoneH1x, complete cds, (xx) D86974 Human mRNA for KIAA0220 gene, partialcds, (xxi) M60974 Human growth arrest and DNA-damage-inducible protein(gadd45) mRNA, complete cds, (xxii) X68277 H. sapiens CL 100 mRNA forprotein tyrosine phosphatase, (xxiii) L13391 Human helix-loop-helixbasic phosphoprotein (GOS8) gene, complete cds, (xxiv) M31627 Human Xbox binding protein-1 (XBP-1) mRNA, complete cds, (xxv) U40369 Humanspermidine/spermine N1-acetyltransferase (SSAT) gene, complete cds,(xxvi) X52560 Nuclear Factor Nf-I1, (xxvii) X61123 Human BTG1 mRNA,(xxviii) U20734 Human transcription factor junB (junB) gene, 5′ regionand complete cds, (xxix) U35048 Human TSC-22 protein mRNA, complete cds,(xxx) M69043 H. sapiens MAD-3 mRNA encoding IkB-like activity, completecds, (xxxi) X51345 Human jun-B mRNA for JUN-B protein, (xxxii) S68616Na+/H+ exchanger NHE-1 isoform [human, heart, mRNA, 4516 nt], (xxxiii)X89750 H. sapiens mRNA for TGIF protein, (xxxiv) X69111 H. sapiens HLH1R21 mRNA for helix-loop-helix protein, (xxxv) U14603 Humanprotein-tyrosine phosphatase (HU-PP-1) mRNA, partial sequence, (xxxvi)X52541 Human mRNA for early growth response protein 1 (hEGR1), (xxxvii)D50683 H. sapiens mRNA for TGF-betaIIR alpha, complete cds, (xxxviii)M92843 H. sapiens zinc finger transcriptional regulator mRNA, completecds, (xxxix) X91247 H. sapiens mRNA for thioredoxin reductase, (xl)U05875 Human clone pSK1 interferon gamma receptor accessory factor-1(AF-1) mRNA, comp, (xli) L19314 Human HRY gene, complete cds, (xlii)M30703 Human amphiregulin (AR) gene, exon 6, clones lambda-ARH(6,12),(xliii) U34252 Human gamma-aminobutyraldehyde dehydrogenase mRNA,complete cds, (xliv) S78825 Id1, (xlv) D85429 H. sapiens gene for heatshock protein 40, complete cds, (xlvi) U41766 Humanmetalloprotease/disintegrin/cysteine-rich protein precursor (MDC9) mRNA,(xlvii) U89336 Human HLA class III region containing NOTCH4 gene,partial sequence, homeobox PB, (xlviii) M69181 Human nonmuscle myosinheavy chain-B (MYH10) mRNA, partial cds, (xlix) D15050 Human mRNA fortranscription factor AREB6, complete cds, (l) U28386 Human nuclearlocalization sequence receptor hSRP1alpha mRNA, complete cds, (li)L77886 Human protein tyrosine phosphatase mRNA, complete cds, (lii)X64330 H. sapiens mRNA for ATP-citrate lyase, (liii) U37122 Humanadducin gamma subunit mRNA, complete cds, (liv) X74008 H. sapiens mRNAfor protein phosphatase 1 gamma, (lv) U60205 Human methyl sterol oxidase(ERG25) mRNA, complete cds, (lvi) X76534 H. sapiens NMB mRNA, (lvii)D87071 Human mRNA for KIAA0233 gene, complete cds, (lviii) U90716 Humancell surface protein HCAR mRNA, complete cds, (lix) M91083 HumanDNA-binding protein (HRC1) mRNA, complete cds, (lx) U29607 Humanmethionine aminopeptidase mRNA, complete cds, (lxi) M76482 Human 130-kDpemphigus vulgaris antigen mRNA, complete cds, (lxii) U72066 H. sapiensCtBP interacting protein CtIP (CtIP) mRNA, complete cds, (lxiii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (lxiv) X12953Human rab2 mRNA, YPT1-related and member of ras family, (lxv) M60483Human protein phosphatase 2A catalytic subunit-alpha gene, complete cds,(lxvi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (lxvii) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (lxviii) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(lxix) D50840 H. sapiens mRNA for ceramide glucosyltransferase, completecds, (lxx) L31801 H. sapiens monocarboxylate transporter 1 (SLC16A1)mRNA, complete cds, (lxxi) S74017 Nrf2=NF−E2-like basic leucine zippertranscriptional activator [human, hemin-in, (lxxii) X87241 H. sapiensmRNA for hFat protein, (lxxiii) X52425 Human IL-4-R mRNA for theinterleukin 4 receptor, (lxxiv) D79994 Human mRNA for KIAA0172 gene,partial cds, (lxxv) M58286 H. sapiens tumor necrosis factor receptormRNA, complete cds, (lxxvi) M13829 Human putative raf related protein(pks/a-raf) mRNA, partial cds, (lxxvii) X78992 H. sapiens ERF-2 mRNA,(lxxviii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (lxxix) U88629 Human RNA polymeraseII elongation factor ELL2, complete cds, (lxxx) X52611 Human mRNA fortranscription factor AP-2, (lxxxi) U28749 Human high-mobility groupphosphoprotein isoform I-C (HMGIC) mRNA, complete cds, (lxxxii) L00058Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank, (lxxxiii)L26336 Heat Shock Protein, 70 Kda (Gb:Y00371, (lxxxiv) L08246 Humanmyeloid cell differentiation protein (MCL1) mRNA, (lxxxv) S73591brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic,leukemia cells (lxxxvi) J05211 Desmoplakin, (lxxxvii)L00352 Human low density lipoprotein receptor gene, exon 18, (lxxxviii)Y13647 Stearoyl-Coenzymea Desaturase, (lxxxix) X77794 H. sapiens mRNAfor cyclin G1, (xc) M90656 Human gamma-glutamylcysteine synthetase (GCS)mRNA, complete cds, (xci) M13929 Human c-myc-P64 mRNA, initiating frompromoter P0, (HLmyc2.5) partial cds, (xcii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (xciii) X80692 H. sapiens ERK3 mRNA,and (xciv) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114; and (c)the third response comprises the altered pattern of expression of atleast one protein that is at least 90% identical to a polypeptideencoded by a polynucleotide selected from the group consisting of: (i)M20030 Human small proline rich protein (sprII) mRNA, clone 930, (ii)X53065, (iii) M13903 Human involucrin gene, exon 2, (iv) M22918 Myosin,Light Chain, Alkali, Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice,(v) L10343 Huma elafin gene, complete cds, (vi) M63573 Human secretedcyclophilin-like protein (SCYLP) mRNA, complete cds, (vii) M21302 Humansmall proline rich protein (sprII) mRNA, clone 174N, (viii) Y00787 HumanmRNA for MDNCF (monocyte-derived neutrophil chemotactic factor), (ix)X57985 H.sapiens genes for histones H2B.1 and H2A, (x) L05188 Homosapiens small proline-rich protein 2 (SPRR2B) gene, complete cds, (xi)X70326 Macmarcks, (xii) X67325 H.sapiens p27 mRNA, (xiii) L19779 Homosapiens histone H2A.2 mRNA, complete cds, (xiv) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, (xv) D45248 Human mRNA for proteasome activator hPA28subunit beta, complete cds, (xvi) Z22548 H.sapiens thiol-specificantioxidant protein mRNA, (xvii) M22918 Myosin, Light Chain, Alkali,Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice, (xviii) X06956Tubulin, Alpha 1, Isoform 44, (xix) V00594 Human mRNA formetallothionein from cadmium-treated cells, (xx) M80254 H.sapienscyclophilin isoform (hCyP3) mRNA, complete cds, (xxi) U04636 Humancyclooxygenase-2 (hCox-2) gene, complete cds, (xxii) Z14244 H.sapienscoxVIIb mRNA for cytochrome c oxidase subunit VIIb, (xxiii) X99920H.sapiens mRNA for S100 calcium-binding protein A13, (xxiv) U62800 Humancystatin M (CST6) mRNA, complete cds, (xxv) L08069 Human heat shockprotein, E. coli DnaJ homologue mRNA, complete cds, (xxvi) L20688 HumanGDP-dissociation inhibitor protein (Ly-GDI) mRNA, complete cds, (xxvii)M13755 Human interferon-induced 17-kDa/15-kDa protein mRNA, completecds, (xxviii) M60278 Human heparin-binding EGF-like growth factor mRNA,complete cds, (xxix) AF001294 Homo sapiens IPL (IPL) mRNA, complete cds,(xxx) X54489 Human gene for melanoma growth stimulatory activity (MGSA),(xxxi) M21186 Human neutrophil cytochrome b light chain p22 phagocyteb-cytochrome mRNA, compl, (xxxii) D42040 Human mRNA for KIAA9001 gene,complete cds, (xxxiii) V00599 Tubulin, Beta, (xxxiv) U37690 Human RNApolymerase II subunit (hsRPB10) mRNA, complete cds, (xxxv) M21005 Humanmigration inhibitory factor-related protein 8 (MRP8) gene, complete cds,(xxxvi) M37583 Human histone (H2A.Z) mRNA, complete cds, (xxxvii) Z49989H.sapiens mRNA for smoothelin, (xxxviii) L24564 Human Rad mRNA, completecds, (xxxix) D49824 Human HLA-B null allele mRNA, (xl) M59465 Humantumor necrosis factor alpha inducible protein A20 mRNA, complete cds,(xli) S54005 thymosin beta-10 [human, metastatic melanoma cell line,mRNA, 453 nt], (xlii) Z49254 H.sapiens L23-related mRNA, (xliii) M22919Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629), Smooth Muscle,Alt. Spli, (xliv) U70660 Human copper transport protein HAH1 (HAH1)mRNA, complete cds, (xlv) AF006084 Homo sapiens Arp⅔ protein complexsubunit p41-Arc (ARC41) mRNA, complete cds, (xlvi) X62083 H.sapiens mRNAfor Drosophila female sterile homeotic (FSH) homologue, (xlvii) D86974Human mRNA for KIAA0220 gene, partial cds, (xlviii) M72885 Human GOS2gene, 5′ flank and cds, (xlix) S80437 fatty acid synthase {3′ region}[human, breast and HepG2 cells, mRNA Partial, 22, (l) X04654 Human mRNAfor U1 RNA-associated 70K protein, (li) t M26311 Human cystic fibrosisantigen mRNA, complete cds, (lii) X14850 Human H2A.X mRNA encodinghistone H2A.X, (liii) M14328 Human alpha enolase mRNA, complete cds,(liv) U07919 Human aldehyde dehydrogenase 6 mRNA, complete cds, (lv)M28130 Human interleukin 8 (IL8) gene, complete cds, (lvi) Z21507H.sapiens EF-1delta gene encoding human elongation factor-1-delta,(ivii) M92934 Human connective tissue growth factor, complete cds,(lviii) M27436 Human tissue factor gene, complete cds, with a Alurepetitive sequence in the 3′, (lix) X74874 H. sapiens gene for RNA polII largest subunit, exon 1, (lx) X57351 Human 1-8D gene frominterferon-inducible gene family, (lxi) X52979 Human gene for smallnuclear ribonucleoproteins SmB and SmB′, (lxii) U41515 Human deleted insplit hand/split foot 1 (DSS 1) mRNA, complete cds, (lxiii) D28235 HumanPTGS2 gene for prostaglandin endoperoxide synthase-2, complete cds,(lxiv) Y00503 Human mRNA for keratin
 19. (lxv) M57731 Human gro-betamRNA, complete cds, (lxvi) D50840 Homo sapiens mRNA for ceramideglucosyltransferase, complete cds, (lxvii) U52101 Human YMP mRNA,complete cds. (lxviii) D13413 Human mRNA for tumor-associated 120 kDanuclear protein p120, partial cds(carbox, (lxix) L42379 Homo sapiensbone-derived growth factor (BPGF-1) mRNA, complete cds, (lxx) X52426 H.sapiens mRNA for cytokeratin 13, (lxxi) J04456 Human 14 kd lectin mRNA,complete cds, (lxxii) S78771 NAT=CpG island-associated gene [human,mRNA, 1741 nt], (lxxiii) M26730 Human mitochondrial ubiquinone-bindingprotein (QP) gene, exon 4, (lxxiv) U26727 Human p16INK4/MTS1 mRNA,complete cds, (lxxv) X92896 H.sapiens mRNA for ITBA2 protein, (lxxvi)Z69043 H.sapiens mRNA translocon-associated protein delta subunitprecursor, (lxxvii) L76568 Homo sapiens excision and cross link repairprotein (ERCC4) gene, complete genom, (lxxviii) M12125 Human fibroblastmuscle-type tropomyosin mRNA, complete cds, (lxxix) U09937 Humanurokinase-type plasminogen receptor, exon 7, (lxxx) X15822 Human COXVIIa-L mRNA for liver-specific cytochrome c oxidase (EC 1.9.3.1.),(lxxxi) M34516 Human omega light chain protein 14.1 (Ig lambda chainrelated) gene, exon 3, (lxxxii) U53830 Homo sapiens interferonregulatory factor 7A mRNA, complete cds, (lxxxiii) X82693 H.sapiens mRNAfor E48 antigen, (lxxxiv) M58026 Human NB-1 mRNA, complete cds, (lxxxv)M90657 Human tumor antigen (L6) mRNA, complete cds, (lxxxvi) X57579H.sapiens activin beta-A subunit (exon 2), (lxxxvii) D38251 Human mRNAfor RPB5 (XAP4), complete cds, (lxxxviii) D89667 Homo sapiens mRNA forc-myc binding protein, complete cds, (lxxxix) AB000584 Homo sapiens mRNAfor TGF-beta superfamily protein, complete cds, (xc) L76200 Humanguanylate kinase (GUK1) mRNA, complete cds, (xci) J04794 Human aldehydereductase mRNA, complete cds, (xcii) X52882 Human t-complex polypeptide1 gene, (xciii) M79463 Human PML-2 mRNA, complete CDS, (xciv) Y09022H.sapiens mRNA for Not56-like protein, (xcv) M12529 Human apolipoproteinE mRNA, complete cds, (xcvi) X71129 H.sapiens mRNA for electron transferflavoprotein beta subunit, (xcvii) X83416 H.sapiens PrP gene, exon 2,(xcviii) D89052 Homo sapiens mRNA for proton-ATPase-like protein,complete cds, (xcix) M60974 Human growth arrest and DNA-damage-inducibleprotein (gadd45) mRNA, complete cds, c) M16364 Human creatine kinase-BmRNA, complete cds, (ci) D38305 Human mRNA for Tob, complete cds, (cii)X87679 Major Histocompatibility Complex, Class I, E (Gb:M21533), (ciii)Z29505 H.sapiens mRNA for nucleic acid binding protein sub2.3, (civ)K02574, (cv) U09813 Human mitochondrial ATP synthase subunit 9, P3 genecopy, mRNA, nuclear gene enc, (cvi) X67951 H.sapiens mRNA forproliferation-associated gene (pag), (cvii) J04611 Human lupus p70 (Ku)autoantigen protein mRNA, complete cds, (cviii) U09578 Homo sapiensMAPKAP kinase (3 pK) mRNA, complete cds, (cix) X53800 Human mRNA formacrophage inflammatory protein-2beta (MIP2beta), (cx) V00599 Tubulin,Beta 2, (cxi) U69126 Human FUSE binding protein 2 (FBP2) mRNA, partialcds, (cxii) X53416 Human mRNA for actin-binding protein (filamin)(ABP-280), (cxiii) U90546 Human butyrophilin (BTF4) mRNA, complete cds,(cxiv) M58459 Human ribosomal protein (RPS4Y) isoform mRNA, completecds, (cxv) M19961 Human cytochrome c oxidase subunit Vb (coxVb) mRNA,complete cds, (cxvi) U65579 Human mitochondrial NADHdehydrogenase-ubiquinone Fe-S protein 8, 23 kDa subunit, (cxvii) X77794H.sapiens mRNA for cyclin G1, (cxviii) M29064 Human hnRNP B1 proteinmRNA, (cxix) D21853 Human mRNA for KIAA0111 gene, complete cds, (cxx)X78687 H.sapiens G9 gene encoding sialidase, (cxxi) X15729 Human mRNAfor nuclear p68 protein, (cxxii) X04828 Human mRNA for G(i) proteinalpha-subunit (adenylate cyclase inhibiting GTP-bind, (cxxiii) L27943Homo sapiens cytidine dearninase (CDA) mRNA, complete cds, (cxxiv)L40391 Homo sapiens (clone s153) mRNA fragment, (cxxv) D42123 Homosapiens mRNA for ESP1/CRP2, complete cds, (cxxvi) X74104 H.sapiens mRNAfor TRAP beta subunit, (cxxvii) M84332 Human ADP-ribosylation factor 1gene, exons 2-5, (cxxviii) L37127 Homo sapiens RNA polymerase II mRNA,complete cds, (cxxix) M92843 H.sapiens zinc finger transcriptionalregulator mRNA, complete cds, (cxxx) U07664 Human HB9 homeobox gene,exons 2 and 3 and complete cds, (cxxxi) L48546 Homo sapiens tuberin(TSC2) gene, exons 38, 39, 40 and 41, (cxxxii) X53586 Human mRNA forintegrin alpha6, (cxxxiii) t D21852 Human mRNA for KIAA0029 gene,partial cds, (cxxxiv) L11066 Human mRNA sequence, (cxxxv) J04444 Humancytochrome c-1 gene, complete cds, (cxxxvi) M95787 Human 22 kDa smoothmuscle protein (SM22) mRNA, complete cds, (cxxxvii) L07517 Mucin 6,Gastric (Gb:L07517), (cxxxviii) X91247 H.sapiens mRNA for thioredoxinreductase, (cxxxix) L11672 Human Kruppel related zinc finger protein(HTF10) mRNA, complete cds, (cxl) U30999 Human (memc) mRNA, 3′UTR,(cxli) U01337 Human Ser/Thr protein kinase (A-RAF-1) gene, complete cds,(cxlii) U28480 Uncoupling Protein Ucp, (cxliii) X12794 Human v-erbArelated ear-2 gene, (cxliv) L22005 Human ubiquitin conjugating enzymemRNA, partial cds, (cxlv) M12886 Human T-cell receptor active beta-chainmRNA, complete cds, (cxlvi) Y08915 H.sapiens mRNA for alpha 4 protein,(cxlvii) M24547 Amyloid Beta (A4) Precursor Protein, Alt. Splice 2,A4(751), (cxlviii) X76717 H.sapiens MT-1l mRNA, (cxlix) M64347 Humannovel growth factor receptor mRNA, 3′ cds, (cl) X05409 Human RNA formitochondrial aldehyde dehydrogenase I ALDH I (EC 1.2.1.3), (cli) D87469Human mRNA for KIAA0279 gene, partial cds, (clii) M58603 Human nuclearfactor kappa-B DNA binding subunit (NF-kappa-B) mRNA, complete cds,(cliii) M76482 Human 130-kD pemphigus vulgaris antigen mRNA, completecds, (cliv) X06323 Human MRL3 mRNA for ribosomal protein L3 homologue (MRL3=mammalian ribosome L, (clv) X78992 H.sapiens ERF-2 mRNA, (clvi)L41351 Homo sapiens prostasin mRNA, complete cds, (clvii) X75342H.sapiens SHB mRNA, (clviii) U83115 Human non-lens beta gamma-crystallinlike protein (AIM1) mRNA, partial cds, (clix) U88629 Human RNApolymerase II elongation factor ELL2, complete cds, (clx) S78825 Id1,(clxi) U28811 Human cysteine-rich fibroblast growth factor receptor(CFR-1) mRNA, complete cds, (clxii) M58286 Homo sapiens tumor necrosisfactor receptor mRNA, complete cds, (clxiii) D78129 Homo sapiens mRNAfor squalene epoxidase, partial cds, (clxiv) D14874 Homo sapiens mRNAfor adrenomedullin precursor, complete cds, (clxv) Z26317 H.sapiens mRNAfor desmoglein 2, (clxvi) L19267 Homo sapiens 59 protein mRNA, 3′ end,(clxvii) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114, (clxviii)U33821 Human tax1-binding protein TXBP151 mRNA, complete cds, (clxix)U52100 Human XMP mRNA, complete cds, (clxx) L31801 Homo sapiensmonocarboxylate transporter 1 (SLC16A1) mRNA, complete cds, (clxxi)L00058 Human (GH) geriline c-myc proto-oncogene, exon 3 and 3′ flank,(clxxii) U52426 Homo sapiens GOK (STIM1) mRNA, complete cds, (clxxiii)M80244 Human E16 mRNA, complete cds, (clxxiv) U56418 Humanlysophosphatidic acid acyltransferase-beta mRNA, complete cds, (clxxv)L38490 Homo sapiens ADP-ribosylation factor mRNA, complete cds, (clxxvi)U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (clxxvii) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (clxxviii) M38258 Human retinoic acid receptor gamma 1mRNA, complete cds, (clxxix) X89750 H.sapiens mRNA for TGIF protein,(clxxx) D85429 Homo sapiens gene for heat shock protein 40, completecds, (clxxxi) J05211 Desmoplakin I, (clxxxii) M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds, (clxxxiii) X80695 H.sapiens OXA1HsmRNA, (clxxxiv) M54915 Human h-pim-1 protein (h-pim-1) mRNA, completecds, (clxxxv) D83777 Human mRNA for KIAA0193 gene, complete cds,(clxxxvi) D31883 Human mRNA for KIAA0059 gene, complete cds, (clxxxvii)U00968 Human SREBP-1 mRNA, complete cds, (clxxxviii) K03195 Human(HepG2) glucose transporter gene mRNA, complete cds, (clxxxix) D86965Human mRNA for KIAA0210 gene, complete cds, (cxc) Z30643 H.sapiens mRNAfor chloride channel (putative) 2139 bp, (cxci) D14520 Human mRNA forGC-Box binding protein BTEB2, complete cds, (cxcii) D87462 Human mRNAfor KIAA0272 gene, partial cds, (cxciii) X80692 H.sapiens ERK3 mRNA,(cxciv) X90858 H.sapiens mRNA for uridine phosphorylase, (cxcv) M57763Human ADP-ribosylation factor (hARF6) mRNA, complete cds, (cxcvi) X92720H.sapiens mRNA for phosphoenolpyruvate carboxykinase, (cxcvii) M81601Human transcription elongation factor (SII) mRNA, complete cds,(cxcviii) X52611 Human mRNA for transcription factor AP-2, (cxcix)U09587 Human glycyl-tRNA synthetase mRNA, complete cds, (cc) U14550Human sialyltransferase SThM (sthm) mRNA, complete cds, (cci) D90209Human mRNA for DNA binding protein TAXREB67, (ccii) X77366 H.sapiensHBZ17 mRNA, (cciii) X76534 H.sapiens NMB mRNA, (cciv) U37519 Humanaldehyde dehydrogenase (ALDH8) mRNA, complete cds, (ccv) M83667 HumanNF-IL6-beta protein mRNA, complete cds, (ccvi) U53347 Human neutralamino acid transporter B mRNA, complete cds, (ccvii) L09229 Humanlong-chain acyl-coenzyme A synthetase (FACL1) mRNA, complete cds,(ccviii) S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, (ccix) M13929 Human c-myc-P64 mRNA,initiating from promoter P0, (HLmyc2.5) partial cds, (ccx) M55268 Humancasein kinase II alpha′ subunit mRNA, complete cds, (ccxi) M77836 Humanpyrroline 5-carboxylate reductase mRNA, complete cds, (ccxii)HG2724-HT2820_at S75762 Oncogene Tls/Chop, Fusion Activated, (ccxiii)U72066 Homo sapiens CtBP interacting protein CtIP (CtIP) mRNA, completecds, (ccxiv) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (ccxv) M27396 Human asparaginesynthetase mRNA, complete cds, (ccxvi) X01630 Human mRNA forargininosuccinate synthetase, (ccxvii) D32050 Human mRNA for alanyl-tRNAsynthetase, complete cds, (ccxviii) M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, (ccxix) J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,and (ccxx) X69111 H.sapiens HLH 1R21 mRNA for helix-loop-helix protein.90. The method according to claim 82, wherein the cell is an epidermalcell.
 91. The method according to claim 82 wherein the cell is selectedfrom the group consisting of a keratinocyte, a Langerhans cell, amelanocyte, and a fibroblast cell.
 92. The method according to claim 82,wherein the protein is isolated at a time point between about 0.5 hoursto about 2 hours post-ultraviolet radiation exposure.
 93. The methodaccording to claim 82, wherein the protein is isolated at a time pointbetween about 4 hours to about 8 hours post-ultraviolet radiationexposure.
 94. The method according to claim 82, wherein the protein isisolated at a time point between about 16 hours to about 24 hours postultraviolet radiation exposure.
 95. The method according to claim 82,wherein the levels of a plurality of proteins is measured by ELISA. 96.A pharmaceutical composition for modulating the response of a cell toultraviolet radiation exposure comprising: (a) a compound in sufficientquantity to modulate the response of the cell to ultraviolet radiationexposure, the response being an altered pattern of expressioncomprising: (i) a first response comprising the altered pattern ofexpression of at least one of a transcription factor protein, a signaltransducing protein, and a mitochondrial protein; (ii) a second responsecomprising the altered pattern of expression of at least one of a of asecreted growth factor protein, a cytokine protein, and a chemokineprotein; and (iii) a third response comprising the altered pattern ofexpression of at least one of an actin-binding protein, a desmosomalprotein, and a tubulin protein; and (b) a pharmaceutically acceptablecarrier.
 97. The pharmaceutical composition of claim 96, wherein thefirst response further comprises proteins encoded by the nucleic acidmolecules at least 90% identical to the polynucleotides of the groupconsisting of: (i) M62831 Human transcription factor ETR101 mRNA,complete cds, (ii) X68277 H. sapiens CL 100 mRNA for protein tyrosinephosphatase, (iii) L04731 H. sapiens translocation T(4:11) of ALL-1 geneto chromosome 4, (iv) X56681 Human junD mRNA, (v) U20734 Humantranscription factor junB (junB) gene, 5′ region and complete cds, (vi)L38951 H. sapiens importin beta subunit mRNA, complete cds, (vii) D87071Human mRNA for KIAA0233 gene, complete cds, (viii) M72885 Human GOS2gene, 5′ flank and cds, (ix) M92843 H. sapiens zinc fingertranscriptional regulator mRNA, complete cds, (x) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, (xi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (xii) D86988Human mRNA for KIAA0221 gene, complete cds, (xiii) L19779 H. sapienshistone H2A.2 mRNA, complete cds, (xiv) U62317 Chromosome 22q13 BACClone CIT987SK-384D8 complete sequence, (xv) X04412 Human mRNA forplasma gelsolin, (xvi) L27706 Human chaperonin protein (Tcp20) genecomplete cds, (xvii) X61123 Human BTG1 mRNA, (xviii) M60974growth arrestand DNA-damage-inducible protein (gadd45) mRNA, complete cds, (xix)L19437 Human transaldolase mRNA containing transposable element,complete cds, (xx) X57985 H. sapiens genes for histones H2B.1 and H2A,(xxi) D90086 Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunitgene, exons 1-10, (xxii) M34182 Human testis-specific protein kinasegamma-subunit mRNA, complete cds, (xxiii) L16862 H. sapiens Gprotein-coupled receptor kinase (GRK6) mRNA, complete cds, (xxiv) D13705Human mRNA for fatty acids omega-hydroxylase (cytochrome P-450HKV),complete cd, (xxv) U37122 Human adducin gamma subunit mRNA, completecds, (xxvi) D45906 H. sapiens mRNA for LIMK-2, complete cds, (xxvii)U07664 Human HB9 homeobox gene, exons 2 and 3 and complete cds, (xxviii)D87438 Human mRNA for KIAA0251 gene, partial cds, (xxix) L37042 H.sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds,(xxx) D14043 Human mRNA for MGC-24, complete cds, (xxxi) D13988 Humanrab GDI mRNA, complete cds, (xxxii) U28480 Uncoupling Protein Uc,(xxxiii) D50840 H. sapiens mRNA for ceramide glucosyltransferase,complete cds, (xxxiv) M55265 Human casein kinase II alpha subunit mRNA,complete cds, (xxxv) M96803 Human general beta-spectrin (SPTBN1) mRNA,complete cds, (xxxvi) U89336 Human HLA class III region containingNOTCH4 gene, partial sequence, homeobox P, (xxxvii) D87442 Human mRNAfor KIAA0253 gene, partial cds, (xxxviii) J03161 Human serum responsefactor (SRF) mRNA, complete cds, (xxxix) D86965 Human mRNA for KIAA0210gene, complete cds, (xl) U17327 Human neuronal nitric oxide synthase(NOS1) mRNA, complete cds, (xli) D86966 Human mRNA for KIAA0211 gene,complete cds, (xlii) D85527 H. sapiens mRNA for LIM domain, partial cds,(xliii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (xliv) X59434 Human rohu mRNA forrhodanese, (xlv) M13929 Human c-myc-P64 mRNA, initiating from promoterP0, (HLmyc2.5) partial cds, and (xlvi) J05211 Desmoplaki.
 98. Thepharmaceutical composition of claim 96, wherein the second responsefurther comprises proteins encoded by the nucleic acid molecules atleast 90% identical to the polynucleotides of the group consisting of:(i) M57731 Human gro-beta mRNA, complete cds, (ii) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, (iii) Y00787 Human mRNA for MDNCF (monocyte-derivedneutrophil chemotactic factor), (iv) X54489 Human gene for melanomagrowth stimulatory activity (MGSA), (v) M72885 Human GOS2 gene, 5′ flankand cds, (vi) M62831 Human transcription factor ETR101 mRNA, completecds, (vii) M28130 Human interleukin 8 (IL8) gene, complete cds, (viii)X57985 H. sapiens genes for histones H2B.1 and H2A, (ix) X53800 HumanmRNA for macrophage inflammatory protein-2beta (MIP2beta), (x) L19779 H.sapiens histone H2A.2 mRNA, complete cds, (xi) AF001294 H. sapiens IPL(IPL) mRNA, complete cds, (xii) X56681 Human junD mRNA, (xiii) S75762Oncogene Tls/Chop, Fusion Activate, (xiv) M84739 Human autoantigencalreticulin mRNA, complete cds, (xv) M21302 Human small proline richprotein (sprlI) mRNA, clone 174N, (xvi) V00599 Tubulin, Bet, (xvii)X70326 Macmarck, (xviii) D10923 Human mRNA for HM74, (xix) D64142 HumanmRNA for histone H1x, complete cds, (xx) D86974 Human mRNA for KIAA0220gene, partial cds, (xxi) M60974 Human growth arrest andDNA-damage-inducible protein (gadd45) mRNA, complete cds, (xxii) X68277H. sapiens CL 100 mRNA for protein tyrosine phosphatase, (xxiii) L13391Human helix-loop-helix basic phosphoprotein (GOS8) gene, complete cds,(xxiv) M31627 Human X box binding protein-1 (XBP-1) mRNA, complete cds,(xxv) U40369 Human spermidine/spermine N1-acetyltransferase (SSAT) gene,complete cds, (xxvi) X52560 Nuclear Factor Nf-I1, (xxvii) X61123 HumanBTG1 mRNA, (xxviii) U20734 Human transcription factor junB (junB) gene,5′ region and complete cds, (xxix) U35048 Human TSC-22 protein mRNA,complete cds, (xxx) M69043 H. sapiens MAD-3 mRNA encoding IkB-likeactivity, complete cds, (xxxi) X51345 Human jun-B mRNA for JUN-Bprotein, (xxxii) S68616 Na+/H+ exchanger NHE-1 isoform [human, heart,mRNA, 4516 nt], (xxxiii) X89750 H. sapiens mRNA for TGIF protein,(xxxiv) X69111 H. sapiens HLH 1R21 mRNA for helix-loop-helix protein,(xxxv) U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (xxxvi) X52541 Human mRNA for early growth response protein 1(hEGR1), (xxxvii) D50683 H. sapiens mRNA for TGF-betaIIR alpha, completecds, (xxxviii) M92843 H. sapiens zinc finger transcriptional regulatormRNA, complete cds, (xxxix) X91247 H. sapiens mRNA for thioredoxinreductase, (xl) U05875 Human clone pSK1 interferon gamma receptoraccessory factor-1 (AF-1) mRNA, comp, (xli) L19314 Human HRY gene,complete cds, (xlii) M30703 Human amphiregulin (AR) gene, exon 6, cloneslambda-ARH(6,12), (xliii) U34252 Human gamma-aminobutyraldehydedehydrogenase mRNA, complete cds, (xliv) S78825 Id1, (xlv) D85429 H.sapiens gene for heat shock protein 40, complete cds, (xlvi) U41766Human metalloprotease/disintegrin/cysteine-rich protein precursor (MDC9)mRNA, (xlvii) U89336 Human HLA class III region containing NOTCH4 gene,partial sequence, homeobox PB, (xlviii) M69181 Human nonmuscle myosinheavy chain-B (MYH10) mRNA, partial cds, (xlix) D15050 Human mRNA fortranscription factor AREB6, complete cds, (l) U28386 Human nuclearlocalization sequence receptor hSRP1alpha mRNA, complete cds, (li)L77886 Human protein tyrosine phosphatase mRNA, complete cds, (lii)X64330 H. sapiens mRNA for ATP-citrate lyase, (liii) U37122 Humanadducin gamma subunit mRNA, complete cds, (liv) X74008 H. sapiens mRNAfor protein phosphatase 1 gamma, (lv) U60205 Human methyl sterol oxidase(ERG25) mRNA, complete cds, (lvi) X76534 H. sapiens NMB mRNA, (lvii)D87071 Human mRNA for KIAA0233 gene, complete cds, (lviii) U90716 Humancell surface protein HCAR mRNA, complete cds, (lix) M91083 HumanDNA-binding protein (HRC1) mRNA, complete cds, (lx) U29607 Humanmethionine aminopeptidase mRNA, complete cds, (lxi) M76482 Human 130-kDpemphigus vulgaris antigen mRNA, complete cds, (lxii) U72066 H. sapiensCtBP interacting protein CtIP (CtIP) mRNA, complete cds, (lxiii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (lxiv) X12953Human rab2 mRNA, YPT1-related and member of ras family, (lxv) M60483Human protein phosphatase 2A catalytic subunit-alpha gene, complete cds,(lxvi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (lxvii) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (lxviii) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(lxix) D50840 H. sapiens mRNA for ceramide glucosyltransferase, completecds, (lxx) L31801 H. sapiens monocarboxylate transporter 1 (SLC16A1)mRNA, complete cds, (lxxi) S74017 Nrf2=NF−E2-like basic leucine zippertranscriptional activator [human, hemin-in, (lxxii) X87241 H. sapiensmRNA for hFat protein, (lxxiii) X52425 Human IL-4-R mRNA for theinterleukin 4 receptor, (lxxiv) D79994 Human mRNA for KIAA0172 gene,partial cds, (lxxv) M58286 H. sapiens tumor necrosis factor receptormRNA, complete cds, (lxxvi) M13829 Human putative raf related protein(pks/a-raf) mRNA, partial cds, (lxxvii) X78992 H. sapiens ERF-2 mRNA,(lxxviii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (lxxix) U88629 Human RNA polymeraseII elongation factor ELL2, complete cds, (lxxx) X52611 Human mRNA fortranscription factor AP-2, (lxxxi) U28749 Human high-mobility groupphosphoprotein isoform I-C (HMGIC) mRNA, complete cds, (lxxxii) L00058Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank, (lxxxiii)L26336 Heat Shock Protein, 70 Kda (Gb:Y00371, (lxxxiv) L08246 Humanmyeloid cell differentiation protein (MCL1) mRNA, (lxxxv) S73591brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic,leukemia cells (lxxxvi) J05211 Desmoplakin, (lxxxvii)L00352 Human low density lipoprotein receptor gene, exon 18, (lxxxviii)Y13647 Stearoyl-Coenzymea Desaturase, (lxxxix) X77794 H. sapiens mRNAfor cyclin G1, (xc) M90656 Human gamma-glutamylcysteine synthetase (GCS)mRNA, complete cds, (xci) M13929 Human c-myc-P64 mRNA, initiating frompromoter P0, (HLmyc2.5) partial cds, (xcii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (xciii) X80692 H. sapiens ERK3 mRNA,and (xciv) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf
 114. 99. Thepharmaceutical composition of claim 96, wherein the third responsefurther comprises proteins encoded by the nucleic acid molecules atleast 90% identical to the polynucleotides of the group consisting of:(i) M20030 Human small proline rich protein (sprII) mRNA, clone 930,(ii) X53065, (iii) M13903 Human involucrin gene, exon 2, (iv) M22918Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629), Non-Muscle, Alt.Splice, (v) L10343 Huma elafin gene, complete cds, (vi) M63573 Humansecreted cyclophilin-like protein (SCYLP) mRNA, complete cds, (vii)M21302 Human small proline rich protein (sprII) mRNA, clone 174N, (viii)Y00787 Human mRNA for MDNCF (monocyte-derived neutrophil chemotacticfactor), (ix) X57985 H.sapiens genes for histones H2B.1 and H2A, (x)L05188 Homo sapiens small proline-rich protein 2 (SPRR2B) gene, completecds, (xi) X70326 Macmarcks, (xii) X67325 H.sapiens p27 mRNA, (xiii)L19779 Homo sapiens histone H2A.2 mRNA, complete cds, (xiv) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, (xv) D45248 Human mRNA for proteasome activator hPA28subunit beta, complete cds, (xvi) Z22548 H.sapiens thiol-specificantioxidant protein mRNA, (xvii) M22918 Myosin, Light Chain, Alkali,Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice, (xviii) X06956Tubulin, Alpha 1, Isoform 44, (xix) V00594 Human mRNA formetallothionein from cadmium-treated cells, (xx) M80254 H.sapienscyclophilin isoform (hCyP3) mRNA, complete cds, (xxi) U04636 Humancyclooxygenase-2 (hCox-2) gene, complete cds, (xxii) Z14244 H.sapienscoxVIIb mRNA for cytochrome c oxidase subunit VIIb, (xxiii) X99920H.sapiens mRNA for S100 calcium-binding protein A13, (xxiv) U62800 Humancystatin M (CST6) mRNA, complete cds, (xxv) L08069 Human heat shockprotein, E. coli DnaJ homologue mRNA, complete cds, (xxvi) L20688 HumanGDP-dissociation inhibitor protein (Ly-GDI) mRNA, complete cds, (xxvii)M13755 Human interferon-induced 17-kDa/15-kDa protein mRNA, completecds, (xxviii) M60278 Human heparin-binding EGF-like growth factor mRNA,complete cds, (xxix) AF001294 Homo sapiens IPL (IPL) mRNA, complete cds,(xxx) X54489 Human gene for melanoma growth stimulatory activity (MGSA),(xxxi) M21186 Human neutrophil cytochrome b light chain p22 phagocyteb-cytochrome mRNA, compl, (xxxii) D42040 Human mRNA for KIAA9001 gene,complete cds, (xxxiii) V00599 Tubulin, Beta, (xxxiv) U37690 Human RNApolymerase II subunit (hsRPB 10) mRNA, complete cds, (xxxv) M21005 Humanmigration inhibitory factor-related protein 8 (MRP8) gene, complete cds,(xxxvi) M37583 Human histone (H2A.Z) mRNA, complete cds, (xxxvii) Z49989H.sapiens mRNA for smoothelin, (xxxviii) L24564 Human Rad mRNA, completecds, (xxxix) D49824 Human HLA-B null allele mRNA, (xl) M59465 Humantumor necrosis factor alpha inducible protein A20 mRNA, complete cds,(xli) S54005 thymosin beta-10 [human, metastatic melanoma cell line,mRNA, 453 nt], (xlii) Z49254 H.sapiens L23-related mRNA, (xliii) M22919Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629), Smooth Muscle,Alt. Spli, (xliv) U70660 Human copper transport protein HAH1 (HAH1)mRNA, complete cds, (xlv) AF006084 Homo sapiens Arp⅔ protein complexsubunit p41-Arc (ARC41) mRNA, complete cds, (xlvi) X62083 H.sapiens mRNAfor Drosophila female sterile homeotic (FSH) homologue, (xlvii) D86974Human mRNA for KIAA0220 gene, partial cds, (xlviii) M72885 Human GOS2gene, 5′ flank and cds, (xlix) S80437 fatty acid synthase {3′ region}[human, breast and HepG2 cells, mRNA Partial, 22, (l) X04654 Human mRNAfor U1 RNA-associated 70K protein, (li) t M26311 Human cystic fibrosisantigen mRNA, complete cds, (lii) X14850 Human H2A.X mRNA encodinghistone H2A.X, (liii) M14328 Human alpha enolase mRNA, complete cds,(liv) U07919 Human aldehyde dehydrogenase 6 mRNA, complete cds, (lv)M28130 Human interleukin 8 (IL8) gene, complete cds, (lvi) Z21507H.sapiens EF-1delta gene encoding human elongation factor-1-delta,(lvii) M92934 Human connective tissue growth factor, complete cds,(lviii) M27436 Human tissue factor gene, complete cds, with a Alurepetitive sequence in the 3′, (lix) X74874 H.sapiens gene for RNA polII largest subunit, exon 1, (lx) X57351 Human 1-8D gene frominterferon-inducible gene family, (lxi) X52979 Human gene for smallnuclear ribonucleoproteins SmB and SmB′, (lxii) U41515 Human deleted insplit hand/split foot 1 (DSS1) mRNA, complete cds, (lxiii) D28235 HumanPTGS2 gene for prostaglandin endoperoxide synthase-2, complete cds,(lxiv) Y00503 Human mRNA for keratin
 19. (lxv) M57731 Human gro-betamRNA, complete cds, (lxvi) D50840 Homo sapiens mRNA for ceramideglucosyltransferase, complete cds, (lxvii) U52101 Human YMP mRNA,complete cds. (lxviii) D13413 Human mRNA for tumor-associated 120 kDanuclear protein p120, partial cds(carbox, (lxix) L42379 Homo sapiensbone-derived growth factor (BPGF-1) mRNA, complete cds, (lxx) X52426H.sapiens mRNA for cytokeratin 13, (lxxi) J04456 Human 14 kd lectinmRNA, complete cds, (lxxii) S78771 NAT=CpG island-associated gene[human, mRNA, 1741 nt], (lxxiii) M26730 Human mitochondrialubiquinone-binding protein (QP) gene, exon 4, (lxxiv) U26727 Humanp16INK4/MTS1 mRNA, complete cds, (lxxv) X92896 H.sapiens mRNA for ITBA2protein, (lxxvi) Z69043 H.sapiens mRNA translocon-associated proteindelta subunit precursor, (lxxvii) L76568 Homo sapiens excision and crosslink repair protein (ERCC4) gene, complete genom, (lxxviii) M12125 Humanfibroblast muscle-type tropomyosin mRNA, complete cds, (lxxix) U09937Human urokinase-type plasminogen receptor, exon 7, (lxxx) X15822 HumanCOX VIIa-L mRNA for liver-specific cytochrome c oxidase (EC 1.9.3.1.),(lxxxi) M34516 Human omega light chain protein 14.1 (Ig lambda chainrelated) gene, exon 3, (lxxxii) U53830 Homo sapiens interferonregulatory factor 7A mRNA, complete cds, (lxxxiii) X82693 H.sapiens mRNAfor E48 antigen, (lxxxiv) M58026 Human NB-1 mRNA, complete cds, (lxxxv)M90657 Human tumor antigen (L6) mRNA, complete cds, (lxxxvi) X57579H.sapiens activin beta-A subunit (exon 2), (lxxxvii) D38251 Human mRNAfor RPB5 (XAP4), complete cds, (lxxxviii) D89667 Homo sapiens mRNA forc-myc binding protein, complete cds, (lxxxix) AB000584 Homo sapiens mRNAfor TGF-beta superfamily protein, complete cds, (xc) L76200 Humanguanylate kinase (GUK1) mRNA, complete cds, (xci) J04794 Human aldehydereductase mRNA, complete cds, (xcii) X52882 Human t-complex polypeptide1 gene, (xciii) M79463 Human PML-2 mRNA, complete CDS, (xciv) Y09022 H.sapiens mRNA for Not56-like protein, (xcv) M12529 Human apolipoprotein EmRNA, complete cds, (xcvi) X71129 H.sapiens mRNA for electron transferflavoprotein beta subunit, (xcvii) X83416 H.sapiens PrP gene, exon 2,(xcviii) D89052 Homo sapiens mRNA for proton-ATPase-like protein,complete cds, (xcix) M60974 Human growth arrest and DNA-damage-inducibleprotein (gadd45) mRNA, complete cds, (c) M16364 Human creatine kinase-BmRNA, complete cds, (ci) D38305 Human mRNA for Tob, complete cds, (cii)X87679 Major Histocompatibility Complex, Class I, E (Gb:M21533), (ciii)Z29505 H.sapiens mRNA for nucleic acid binding protein sub2.3, (civ)K02574, (cv) U09813 Human mitochondrial ATP synthase subunit 9, P3 genecopy, mRNA, nuclear gene enc, (cvi) X67951 H.sapiens mRNA forproliferation-associated gene (pag), (cvii) J04611 Human lupus p70 (Ku)autoantigen protein mRNA, complete cds, (cviii) U09578 Homo sapiensMAPKAP kinase (3 pK) mRNA, complete cds, (cix) X53800 Human mRNA formacrophage inflammatory protein-2beta (MIP2beta), (cx) V00599 Tubulin,Beta 2, (cxi) U69126 Human FUSE binding protein 2 (FBP2) mRNA, partialcds, (cxii) X53416 Human mRNA for actin-binding protein (filamin)(ABP-280), (cxiii) U90546 Human butyrophilin (BTF4) mRNA, complete cds,(cxiv) M58459 Human ribosomal protein (RPS4Y) isoform mRNA, completecds, (cxv) M19961 Human cytochrome c oxidase subunit Vb (coxVb) mRNA,complete cds, (cxvi) U65579 Human mitochondrial NADHdehydrogenase-ubiquinone Fe-S protein 8, 23 kDa subunit, (cxvii) X77794H.sapiens mRNA for cyclin G1, (cxviii) M29064 Human hnRNP B1 proteinmRNA, (cxix) D21853 Human mRNA for KIAA0111 gene, complete cds, (cxx)X78687 H.sapiens G9 gene encoding sialidase, (cxxi) X15729 Human mRNAfor nuclear p68 protein, (cxxii) X04828 Human mRNA for G(i) proteinalpha-subunit (adenylate cyclase inhibiting GTP-bind, (cxxiii) L27943Homo sapiens cytidine deaminase (CDA) mRNA, complete cds, (cxxiv) L40391Homo sapiens (clone s153) mRNA fragment, (cxxv) D42123 Homo sapiens mRNAfor ESP1/CRP2, complete cds, (cxxvi) X74104 H.sapiens mRNA for TRAP betasubunit, (cxxvii) M84332 Human ADP-ribosylation factor 1 gene, exons2-5, (cxxviii) L37127 Homo sapiens RNA polymerase II mRNA, complete cds,(cxxix) M92843 H.sapiens zinc finger transcriptional regulator mRNA,complete cds, (cxxx) U07664 Human HB9 homeobox gene, exons 2 and 3 andcomplete cds, (cxxxi) L48546 Homo sapiens tuberin (TSC2) gene, exons 38,39, 40 and 41, (cxxxii) X53586 Human mRNA for integrin alpha 6,(cxxxiii) t D21852 Human mRNA for KIAA0029 gene, partial cds, (cxxxiv)L11066 Human mRNA sequence, (cxxxv) J04444 Human cytochrome c-1 gene,complete cds, (cxxxvi) M95787 Human 22 kDa smooth muscle protein (SM22)mRNA, complete cds, (cxxxvii) L07517 Mucin 6, Gastric (Gb:L07517),(cxxxviii) X91247 H.sapiens mRNA for thioredoxin reductase, (cxxxix)L11672 Human Kruppel related zinc finger protein (HTF10) mRNA, completecds, (cxl) U30999 Human (memc) mRNA, 3′UTR, (cxli) U01337 Human Ser/Thrprotein kinase (A-RAF-1) gene, complete cds, (cxlii) U28480 UncouplingProtein Ucp, (cxliii) X12794 Human v-erbA related ear-2 gene, (cxliv)L22005 Human ubiquitin conjugating enzyme mRNA, partial cds, (cxlv)M12886 Human T-cell receptor active beta-chain mRNA, complete cds,(cxlvi) Y08915 H.sapiens mRNA for alpha 4 protein, (cxlvii) M24547Amyloid Beta (A4) Precursor Protein, Alt. Splice 2, A4(751), (cxlviii)X76717 H.sapiens MT-1l mRNA, (cxlix) M64347 Human novel growth factorreceptor mRNA, 3′ cds, (cl) X05409 Human RNA for mitochondrial aldehydedehydrogenase I ALDH I (EC 1.2.1.3), (cli) D87469 Human mRNA forKIAA0279 gene, partial cds, (clii) M58603 Human nuclear factor kappa-BDNA binding subunit (NF-kappa-B) mRNA, complete cds, (cliii) M76482Human 130-kD pemphigus vulgaris antigen mRNA, complete cds, (cliv)X06323 Human MRL3 mRNA for ribosomal protein L3 homologue (MRL3=mammalian ribosome L, (clv) X78992 H.sapiens ERF-2 mRNA, (clvi)L41351 Homo sapiens prostasin mRNA, complete cds, (clvii) X75342H.sapiens SHB mRNA, (clviii) U83115 Human non-lens beta gamma-crystallinlike protein (AIM1) mRNA, partial cds, (clix) U88629 Human RNApolymerase II elongation factor ELL2, complete cds, (clx) S78825 Id1,(clxi) U28811 Human cysteine-rich fibroblast growth factor receptor(CFR-1) mRNA, complete cds, (clxii) M58286 Homo sapiens tumor necrosisfactor receptor mRNA, complete cds, (clxiii) D78129 Homo sapiens mRNAfor squalene epoxidase, partial cds, (clxiv) D14874 Homo sapiens mRNAfor adrenomedullin precursor, complete cds, (clxv) Z26317 H.sapiens mRNAfor desmoglein 2, (clxvi) L19267 Homo sapiens 59 protein mRNA, 3′ end,(clxvii) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114, (clxviii)U33821 Human tax1-binding protein TXBP151 mRNA, complete cds, (clxix)U52100 Human XMP mRNA, complete cds, (clxx) L31801 Homo sapiensmonocarboxylate transporter 1 (SLC16A1) mRNA, complete cds, (clxxi)L00058 Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank,(clxxii) U52426 Homo sapiens GOK (STIM1) mRNA, complete cds, (clxxiii)M80244 Human E16 mRNA, complete cds, (clxxiv) U56418 Humanlysophosphatidic acid acyltransferase-beta mRNA, complete cds, (clxxv)L38490 Homo sapiens ADP-ribosylation factor mRNA, complete cds, (clxxvi)U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (clxxvii) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (clxxviii) M38258 Human retinoic acid receptor gamma 1mRNA, complete cds, (clxxix) X89750 H.sapiens mRNA for TGIF protein,(clxxx) D85429 Homo sapiens gene for heat shock protein 40, completecds, (clxxxi) J05211 Desmoplakin I, (clxxxii) M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds, (clxxxiii) X80695 H.sapiens OXA1HsmRNA, (clxxxiv) M54915 Human h-pim-1 protein (h-pim-1) mRNA, completecds, (clxxxv) D83777 Human mRNA for KIAA0193 gene, complete cds,(clxxxvi) D31883 Human mRNA for KIAA0059 gene, complete cds, (clxxxvii)U00968 Human SREBP-1 mRNA, complete cds, (clxxxviii) K03195 Human(HepG2) glucose transporter gene mRNA, complete cds, (clxxxix) D86965Human mRNA for KIAA0210 gene, complete cds, (cxc) Z30643 H.sapiens mRNAfor chloride channel (putative) 2139 bp, (cxci) D14520 Human mRNA forGC-Box binding protein BTEB2, complete cds, (cxcii) D87462 Human mRNAfor KIAA0272 gene, partial cds, (cxciii) X80692 H.sapiens ERK3 mRNA,(cxciv) X90858 H.sapiens mRNA for uridine phosphorylase, (cxcv) M57763Human ADP-ribosylation factor (hARF6) mRNA, complete cds, (cxcvi) X92720H.sapiens mRNA for phosphoenolpyruvate carboxykinase, (cxcvii) M81601Human transcription elongation factor (SII) mRNA, complete cds,(cxcviii) X52611 Human mRNA for transcription factor AP-2, (cxcix)U09587 Human glycyl-tRNA synthetase mRNA, complete cds, (cc) U14550Human sialyltransferase SThM (sthm) mRNA, complete cds, (cci) D90209Human mRNA for DNA binding protein TAXREB67, (ccii) X77366 H.sapiensHBZ17 mRNA, (cciii) X76534 H.sapiens NMB mRNA, (cciv) U37519 Humanaldehyde dehydrogenase (ALDH8) mRNA, complete cds, (ccv) M83667 HumanNF-IL6-beta protein mRNA, complete cds, (ccvi) U53347 Human neutralamino acid transporter B mRNA, complete cds, (ccvii) L09229 Humanlong-chain acyl-coenzyme A synthetase (FACL1) mRNA, complete cds,(ccviii) S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, (ccix) M13929 Human c-myc-P64 mRNA,initiating from promoter P0, (HLmyc2.5) partial cds, (ccx) M55268 Humancasein kinase II alpha′ subunit mRNA, complete cds, (ccxi) M77836 Humanpyrroline 5-carboxylate reductase mRNA, complete cds, (ccxii)HG2724-HT2820_at S75762 Oncogene Tls/Chop, Fusion Activated, (ccxiii)U72066 Homo sapiens CtBP interacting protein CtIP (CtIP) mRNA, completecds, (ccxiv) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (ccxv) M27396 Human asparaginesynthetase mRNA, complete cds, (ccxvi) X01630 Human mRNA forargininosuccinate synthetase, (ccxvii) D32050 Human mRNA for alanyl-tRNAsynthetase, complete cds, (ccxviii) M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, (ccxix) J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,(ccxx) X69111 H.sapiens HLH 1R21 mRNA for helix-loop-helix protein. (i)M20030 Human small proline rich protein (sprII) mRNA, clone 930, (ii)X53065, (iii) M13903 Human involucrin gene, exon 2, (iv) M22918 Myosin,Light Chain, Alkali, Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice,(v) L10343 Huma elafin gene, complete cds, (vi) M63573 Human secretedcyclophilin-like protein (SCYLP) mRNA, complete cds, (vii) M21302 Humansmall proline rich protein (sprII) mRNA, clone 174N, (viii) Y00787 HumanmRNA for MDNCF (monocyte-derived neutrophil chemotactic factor), (ix)X57985 H.sapiens genes for histones H2B.1 and H2A, (x) L05188 Homosapiens small proline-rich protein 2 (SPRR2B) gene, complete cds, (xi)X70326 Macmarcks, (xii) X67325 H.sapiens p27 mRNA, (xiii) L19779 Homosapiens histone H2A.2 mRNA, complete cds, (xiv) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, (xv) D45248 Human mRNA for proteasome activator hPA28subunit beta, complete cds, (xvi) Z22548 H.sapiens thiol-specificantioxidant protein mRNA, (xvii) M22918 Myosin, Light Chain, Alkali,Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice, (xviii) X06956Tubulin, Alpha 1, Isoform 44, (xix) V00594 Human mRNA formetallothionein from cadmium-treated cells, (xx) M80254 H.sapienscyclophilin isoform (hCyP3) mRNA, complete cds, (xxi) U04636 Humancyclooxygenase-2 (hCox-2) gene, complete cds, (xxii) Z14244 H.sapienscoxVIIb mRNA for cytochrome c oxidase subunit VIIb, (xxiii) X99920H.sapiens mRNA for S100 calcium-binding protein A13, (xxiv) U62800 Humancystatin M (CST6) mRNA, complete cds, (xxv) L08069 Human heat shockprotein, E. coli DnaJ homologue mRNA, complete cds, (xxvi) L20688 HumanGDP-dissociation inhibitor protein (Ly-GDI) mRNA, complete cds, (xxvii)M13755 Human interferon-induced 17-kDa/15-kDa protein mRNA, completecds, (xxviii) M60278 Human heparin-binding EGF-like growth factor mRNA,complete cds, (xxix) AF001294 Homo sapiens IPL (IPL) mRNA, complete cds,(xxx) X54489 Human gene for melanoma growth stimulatory activity (MGSA),(xxxi) M21186 Human neutrophil cytochrome b light chain p22 phagocyteb-cytochrome mRNA, compl, (xxxii) D42040 Human mRNA for KIAA9001 gene,complete cds, (xxxiii) V00599 Tubulin, Beta, (xxxiv) U37690 Human RNApolymerase II subunit (hsRPB10) mRNA, complete cds, (xxxv) M21005 Humanmigration inhibitory factor-related protein 8 (MRP8) gene, complete cds,(xxxvi) M37583 Human histone (H2A.Z) mRNA, complete cds, (xxxvii) Z49989H.sapiens mRNA for smoothelin, (xxxviii) L24564 Human Rad mRNA, completecds, (xxxix) D49824 Human HLA-B null allele mRNA, (xl) M59465 Humantumor necrosis factor alpha inducible protein A20 mRNA, complete cds,(xli) S54005 thymosin beta-10 [human, metastatic melanoma cell line,mRNA, 453 nt], (xlii) Z49254 H.sapiens L23-related mRNA, (xliii) M22919Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629), Smooth Muscle,Alt. Spli, (xliv) U70660 Human copper transport protein HAH1 (HAH1)mRNA, complete cds, (xlv) AF006084 Homo sapiens Arp⅔ protein complexsubunit p41-Arc (ARC41) mRNA, complete cds, (xlvi) X62083 H.sapiens mRNAfor Drosophila female sterile homeotic (FSH) homologue, (xlvii) D86974Human mRNA for KIAA0220 gene, partial cds, (xlviii) M72885 Human GOS2gene, 5′ flank and cds, (xlix) S80437 fatty acid synthase {3′ region}[human, breast and HepG2 cells, mRNA Partial, 22, (l) X04654 Human mRNAfor U1 RNA-associated 70K protein, (li) t M26311 Human cystic fibrosisantigen mRNA, complete cds, (lii) X14850 Human H2A.X mRNA encodinghistone H2A.X, (liii) M14328 Human alpha enolase mRNA, complete cds,(liv) U07919 Human aldehyde dehydrogenase 6 mRNA, complete cds, (lv)M28130 Human interleukin 8 (IL8) gene, complete cds, (lvi) Z21507H.sapiens EF-1delta gene encoding human elongation factor-1-delta,(lvii) M92934 Human connective tissue growth factor, complete cds,(lviii) M27436 Human tissue factor gene, complete cds, with a Alurepetitive sequence in the 3′, (lix) X74874 H.sapiens gene for RNA polII largest subunit, exon 1, (lx) X57351 Human 1-8D gene frominterferon-inducible gene family, (lxi) X52979 Human gene for smallnuclear ribonucleoproteins SmB and SmB′, (lxii) U41515 Human deleted insplit hand/split foot 1 (DSS1) rrRNA, complete cds, (lxiii) D28235 HumanPTGS2 gene for prostaglandin endoperoxide synthase-2, complete cds,(lxiv) Y00503 Human mRNA for keratin
 19. (lxv) M57731 Human gro-betamRNA, complete cds, (lxvi) D50840 Homo sapiens mRNA for ceramnideglucosyltransferase, complete cds, (lxvii) U52101 Human YMP mRNA,complete cds. (lxviii) D13413 Human mRNA for tumor-associated 120 kDanuclear protein p120, partial cds(carbox, (lxix) L42379 Homo sapiensbone-derived growth factor (BPGF-1) mRNA, complete cds, (lxx) X52426H.sapiens mRNA for cytokeratin 13, (lxxi) J04456 Human 14 kd lectinmRNA, complete cds, (lxxii) S78771 NAT=CpG island-associated gene[human, mRNA, 1741 nt], (lxxiii) M26730 Human mitochondrialubiquinone-binding protein (QP) gene, exon 4, (lxxiv) U26727 Humanp16INK4/MTS1 mRNA, complete cds, (lxxv) X92896 H.sapiens mRNA for ITBA2protein, (lxxvi) Z69043 H.sapiens mRNA translocon-associated proteindelta subunit precursor, (lxxvii) L76568 Homo sapiens excision and crosslink repair protein (ERCC4) gene, complete genom, (lxxviii) M12125 Humanfibroblast muscle-type tropomyosin mRNA, complete cds, (lxxix) U09937Human urokinase-type plasminogen receptor, exon 7, (lxxx) X15822 HumanCOX VIIa-L mRNA for liver-specific cytochrome c oxidase (EC 1.9.3.1.),(lxxxi) M34516 Human omega light chain protein 14.1 (Ig lambda chainrelated) gene, exon 3, (lxxxii) U53830 Homo sapiens interferonregulatory factor 7A mRNA, complete cds, (lxxxiii) X82693 H.sapiens mRNAfor E48 antigen, (lxxxiv) M58026 Human NB-1 mRNA, complete cds, (lxxxv)M90657 Human tumor antigen (L6) mRNA, complete cds, (lxxxvi) X57579H.sapiens activin beta-A subunit (exon 2), (lxxxvii) D38251 Human mRNAfor RPB5 (XAP4), complete cds, (lxxxviii) D89667 Homo sapiens mRNA forc-myc binding protein, complete cds, (lxxxix) AB000584 Homo sapiens mRNAfor TGF-beta superfamily protein, complete cds, (xc) L76200 Humanguanylate kinase (GUK1) mRNA, complete cds, (xci) J04794 Human aldehydereductase mRNA, complete cds, (xcii) X52882 Human t-complex polypeptide1 gene, (xciii) M79463 Human PML-2 mRNA, complete CDS, (xciv) Y09022 H.sapiens mRNA for Not56-like protein, (xcv) M12529 Human apolipoprotein EmRNA, complete cds, (xcvi) X71129 H.sapiens mRNA for electron transferflavoprotein beta subunit, (xcvii) X83416 H.sapiens PrP gene, exon 2,(xcviii) D89052 Homo sapiens mRNA for proton-ATPase-like protein,complete cds, (xcix) M60974 Human growth arrest and DNA-damage-inducibleprotein (gadd45) mRNA, complete cds, (c) M16364 Human creatine kinase-BmRNA, complete cds, (ci) D38305 Human mRNA for Tob, complete cds, (cii)X87679 Major Histocompatibility Complex, Class I, E (Gb:M21533), (ciii)Z29505 H.sapiens mRNA for nucleic acid binding protein sub2.3, (civ)K02574, (cv) U09813 Human mitochondrial ATP synthase subunit 9, P3 genecopy, mRNA, nuclear gene enc, (cvi) X67951 H.sapiens mRNA forproliferation-associated gene (pag), (cvii) J04611 Human lupus p70 (Ku)autoantigen protein mRNA, complete cds, (cviii) U09578 Homo sapiensMAPKAP kinase (3 pK) mRNA, complete cds, (cix) X53800 Human mRNA formacrophage inflammatory protein-2beta (MIP2beta), (cx) V00599 Tubulin,Beta 2, (cxi) U69126 Human FUSE binding protein 2 (FBP2) mRNA, partialcds, (cxii) X53416 Human mRNA for actin-binding protein (filamin)(ABP-280), (cxiii) U90546 Human butyrophilin (BTF4) mRNA, complete cds,(cxiv) M58459 Human ribosomal protein (RPS4Y) isoform mRNA, completecds, (cxv) M19961 Human cytochrome c oxidase subunit Vb (coxVb) mRNA,complete cds, (cxvi) U65579 Human mitochondrial NADHdehydrogenase-ubiquinone Fe-S protein 8, 23 kDa subunit, (cxvii) X77794H. sapiens mRNA for cyclin G1, (cxviii) M29064 Human hnRNP B1 proteinmRNA, (cxix) D21853 Human mRNA for KIAA0111 gene, complete cds, (cxx)X78687 H.sapiens G9 gene encoding sialidase, (cxxi) X15729 Human mRNAfor nuclear p68 protein, (cxxii) X04828 Human mRNA for G(i) proteinalpha-subunit (adenylate cyclase inhibiting GTP-bind, (cxxiii) L27943Homo sapiens cytidine deaminase (CDA) mRNA, complete cds, (cxxiv) L40391Homo sapiens (clone s153) mRNA fragment, (cxxv) D42123 Homo sapiens mRNAfor ESP1/CRP2, complete cds, (cxxvi) X74104 H.sapiens mRNA for TRAP betasubunit, (cxxvii) M84332 Human ADP-ribosylation factor 1 gene, exons2-5, (cxxviii) L37127 Homo sapiens RNA polymerase II mRNA, complete cds,(cxxix) M92843 H.sapiens zinc finger transcriptional regulator mRNA,complete cds, (cxxx) U07664 Human HB9 homeobox gene, exons 2 and 3 andcomplete cds, (cxxxi) L48546 Homo sapiens tuberin (TSC2) gene, exons 38,39, 40 and 41, (cxxxii) X53586 Human mRNA for integrin alpha 6,(cxxxiii) t D21852 Human mRNA for KIAA0029 gene, partial cds, (cxxxiv)L11066 Human mRNA sequence, (cxxxv) J04444 Human cytochrome c-1 gene,complete cds, (cxxxvi) M95787 Human 22 kDa smooth muscle protein (SM22)mRNA, complete cds, (cxxxvii) L07517 Mucin 6, Gastric (Gb:L07517),(cxxxviii) X91247 H.sapiens mRNA for thioredoxin reductase, (cxxxix)L11672 Human Kruppel related zinc finger protein (HTF10) mRNA, completecds, (cxl) U30999 Human (memc) mRNA, 3′UTR, (cxli) U01337 Human Ser/Thrprotein kinase (A-RAF-1) gene, complete cds, (cxlii) U28480 UncouplingProtein Ucp, (cxliii) X12794 Human v-erbA related ear-2 gene, (cxliv)L22005 Human ubiquitin conjugating enzyme mRNA, partial cds, (cxlv)M12886 Human T-cell receptor active beta-chain mRNA, complete cds,(cxlvi) Y08915 H.sapiens mRNA for alpha 4 protein, (cxlvii) M24547Amyloid Beta (A4) Precursor Protein, Alt. Splice 2, A4(751), (cxlviii)X76717 H.sapiens MT-1l mRNA, (cxlix) M64347 Human novel growth factorreceptor mRNA, 3′ cds, (cl) X05409 Human RNA for miitochondrial aldehydedehydrogenase I ALDH I (EC 1.2.1.3), (cli) D87469 Human mRNA forKIAA0279 gene, partial cds, (clii) M58603 Human nuclear factor kappa-BDNA binding subunit (NF-kappa-B) mRNA, complete cds, (cliii) M76482Human 130-kD pemphigus vulgaris antigen mRNA, complete cds, (cliv)X06323 Human MRL3 mRNA for ribosomal protein L3 homologue (MRL3=mammalian ribosome L, (clv) X78992 H.sapiens ERF-2 mRNA, (clvi)L41351 Homo sapiens prostasin mRNA, complete cds, (clvii) X75342H.sapiens SHB mRNA, (clviii) U83115 Human non-lens beta gamma-crystallinlike protein (AIMI) mRNA, partial cds, (clix) U88629 Human RNApolymerase II elongation factor ELL2, complete cds, (clx) S78825 Id1,(clxi) U28811 Human cysteine-rich fibroblast growth factor receptor(CFR-1) mRNA, complete cds, (clxii) M58286 Homo sapiens tumor necrosisfactor receptor mRNA, complete cds, (clxiii) D78129 Homo sapiens mRNAfor squalene epoxidase, partial cds, (clxiv) D14874 Homo sapiens mRNAfor adrenomedullin precursor, complete cds, (clxv) Z26317 H.sapiens mRNAfor desmoglein 2, (clxvi) L19267 Homo sapiens 59 protein mRNA, 3′ end,(clxvii) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114, (clxviii)U33821 Human tax1-binding protein TXBP151 mRNA, complete cds, (clxix)U52100 Human XMP mRNA, complete cds, (clxx) L31801 Homo sapiensmonocarboxylate transporter 1 (SLC16A1) mRNA, complete cds, (clxxi)L00058 Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank,(clxxii) U52426 Homo sapiens GOK (STIM1) mRNA, complete cds, (clxxiii)M80244 Human E16 mRNA, complete cds, (clxxiv) U56418 Humanlysophosphatidic acid acyltransferase-beta mRNA, complete cds, (clxxv)L38490 Homo sapiens ADP-ribosylation factor mRNA, complete cds, (clxxvi)U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (clxxvii) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (clxxviii) M38258 Human retinoic acid receptor gamma 1mRNA, complete cds, (clxxix) X89750 H.sapiens mRNA for TGIF protein,(clxxx) D85429 Homo sapiens gene for heat shock protein 40, completecds, (clxxxi) J05211 Desmoplakin I, (clxxxii) M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds, (clxxxiii) X80695 H.sapiens OXA1HsmRNA, (clxxxiv) M54915 Human h-pim-1 protein (h-pim-1) mRNA, completecds, (clxxxv) D83777 Human mRNA for KIAA0193 gene, complete cds,(clxxxvi) D31883 Human mRNA for KIAA0059 gene, complete cds, (clxxxvii)U00968 Human SREBP-1 mRNA, complete cds, (clxxxviii) K03195 Human(HepG2) glucose transporter gene mRNA, complete cds, (clxxxix) D86965Human mRNA for KIAA0210 gene, complete cds, (cxc) Z30643 H.sapiens mRNAfor chloride channel (putative) 2139 bp, (cxci) D14520 Human mRNA forGC-Box binding protein BTEB2, complete cds, (cxcii) D87462 Human mRNAfor KIAA0272 gene, partial cds, (cxciii) X80692 H.sapiens ERK3 mRNA,(cxciv) X90858 H.sapiens mRNA for uridine phosphorylase, (cxcv) M57763Human ADP-ribosylation factor (hARF6) mRNA, complete cds, (cxcvi) X92720H.sapiens mRNA for phosphoenolpyruvate carboxykinase, (cxcvii) M81601Human transcription elongation factor (SII) mRNA, complete cds,(cxcviii) X52611 Human mRNA for transcription factor AP-2, (cxcix)U09587 Human glycyl-tRNA synthetase mRNA, complete cds, (cc) U14550Human sialyltransferase SThM (sthm) mRNA, complete cds, (cci) D90209Human mRNA for DNA binding protein TAXREB67, (ccii) X77366 H.sapiensHBZ17 mRNA, (cciii) X76534 H.sapiens NMB mRNA, (cciv) U37519 Humanaldehyde dehydrogenase (ALDH8) mRNA, complete cds, (ccv) M83667 HumanNF-IL6-beta protein mRNA, complete cds, (ccvi) U53347 Human neutralamino acid transporter B mRNA, complete cds, (ccvii) L09229 Humanlong-chain acyl-coenzyme A synthetase (FACLI) mRNA, complete cds,(ccviii) S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, (ccix) M13929 Human c-myc-P64 mRNA,initiating from promoter P0, (HLmyc2.5) partial cds, (ccx) M55268 Humancasein kinase II alpha′ subunit mRNA, complete cds, (ccxi) M77836 Humanpyrroline 5-carboxylate reductase mRNA, complete cds, (ccxii)HG2724-HT2820_at S75762 Oncogene Tls/Chop, Fusion Activated, (ccxiii)U72066 Homo sapiens CtBP interacting protein CtIP (CtIP) mRNA, completecds, (ccxiv) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (ccxv) M27396 Human asparaginesynthetase mRNA, complete cds, (ccxvi) X01630 Human mRNA forargininosuccinate synthetase, (ccxvii) D32050 Human mRNA for alanyl-tRNAsynthetase, complete cds, (ccxviii) M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, (ccxix) J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,and (ccxx) X69111 H.sapiens HLH 1R21 mRNA for helix-loop-helix protein.100. The composition of claim 96, wherein modulation of expressionconstitutes a reduction in ultraviolet radiation exposure-inducedprotein expression.
 101. The composition of claim 96, wherein modulationof expression constitutes a reduction in ultraviolet radiationexposure-repressed protein expression.
 102. A screening method for thedetection of a compound that simulates the response of a cell toultraviolet radiation exposure, comprising: (a) contacting the cell withthe compound; (b) measuring a level of at least one RNA molecule in thecontacted cell, (c) determining that the level of at least one RNAmolecule is substantially similar to the level of the RNA found in thecell in response to ultraviolet radiation exposure, wherein the responseof the cell to ultraviolet radiation exposure is characterized byaltered expression of the following: (i) a first response comprising thealtered pattern of expression of at least one polynucleotide selectedfrom the group consisting of a nucleic acid molecule encoding atranscription factor protein, a nucleic acid molecule encoding a signaltransducing protein, and a nucleic acid molecule encoding amitochondrial protein; (ii) a second response comprising the alteredpattern of expression of at least one polynucleotide selected from thegroup consisting of a nucleic acid molecule encoding a secreted growthfactor, a nucleic acid molecule encoding a cytokine, and a nucleic acidmolecule encoding a chemokine; and (iii) a third response comprising thealtered pattern of expression of at least one polynucleotide selectedfrom the group consisting of a nucleic acid molecule encoding anactin-binding protein, a nucleic acid molecule encoding a desmosomalprotein, and a nucleic acid molecule encoding a tubulin protein; whereina determination that the level of expression of at least one RNAmolecule is substantially similar to the altered expression found in thefirst response, the second response or the third response indicates thatthe compound simulates exposure of the cell to ultraviolet radiation.103. The method according to claim 102, wherein: (a) the first responseis further limited to nucleic acid molecules at least 90% identical tothe polynucleotides of the group consisting of: (i) M62831 Humantranscription factor ETR101 mRNA, complete cds, (ii) X68277 H. sapiensCL 100 mRNA for protein tyrosine phosphatase, (iii) L04731 H. sapienstranslocation T(4:11) of ALL-1 gene to chromosome 4, (iv) X56681 HumanjunD mRNA, (v) U20734 Human transcription factor junB (junB) gene, 5′region and complete cds, (vi) L38951 H. sapiens importin beta subunitmRNA, complete cds, (vii) D87071 Human mRNA for KIAA0233 gene, completecds, (viii) M72885 Human GOS2 gene, 5′ flank and cds, (ix) M92843 H.sapiens zinc finger transcriptional regulator mRNA, complete cds, (x)S81914 IEX-1=radiation-inducible immediate-early gene [human, placenta,mRNA Partial, (xi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (xii)D86988 Human mRNA for KIAA0221 gene, complete cds, (xiii) L19779 H.sapiens histone H2A.2 mRNA, complete cds, (xiv) U62317 Chromosome 22q13BAC Clone CIT987SK-384D8 complete sequence, (xv) X04412 Human mRNA forplasma gelsolin, (xvi) L27706 Human chaperonin protein Tcp20) genecomplete cds, (xvii) X61123 Human BTG1 mRNA, (xviii) M60974growth arrestand DNA-damage-inducible protein (gadd45) mRNA, complete cds, (xix)L19437 Human transaldolase mRNA containing transposable element,complete cds, (xx) X57985 H. sapiens genes for histones H2B.1 and H2A,(xxi) D90086 Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunitgene, exons 1-10, (xxii) M34182 Human testis-specific protein kinasegamma-subunit mRNA, complete cds, (xxiii) L16862 H. sapiens Gprotein-coupled receptor kinase (GRK6) mRNA, complete cds, (xxiv) D13705Human mRNA for fatty acids omega-hydroxylase (cytochrome P-450HKV),complete cd, (xxv) U37122 Human adducin gamma subunit mRNA, completecds, (xxvi) D45906 H. sapiens mRNA for LIMK-2, complete cds, (xxvii)U07664 Human HB9 homeobox gene, exons 2 and 3 and complete cds, (xxviii)D87438 Human mRNA for KIAA0251 gene, partial cds, (xxix) L37042 H.sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds,(xxx) D14043 Human mRNA for MGC-24, complete cds, (xxxi) D13988 Humanrab GDI mRNA, complete cds, (xxxii) U28480 Uncoupling Protein Uc,(xxxiii) D50840 H. sapiens mRNA for ceramide glucosyltransferase,complete cds, (xxxiv) M55265 Human casein kinase II alpha subunit mRNA,complete cds, (xxxv) M96803 Human general beta-spectrin (SPTBN1) mRNA,complete cds, (xxxvi) U89336 Human HLA class III region containingNOTCH4 gene, partial sequence, homeobox P, (xxxvii) D87442 Human mRNAfor KIAA0253 gene, partial cds, (xxxviii) J03161 Human serum responsefactor (SRF) mRNA, complete cds, (xxxix) D86965 Human mRNA for KIAA0210gene, complete cds, (xl) U17327 Human neuronal nitric oxide synthase(NOS1) mRNA, complete cds, (xli) D86966 Human mRNA for KIAA0211 gene,complete cds, (xlii) D85527 H. sapiens mRNA for LIM domain, partial cds,(xliii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (xliv) X59434 Human rohu mRNA forrhodanese, (xlv) M13929 Human c-myc-P64 mRNA, initiating from promoterP0, (HLmyc2.5) partial cds, and (xlvi) J05211 Desmoplakin; (b) thesecond response is further limited to nucleic acid molecules at least90% identical to the polynucleotides of the group consisting of: (i)M57731 Human gro-beta mRNA, complete cds, (ii) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, (iii) Y00787 Human mRNA for MDNCF (monocyte-derivedneutrophil chemotactic factor), (iv) X54489 Human gene for melanomagrowth stimulatory activity (MGSA), (v) M72885 Human GOS2 gene, 5′ flankand cds, (vi) M62831 Human transcription factor ETR101 mRNA, completecds, (vii) M28130 Human interleukin 8 (IL8) gene, complete cds, (viii)X57985 H. sapiens genes for histones H2B.1 and H2A, (ix) X53800 HumanmRNA for macrophage inflammatory protein-2beta (MIP2beta), (x) L19779 H.sapiens histone H2A.2 mRNA, complete cds, (xi) AF001294 H. sapiens IPL(IPL) mRNA, complete cds, (xii) X56681 Human junD mRNA, (xiii) S75762Oncogene Tls/Chop, Fusion Activate, (xiv) M84739 Human autoantigencalreticulin mRNA, complete cds, (xv) M21302 Human small proline richprotein (sprlI) mRNA, clone 174N, (xvi) V00599 Tubulin, Bet, (xvii)X70326 Macmarck, (xviii) D10923 Human mRNA for HM74, (xix) D64142 HumanmRNA for histone H1x, complete cds, (xx) D86974 Human mRNA for KIAA0220gene, partial cds, (xxi) M60974 Human growth arrest andDNA-damage-inducible protein (gadd45) mRNA, complete cds, (xxii) X68277H. sapiens CL 100 mRNA for protein tyrosine phosphatase, (xxiii) L13391Human helix-loop-helix basic phosphoprotein (GOS8) gene, complete cds,(xxiv) M31627 Human X box binding protein-1 (XBP-1) mRNA, complete cds,(xxv) U40369 Human spermidine/spermine N1-acetyltransferase (SSAT) gene,complete cds, (xxvi) X52560 Nuclear Factor Nf-I1, (xxvii) X61123 HumanBTG1 mRNA, (xxviii) U20734 Human transcription factor junB (junB) gene,5′ region and complete cds, (xxix) U35048 Human TSC-22 protein mRNA,complete cds, (xxx) M69043 H. sapiens MAD-3 mRNA encoding IkB-likeactivity, complete cds, (xxxi) X51345 Human jun-B mRNA for JUN-Bprotein, (xxxii) S68616 Na+/H+ exchanger NHE-1 isoform [human, heart,mRNA, 4516 nt], (xxxiii) X89750 H. sapiens mRNA for TGIF protein,(xxxiv) X69111 H. sapiens HLH 1R21 mRNA for helix-loop-helix protein,(xxxv) U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (xxxvi) X52541 Human mRNA for early growth response protein 1(hEGR1), (xxxvii) D50683 H. sapiens mRNA for TGF-betaIIR alpha, completecds, (xxxviii) M92843 H. sapiens zinc finger transcriptional regulatormRNA, complete cds, (xxxix) X91247 H. sapiens mRNA for thioredoxinreductase, (xl) U05875 Human clone pSK1 interferon gamma receptoraccessory factor-1 (AF-1) mRNA, comp, (xli) L19314 Human HRY gene,complete cds, (xlii) M30703 Human amphiregulin (AR) gene, exon 6, cloneslambda-ARH(6,12), (xliii) U34252 Human gamma-aminobutyraldehydedehydrogenase mRNA, complete cds, (xliv) S78825 Id1, (xlv) D85429 H.sapiens gene for heat shock protein 40, complete cds, (xlvi) U41766Human metalloprotease/disintegrin/cysteine-rich protein precursor (MDC9)mRNA, (xlvii) U89336 Human HLA class III region containing NOTCH4 gene,partial sequence, homeobox PB, (xlviii) M69181 Human nonmuscle myosinheavy chain-B (MYH10) mRNA, partial cds, (xlix) D15050 Human mRNA fortranscription factor AREB6, complete cds, (l) U28386 Human nuclearlocalization sequence receptor hSRP1alpha mRNA, complete cds, (li)L77886 Human protein tyrosine phosphatase mRNA, complete cds, (lii)X64330 H. sapiens mRNA for ATP-citrate lyase, (liii) U37122 Humanadducin gamma subunit mRNA, complete cds, (liv) X74008 H. sapiens mRNAfor protein phosphatase 1 gamma, (lv) U60205 Human methyl sterol oxidase(ERG25) mRNA, complete cds, (lvi) X76534 H. sapiens NMB mRNA, (lvii)D87071 Human mRNA for KIAA0233 gene, complete cds, (lviii) U90716 Humancell surface protein HCAR mRNA, complete cds, (lix) M91083 HumanDNA-binding protein (HRC1) mRNA, complete cds, (lx) U29607 Humanmethionine aminopeptidase mRNA, complete cds, (lxi) M76482 Human 130-kDpemphigus vulgaris antigen mRNA, complete cds, (lxii) U72066 H. sapiensCtBP interacting protein CtIP (CtIP) mRNA, complete cds, (lxiii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (lxiv) X12953Human rab2 mRNA, YPT1-related and member of ras family, (lxv) M60483Human protein phosphatase 2A catalytic subunit-alpha gene, complete cds,(lxvi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (lxvii) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (lxviii) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(lxix) D50840 H. sapiens mRNA for ceramide glucosyltransferase, completecds, (lxx) L31801 H. sapiens monocarboxylate transporter 1 (SLC16A1)mRNA, complete cds, (lxxi) S74017 Nrf2=NF−E2-like basic leucine zippertranscriptional activator [human, hemin-in, (lxxii) X87241 H. sapiensmRNA for hFat protein, (lxxiii) X52425 Human IL-4-R mRNA for theinterleukin 4 receptor, (lxxiv) D79994 Human mRNA for KIAA0172 gene,partial cds, (lxxv) M58286 H. sapiens tumor necrosis factor receptormRNA, complete cds, (lxxvi) M13829 Human putative raf related protein(pks/a-raf) mRNA, partial cds, (lxxvii) X78992 H. sapiens ERF-2 mRNA,(lxxviii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (lxxix) U88629 Human RNA polymeraseII elongation factor ELL2, complete cds, (lxxx) X52611 Human mRNA fortranscription factor AP-2, (lxxxi) U28749 Human high-mobility groupphosphoprotein isoform I-C (HMGIC) mRNA, complete cds, (lxxxii) L00058Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank, (lxxxiii)L26336 Heat Shock Protein, 70 Kda (Gb:Y00371, (lxxxiv) L08246 Humanmyeloid cell differentiation protein (MCL1) mRNA, (lxxxv) S73591brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic,leukemia cells (lxxxvi) J05211 Desmoplakin, (lxxxvii)L00352 Human low density lipoprotein receptor gene, exon 18, (lxxxviii)Y13647 Stearoyl-Coenzymea Desaturase, (lxxxix) X77794 H. sapiens mRNAfor cyclin G1, (xc) M90656 Human gamma-glutamylcysteine synthetase (GCS)mRNA, complete cds, (xci) M13929 Human c-myc-P64 mRNA, initiating frompromoter P0, (HLmyc2.5) partial cds, (xcii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (xciii) X80692 H. sapiens ERK3 mRNA,and (xciv) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114; and (c)the third response is further limited to nucleic acid molecules at least90% identical to the polynucleotides of the group consisting of: (i)M20030 Human small proline rich protein (sprII) mRNA, clone 930, (ii)X53065, (iii) M13903 Human involucrin gene, exon 2, (iv) M22918 Myosin,Light Chain, Alkali, Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice,(v) L10343 Huma elafin gene, complete cds, (vi) M63573 Human secretedcyclophilin-like protein (SCYLP) mRNA, complete cds, (vii) M21302 Humansmall proline rich protein (sprII) mRNA, clone 174N, (viii) Y00787 HumanmRNA for MDNCF (monocyte-derived neutrophil chemotactic factor), (ix)X57985 H.sapiens genes for histones H2B.1 and H2A, (x) L05188 Homosapiens small proline-rich protein 2 (SPRR2B) gene, complete cds, (xi)X70326 Macmarcks, (xii) X67325 H.sapiens p27 mRNA, (xiii) L19779 Homosapiens histone H2A.2 mRNA, complete cds, (xiv) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, (xv) D45248 Human mRNA for proteasome activator hPA28subunit beta, complete cds, (xvi) Z22548 H.sapiens thiol-specificantioxidant protein mRNA, (xvii) M22918 Myosin, Light Chain, Alkali,Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice, (xviii) X06956Tubulin, Alpha 1, Isoform 44, (xix) V00594 Human mRNA formetallothionein from cadmium-treated cells, (xx) M80254 H.sapienscyclophilin isoform (hCyP3) mRNA, complete cds, (xxi) U04636 Humancyclooxygenase-2 (hCox-2) gene, complete cds, (xxii) Z14244 H.sapienscoxVIIb mRNA for cytochrome c oxidase subunit VIIb, (xxiii) X99920H.sapiens mRNA for S100 calcium-binding protein A13, (xxiv) U62800 Humancystatin M (CST6) mRNA, complete cds, (xxv) L08069 Human heat shockprotein, E. coli DnaJ homologue mRNA, complete cds, (xxvi) L20688 HumanGDP-dissociation inhibitor protein (Ly-GDI) mRNA, complete cds, (xxvii)M13755 Human interferon-induced 17-kDa/15-kDa protein mRNA, completecds, (xxviii) M60278 Human heparin-binding EGF-like growth factor mRNA,complete cds, (xxix) AF001294 Homo sapiens IPL (IPL) mRNA, complete cds,(xxx) X54489 Human gene for melanoma growth stimulatory activity (MGSA),(xxxi) M21186 Human neutrophil cytochrome b light chain p22 phagocyteb-cytochrome mRNA, compl, (xxxii) D42040 Human mRNA for KIAA9001 gene,complete cds, (xxxiii) V00599 Tubulin, Beta, (xxxiv) U37690 Human RNApolymerase II subunit (hsRPB10) mRNA, complete cds, (xxxv) M21005 Humanmigration inhibitory factor-related protein 8 (MRP8) gene, complete cds,(xxxvi) M37583 Human histone (H2A.Z) mRNA, complete cds, (xxxvii) Z49989H.sapiens mRNA for smoothelin, (xxxviii) L24564 Human Rad mRNA, completecds, (xxxix) D49824 Human HLA-B null allele mRNA, (xl) M59465 Humantumor necrosis factor alpha inducible protein A20 nRNA, complete cds,(xli) S54005 thymosin beta-10 [human, metastatic melanoma cell line,mRNA, 453 nt], (xlii) Z49254 H.sapiens L23-related mRNA, (xliii) M22919Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629), Smooth Muscle,Alt. Spli, (xliv) U70660 Human copper transport protein HAH1 (HAH1)mRNA, complete cds, (xlv) AF006084 Homo sapiens Arp⅔ protein complexsubunit p41-Arc (ARC41) mRNA, complete cds, (xlvi) X62083 H.sapiens mRNAfor Drosophila female sterile homeotic (FSH) homologue, (xlvii) D86974Human mRNA for KIAA0220 gene, partial cds, (xlviii) M72885 Human GOS2gene, 5′ flank and cds, (xlix) S80437 fatty acid synthase {3′ region}[human, breast and HepG2 cells, mRNA Partial, 22, (l) X04654 Human mRNAfor U1 RNA-associated 70K protein, (li) t M26311 Human cystic fibrosisantigen mRNA, complete cds, (lii) X14850 Human H2A.X mRNA encodinghistone H2A.X, (liii) M14328 Human alpha enolase mRNA, complete cds,(liv) U07919 Human aldehyde dehydrogenase 6 mRNA, complete cds, (lv)M28130 Human interleukin 8 (IL8) gene, complete cds, (lvi) Z21507H.sapiens EF-1delta gene encoding human elongation factor-1-delta,(ivii) M92934 Human connective tissue growth factor, complete cds,(lviii) M27436 Human tissue factor gene, complete cds, with a Alurepetitive sequence in the 3′, (lix) X74874 H. sapiens gene for RNA polII largest subunit, exon 1, (lx) X57351 Human 1-8D gene frominterferon-inducible gene family, (lxi) X52979 Human gene for smallnuclear ribonucleoproteins SmB and SmB′, (lxii) U41515 Human deleted insplit hand/split foot 1 (DSS 1) mRNA, complete cds, (lxiii) D28235 HumanPTGS2 gene for prostaglandin endoperoxide synthase-2, complete cds,(lxiv) Y00503 Human mRNA for keratin
 19. (lxv) M57731 Human gro-betamRNA, complete cds, (lxvi) D50840 Homo sapiens mRNA for ceramideglucosyltransferase, complete cds, (lxvii) U52101 Human YMP mRNA,complete cds. (lxviii) D13413 Human mRNA for tumor-associated 120 kDanuclear protein p120, partial cds(carbox, (lxix) L42379 Homo sapiensbone-derived growth factor (BPGF-1) mRNA, complete cds, (lxx) X52426 H.sapiens mRNA for cytokeratin 13, (lxxi) J04456 Human 14 kd lectin mRNA,complete cds, (lxxii) S78771 NAT=CpG island-associated gene [human,mRNA, 1741 nt], (lxxiii) M26730 Human mitochondrial ubiquinone-bindingprotein (QP) gene, exon 4, (lxxiv) U26727 Human p16INK4/MTS1 mRNA,complete cds, (lxxv) X92896 H.sapiens mRNA for ITBA2 protein, (lxxvi)Z69043 H.sapiens mRNA translocon-associated protein delta subunitprecursor, (lxxvii) L76568 Homo sapiens excision and cross link repairprotein (ERCC4) gene, complete genom, (lxxviii) M12125 Human fibroblastmuscle-type tropomyosin mRNA, complete cds, (lxxix) U09937 Humanurokinase-type plasminogen receptor, exon 7, (lxxx) X15822 Human COXVIIa-L mRNA for liver-specific cytochrome c oxidase (EC 1.9.3.1.),(lxxxi) M34516 Human omega light chain protein 14.1 (Ig lambda chainrelated) gene, exon 3, (lxxxii) U53830 Homo sapiens interferonregulatory factor 7A mRNA, complete cds, (lxxxiii) X82693 H.sapiens mRNAfor E48 antigen, (lxxxiv) M58026 Human NB-1 mRNA, complete cds, (lxxxv)M90657 Human tumor antigen (L6) mRNA, complete cds, (lxxxvi) X57579H.sapiens activin beta-A subunit (exon 2), (lxxxvii) D38251 Human mRNAfor RPB5 (XAP4), complete cds, (lxxxviii) D89667 Homo sapiens mRNA forc-myc binding protein, complete cds, (lxxxix) AB000584 Homo sapiens mRNAfor TGF-beta superfamily protein, complete cds, (xc) L76200 Humanguanylate kinase (GUK1) mRNA, complete cds, (xci) J04794 Human aldehydereductase mRNA, complete cds, (xcii) X52882 Human t-complex polypeptide1 gene, (xciii) M79463 Human PML-2 mRNA, complete CDS, (xciv) Y09022H.sapiens mRNA for Not56-like protein, (xcv) M12529 Human apolipoproteinE mRNA, complete cds, (xcvi) X71129 H.sapiens mRNA for electron transferflavoprotein beta subunit, (xcvii) X83416 H.sapiens PrP gene, exon 2,(xcviii) D89052 Homo sapiens mRNA for proton-ATPase-like protein,complete cds, (xcix) M60974 Human growth arrest and DNA-damage-inducibleprotein (gadd45) mRNA, complete cds, c) M16364 Human creatine kinase-BmRNA, complete cds, (ci) D38305 Human mRNA for Tob, complete cds, (cii)X87679 Major Histocompatibility Complex, Class I, E (Gb:M21533), (ciii)Z29505 H.sapiens mRNA for nucleic acid binding protein sub2.3, (civ)K02574, (cv) U09813 Human mitochondrial ATP synthase subunit 9, P3 genecopy, mRNA, nuclear gene enc, (cvi) X67951 H.sapiens mRNA forproliferation-associated gene (pag), (cvii) J04611 Human lupus p70 (Ku)autoantigen protein mRNA, complete cds, (cviii) U09578 Homo sapiensMAPKAP kinase (3 pK) mRNA, complete cds, (cix) X53800 Human mRNA formacrophage inflammatory protein-2beta (MIP2beta), (cx) V00599 Tubulin,Beta 2, (cxi) U69126 Human FUSE binding protein 2 (FBP2) mRNA, partialcds, (cxii) X53416 Human mRNA for actin-binding protein (filamin)(ABP-280), (cxiii) U90546 Human butyrophilin (BTF4) mRNA, complete cds,(cxiv) M58459 Human ribosomal protein (RPS4Y) isoform mRNA, completecds, (cxv) M19961 Human cytochrome c oxidase subunit Vb (coxVb) mRNA,complete cds, (cxvi) U65579 Human mitochondrial NADHdehydrogenase-ubiquinone Fe-S protein 8, 23 kDa subunit, (cxvii) X77794H.sapiens mRNA for cyclin G1, (cxviii) M29064 Human hnRNP B1 proteinmRNA, (cxix) D21853 Human mRNA for KIAA0111 gene, complete cds, (cxx)X78687 H.sapiens G9 gene encoding sialidase, (cxxi) X15729 Human mRNAfor nuclear p68 protein, (cxxii) X04828 Human mRNA for G(i) proteinalpha-subunit (adenylate cyclase inhibiting GTP-bind, (cxxiii) L27943Homo sapiens cytidine dearninase (CDA) mRNA, complete cds, (cxxiv)L40391 Homo sapiens (clone s153) mRNA fragment, (cxxv) D42123 Homosapiens mRNA for ESP1/CRP2, complete cds, (cxxvi) X74104 H.sapiens mRNAfor TRAP beta subunit, (cxxvii) M84332 Human ADP-ribosylation factor 1gene, exons 2-5, (cxxviii) L37127 Homo sapiens RNA polymerase II mRNA,complete cds, (cxxix) M92843 H.sapiens zinc finger transcriptionalregulator mRNA, complete cds, (cxxx) U07664 Human HB9 homeobox gene,exons 2 and 3 and complete cds, (cxxxi) L48546 Homo sapiens tuberin(TSC2) gene, exons 38, 39, 40 and 41, (cxxxii) X53586 Human mRNA forintegrin alpha6, (cxxxiii) t D21852 Human mRNA for KIAA0029 gene,partial cds, (cxxxiv) L11066 Human mRNA sequence, (cxxxv) J04444 Humancytochrome c-1 gene, complete cds, (cxxxvi) M95787 Human 22 kDa smoothmuscle protein (SM22) mRNA, complete cds, (cxxxvii) L07517 Mucin 6,Gastric (Gb:L07517), (cxxxviii) X91247 H.sapiens mRNA for thioredoxinreductase, (cxxxix) L11672 Human Kruppel related zinc finger protein(HTF10) mRNA, complete cds, (cxl) U30999 Human (memc) mRNA, 3′UTR,(cxli) U01337 Human Ser/Thr protein kinase (A-RAF-1) gene, complete cds,(cxlii) U28480 Uncoupling Protein Ucp, (cxliii) X12794 Human v-erbArelated ear-2 gene, (cxliv) L22005 Human ubiquitin conjugating enzymemRNA, partial cds, (cxlv) M12886 Human T-cell receptor active beta-chainmRNA, complete cds, (cxlvi) Y08915 H.sapiens mRNA for alpha 4 protein,(cxlvii) M24547 Amyloid Beta (A4) Precursor Protein, Alt. Splice 2,A4(751), (cxlviii) X76717 H.sapiens MT-1l mRNA, (cxlix) M64347 Humannovel growth factor receptor mRNA, 3′ cds, (cl) X05409 Human RNA formitochondrial aldehyde dehydrogenase I ALDH I (EC 1.2.1.3), (cli) D87469Human mRNA for KIAA0279 gene, partial cds, (clii) M58603 Human nuclearfactor kappa-B DNA binding subunit (NF-kappa-B) mRNA, complete cds,(cliii) M76482 Human 130-kD pemphigus vulgaris antigen mRNA, completecds, (cliv) X06323 Human MRL3 mRNA for ribosomal protein L3 homologue (MRL3=mammalian ribosome L, (clv) X78992 H.sapiens ERF-2 mRNA, (clvi)L41351 Homo sapiens prostasin mRNA, complete cds, (clvii) X75342H.sapiens SHB mRNA, (clviii) U83115 Human non-lens beta gamma-crystallinlike protein (AIM1) mRNA, partial cds, (clix) U88629 Human RNApolymerase II elongation factor ELL2, complete cds, (clx) S78825 Id1,(clxi) U28811 Human cysteine-rich fibroblast growth factor receptor(CFR- 1) mRNA, complete cds, (clxii) M58286 Homo sapiens tumor necrosisfactor receptor mRNA, complete cds, (clxiii) D78129 Homo sapiens mRNAfor squalene epoxidase, partial cds, (clxiv) D14874 Homo sapiens mRNAfor adrenomedullin precursor, complete cds, (clxv) Z26317 H.sapiens mRNAfor desmoglein 2, (clxvi) L19267 Homo sapiens 59 protein mRNA, 3′ end,(clxvii) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114, (clxviii)U33821 Human tax1-binding protein TXBP151 mRNA, complete cds, (clxix)U52100 Human XMP mRNA, complete cds, (clxx) L31801 Homo sapiensmonocarboxylate transporter 1 (SLC16A1) mRNA, complete cds, (clxxi)L00058 Human (GH) geriline c-myc proto-oncogene, exon 3 and 3′ flank,(clxxii) U52426 Homo sapiens GOK (STIM1) mRNA, complete cds, (clxxiii)M80244 Human E16 mRNA, complete cds, (clxxiv) U56418 Humanlysophosphatidic acid acyltransferase-beta mRNA, complete cds, (clxxv)L38490 Homo sapiens ADP-ribosylation factor mRNA, complete cds, (clxxvi)U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (clxxvii) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (clxxviii) M38258 Human retinoic acid receptor gamma 1mRNA, complete cds, (clxxix) X89750 H.sapiens mRNA for TGIF protein,(clxxx) D85429 Homo sapiens gene for heat shock protein 40, completecds, (clxxxi) J05211 Desmoplakin I, (clxxxii) M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds, (clxxxiii) X80695 H.sapiens OXA1HsmRNA, (clxxxiv) M54915 Human h-pim-1 protein (h-pim-1) mRNA, completecds, (clxxxv) D83777 Human mRNA for KIAA0193 gene, complete cds,(clxxxvi) D31883 Human mRNA for KIAA0059 gene, complete cds, (clxxxvii)U00968 Human SREBP-1 mRNA, complete cds, (clxxxviii) K03195 Human(HepG2) glucose transporter gene mRNA, complete cds, (clxxxix) D86965Human mRNA for KIAA0210 gene, complete cds, (cxc) Z30643 H.sapiens mRNAfor chloride channel (putative) 2139 bp, (cxci) D14520 Human mRNA forGC-Box binding protein BTEB2, complete cds, (cxcii) D87462 Human mRNAfor KIAA0272 gene, partial cds, (cxciii) X80692 H.sapiens ERK3 mRNA,(cxciv) X90858 H.sapiens mRNA for uridine phosphorylase, (cxcv) M57763Human ADP-ribosylation factor (hARF6) mRNA, complete cds, (cxcvi) X92720H.sapiens mRNA for phosphoenolpyruvate carboxykinase, (cxcvii) M81601Human transcription elongation factor (SII) mRNA, complete cds,(cxcviii) X52611 Human mRNA for transcription factor AP-2, (cxcix)U09587 Human glycyl-tRNA synthetase mRNA, complete cds, (cc) U14550Human sialyltransferase SThM (sthm) mRNA, complete cds, (cci) D90209Human mRNA for DNA binding protein TAXREB67, (ccii) X77366 H.sapiensHBZ17 mRNA, (cciii) X76534 H.sapiens NMB mRNA, (cciv) U37519 Humanaldehyde dehydrogenase (ALDH8) mRNA, complete cds, (ccv) M83667 HumanNF-IL6-beta protein mRNA, complete cds, (ccvi) U53347 Human neutralamino acid transporter B mRNA, complete cds, (ccvii) L09229 Humanlong-chain acyl-coenzyme A synthetase (FACL1) mRNA, complete cds,(ccviii) S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, (ccix) M13929 Human c-myc-P64 mRNA,initiating from promoter P0, (HLmyc2.5) partial cds, (ccx) M55268 Humancasein kinase II alpha′ subunit mRNA, complete cds, (ccxi) M77836 Humanpyrroline 5-carboxylate reductase mRNA, complete cds, (ccxii)HG2724-HT2820_at S75762 Oncogene Tls/Chop, Fusion Activated, (ccxiii)U72066 Homo sapiens CtBP interacting protein CtIP (CtIP) mRNA, completecds, (ccxiv) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (ccxv) M27396 Human asparaginesynthetase mRNA, complete cds, (ccxvi) X01630 Human mRNA forargininosuccinate synthetase, (ccxvii) D32050 Human mRNA for alanyl-tRNAsynthetase, complete cds, (ccxviii) M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, (ccxix) J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,and (ccxx) X69111 H.sapiens HLH 1R21 mRNA for helix-loop-helix protein.104. A screening method for the detection of a compound that simulatesthe response of a cell to ultraviolet radiation exposure comprising: (a)contacting the cell with the compound; (b) measuring a level of at leastone protein in the contacted cell; (c) determining whether the level ofat least one protein is substantially similar to the level found in thecell in response to exposure of ultraviolet radiation, wherein theresponse of the cell to ultraviolet radiation exposure is characterizedby altered expression of the following: (i) a first response comprisingthe altered pattern of expression of at least one protein selected fromthe group consisting of a transcription factor protein, a signaltransduction protein, and a mitochondrial protein; (ii) a secondresponse comprising the altered pattern of expression of at least oneprotein selected from the group consisting of a secreted growth factorprotein, a cytokine protein, and a chemokine protein; and (iii) a thirdresponse comprising the altered pattern of expression of at least oneprotein selected from the group consisting of an actin binding protein,a desmosomal protein, and a tubulin protein, and wherein a determinationthat the level of at least one protein molecule is substantially similarto the altered expression found in the first response, the secondresponse or the third response indicates that the compound simulates theresponse of the cell to ultraviolet radiation exposure.
 105. The methodaccording to claim 104, wherein: (a) the first response is furtherlimited to proteins at least 90%identical to the proteins encoded by thepolynucleotides of the group consisting of: (i) M62831 Humantranscription factor ETR101 mRNA, complete cds, (ii) X68277 H. sapiensCL 100 mRNA for protein tyrosine phosphatase, (iii) L04731 H. sapienstranslocation T(4:11) of ALL-1 gene to chromosome 4, (iv) X56681 HumanjunD mRNA, (v) U20734 Human transcription factor junB (junB) gene, 5′region and complete cds, (vi) L38951 H. sapiens importin beta subunitmRNA, complete cds, (vii) D87071 Human mRNA for KIAA0233 gene, completecds, (viii) M72885 Human GOS2 gene, 5′ flank and cds, (ix) M92843 H.sapiens zinc finger transcriptional regulator mRNA, complete cds, (x)S81914 IEX-1=radiation-inducible immediate-early gene [human, placenta,mRNA Partial, (xi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (xii)D86988 Human mRNA for KIAA0221 gene, complete cds, (xiii) L19779 H.sapiens histone H2A.2 mRNA, complete cds, (xiv) U62317 Chromosome 22q13BAC Clone CIT987SK-384D8 complete sequence, (xv) X04412 Human mRNA forplasma gelsolin, (xvi) L27706 Human chaperonin protein Tcp20) genecomplete cds, (xvii) X61123 Human BTG1 mRNA, (xviii) M60974growth arrestand DNA-damage-inducible protein (gadd45) mRNA, complete cds, (xix)L19437 Human transaldolase mRNA containing transposable element,complete cds, (xx) X57985 H. sapiens genes for histones H2B.1 and H2A,(xxi) D90086 Human pyruvate dehydrogenase (EC 1.2.4.1) beta subunitgene, exons 1-10, (xxii) M34182 Human testis-specific protein kinasegamma-subunit mRNA, complete cds, (xxiii) L16862 H. sapiens Gprotein-coupled receptor kinase (GRK6) mRNA, complete cds, (xxiv) D13705Human mRNA for fatty acids omega-hydroxylase (cytochrome P-450HKV),complete cd, (xxv) U37122 Human adducin gamma subunit mRNA, completecds, (xxvi) D45906 H. sapiens mRNA for LIMK-2, complete cds, (xxvii)U07664 Human HB9 homeobox gene, exons 2 and 3 and complete cds, (xxviii)D87438 Human mRNA for KIAA0251 gene, partial cds, (xxix) L37042 H.sapiens casein kinase I alpha isoform (CSNK1A1) mRNA, complete cds,(xxx) D14043 Human mRNA for MGC-24, complete cds, (xxxi) D13988 Humanrab GDI mRNA, complete cds, (xxxii) U28480 Uncoupling Protein Uc,(xxxiii) D50840 H. sapiens mRNA for ceramide glucosyltransferase,complete cds, (xxxiv) M55265 Human casein kinase II alpha subunit mRNA,complete cds, (xxxv) M96803 Human general beta-spectrin (SPTBN1) mRNA,complete cds, (xxxvi) U89336 Human HLA class III region containingNOTCH4 gene, partial sequence, homeobox P, (xxxvii) D87442 Human mRNAfor KIAA0253 gene, partial cds, (xxxviii) J03161 Human serum responsefactor (SRF) mRNA, complete cds, (xxxix) D86965 Human mRNA for KIAA0210gene, complete cds, (xl) U17327 Human neuronal nitric oxide synthase(NOS1) mRNA, complete cds, (xli) D86966 Human mRNA for KIAA0211 gene,complete cds, (xlii) D85527 H. sapiens mRNA for LIM domain, partial cds,(xliii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (xliv) X59434 Human rohu mRNA forrhodanese, (xlv) M13929 Human c-myc-P64 mRNA, initiating from promoterP0, (HLmyc2.5) partial cds, and (xlvi) J05211 Desmoplaki. (b) the secondresponse is further limited to proteins at least 90% identical to theproteins encoded by the polynucleotides of the group consisting of: (i)M57731 Human gro-beta mRNA, complete cds, (ii) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, (iii) Y00787 Human mRNA for MDNCF (monocyte-derivedneutrophil chemotactic factor), (iv) X54489 Human gene for melanomagrowth stimulatory activity (MGSA), (v) M72885 Human GOS2 gene, 5′ flankand cds, (vi) M62831 Human transcription factor ETR101 mRNA, completecds, (vii) M28130 Human interleukin 8 (IL8) gene, complete cds, (viii)X57985 H. sapiens genes for histones H2B.1 and H2A, (ix) X53800 HumanmRNA for macrophage inflammatory protein-2beta (MIP2beta), (x) L19779 H.sapiens histone H2A.2 mRNA, complete cds, (xi) AF001294 H. sapiens IPL(IPL) mRNA, complete cds, (xii) X56681 Human junD mRNA, (xiii) S75762Oncogene Tls/Chop, Fusion Activate, (xiv) M84739 Human autoantigencalreticulin mRNA, complete cds, (xv) M21302 Human small proline richprotein (sprlI) mRNA, clone 174N, (xvi) V00599 Tubulin, Bet, (xvii)X70326 Macmarck, (xviii) D10923 Human mRNA for HM74, (xix) D64142 HumanmRNA for histone H1x, complete cds, (xx) D86974 Human mRNA for KIAA0220gene, partial cds, (xxi) M60974 Human growth arrest andDNA-damage-inducible protein (gadd45) mRNA, complete cds, (xxii) X68277H. sapiens CL 100 mRNA for protein tyrosine phosphatase, (xxiii) L13391Human helix-loop-helix basic phosphoprotein (GOS8) gene, complete cds,(xxiv) M31627 Human X box binding protein-1 (XBP-1) mRNA, complete cds,(xxv) U40369 Human spermidine/spermine N1-acetyltransferase (SSAT) gene,complete cds, (xxvi) X52560 Nuclear Factor Nf-I1, (xxvii) X61123 HumanBTG1 mRNA, (xxviii) U20734 Human transcription factor junB (junB) gene,5′ region and complete cds, (xxix) U35048 Human TSC-22 protein mRNA,complete cds, (xxx) M69043 H. sapiens MAD-3 mRNA encoding IkB-likeactivity, complete cds, (xxxi) X51345 Human jun-B mRNA for JUN-Bprotein, (xxxii) S68616 Na+/H+ exchanger NHE-1 isoform [human, heart,mRNA, 4516 nt], (xxxiii) X89750 H. sapiens mRNA for TGIF protein,(xxxiv) X69111 H. sapiens HLH 1R21 mRNA for helix-loop-helix protein,(xxxv) U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (xxxvi) X52541 Human mRNA for early growth response protein 1(hEGR1), (xxxvii) D50683 H. sapiens mRNA for TGF-betaIIR alpha, completecds, (xxxviii) M92843 H. sapiens zinc finger transcriptional regulatormRNA, complete cds, (xxxix) X91247 H. sapiens mRNA for thioredoxinreductase, (xl) U05875 Human clone pSK1 interferon gamma receptoraccessory factor-1 (AF-1) mRNA, comp, (xli) L19314 Human HRY gene,complete cds, (xlii) M30703 Human amphiregulin (AR) gene, exon 6, cloneslambda-ARH(6,12), (xliii) U34252 Human gamma-aminobutyraldehydedehydrogenase mRNA, complete cds, (xliv) S78825 Id1, (xlv) D85429 H.sapiens gene for heat shock protein 40, complete cds, (xlvi) U41766Human metalloprotease/disintegrin/cysteine-rich protein precursor (MDC9)mRNA, (xlvii) U89336 Human HLA class III region containing NOTCH4 gene,partial sequence, homeobox PB, (xlviii) M69181 Human nonmuscle myosinheavy chain-B (MYH10) mRNA, partial cds, (xlix) D15050 Human mRNA fortranscription factor AREB6, complete cds, (l) U28386 Human nuclearlocalization sequence receptor hSRP1alpha mRNA, complete cds, (li)L77886 Human protein tyrosine phosphatase mRNA, complete cds, (lii)X64330 H. sapiens mRNA for ATP-citrate lyase, (liii) U37122 Humanadducin gamma subunit mRNA, complete cds, (liv) X74008 H. sapiens mRNAfor protein phosphatase 1 gamma, (lv) U60205 Human methyl sterol oxidase(ERG25) mRNA, complete cds, (lvi) X76534 H. sapiens NMB mRNA, (lvii)D87071 Human mRNA for KIAA0233 gene, complete cds, (lviii) U90716 Humancell surface protein HCAR mRNA, complete cds, (lix) M91083 HumanDNA-binding protein (HRC1) mRNA, complete cds, (lx) U29607 Humanmethionine aminopeptidase mRNA, complete cds, (lxi) M76482 Human 130-kDpemphigus vulgaris antigen mRNA, complete cds, (lxii) U72066 H. sapiensCtBP interacting protein CtIP (CtIP) mRNA, complete cds, (lxiii) K03195Human (HepG2) glucose transporter gene mRNA, complete cds, (lxiv) X12953Human rab2 mRNA, YPT1-related and member of ras family, (lxv) M60483Human protein phosphatase 2A catalytic subunit-alpha gene, complete cds,(lxvi) U72649 Human BTG2 (BTG2) mRNA, complete cds, (lxvii) D14520 HumanmRNA for GC-Box binding protein BTEB2, complete cds, (lxviii) L08069Human heat shock protein, E. coli DnaJ homologue mRNA, complete cds,(lxix) D50840 H. sapiens mRNA for ceramide glucosyltransferase, completecds, (lxx) L31801 H. sapiens monocarboxylate transporter 1 (SLC16A1)mRNA, complete cds, (lxxi) S74017 Nrf2=NF−E2-like basic leucine zippertranscriptional activator [human, hemin-in, (lxxii) X87241 H. sapiensmRNA for hFat protein, (lxxiii) X52425 Human IL-4-R mRNA for theinterleukin 4 receptor, (lxxiv) D79994 Human mRNA for KIAA0172 gene,partial cds, (lxxv) M58286 H. sapiens tumor necrosis factor receptormRNA, complete cds, (lxxvi) M13829 Human putative raf related protein(pks/a-raf) mRNA, partial cds, (lxxvii) X78992 H. sapiens ERF-2 mRNA,(lxxviii) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (lxxix) U88629 Human RNA polymeraseII elongation factor ELL2, complete cds, (lxxx) X52611 Human mRNA fortranscription factor AP-2, (lxxxi) U28749 Human high-mobility groupphosphoprotein isoform I-C (HMGIC) mRNA, complete cds, (lxxxii) L00058Human (GH) germline c-myc proto-oncogene, exon 3 and 3′ flank, (lxxxiii)L26336 Heat Shock Protein, 70 Kda (Gb:Y00371, (lxxxiv) L08246 Humanmyeloid cell differentiation protein (MCL1) mRNA, (lxxxv) S73591brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic,leukemia cells (lxxxvi) J05211 Desmoplakin, (lxxxvii)L00352 Human low density lipoprotein receptor gene, exon 18, (lxxxviii)Y13647 Stearoyl-Coenzymea Desaturase, (lxxxix) X77794 H. sapiens mRNAfor cyclin G1, (xc) M90656 Human gamma-glutamylcysteine synthetase (GCS)mRNA, complete cds, (xci) M13929 Human c-myc-P64 mRNA, initiating frompromoter P0, (HLmyc2.5) partial cds, (xcii) D78129 H. sapiens mRNA forsqualene epoxidase, partial cds, (xciii) X80692 H. sapiens ERK3 mRNA,and (xciv) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114; and (c)the third response is further limited to proteins at least 90%identicalto the proteins encoded by the polynucleotides of the group consistingof: (i) M20030 Human small proline rich protein (sprII) mRNA, clone 930,(ii) X53065, (iii) M13903 Human involucrin gene, exon 2, (iv) M22918Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629), Non-Muscle, Alt.Splice, (v) L10343 Huma elafin gene, complete cds, (vi) M63573 Humansecreted cyclophilin-like protein (SCYLP) mRNA, complete cds, (vii)M21302 Human small proline rich protein (sprII) mRNA, clone 174N, (viii)Y00787 Human mRNA for MDNCF (monocyte-derived neutrophil chemotacticfactor), (ix) X57985 H.sapiens genes for histones H2B.1 and H2A, (x)L05188 Homo sapiens small proline-rich protein 2 (SPRR2B) gene, completecds, (xi) X70326 Macmarcks, (xii) X67325 H.sapiens p27 mRNA, (xiii)L19779 Homo sapiens histone H2A.2 mRNA, complete cds, (xiv) S81914IEX-1=radiation-inducible immediate-early gene [human, placenta, mRNAPartial, 1, (xv) D45248 Human mRNA for proteasome activator hPA28subunit beta, complete cds, (xvi) Z22548 H.sapiens thiol-specificantioxidant protein mRNA, (xvii) M22918 Myosin, Light Chain, Alkali,Smooth Muscle (Gb:U02629), Non-Muscle, Alt. Splice, (xviii) X06956Tubulin, Alpha 1, Isoform 44, (xix) V00594 Human mRNA formetallothionein from cadmium-treated cells, (xx) M80254 H.sapienscyclophilin isoform (hCyP3) mRNA, complete cds, (xxi) U04636 Humancyclooxygenase-2 (hCox-2) gene, complete cds, (xxii) Z14244 H.sapienscoxVIIb mRNA for cytochrome c oxidase subunit VIIb, (xxiii) X99920H.sapiens mRNA for S100 calcium-binding protein A13, (xxiv) U62800 Humancystatin M (CST6) mRNA, complete cds, (xxv) L08069 Human heat shockprotein, E. coli DnaJ homologue mRNA, complete cds, (xxvi) L20688 HumanGDP-dissociation inhibitor protein (Ly-GDI) mRNA, complete cds, (xxvii)M13755 Human interferon-induced 17-kDa/15-kDa protein mRNA, completecds, (xxviii) M60278 Human heparin-binding EGF-like growth factor mRNA,complete cds, (xxix) AF001294 Homo sapiens IPL (IPL) mRNA, complete cds,(xxx) X54489 Human gene for melanoma growth stimulatory activity (MGSA),(xxxi) M21186 Human neutrophil cytochrome b light chain p22 phagocyteb-cytochrome mRNA, compl, (xxxii) D42040 Human mRNA for KIAA9001 gene,complete cds, (xxxiii) V00599 Tubulin, Beta, (xxxiv) U37690 Human RNApolymerase II subunit (hsRPB10) mRNA, complete cds, (xxxv) M21005 Humanmigration inhibitory factor-related protein 8 (MRP8) gene, complete cds,(xxxvi) M37583 Human histone (H2A.Z) mRNA, complete cds, (xxxvii) Z49989H.sapiens mRNA for smoothelin, (xxxviii) L24564 Human Rad mRNA, completecds, (xxxix) D49824 Human HLA-B null allele mRNA, (xl) M59465 Humantumor necrosis factor alpha inducible protein A20 nRNA, complete cds,(xli) S54005 thymosin beta-10 [human, metastatic melanoma cell line,mRNA, 453 nt], (xlii) Z49254 H.sapiens L23-related mRNA, (xliii) M22919Myosin, Light Chain, Alkali, Smooth Muscle (Gb:U02629), Smooth Muscle,Alt. Spli, (xliv) U70660 Human copper transport protein HAH1 (HAH1)mRNA, complete cds, (xlv) AF006084 Homo sapiens Arp⅔ protein complexsubunit p41-Arc (ARC41) mRNA, complete cds, (xlvi) X62083 H.sapiens mRNAfor Drosophila female sterile homeotic (FSH) homologue, (xlvii) D86974Human mRNA for KIAA0220 gene, partial cds, (xlviii) M72885 Human GOS2gene, 5′ flank and cds, (xlix) S80437 fatty acid synthase {3′ region}[human, breast and HepG2 cells, mRNA Partial, 22, (l) X04654 Human mRNAfor U1 RNA-associated 70K protein, (li) t M26311 Human cystic fibrosisantigen mRNA, complete cds, (lii) X14850 Human H2A.X mRNA encodinghistone H2A.X, (liii) M14328 Human alpha enolase mRNA, complete cds,(liv) U07919 Human aldehyde dehydrogenase 6 mRNA, complete cds, (lv)M28130 Human interleukin 8 (IL8) gene, complete cds, (lvi) Z21507H.sapiens EF-1delta gene encoding human elongation factor-1-delta,(ivii) M92934 Human connective tissue growth factor, complete cds,(lviii) M27436 Human tissue factor gene, complete cds, with a Alurepetitive sequence in the 3′, (lix) X74874 H. sapiens gene for RNA polII largest subunit, exon 1, (lx) X57351 Human 1-8D gene frominterferon-inducible gene family, (lxi) X52979 Human gene for smallnuclear ribonucleoproteins SmB and SmB′, (lxii) U41515 Human deleted insplit hand/split foot 1 (DSS 1) mRNA, complete cds, (lxiii) D28235 HumanPTGS2 gene for prostaglandin endoperoxide synthase-2, complete cds,(lxiv) Y00503 Human mRNA for keratin
 19. (lxv) M57731 Human gro-betamRNA, complete cds, (lxvi) D50840 Homo sapiens mRNA for ceramideglucosyltransferase, complete cds, (lxvii) U52101 Human YMP mRNA,complete cds. (lxviii) D13413 Human mRNA for tumor-associated 120 kDanuclear protein p120, partial cds(carbox, (lxix) L42379 Homo sapiensbone-derived growth factor (BPGF-1) mRNA, complete cds, (lxx) X52426 H.sapiens mRNA for cytokeratin 13, (lxxi) J04456 Human 14 kd lectin mRNA,complete cds, (lxxii) S78771 NAT=CpG island-associated gene [human,mRNA, 1741 nt], (lxxiii) M26730 Human mitochondrial ubiquinone-bindingprotein (QP) gene, exon 4, (lxxiv) U26727 Human p16INK4/MTS1 mRNA,complete cds, (lxxv) X92896 H.sapiens mRNA for ITBA2 protein, (lxxvi)Z69043 H.sapiens mRNA translocon-associated protein delta subunitprecursor, (lxxvii) L76568 Homo sapiens excision and cross link repairprotein (ERCC4) gene, complete genom, (lxxviii) M12125 Human fibroblastmuscle-type tropomyosin mRNA, complete cds, (lxxix) U09937 Humanurokinase-type plasminogen receptor, exon 7, (lxxx) X15822 Human COXVIIa-L mRNA for liver-specific cytochrome c oxidase (EC 1.9.3.1.),(lxxxi) M34516 Human omega light chain protein 14.1 (Ig lambda chainrelated) gene, exon 3, (lxxxii) U53830 Homo sapiens interferonregulatory factor 7A mRNA, complete cds, (lxxxiii) X82693 H.sapiens mRNAfor E48 antigen, (lxxxiv) M58026 Human NB-1 mRNA, complete cds, (lxxxv)M90657 Human tumor antigen (L6) mRNA, complete cds, (lxxxvi) X57579H.sapiens activin beta-A subunit (exon 2), (lxxxvii) D38251 Human mRNAfor RPB5 (XAP4), complete cds, (lxxxviii) D89667 Homo sapiens mRNA forc-myc binding protein, complete cds, (lxxxix) AB000584 Homo sapiens mRNAfor TGF-beta superfamily protein, complete cds, (xc) L76200 Humanguanylate kinase (GUK1) mRNA, complete cds, (xci) J04794 Human aldehydereductase mRNA, complete cds, (xcii) X52882 Human t-complex polypeptide1 gene, (xciii) M79463 Human PML-2 mRNA, complete CDS, (xciv) Y09022H.sapiens mRNA for Not56-like protein, (xcv) M12529 Human apolipoproteinE mRNA, complete cds, (xcvi) X71129 H.sapiens mRNA for electron transferflavoprotein beta subunit, (xcvii) X83416 H.sapiens PrP gene, exon 2,(xcviii) D89052 Homo sapiens mRNA for proton-ATPase-like protein,complete cds, (xcix) M60974 Human growth arrest and DNA-damage-inducibleprotein (gadd45) mRNA, complete cds, c) M16364 Human creatine kinase-BmRNA, complete cds, (ci) D38305 Human mRNA for Tob, complete cds, (cii)X87679 Major Histocompatibility Complex, Class I, E (Gb:M21533), (ciii)Z29505 H.sapiens mRNA for nucleic acid binding protein sub2.3, (civ)K02574, (cv) U09813 Human mitochondrial ATP synthase subunit 9, P3 genecopy, mRNA, nuclear gene enc, (cvi) X67951 H.sapiens mRNA forproliferation-associated gene (pag), (cvii) J04611 Human lupus p70 (Ku)autoantigen protein mRNA, complete cds, (cviii) U09578 Homo sapiensMAPKAP kinase (3 pK) mRNA, complete cds, (cix) X53800 Human mRNA formacrophage inflammatory protein-2beta (MIP2beta), (cx) V00599 Tubulin,Beta 2, (cxi) U69126 Human FUSE binding protein 2 (FBP2) mRNA, partialcds, (cxii) X53416 Human mRNA for actin-binding protein (filamin)(ABP-280), (cxiii) U90546 Human butyrophilin (BTF4) mRNA, complete cds,(cxiv) M58459 Human ribosomal protein (RPS4Y) isoform mRNA, completecds, (cxv) M19961 Human cytochrome c oxidase subunit Vb (coxVb) mRNA,complete cds, (cxvi) U65579 Human mitochondrial NADHdehydrogenase-ubiquinone Fe-S protein 8, 23 kDa subunit, (cxvii) X77794H.sapiens mRNA for cyclin G1, (cxviii) M29064 Human hnRNP B1 proteinmRNA, (cxix) D21853 Human mRNA for KIAA0111 gene, complete cds, (cxx)X78687 H.sapiens G9 gene encoding sialidase, (cxxi) X15729 Human mRNAfor nuclear p68 protein, (cxxii) X04828 Human mRNA for G(i) proteinalpha-subunit (adenylate cyclase inhibiting GTP-bind, (cxxiii) L27943Homo sapiens cytidine dearninase (CDA) mRNA, complete cds, (cxxiv)L40391 Homo sapiens (clone s153) mRNA fragment, (cxxv) D42123 Homosapiens mRNA for ESP1/CRP2, complete cds, (cxxvi) X74104 H.sapiens mRNAfor TRAP beta subunit, (cxxvii) M84332 Human ADP-ribosylation factor 1gene, exons 2-5, (cxxviii) L37127 Homo sapiens RNA polymerase II mRNA,complete cds, (cxxix) M92843 H.sapiens zinc finger transcriptionalregulator mRNA, complete cds, (cxxx) U07664 Human HB9 homeobox gene,exons 2 and 3 and complete cds, (cxxxi) L48546 Homo sapiens tuberin(TSC2) gene, exons 38, 39, 40 and 41, (cxxxii) X53586 Human mRNA forintegrin alpha6, (cxxxiii) t D21852 Human mRNA for KIAA0029 gene,partial cds, (cxxxiv) L11066 Human mRNA sequence, (cxxxv) J04444 Humancytochrome c-1 gene, complete cds, (cxxxvi) M95787 Human 22 kDa smoothmuscle protein (SM22) mRNA, complete cds, (cxxxvii) L07517 Mucin 6,Gastric (Gb:L07517), (cxxxviii) X91247 H.sapiens mRNA for thioredoxinreductase, (cxxxix) L11672 Human Kruppel related zinc finger protein(HTF10) mRNA, complete cds, (cxl) U30999 Human (memc) mRNA, 3′UTR,(cxli) U01337 Human Ser/Thr protein kinase (A-RAF-1) gene, complete cds,(cxlii) U28480 Uncoupling Protein Ucp, (cxliii) X12794 Human v-erbArelated ear-2 gene, (cxliv) L22005 Human ubiquitin conjugating enzymemRNA, partial cds, (cxlv) M12886 Human T-cell receptor active beta-chainmRNA, complete cds, (cxlvi) Y08915 H.sapiens mRNA for alpha 4 protein,(cxlvii) M24547 Amyloid Beta (A4) Precursor Protein, Alt. Splice 2,A4(751), (cxlviii) X76717 H.sapiens MT-1l mRNA, (cxlix) M64347 Humannovel growth factor receptor mRNA, 3′ cds, (cl) X05409 Human RNA formitochondrial aldehyde dehydrogenase I ALDH I (EC 1.2.1.3), (cli) D87469Human mRNA for KIAA0279 gene, partial cds, (clii) M58603 Human nuclearfactor kappa-B DNA binding subunit (NF-kappa-B) mRNA, complete cds,(cliii) M76482 Human 130-kD pemphigus vulgaris antigen mRNA, completecds, (cliv) X06323 Human MRL3 mRNA for ribosomal protein L3 homologue (MRL3=mammalian ribosome L, (clv) X78992 H.sapiens ERF-2 mRNA, (clvi)L41351 Homo sapiens prostasin mRNA, complete cds, (clvii) X75342H.sapiens SHB mRNA, (clviii) U83115 Human non-lens beta gamma-crystallinlike protein (AIM1) mRNA, partial cds, (clix) U88629 Human RNApolymerase II elongation factor ELL2, complete cds, (clx) S78825 Id1,(clxi) U28811 Human cysteine-rich fibroblast growth factor receptor(CFR- 1) mRNA, complete cds, (clxii) M58286 Homo sapiens tumor necrosisfactor receptor mRNA, complete cds, (clxiii) D78129 Homo sapiens mRNAfor squalene epoxidase, partial cds, (clxiv) D14874 Homo sapiens mRNAfor adrenomedullin precursor, complete cds, (clxv) Z26317 H.sapiens mRNAfor desmoglein 2, (clxvi) L19267 Homo sapiens 59 protein mRNA, 3′ end,(clxvii) J00120 Proto-Oncogene C-Myc, Alt. Splice 3, Orf 114, (clxviii)U33821 Human tax1-binding protein TXBP151 mRNA, complete cds, (clxix)U52100 Human XMP mRNA, complete cds, (clxx) L31801 Homo sapiensmonocarboxylate transporter 1 (SLC16A1) mRNA, complete cds, (clxxi)L00058 Human (GH) geriline c-myc proto-oncogene, exon 3 and 3′ flank,(clxxii) U52426 Homo sapiens GOK (STIM1) mRNA, complete cds, (clxxiii)M80244 Human E16 mRNA, complete cds, (clxxiv) U56418 Humanlysophosphatidic acid acyltransferase-beta mRNA, complete cds, (clxxv)L38490 Homo sapiens ADP-ribosylation factor mRNA, complete cds, (clxxvi)U14603 Human protein-tyrosine phosphatase (HU-PP-1) mRNA, partialsequence, (clxxvii) L77886 Human protein tyrosine phosphatase mRNA,complete cds, (clxxviii) M38258 Human retinoic acid receptor gamma 1mRNA, complete cds, (clxxix) X89750 H.sapiens mRNA for TGIF protein,(clxxx) D85429 Homo sapiens gene for heat shock protein 40, completecds, (clxxxi) J05211 Desmoplakin I, (clxxxii) M31627 Human X box bindingprotein-1 (XBP-1) mRNA, complete cds, (clxxxiii) X80695 H.sapiens OXA1HsmRNA, (clxxxiv) M54915 Human h-pim-1 protein (h-pim-1) mRNA, completecds, (clxxxv) D83777 Human mRNA for KIAA0193 gene, complete cds,(clxxxvi) D31883 Human mRNA for KIAA0059 gene, complete cds, (clxxxvii)U00968 Human SREBP-1 mRNA, complete cds, (clxxxviii) K03195 Human(HepG2) glucose transporter gene mRNA, complete cds, (clxxxix) D86965Human mRNA for KIAA0210 gene, complete cds, (cxc) Z30643 H.sapiens mRNAfor chloride channel (putative) 2139 bp, (cxci) D14520 Human mRNA forGC-Box binding protein BTEB2, complete cds, (cxcii) D87462 Human mRNAfor KIAA0272 gene, partial cds, (cxciii) X80692 H.sapiens ERK3 mRNA,(cxciv) X90858 H.sapiens mRNA for uridine phosphorylase, (cxcv) M57763Human ADP-ribosylation factor (hARF6) mRNA, complete cds, (cxcvi) X92720H.sapiens mRNA for phosphoenolpyruvate carboxykinase, (cxcvii) M81601Human transcription elongation factor (SII) mRNA, complete cds,(cxcviii) X52611 Human mRNA for transcription factor AP-2, (cxcix)U09587 Human glycyl-tRNA synthetase mRNA, complete cds, (cc) U14550Human sialyltransferase SThM (sthm) mRNA, complete cds, (cci) D90209Human mRNA for DNA binding protein TAXREB67, (ccii) X77366 H.sapiensHBZ17 mRNA, (cciii) X76534 H.sapiens NMB mRNA, (cciv) U37519 Humanaldehyde dehydrogenase (ALDH8) mRNA, complete cds, (ccv) M83667 HumanNF-IL6-beta protein mRNA, complete cds, (ccvi) U53347 Human neutralamino acid transporter B mRNA, complete cds, (ccvii) L09229 Humanlong-chain acyl-coenzyme A synthetase (FACL1) mRNA, complete cds,(ccviii) S73591 brain-expressed HHCPA78 homolog [human, HL-60 acutepromyelocytic leukemia cells, (ccix) M13929 Human c-myc-P64 mRNA,initiating from promoter P0, (HLmyc2.5) partial cds, (ccx) M55268 Humancasein kinase II alpha′ subunit mRNA, complete cds, (ccxi) M77836 Humanpyrroline 5-carboxylate reductase mRNA, complete cds, (ccxii)HG2724-HT2820_at S75762 Oncogene Tls/Chop, Fusion Activated, (ccxiii)U72066 Homo sapiens CtBP interacting protein CtIP (CtIP) mRNA, completecds, (ccxiv) U42031 Human 54 kDa progesterone receptor-associatedimmunophilin FKBP54 mRNA, partial, (ccxv) M27396 Human asparaginesynthetase mRNA, complete cds, (ccxvi) X01630 Human mRNA forargininosuccinate synthetase, (ccxvii) D32050 Human mRNA for alanyl-tRNAsynthetase, complete cds, (ccxviii) M90656 Human gamma-glutamylcysteinesynthetase (GCS) mRNA, complete cds, (ccxix) J04102 Humanerythroblastosis virus oncogene homolog 2 (ets-2) mRNA, complete cds,and (ccxx) X69111 H.sapiens HLH 1R21 mRNA for helix-loop-helix protein.106. A screening method for the detection of a compound that modulates aresponse of a cell to ultraviolet radiation exposure, the response beingan altered pattern of expression determined by gene expression arrayanalysis, comprising: (a) contacting the cell with the compound; (b)exposing the cell to ultraviolet radiation that would otherwise induceinduce the response; and (c) measuring the levels of a plurality of RNAmolecules in the cell for at least one time point after ultravioletradiation exposure by gene array expression analysis; and wherein achange in the response of the cell to ultraviolet radiation exposureindicates that the compound modulates the response of the cell toultraviolet radiation exposure.
 107. A screening method for thedetection of a compound that modulates a response of a cell toultraviolet radiation exposure, the response being an altered pattern ofexpression determined by gene expression array analysis, comprising: (a)contacting the cell with the compound; (b) exposing the cell toultraviolet radiation that would otherwise induce the response; and (c)measuring the levels of a plurality of proteins in the cell for at leastone time point after ultraviolet radiation exposure by gene arrayexpression analysis; and wherein a change in the response of the cell toultraviolet radiation exposure indicates that the compound modulates theresponse of the cell to ultraviolet radiation exposure.
 108. Apharmaceutical composition for modulating the response of a cell toultraviolet radiation exposure, the response being an altered pattern ofexpression determined by gene expression array analysis, comprising: (a)a compound in sufficient quantity to modulate the response of the cellto ultraviolet radiation exposure; and (b) a pharmaceutically acceptablecarrier.